Version 1
: Received: 25 October 2024 / Approved: 26 October 2024 / Online: 28 October 2024 (14:47:10 CET)
How to cite:
Aljboor, G. S.; Radoi, M. P.; Toader, C.; Covache-Busuioc, R. A.; Papacocea, M. T. Hypopituitarism Associated with Non-Traumatic Subarachnoid Haemorrhage: A Narrative Review. Preprints2024, 2024102077. https://doi.org/10.20944/preprints202410.2077.v1
Aljboor, G. S.; Radoi, M. P.; Toader, C.; Covache-Busuioc, R. A.; Papacocea, M. T. Hypopituitarism Associated with Non-Traumatic Subarachnoid Haemorrhage: A Narrative Review. Preprints 2024, 2024102077. https://doi.org/10.20944/preprints202410.2077.v1
Aljboor, G. S.; Radoi, M. P.; Toader, C.; Covache-Busuioc, R. A.; Papacocea, M. T. Hypopituitarism Associated with Non-Traumatic Subarachnoid Haemorrhage: A Narrative Review. Preprints2024, 2024102077. https://doi.org/10.20944/preprints202410.2077.v1
APA Style
Aljboor, G. S., Radoi, M. P., Toader, C., Covache-Busuioc, R. A., & Papacocea, M. T. (2024). Hypopituitarism Associated with Non-Traumatic Subarachnoid Haemorrhage: A Narrative Review. Preprints. https://doi.org/10.20944/preprints202410.2077.v1
Chicago/Turabian Style
Aljboor, G. S., Razvan Adrian Covache-Busuioc and Marius Toma Papacocea. 2024 "Hypopituitarism Associated with Non-Traumatic Subarachnoid Haemorrhage: A Narrative Review" Preprints. https://doi.org/10.20944/preprints202410.2077.v1
Abstract
Background: Hypopituitarism is a potentially serious but often underdiagnosed condition that can occur following non-traumatic subarachnoid hemorrhage (SAH). The condition is characterized by the partial or complete deficiency of one or more pituitary hormones, leading to a range of clinical manifestations that may complicate the recovery process. This narrative review aims to synthesize the current literature on the prevalence, pathophysiology, and clinical implications of hypopituitarism associated with non-traumatic SAH. Methods: A comprehensive review of the literature was conducting by authors using databases such as PubMed, MEDLINE, and Scopus, focusing on studies published in the last two decades. Studies were selected based on their relevance to the topic, with an emphasis on those that reported on the prevalence, diagnostic approaches, pathophysiological mechanisms, and clinical outcomes of hypopituitarism post-SAH. Results: The review revealed a wide variability in the reported prevalence of hypopituitarism following non-traumatic SAH, ranging from 14% to 92.3%, depending on the diagnostic criteria, timing of assessment, and hormonal axes evaluated. Commonly affected hormones include growth hormone, gonadotropins, and cortisol. The pathophysiology of hypopituitarism in this context is multifactorial, involving ischemic damage, inflammation, and direct mechanical injury to the hypothalamic-pituitary axis. While some studies suggest a link between hypopituitarism and adverse clinical outcomes, the evidence remain inconclusive, highlighting the need for standardized diagnostic protocols and longitudinal studies. Conclusion: Hypopituitarism is a prevalent but often overlooked complication of non-traumatic SAH, with significant potential implications for long-term health outcomes. Routine endocrine evaluation and management of pituitary deficiencies are recommended to improve patient care. Future research should focus on refining diagnostic criteria, elucidating the underlying mechanisms, and evaluating the long-term impact of hormone replacement therapy in this patient population.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
