Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Molecular Signatures of Aeroallergen Sensitization in Respiratory Allergy: A Comparative Study Across Climate-Matched Populations

Ruperto González-Pérez
* ORCID logo ,
César Alberto Galván-Calle
,
Tania Galán
,
Paloma Poza-Guedes
,
Inmaculada Sánchez-Machín
ORCID logo ,
Oscar Calderon-Llosa
,
Fernando Pineda
ORCID logo
Version 1 : Received: 31 October 2024 / Approved: 1 November 2024 / Online: 1 November 2024 (18:11:22 CET)

How to cite: González-Pérez, R.; Galván-Calle, C. A.; Galán, T.; Poza-Guedes, P.; Sánchez-Machín, I.; Calderon-Llosa, O.; Pineda, F. Molecular Signatures of Aeroallergen Sensitization in Respiratory Allergy: A Comparative Study Across Climate-Matched Populations. Preprints 2024, 2024110030. https://doi.org/10.20944/preprints202411.0030.v1 González-Pérez, R.; Galván-Calle, C. A.; Galán, T.; Poza-Guedes, P.; Sánchez-Machín, I.; Calderon-Llosa, O.; Pineda, F. Molecular Signatures of Aeroallergen Sensitization in Respiratory Allergy: A Comparative Study Across Climate-Matched Populations. Preprints 2024, 2024110030. https://doi.org/10.20944/preprints202411.0030.v1

Abstract

Climate change is significantly altering the dynamics of airborne allergens, affecting their seasonality, allergenicity, and geographic distribution, which correlates with increasing rates of allergic diseases. This study investigates aeroallergen sensitization among populations from Tenerife, Spain, and Lima, Peru—two regions with similar climates but distinct socio-economic conditions. Our findings reveal that Spanish individuals, particularly those with asthma, demonstrate higher sensitization levels to a broader range of allergens, especially mites, with 85% of participants reacting to at least one mite allergen. In contrast, Peruvian patients exhibit a narrower spectrum of sensitization. These results highlight the influence of environmental factors, such as pollution and socioeconomic disparities, on allergen exposure and immune responses. Moreover, the study underscores the necessity for region-specific diagnostic and therapeutic strategies to effectively address these variations. By elucidating the intricate relationship between climate change, environmental factors, and allergen sensitization, this research offers insights into respiratory allergic conditions, advocating for tailored interventions to mitigate their impact across diverse populations.

Keywords

Aerobiology; Exposome; Allergens; Allergic rhinitis; Allergic asthma; Climate change

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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