Xu, H.; Yang, Y.; Li, F.; Yang, Y. Pd-Catalyzed Aromatic Dual C-H Acylations and Intramolecular Cyclization: Access to Quinoline substituted Hydroxyl Isoindolones. Preprints2024, 2024102049. https://doi.org/10.20944/preprints202410.2049.v1
APA Style
Xu, H., Yang, Y., Li, F., & Yang, Y. (2024). Pd-Catalyzed Aromatic Dual C-H Acylations and Intramolecular Cyclization: Access to Quinoline substituted Hydroxyl Isoindolones. Preprints. https://doi.org/10.20944/preprints202410.2049.v1
Chicago/Turabian Style
Xu, H., Fei Li and Yuzhu Yang. 2024 "Pd-Catalyzed Aromatic Dual C-H Acylations and Intramolecular Cyclization: Access to Quinoline substituted Hydroxyl Isoindolones" Preprints. https://doi.org/10.20944/preprints202410.2049.v1
Abstract
A palladium-catalyzed aromatic dual C-H acylations followed with intramolecular cyclizations have been developed by the assistance of bidentate N-(quinolin-8-yl)benzamide. This tandem process involves the formation of three new chemical bonds, providing access to novel quinoline substituted hydroxyl isoindolones skeleton under simple reaction conditions. The deuterium-labeled competition reaction has revealed that C-H bond cleavage is the turnover limiting step.
Chemistry and Materials Science, Organic Chemistry
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