PreprintArticleVersion 1This version is not peer-reviewed
D-Dimers and MPO Are No Suitable Biomarkers for Application in Abdominal Aortic Aneurysm (AAA) Surveillance in a Real-World Setting of Vascular Surgery Patients
Version 1
: Received: 28 October 2024 / Approved: 29 October 2024 / Online: 29 October 2024 (06:23:02 CET)
How to cite:
Siegrist, H.; Spieler, A.; Peters, A. S.; Passek, K. H.; Boeckler, D.; Dihlmann, S. D-Dimers and MPO Are No Suitable Biomarkers for Application in Abdominal Aortic Aneurysm (AAA) Surveillance in a Real-World Setting of Vascular Surgery Patients. Preprints2024, 2024102260. https://doi.org/10.20944/preprints202410.2260.v1
Siegrist, H.; Spieler, A.; Peters, A. S.; Passek, K. H.; Boeckler, D.; Dihlmann, S. D-Dimers and MPO Are No Suitable Biomarkers for Application in Abdominal Aortic Aneurysm (AAA) Surveillance in a Real-World Setting of Vascular Surgery Patients. Preprints 2024, 2024102260. https://doi.org/10.20944/preprints202410.2260.v1
Siegrist, H.; Spieler, A.; Peters, A. S.; Passek, K. H.; Boeckler, D.; Dihlmann, S. D-Dimers and MPO Are No Suitable Biomarkers for Application in Abdominal Aortic Aneurysm (AAA) Surveillance in a Real-World Setting of Vascular Surgery Patients. Preprints2024, 2024102260. https://doi.org/10.20944/preprints202410.2260.v1
APA Style
Siegrist, H., Spieler, A., Peters, A. S., Passek, K. H., Boeckler, D., & Dihlmann, S. (2024). D-Dimers and MPO Are No Suitable Biomarkers for Application in Abdominal Aortic Aneurysm (AAA) Surveillance in a Real-World Setting of Vascular Surgery Patients. Preprints. https://doi.org/10.20944/preprints202410.2260.v1
Chicago/Turabian Style
Siegrist, H., Dittmar Boeckler and Susanne Dihlmann. 2024 "D-Dimers and MPO Are No Suitable Biomarkers for Application in Abdominal Aortic Aneurysm (AAA) Surveillance in a Real-World Setting of Vascular Surgery Patients" Preprints. https://doi.org/10.20944/preprints202410.2260.v1
Abstract
There is currently no clinically valid biomarker for predicting the growth and prognosis of abdominal aortic aneurysms (AAA). The most promising candidates with highest diagnostic values are plasma D-dimers and markers of activated neutrophils, i.e. myeloperoxidase (MPO) or cell-free DNA. So far, case-control studies on these markers were almost exclusively performed by using healthy individuals for control. To validate the value of these markers in the clinical setting of a vascular surgery department, we analysed the diagnostic and prognostic potential of plasma D-dimers and MPO in 177 AAA patients versus 138 non-AAA patients with different vascular diseases. Significantly elevated levels of D-dimers were recorded for AAA patients compared with non-AAA patients, although the difference between the two groups was significantly smaller than in other studies comparing AAA patients with healthy controls. Surprisingly, MPO levels were significantly higher in non-AAA patients than in AAA patients. After adjusting for the confounding factors sex, peripheral artery disease (PAD) and internal carotid stenosis in multivariate regression models, neither D-dimers nor MPO remained independent correlates of AAA. In contrast, D-dimer plasma levels correlated well with the maximal aortic diameter. Combined analysis of D-dimers and circulating cell-free DNA levels derived from a previous study, failed to improve the predictive values for the maximal aortic diameter. In conclusion, our data show that D-dimers and MPO are no suitable biomarkers for monitoring AAA in a real-world setting of mixed vascular surgery patients.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
