Version 1
: Received: 4 November 2024 / Approved: 5 November 2024 / Online: 5 November 2024 (08:55:18 CET)
How to cite:
Miłek, T.; Grzeczkowicz, A.; Lipko, A.; Mesjasz, M.; Oklesiński, L.; Kwiatkowska, A.; Strawski, M.; Drabik, M.; Granicka, L. H. Oxygenated Layer Coating for Enhancing the Healing Process of Non-Healing Wounds-Case Report. Preprints2024, 2024110279. https://doi.org/10.20944/preprints202411.0279.v1
Miłek, T.; Grzeczkowicz, A.; Lipko, A.; Mesjasz, M.; Oklesiński, L.; Kwiatkowska, A.; Strawski, M.; Drabik, M.; Granicka, L. H. Oxygenated Layer Coating for Enhancing the Healing Process of Non-Healing Wounds-Case Report. Preprints 2024, 2024110279. https://doi.org/10.20944/preprints202411.0279.v1
Miłek, T.; Grzeczkowicz, A.; Lipko, A.; Mesjasz, M.; Oklesiński, L.; Kwiatkowska, A.; Strawski, M.; Drabik, M.; Granicka, L. H. Oxygenated Layer Coating for Enhancing the Healing Process of Non-Healing Wounds-Case Report. Preprints2024, 2024110279. https://doi.org/10.20944/preprints202411.0279.v1
APA Style
Miłek, T., Grzeczkowicz, A., Lipko, A., Mesjasz, M., Oklesiński, L., Kwiatkowska, A., Strawski, M., Drabik, M., & Granicka, L. H. (2024). Oxygenated Layer Coating for Enhancing the Healing Process of Non-Healing Wounds-Case Report. Preprints. https://doi.org/10.20944/preprints202411.0279.v1
Chicago/Turabian Style
Miłek, T., Monika Drabik and Ludomira H. Granicka. 2024 "Oxygenated Layer Coating for Enhancing the Healing Process of Non-Healing Wounds-Case Report" Preprints. https://doi.org/10.20944/preprints202411.0279.v1
Abstract
The ever-increasing problem of chronic, non-healing wound treatment is a challenge in contemporary medicine. The study aims to verify the effect of a designed dressing containing coating involving oxygenating factors on promoting wound healing in all healing phases in a single clinical case. The alginate-based coating, which incorporates the oxygenating factor, was produced. The obtained surface physicochemical features were examined using FTIR and AFM microscopy. The bandage support was modified with elaborated coating and applied to the patients who suffered from chronic wounds (treated with non-modified commercially available bandage) and required treatment at least 3 months before starting the study. During bandage application, the chosen characteristics of the wound healing process were examined. Histological evaluation of granulation tissue confirmed the presence of fibroblasts, hemorrhage, and lymphocytes during the second week of treatment. Moreover, epithelization tissue in the third week of treatment exhibited the presence of keratinocytes. The 100% wound reduction was observed between 3-4 weeks of treatment with modified dressing. The applied coating, which provides a smooth surface of contact with the wound, inducing the remodeling phase in up to 4 weeks of treatment, can be recommended to be developed for hard-to-heal wound treatment.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
