Version 1
: Received: 25 October 2024 / Approved: 25 October 2024 / Online: 28 October 2024 (13:35:02 CET)
How to cite:
Voros, C.; Mavrogianni, D.; Stavros, S.; Papamentzelopoulou, M.; Dimitroulia, E.; Doumplis, D.; Mathiopoulos, D.; Loutradis, D. CART (Cocaine- and Amphetamine-Regulated Transcript): A New Identified Intrafollicular Mediator in Ovulation Induction Protocols. Preprints2024, 2024102146. https://doi.org/10.20944/preprints202410.2146.v1
Voros, C.; Mavrogianni, D.; Stavros, S.; Papamentzelopoulou, M.; Dimitroulia, E.; Doumplis, D.; Mathiopoulos, D.; Loutradis, D. CART (Cocaine- and Amphetamine-Regulated Transcript): A New Identified Intrafollicular Mediator in Ovulation Induction Protocols. Preprints 2024, 2024102146. https://doi.org/10.20944/preprints202410.2146.v1
Voros, C.; Mavrogianni, D.; Stavros, S.; Papamentzelopoulou, M.; Dimitroulia, E.; Doumplis, D.; Mathiopoulos, D.; Loutradis, D. CART (Cocaine- and Amphetamine-Regulated Transcript): A New Identified Intrafollicular Mediator in Ovulation Induction Protocols. Preprints2024, 2024102146. https://doi.org/10.20944/preprints202410.2146.v1
APA Style
Voros, C., Mavrogianni, D., Stavros, S., Papamentzelopoulou, M., Dimitroulia, E., Doumplis, D., Mathiopoulos, D., & Loutradis, D. (2024). CART (Cocaine- and Amphetamine-Regulated Transcript): A New Identified Intrafollicular Mediator in Ovulation Induction Protocols. Preprints. https://doi.org/10.20944/preprints202410.2146.v1
Chicago/Turabian Style
Voros, C., Dimitris Mathiopoulos and Dimitrios Loutradis. 2024 "CART (Cocaine- and Amphetamine-Regulated Transcript): A New Identified Intrafollicular Mediator in Ovulation Induction Protocols" Preprints. https://doi.org/10.20944/preprints202410.2146.v1
Abstract
The present study investigates the relationship between cocaine- and amphetamine-regulated transcript (CART) expression, leptin, and hormone profiles (progesterone, testosterone, androstenedione, estradiol, FSH, and hCG) across four ovulation induction protocols (HMG, HMG/hCG, rFSH, and rFSH/hCG), as well as the association between FSH receptor (FSHR) Ser680Asn polymorphisms, CART expression, and IVF outcomes. Data were acquired from 94 women who underwent controlled ovarian stimulation (COS). The outcomes showed no significant variations in BMI between the four stimulation protocols (p-values ranged from 0.244 to 0.909). CART expression had no significant correlation with hormone levels in the entire cohort (progesterone, testosterone, androstenedione, FSH, hCG, and estradiol; p > 0.05). However, CART levels were shown to be adversely linked with the number of follicles >12 mm (r = -0.251, p = 0.018), total oocytes (r = -0.247, p = 0.019), and oocyte maturity (r = -0.212, p = 0.048). A significant negative association was also revealed between CART expression and the thyroid hormone T3 (r = -0.319, p = 0.048). In terms of FSHR polymorphisms, the SER/SER genotype was linked to greater CART levels (mean 4.198 ± 2.257) than the SER/ASN and ASN/ASN groups (p = 0.031). These data indicate that CART expression and FSHR polymorphisms may affect ovarian response and oocyte quality in IVF patients.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
