PreprintArticleVersion 1This version is not peer-reviewed
The Langmuir Monolayer as a Model Membrane System for Studying the Interactions of Poly(butyl Cyanoacrylate) Nanoparticles with Phospholipids at the Air/Water Interface
Version 1
: Received: 30 October 2024 / Approved: 30 October 2024 / Online: 30 October 2024 (15:52:09 CET)
How to cite:
Yordanov, G.; Minkov, I.; Balashev, K. The Langmuir Monolayer as a Model Membrane System for Studying the Interactions of Poly(butyl Cyanoacrylate) Nanoparticles with Phospholipids at the Air/Water Interface. Preprints2024, 2024102482. https://doi.org/10.20944/preprints202410.2482.v1
Yordanov, G.; Minkov, I.; Balashev, K. The Langmuir Monolayer as a Model Membrane System for Studying the Interactions of Poly(butyl Cyanoacrylate) Nanoparticles with Phospholipids at the Air/Water Interface. Preprints 2024, 2024102482. https://doi.org/10.20944/preprints202410.2482.v1
Yordanov, G.; Minkov, I.; Balashev, K. The Langmuir Monolayer as a Model Membrane System for Studying the Interactions of Poly(butyl Cyanoacrylate) Nanoparticles with Phospholipids at the Air/Water Interface. Preprints2024, 2024102482. https://doi.org/10.20944/preprints202410.2482.v1
APA Style
Yordanov, G., Minkov, I., & Balashev, K. (2024). The Langmuir Monolayer as a Model Membrane System for Studying the Interactions of Poly(butyl Cyanoacrylate) Nanoparticles with Phospholipids at the Air/Water Interface. Preprints. https://doi.org/10.20944/preprints202410.2482.v1
Chicago/Turabian Style
Yordanov, G., Ivan Minkov and Konstantin Balashev. 2024 "The Langmuir Monolayer as a Model Membrane System for Studying the Interactions of Poly(butyl Cyanoacrylate) Nanoparticles with Phospholipids at the Air/Water Interface" Preprints. https://doi.org/10.20944/preprints202410.2482.v1
Abstract
Poly(butyl cyanoacrylate) (PBCA) nanoparticles have numerous applications, including drug and gene delivery, molecular imaging, and cancer therapy. To uncover the molecular mechanisms underlying their interactions with cell membranes, we utilized a Langmuir monolayer as a model membrane system. This approach enabled us to investigate the processes of penetration and reorganization of PBCA nanoparticles when deposited in a phospholipid monolayer subphase. Atomic force microscopy (AFM) was employed to visualize Langmuir–Blodgett (LB) films of these nanoparticles. Additionally, we examined the state of a monolayer of Pluronic F68, a stabilizer of PBCA nanoparticles in suspension, by measuring changes in relative surface area and surface potential over time in the barostatic regime following PBCA suspension spreading. Based on these findings, we propose a molecular mechanism for nanoparticle reorganization at the air–water interface.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
