Identification of New Polyacetylenes from Dendropanax morbifera with PPAR-α Activity Study
How to cite: Piao, D.; Youn, I.; Huynh, T.-H.; Kim, H. W.; Noh, S. G.; Chung, H. Y.; Oh, D.-C.; Seo, E. K. Identification of New Polyacetylenes from Dendropanax morbifera with PPAR-α Activity Study. Preprints 2024, 2024102138. https://doi.org/10.20944/preprints202410.2138.v1 Piao, D.; Youn, I.; Huynh, T.-H.; Kim, H. W.; Noh, S. G.; Chung, H. Y.; Oh, D.-C.; Seo, E. K. Identification of New Polyacetylenes from Dendropanax morbifera with PPAR-α Activity Study. Preprints 2024, 2024102138. https://doi.org/10.20944/preprints202410.2138.v1
Abstract
Dendropanax morbifera Leveille is a traditional medicine used to treat migraine headache and dysmenorrhea. In this study, a new phenolic glycoside, morbiferoside A (1), and three polyacetylenes, methyl (10E,9R,16R)-16-acetoxy-9-hydroxyoctadeca-10,17-dien-12,14-diynoate (2), methyl (10E,9R,16S)-9,16-dihydroxyoctadeca-10-en-12,14-diynoate (3), and methyl (10Z,9R,16S)-9,16-dihydroxyoctadeca-10,17-dien-12,14-diynoate (4), were isolated from the aerial parts of D. morbifera, together with seven known compounds (5–11). Importantly, the isolates, 7 and 9 were found in the family Araliaceae for the first time in this study. Compounds 1−11 were evaluated for their binding affinity to AMPK and CTSS receptors using in silico docking simulations. Only compound 8 increased the protein expression levels of PPAR-α, Sirt1, and AMPK when administered to HepG2 cells as a PPAR-α agonist. On the other hand, 8 did not produce any significant reduction in CTSS activity. This study could pave the way for the discovery of novel treatments from D. morbifera targeting PPAR-α and AMPK.
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