Version 1
: Received: 28 October 2024 / Approved: 29 October 2024 / Online: 29 October 2024 (17:03:24 CET)
How to cite:
Mochel, J.; Ward, J. Treatment of Canine Myxomatous Mitral Valve Disease:Current and Future Approaches. Preprints2024, 2024102323. https://doi.org/10.20944/preprints202410.2323.v1
Mochel, J.; Ward, J. Treatment of Canine Myxomatous Mitral Valve Disease:Current and Future Approaches. Preprints 2024, 2024102323. https://doi.org/10.20944/preprints202410.2323.v1
Mochel, J.; Ward, J. Treatment of Canine Myxomatous Mitral Valve Disease:Current and Future Approaches. Preprints2024, 2024102323. https://doi.org/10.20944/preprints202410.2323.v1
APA Style
Mochel, J., & Ward, J. (2024). Treatment of Canine Myxomatous Mitral Valve Disease:Current and Future Approaches. Preprints. https://doi.org/10.20944/preprints202410.2323.v1
Chicago/Turabian Style
Mochel, J. and Jessica Ward. 2024 "Treatment of Canine Myxomatous Mitral Valve Disease:Current and Future Approaches" Preprints. https://doi.org/10.20944/preprints202410.2323.v1
Abstract
Myxomatous mitral valve disease (MMVD) is a leading cause of cardiac morbidity and mortality in dogs, requiring targeted intervention at various stages of disease progression. MMVD is characterized by thickening of the mitral valve leaflets, leading to mitral regurgitation and cardiac remodeling. This progressive disease impairs valve function, causing volume overload in the left atrium and ventricle, which can eventually lead to congestive heart failure. MMVD involves complex mechanisms, including genetic predisposition, neurohormonal activation, and mechanical stress on the valve. Thickened valve leaflets fail to seal properly during systole, resulting in mitral regurgitation and increased left atrial pressure. This triggers compensatory mechanisms like activation of the renin-angiotensin-aldosterone system (RAAS), contributing to further cardiac remodeling. Chronic RAAS activation results in fluid retention, vasoconstriction, and fibrosis, all of which can worsen heart failure. This mini-review provides an overview of current therapeutic strategies for the management of MMVD and discusses preliminary findings from our consortium regarding the preclinical and clinical efficacy of the sodium-glucose co-transporter type-2 (SGLT-2) inhibitor, dapagliflozin, in dogs.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
