Version 1
: Received: 5 November 2024 / Approved: 6 November 2024 / Online: 7 November 2024 (07:21:50 CET)
How to cite:
Matasariu, D.-R.; Bujor, I.-E.; Mandici, C. E.; Lozneanu, L.; Boiculese, V. L.; Grigore, M.; Oancea, M.; Ursache, A. A. What Unraveled Mysteries Lie in the Interplay of CD44, Vitamin D, and COX-2 in Endometriosis?. Preprints2024, 2024110384. https://doi.org/10.20944/preprints202411.0384.v1
Matasariu, D.-R.; Bujor, I.-E.; Mandici, C. E.; Lozneanu, L.; Boiculese, V. L.; Grigore, M.; Oancea, M.; Ursache, A. A. What Unraveled Mysteries Lie in the Interplay of CD44, Vitamin D, and COX-2 in Endometriosis?. Preprints 2024, 2024110384. https://doi.org/10.20944/preprints202411.0384.v1
Matasariu, D.-R.; Bujor, I.-E.; Mandici, C. E.; Lozneanu, L.; Boiculese, V. L.; Grigore, M.; Oancea, M.; Ursache, A. A. What Unraveled Mysteries Lie in the Interplay of CD44, Vitamin D, and COX-2 in Endometriosis?. Preprints2024, 2024110384. https://doi.org/10.20944/preprints202411.0384.v1
APA Style
Matasariu, D. R., Bujor, I. E., Mandici, C. E., Lozneanu, L., Boiculese, V. L., Grigore, M., Oancea, M., & Ursache, A. A. (2024). What Unraveled Mysteries Lie in the Interplay of CD44, Vitamin D, and COX-2 in Endometriosis?. Preprints. https://doi.org/10.20944/preprints202411.0384.v1
Chicago/Turabian Style
Matasariu, D., Mihaela Oancea and and Alexandra Ursache. 2024 "What Unraveled Mysteries Lie in the Interplay of CD44, Vitamin D, and COX-2 in Endometriosis?" Preprints. https://doi.org/10.20944/preprints202411.0384.v1
Abstract
(1) Background: Our study aimed to examine tissue expression of CD44, vitamin D receptor (VDR), and cyclooxygenase 2 (COX-2) in endometriosis-affected women with and without progestin treatment and to inquire about their implications in the pathogenesis of endometriosis. (2) Methods: A cohort of 60 women diagnosed with endometriosis was divided into two groups, of which 26 received progestin treatment and 34 without treatment. We conducted an immunohistochemical (IHC) analysis of paraffin-embedded endometriosis tissue samples collected post endometriosis surgery. The primary goal was to elucidate VDR, COX-2, and CD44 expression patterns. (3) Results: CD44 evaluation revealed a positive score in 32 (60%) of the untreated cases, and 21 (40%) of the treated ones, but the difference didn’t reach statistical significance. VDR was observed to be higher in the group without treatment, with 32 individuals (88.9%) showing positive expression, compared to 20 individuals (83.33%) in the treatment group. Endometriotic tissue consistently demonstrated uniformly strong membrane positivity for COX-2 in all of our 60 included cases. (4) Conclusions: IHC analysis of VDR, CD44, and COX-2 are supplementary tools for risk stratification and prognostic evaluation in patients diagnosed with endometriosis. Notably, this study highlights the immunological differences between untreated and treated endometriosis.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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