Preprint Article Version 1 This version is not peer-reviewed

Local Dynamic Stability of Trunk During Gait Can Detect Dynamic Imbalance in Subjects with Episodic Migraine

Stefano Filippo Castiglia
ORCID logo ,
Gabriele Sebastianelli
ORCID logo ,
Chiara Abagnale
,
Francesco Casillo
,
Dante Trabassi
,
Cherubino Di Lorenzo
ORCID logo ,
Lucia Ziccardi
ORCID logo ,
Vincenzo Parisi
,
Antonio Di Renzo
,
Roberto De Icco
,
Cristina Tassorelli
ORCID logo ,
Mariano Serrao
ORCID logo ,
Gianluca Coppola
* ORCID logo
Version 1 : Received: 1 November 2024 / Approved: 1 November 2024 / Online: 4 November 2024 (03:49:44 CET)

How to cite: Castiglia, S. F.; Sebastianelli, G.; Abagnale, C.; Casillo, F.; Trabassi, D.; Di Lorenzo, C.; Ziccardi, L.; Parisi, V.; Di Renzo, A.; De Icco, R.; Tassorelli, C.; Serrao, M.; Coppola, G. Local Dynamic Stability of Trunk During Gait Can Detect Dynamic Imbalance in Subjects with Episodic Migraine. Preprints 2024, 2024110054. https://doi.org/10.20944/preprints202411.0054.v1 Castiglia, S. F.; Sebastianelli, G.; Abagnale, C.; Casillo, F.; Trabassi, D.; Di Lorenzo, C.; Ziccardi, L.; Parisi, V.; Di Renzo, A.; De Icco, R.; Tassorelli, C.; Serrao, M.; Coppola, G. Local Dynamic Stability of Trunk During Gait Can Detect Dynamic Imbalance in Subjects with Episodic Migraine. Preprints 2024, 2024110054. https://doi.org/10.20944/preprints202411.0054.v1

Abstract

Background/Hypothesis: Motion sensitivity symptoms, like dizziness or unsteadiness, are frequently reported as non-headache symptoms of migraine. Postural imbalance has been observed in subjects with vestibular migraine, chronic migraine, and aura. We aimed to assess the ability of largest Lyapunov’s exponent for short time – series (sLLE), which reflects the ability to cope with internal perturbations during gait, to detect differences in local dynamic stability between individuals with migraine without aura (MO) with an episodic pattern and healthy subjects (HS). Methods: Trunk accelerations of 47 MO and 38 HS were recorded during gait using an inertial measurement unit. The discriminative ability of sLLE was assessed through receiver operating characteristics curves and cutoff analysis. Partial correlation analysis was conducted between the clinical and gait variables, excluding the effects of gait speed. Results: MO showed higher sLLE values, and reduced pelvic rotation, pelvic tilt, and stride length values. sLLEML and pelvic rotation showed good ability to discriminate between MO and HS and correlated with the perceived pain, MIgraine Disability Assessment Score, and each other. Conclusions: These findings may provide new insights into the postural balance control mechanism in subjects with MO and introduce the sLLEML as a potential measure of dynamic instability in MO.

Keywords

Motion sensitivity; Lyapunov’s exponent; pelvic rotation; postural balance; accelerometry; movement analysis; headache

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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