PreprintArticleVersion 1This version is not peer-reviewed
Comparing Different Montages of Transcranial Direct Current Stimulation in Treating Treatment-Resistant Obsessive–Compulsive Disorder: A Randomized, Single-Blind Clinical Trial
Version 1
: Received: 31 October 2024 / Approved: 31 October 2024 / Online: 1 November 2024 (09:43:43 CET)
How to cite:
Chu, C.-S.; Lin, Y.-Y.; Huang, C. C.-Y.; Chung, Y.-A.; Park, S. Y.; Chang, W.-C.; Chang, C.-C.; Chang, H.-A. Comparing Different Montages of Transcranial Direct Current Stimulation in Treating Treatment-Resistant Obsessive–Compulsive Disorder: A Randomized, Single-Blind Clinical Trial. Preprints2024, 2024110018. https://doi.org/10.20944/preprints202411.0018.v1
Chu, C.-S.; Lin, Y.-Y.; Huang, C. C.-Y.; Chung, Y.-A.; Park, S. Y.; Chang, W.-C.; Chang, C.-C.; Chang, H.-A. Comparing Different Montages of Transcranial Direct Current Stimulation in Treating Treatment-Resistant Obsessive–Compulsive Disorder: A Randomized, Single-Blind Clinical Trial. Preprints 2024, 2024110018. https://doi.org/10.20944/preprints202411.0018.v1
Chu, C.-S.; Lin, Y.-Y.; Huang, C. C.-Y.; Chung, Y.-A.; Park, S. Y.; Chang, W.-C.; Chang, C.-C.; Chang, H.-A. Comparing Different Montages of Transcranial Direct Current Stimulation in Treating Treatment-Resistant Obsessive–Compulsive Disorder: A Randomized, Single-Blind Clinical Trial. Preprints2024, 2024110018. https://doi.org/10.20944/preprints202411.0018.v1
APA Style
Chu, C. S., Lin, Y. Y., Huang, C. C. Y., Chung, Y. A., Park, S. Y., Chang, W. C., Chang, C. C., & Chang, H. A. (2024). Comparing Different Montages of Transcranial Direct Current Stimulation in Treating Treatment-Resistant Obsessive–Compulsive Disorder: A Randomized, Single-Blind Clinical Trial. Preprints. https://doi.org/10.20944/preprints202411.0018.v1
Chicago/Turabian Style
Chu, C., Chuan-Chia Chang and Hsin-An Chang. 2024 "Comparing Different Montages of Transcranial Direct Current Stimulation in Treating Treatment-Resistant Obsessive–Compulsive Disorder: A Randomized, Single-Blind Clinical Trial" Preprints. https://doi.org/10.20944/preprints202411.0018.v1
Abstract
Background: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation for treatment-resistant obsessive-compulsive disorder (OCD). We aim to compare treatment out-comes with newly developed dual-stie cathodal tDCS over the orbitofrontal cortex (OFC) and pre-supplementary motor area (pre-SMA) and two previously reported montages (cerebel-lum-OFC and pre-SMA) in patients with treatment-resistant OCD. Methods: Eighteen OCD pa-tients were randomly allocated to receive twice-daily 2mA/20min sessions for 10 consecutive weekdays with the active cathode placed on the cerebellum-OFC, bilaterally pre-SMA or OFC-pre-SMA tDCS. The primary outcome was the change of the Yale-Brown Obsessive–Compulsive Scale (Y-BOCS). Resting electroencephalogram (EEG) was recorded to obtain the default mode network (DMN) via low resolution electromagnetic tomography. Each patient re-ceived one-week and one-month follow-ups after 2-week stimulation. Results: At the end of stimulation, the Y-BOCS scores in the cerebellum-OFC, pre-SMA, and OFC-pre-SMA tDCS groups (each group, n=6) was decreased 14.15 ± 13.31, 7.4 ± 9.59, and 20.75 ± 8.70 %, respectively but no significant differences were found between groups. In the OFC-pre-SMA tDCS group, OC symptoms significantly decreased by a mean of -20.75% immediately after the 20th tDCS session and the improvement remained 1 week and 1 month after tDCS. For EEG source functional connectivity (FC) analyses, increased FC within the frontal network was found after OFC-pre-SMA tDCS whereas decreased FC within the DMN was observed after cerebellum-OFC tDCS. Conclusions: Dual-site cathodal tDCS over the OFC and pre-SMA might be the promising montage to treat patients with treatment-resistant OCD. Future studies using randomized sham-controlled designs are needed.
Keywords
electroencephalogram; functional connectivity; obsessive-compulsive disorder; pre-supplementary motor area; transcranial direct current stimulation
Subject
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
