Guzzetti, C.; Ibba, A.; Incandela, V.; Loche, S. GH Therapy in Non–Growth Hormone Deficient Children. Preprints2024, 2024110325. https://doi.org/10.20944/preprints202411.0325.v1
APA Style
Guzzetti, C., Ibba, A., Incandela, V., & Loche, S. (2024). GH Therapy in Non–Growth Hormone Deficient Children. Preprints. https://doi.org/10.20944/preprints202411.0325.v1
Chicago/Turabian Style
Guzzetti, C., Valeria Incandela and Sandro Loche. 2024 "GH Therapy in Non–Growth Hormone Deficient Children" Preprints. https://doi.org/10.20944/preprints202411.0325.v1
Abstract
Before 1985 growth hormone (GH) was extracted from human pituitaries, and its therapeutic use was limited to children with severe GH deficiency (GHD). The availability of unlimited amount of recombinant GH (rhGH) allowed to investigate the efficacy of rhGH therapy in a number of con-ditions other than GHD. Nowadays, patients with Turner syndrome, SHOX deficiency, Noonan syndrome, Prader-Willi syndrome, idiopathic short stature, chronic kidney disease, and children born small for gestational age can be treated with rhGH in order to improve adult height. In pa-tients with Prader-Willi syndrome rhGH therapy also improves body composition and cognitive function. Large post-marketing multinational studies in a huge number of pediatric patients demonstrated a good safety profile for rhGH. Recently, long-acting formulations of rhGH have been approved and licensed for GHD, and clinical trials are ongoing for other conditions. In this paper, we will review the use of rhGH for the treatment of children with conditions other than GHD.
Keywords
children; growth hormone; Turner syndrome; SHOX deficiency; Noonan syndrome; small for gestational age; Prader-Willi syndrome; idiopathic short stature; chronic kidney disease; long acting growth hormone
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
