Version 1
: Received: 4 November 2024 / Approved: 5 November 2024 / Online: 6 November 2024 (09:00:17 CET)
How to cite:
Beça, S.; Baños, N.; Borrell, M.; Ruiz-Ortiz, E.; Pérez-Isidro, A.; Cervera, R.; Reverter, J. C.; Tàssies, D.; Espinosa, G. Pregnancy Outcomes in Non-Criteria Obstetric Antiphospholipid Syndrome: Analysis of a Cohort of 91 Patients. Preprints2024, 2024110291. https://doi.org/10.20944/preprints202411.0291.v1
Beça, S.; Baños, N.; Borrell, M.; Ruiz-Ortiz, E.; Pérez-Isidro, A.; Cervera, R.; Reverter, J. C.; Tàssies, D.; Espinosa, G. Pregnancy Outcomes in Non-Criteria Obstetric Antiphospholipid Syndrome: Analysis of a Cohort of 91 Patients. Preprints 2024, 2024110291. https://doi.org/10.20944/preprints202411.0291.v1
Beça, S.; Baños, N.; Borrell, M.; Ruiz-Ortiz, E.; Pérez-Isidro, A.; Cervera, R.; Reverter, J. C.; Tàssies, D.; Espinosa, G. Pregnancy Outcomes in Non-Criteria Obstetric Antiphospholipid Syndrome: Analysis of a Cohort of 91 Patients. Preprints2024, 2024110291. https://doi.org/10.20944/preprints202411.0291.v1
APA Style
Beça, S., Baños, N., Borrell, M., Ruiz-Ortiz, E., Pérez-Isidro, A., Cervera, R., Reverter, J. C., Tàssies, D., & Espinosa, G. (2024). Pregnancy Outcomes in Non-Criteria Obstetric Antiphospholipid Syndrome: Analysis of a Cohort of 91 Patients. Preprints. https://doi.org/10.20944/preprints202411.0291.v1
Chicago/Turabian Style
Beça, S., Dolores Tàssies and Gerard Espinosa. 2024 "Pregnancy Outcomes in Non-Criteria Obstetric Antiphospholipid Syndrome: Analysis of a Cohort of 91 Patients" Preprints. https://doi.org/10.20944/preprints202411.0291.v1
Abstract
Background: The clinical and laboratory features of patients with non-criteria obstetric antiphospholipid syndrome (NC-OAPS), as well as their pregnancy outcomes and ideal treatment are not clearly determined. The aim of this study is to describe the characteristics and outcomes of pregnancies in NC-OAPS and compare them with an obstetric APS (OAPS) cohort. Methods: Retrospective study conducted in a cohort of women referred to a high-risk obstetric unit of a tertiary hospital. Women that were classified as having OAPS or NC-OAPS were included and compared in terms of clinical and laboratory characteristics, management, and subsequent pregnancy outcomes. Results: We identified 107 women with 143 pregnancies, 91 with NC-OAPS and 16 with OAPS. There were no differences in demographic features between both groups. Women with NC-OAPS were more likely to have recurrent implantation failure and were predominantly positive for a single antiphospholipid antibody (aPL) subtype. Both groups were treated similarly (low dose aspirin plus low molecular weight heparin in 87.4% of NC-OAPS and 83.3% of OAPS, p>0.05). Live birth rate (82.4% and 75.0%, respectively, p>0.05) and adverse pregnancy outcomes (31.6% vs 37.5%, p>0.05) in subsequent pregnancies during follow-up were also similar between groups. Conclusions: This study revealed differences in the previous pregnancy morbidity and aPL profiles in women with NC-OAPS and OAPS, although the therapeutic approach and the outcomes of subsequent pregnancies were similar in both groups.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
