Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Calcitonin Gene Related Peptide in Migraine and Tension-Type Headache in Children During Interictal Period

Jadranka Sekelj Fures
* ,
Vlasta Duranovic
,
Jasna Lenicek Krleza
ORCID logo ,
Ana Katusic Bojanac
ORCID logo ,
Lana Loncar
,
Sanja Pejic-Rosko
,
Ivana Dakovic
,
Andrijana Pilon Far
,
Katarina Vulin
,
Andrea Simic Klaric
Version 1 : Received: 1 November 2024 / Approved: 4 November 2024 / Online: 4 November 2024 (16:11:51 CET)

How to cite: Sekelj Fures, J.; Duranovic, V.; Lenicek Krleza, J.; Katusic Bojanac, A.; Loncar, L.; Pejic-Rosko, S.; Dakovic, I.; Pilon Far, A.; Vulin, K.; Simic Klaric, A. Calcitonin Gene Related Peptide in Migraine and Tension-Type Headache in Children During Interictal Period. Preprints 2024, 2024110209. https://doi.org/10.20944/preprints202411.0209.v1 Sekelj Fures, J.; Duranovic, V.; Lenicek Krleza, J.; Katusic Bojanac, A.; Loncar, L.; Pejic-Rosko, S.; Dakovic, I.; Pilon Far, A.; Vulin, K.; Simic Klaric, A. Calcitonin Gene Related Peptide in Migraine and Tension-Type Headache in Children During Interictal Period. Preprints 2024, 2024110209. https://doi.org/10.20944/preprints202411.0209.v1

Abstract

Background/Objectives: Research on calcitonin gene-related peptide (CGRP) in adult migraine is extensive, but its role in childhood migraine remains unclear. This study aimed to evaluate serum CGRP levels in children experiencing migraine and tension-type headache (TTH) during interictal periods, comparing these levels to age-matched healthy controls. Methods: A total of 66 migraine patients, 59 with TTH, and 53 controls were recruited and strat-ified by headache onset age: under 7, 7-12, and over 12 years. CGRP levels were quantified using enzyme-linked immunosorbent assay (ELISA). Results: Migraine patients showed significantly higher serum CGRP levels than both TTH pa-tients and controls (p < 0.001) with no significant difference between the latter two groups. Among migraine patients, those without aura (MO) exhibited higher CGRP levels than those with aura (MA). CGRP levels were lower in MA patients whose headaches began between ages 7-12 compared to subjects with MO, while no significant differences were found in patients whose headaches began after age 12. Conclusions: These findings suggest elevated serum CGRP is indicative of pediatric migraine, with variations based on migraine type and age of onset. The difference in CGRP in preadolescent migraineurs with and without aura suggest that CGRP levels may vary depending on the age and on migraine type.

Keywords

pediatric migraine; pediatric tension-type headache; CGRP

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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