Version 1
: Received: 26 October 2024 / Approved: 27 October 2024 / Online: 28 October 2024 (13:24:10 CET)
How to cite:
Panov, A. V.; Mayorov, V. I.; Dikalov, S. I. Role of Fatty Acids β-Oxidation in the Metabolic Interactions Between Organs. Preprints2024, 2024102128. https://doi.org/10.20944/preprints202410.2128.v1
Panov, A. V.; Mayorov, V. I.; Dikalov, S. I. Role of Fatty Acids β-Oxidation in the Metabolic Interactions Between Organs. Preprints 2024, 2024102128. https://doi.org/10.20944/preprints202410.2128.v1
Panov, A. V.; Mayorov, V. I.; Dikalov, S. I. Role of Fatty Acids β-Oxidation in the Metabolic Interactions Between Organs. Preprints2024, 2024102128. https://doi.org/10.20944/preprints202410.2128.v1
APA Style
Panov, A. V., Mayorov, V. I., & Dikalov, S. I. (2024). Role of Fatty Acids β-Oxidation in the Metabolic Interactions Between Organs. Preprints. https://doi.org/10.20944/preprints202410.2128.v1
Chicago/Turabian Style
Panov, A. V., Vladimir I. Mayorov and Sergey I. Dikalov. 2024 "Role of Fatty Acids β-Oxidation in the Metabolic Interactions Between Organs" Preprints. https://doi.org/10.20944/preprints202410.2128.v1
Abstract
In recent decades, several discoveries have been made that force us to reconsider old ideas about mitochondria and energy metabolism in the light of these discoveries. In this review, we discuss metabolic interaction between various organs, metabolic significance of the primary substrates and their metabolic pathways, namely aerobic glycolysis, lactate shuttling, and fatty acids β-oxidation. We rely on the new ideas about the supramolecular structure of the mitochondrial respiratory chain (respirasome), the necessity of supporting substrates for fatty acids β-oxidation, and the reverse electron transfer via succinate dehydrogenase during β-oxidation. We conclude that ATP production during fatty acid β-oxidation has its upper limits and thus cannot support high energy demands alone. Meanwhile, β-oxidation creates conditions that significantly accelerate the cycle: glucose-aerobic glycolysis-lactate-gluconeogenesis-glucose. Therefore, glycolytic ATP production becomes an important energy source in high energy demand. In addition, lactate serves as a mitochondrial substrate after converting to pyruvate + H+ by the mitochondrial lactate dehydrogenase. All coupled metabolic pathways are irreversible, and the enzymes are organized into multienzyme structures.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
