Version 1
: Received: 24 October 2024 / Approved: 25 October 2024 / Online: 25 October 2024 (13:31:11 CEST)
How to cite:
Pimenta, L. F.; Federighi Baisi Chagas, E.; Haber, J. F. D. S.; Menegucci, T.; Quesada, K.; Zutin, P.; Zutin, T. L. M.; Cressoni Araújo, A.; Detregiachi, C. R. P.; Lopes, E.; Laurindo, L. F.; Barbalho, S. M.; Guiguer, E. L. Vitamin D Levels on Glycemic Control, Lipid Profile, and Apolipoprotein in Children and Adolescents with Type 1 Diabetes Mellitus. Preprints2024, 2024102044. https://doi.org/10.20944/preprints202410.2044.v1
Pimenta, L. F.; Federighi Baisi Chagas, E.; Haber, J. F. D. S.; Menegucci, T.; Quesada, K.; Zutin, P.; Zutin, T. L. M.; Cressoni Araújo, A.; Detregiachi, C. R. P.; Lopes, E.; Laurindo, L. F.; Barbalho, S. M.; Guiguer, E. L. Vitamin D Levels on Glycemic Control, Lipid Profile, and Apolipoprotein in Children and Adolescents with Type 1 Diabetes Mellitus. Preprints 2024, 2024102044. https://doi.org/10.20944/preprints202410.2044.v1
Pimenta, L. F.; Federighi Baisi Chagas, E.; Haber, J. F. D. S.; Menegucci, T.; Quesada, K.; Zutin, P.; Zutin, T. L. M.; Cressoni Araújo, A.; Detregiachi, C. R. P.; Lopes, E.; Laurindo, L. F.; Barbalho, S. M.; Guiguer, E. L. Vitamin D Levels on Glycemic Control, Lipid Profile, and Apolipoprotein in Children and Adolescents with Type 1 Diabetes Mellitus. Preprints2024, 2024102044. https://doi.org/10.20944/preprints202410.2044.v1
APA Style
Pimenta, L. F., Federighi Baisi Chagas, E., Haber, J. F. D. S., Menegucci, T., Quesada, K., Zutin, P., Zutin, T. L. M., Cressoni Araújo, A., Detregiachi, C. R. P., Lopes, E., Laurindo, L. F., Barbalho, S. M., & Guiguer, E. L. (2024). Vitamin D Levels on Glycemic Control, Lipid Profile, and Apolipoprotein in Children and Adolescents with Type 1 Diabetes Mellitus. Preprints. https://doi.org/10.20944/preprints202410.2044.v1
Chicago/Turabian Style
Pimenta, L. F., Sandra M. Barbalho and Elen Landgraf Guiguer. 2024 "Vitamin D Levels on Glycemic Control, Lipid Profile, and Apolipoprotein in Children and Adolescents with Type 1 Diabetes Mellitus" Preprints. https://doi.org/10.20944/preprints202410.2044.v1
Abstract
Background/Objectives: Type 1 Diabetes Mellitus (T1DM) is the reduction or non-production of insulin. As T1DM increases cardiovascular risk, in addition to glycemic control, the monitoring of other risk factors, such as lipid profile, has gained attention. Vitamin D deficiency has been associated with the pathophysiology of T1DM, metabolic syndrome, and cardiovascular diseases. This study investigated the relationship between vitamin D, glycemic control, and lipid profiles in children and adolescents with T1DM. Methods: This observational study consisted of 81 patients with T1DM. Laboratory test data were collected to determine the lipid profile. Glycated hemoglobin (HbA1c) and fasting glucose levels assessed glycemic control. Results: A significant association was observed between serum vitamin D levels and a pubertal stage and a moderate negative correlation between vitamin D, age, and HbA1c. There is a negative correlation between vitamin D levels and age, as well as with HbA1c, and a positive correlation of HbA1c with glucose, total cholesterol, triglycerides, Low-density lipoprotein (LDL-c), non-HDL cholesterol (non-HDL cholesterol), apolipoprotein B (apoB), and the apolipoprotein B/apolipoprotein A ratio. Finally, the study indicated that vitamin D levels, insulin administration method, and total cholesterol, when considered together, explained approximately 43.6% of the observed variation in HbA1c, highlighting the complex interdependence of these factors in regulating glycemia. Conclusions: Our results show that Vitamin D levels are associated with glycemic control and other biochemical parameters and its control can bring benefits to the patient with T1DM.
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
