Version 1
: Received: 28 October 2024 / Approved: 29 October 2024 / Online: 29 October 2024 (06:20:05 CET)
How to cite:
Cao, Z.; Ding, W. The Principle of Self-Organization in Multicellular Organisms—Fuzzy Regulation of Differentiation and Dedifferentiation. Preprints2024, 2024102255. https://doi.org/10.20944/preprints202410.2255.v1
Cao, Z.; Ding, W. The Principle of Self-Organization in Multicellular Organisms—Fuzzy Regulation of Differentiation and Dedifferentiation. Preprints 2024, 2024102255. https://doi.org/10.20944/preprints202410.2255.v1
Cao, Z.; Ding, W. The Principle of Self-Organization in Multicellular Organisms—Fuzzy Regulation of Differentiation and Dedifferentiation. Preprints2024, 2024102255. https://doi.org/10.20944/preprints202410.2255.v1
APA Style
Cao, Z., & Ding, W. (2024). The Principle of Self-Organization in Multicellular Organisms—Fuzzy Regulation of Differentiation and Dedifferentiation. Preprints. https://doi.org/10.20944/preprints202410.2255.v1
Chicago/Turabian Style
Cao, Z. and Weidong Ding. 2024 "The Principle of Self-Organization in Multicellular Organisms—Fuzzy Regulation of Differentiation and Dedifferentiation" Preprints. https://doi.org/10.20944/preprints202410.2255.v1
Abstract
The gene sets of the two cells produced by each division of the fertilized egg are different, and these differences gradually accumulate. When the similarity between a certain cell and a certain type of cell is below a threshold, the differentiation ability in that direction is lost. When all cells can only have one developmental direction, the expression of zygotic genes is turned on. When a stem cell differentiates, it first divides into two cells. One of two cells, similar to the next level cell, becomes the next level cell, while the other, similar to the mother cell, continues to become the other stem cell. When a cell undergoes dedifferentiation, it expresses a group of genes. When the gene set is similar to the upper level stem cell, the cell undergoes dedifferentiation and becomes the upper level stem cell.
Keywords
gene regulation; embryonic development; cell differentiation; mathematical model
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
