Preprint Review Version 1 This version is not peer-reviewed

Prospects for Combined Treatment of Non-Small Cell Lung Cancer Using Autologous Activated Lymphocytes

Anastasia Ganina
* ,
Manarbek Askarov
,
Larissa Kozina
,
Madina Karimova
,
Yerzhan Shayakhmetov
,
Perizat Mukhamedzhanova
,
Aigul Brimova
,
Daulet Berikbol
,
Elmira Chuvakova
,
Lina Zaripova
,
Abay Baigenzhin
Version 1 : Received: 29 October 2024 / Approved: 29 October 2024 / Online: 31 October 2024 (09:20:30 CET)

How to cite: Ganina, A.; Askarov, M.; Kozina, L.; Karimova, M.; Shayakhmetov, Y.; Mukhamedzhanova, P.; Brimova, A.; Berikbol, D.; Chuvakova, E.; Zaripova, L.; Baigenzhin, A. Prospects for Combined Treatment of Non-Small Cell Lung Cancer Using Autologous Activated Lymphocytes. Preprints 2024, 2024102431. https://doi.org/10.20944/preprints202410.2431.v1 Ganina, A.; Askarov, M.; Kozina, L.; Karimova, M.; Shayakhmetov, Y.; Mukhamedzhanova, P.; Brimova, A.; Berikbol, D.; Chuvakova, E.; Zaripova, L.; Baigenzhin, A. Prospects for Combined Treatment of Non-Small Cell Lung Cancer Using Autologous Activated Lymphocytes. Preprints 2024, 2024102431. https://doi.org/10.20944/preprints202410.2431.v1

Abstract

This review article explores the significance and prospects of using diverse T-cell variants in the context of combined therapy for lung cancer treatment. Recently, there has been an increase in research focused on understanding the critical role of tumor-specific T-lymphocytes and the potential benefits of autologous T-cell-based treatments for individuals with lung cancer. One promising approach involves intravenous administration of ex vivo-activated autologous lymphocytes to improve the immune status of patients with cancer. Investigations are also exploring the factors that influence the success of T-cell therapy and the methods used to stimulate them. Achieving a comprehensive understanding of the characteristics of activated lymphocytes and deciphering the mechanisms underlying their activation of innate anti-tumor immunity will pave the way for numerous clinical trials and the development of innovative strategies for cancer therapy.

Keywords

lymphocytes; lung cancer; tomotherapy; activation; tumor; immunotherapy; immunosuppression

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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