Version 1
: Received: 29 October 2024 / Approved: 29 October 2024 / Online: 29 October 2024 (14:36:16 CET)
How to cite:
Gregnani, M. F.; Martins, L.; Fogel, W. A. Mechanistic Insights into the Interaction of Kinin and Histamine H2 Receptor Pathways in Oxidative Stress. Preprints2024, 2024102335. https://doi.org/10.20944/preprints202410.2335.v1
Gregnani, M. F.; Martins, L.; Fogel, W. A. Mechanistic Insights into the Interaction of Kinin and Histamine H2 Receptor Pathways in Oxidative Stress. Preprints 2024, 2024102335. https://doi.org/10.20944/preprints202410.2335.v1
Gregnani, M. F.; Martins, L.; Fogel, W. A. Mechanistic Insights into the Interaction of Kinin and Histamine H2 Receptor Pathways in Oxidative Stress. Preprints2024, 2024102335. https://doi.org/10.20944/preprints202410.2335.v1
APA Style
Gregnani, M. F., Martins, L., & Fogel, W. A. (2024). Mechanistic Insights into the Interaction of Kinin and Histamine H2 Receptor Pathways in Oxidative Stress. Preprints. https://doi.org/10.20944/preprints202410.2335.v1
Chicago/Turabian Style
Gregnani, M. F., Leonardo Martins and Wieslawa Agnieszka Fogel. 2024 "Mechanistic Insights into the Interaction of Kinin and Histamine H2 Receptor Pathways in Oxidative Stress" Preprints. https://doi.org/10.20944/preprints202410.2335.v1
Abstract
Reactive oxygen species (ROS) encompass various molecular oxygen derivatives naturally produced during aerobic metabolism, including superoxide anion, hydrogen peroxide, and hydroxyl radical. Excessive ROS production leads to oxidative distress, causing cellular damage and contributing to various pathologies, often alongside inflammation. Endogenous sources of ROS include mitochondrial activity and NADPH oxidases. The antioxidant system, comprising enzymes such as superoxide dismutase, peroxiredoxin, and catalase, mitigates ROS-induced damage. This review explores the regulation of ROS by membrane receptors, focusing on B1 and B2 kinin receptors and histamine H2 receptors, which are implicated in vasodilation, angiogenesis, inflammation, and gastric acid secretion. Understanding these interactions provides insights into ROS modulation and its role in disease mechanisms.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
