Zhu, W.; Zhang, X.; Wang, D.; Yao, Q.; Ma, G.-L.; Fan, X. Simulator of the Human Intestinal Microbial Ecosystem (SHIME®): Current Developments, Applications and Future Prospects. Preprints2024, 2024102612. https://doi.org/10.20944/preprints202410.2612.v1
APA Style
Zhu, W., Zhang, X., Wang, D., Yao, Q., Ma, G. L., & Fan, X. (2024). Simulator of the Human Intestinal Microbial Ecosystem (SHIME®): Current Developments, Applications and Future Prospects. Preprints. https://doi.org/10.20944/preprints202410.2612.v1
Chicago/Turabian Style
Zhu, W., Guang-Lei Ma and Xiaohui Fan. 2024 "Simulator of the Human Intestinal Microbial Ecosystem (SHIME®): Current Developments, Applications and Future Prospects" Preprints. https://doi.org/10.20944/preprints202410.2612.v1
Abstract
The human gastrointestinal microbiota plays a vital role in maintaining host health and preventing diseases, prompting the creation of simulators to replicate this intricate system. The Simulator of the Human Intestinal Microbial Ecosystem (SHIME®), a multicompartment dynamic simulator, has emerged as a pivotal in vitro model for studying the interactions and interferences within human gut microbiota. The continuous and real-time monitoring hallmarks, along with the programmatically flexible setup, bestow SHIME® mimicking the entire human intestinal ecosystem with high dynamics and stability, allowing the evaluation of various treatments on bowel microbiota in a con-trolled environment. This review outlines recent developments in SHIME technology, highlighting its applications in food and nutritional science, drug development, and gut health research. Additionally, the prospect of SHIME integrating with other advanced technologies is also discussed.
Keywords
Simulator of the Human Intestinal Microbial Ecosystem; SHIME; human gastrointestinal microbiota; gut microbiome; application; food and nutritional science; drug development; gut health
Subject
Medicine and Pharmacology, Pharmacy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
