Preprint Review Version 1 This version is not peer-reviewed

A Modern View of Placebo Interventions: From Comparative Clinical Trials to Novel Therapies to Quantum Tunnelling

Version 1 : Received: 25 October 2024 / Approved: 26 October 2024 / Online: 28 October 2024 (13:40:23 CET)

How to cite: Niazi, S. K. A Modern View of Placebo Interventions: From Comparative Clinical Trials to Novel Therapies to Quantum Tunnelling. Preprints 2024, 2024102073. https://doi.org/10.20944/preprints202410.2073.v1 Niazi, S. K. A Modern View of Placebo Interventions: From Comparative Clinical Trials to Novel Therapies to Quantum Tunnelling. Preprints 2024, 2024102073. https://doi.org/10.20944/preprints202410.2073.v1

Abstract

Placebo effects are acknowledged and no longer considered inert, as they can trigger neural and organic responses working through circuits involving the rostral anterior cingulate cortex, pontine nucleus, and cerebellum. Recent findings of quantum tunneling have expanded the possible functions of placebo interventions that may explain the rigidity of belief systems and functionality of homeopathy, opening a new chapter of the future of medicine, drawn from the prefrontal cortex, amygdala, anterior cingulate cortex, and striatum. The choice of current interventions, such as psychedelic substances, SSRIs, TMS, and DBS, can be expanded as our knowledge about the placebo intervention improves. At the same time, we need to understand the pros and cons of placebo-controlled clinical trials to ensure that stereotyped clinical trial designs do not hamper new drug development.

Keywords

Placebo trials; pain management; belief systems; organic changes; quantum tunneling; therapeutic applications

Subject

Medicine and Pharmacology, Clinical Medicine

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