Version 1
: Received: 5 November 2024 / Approved: 6 November 2024 / Online: 7 November 2024 (07:22:09 CET)
How to cite:
Peshin, S.; Balla, M.; Singh, S.; Dharia, A.; Kapadia, C.; Krishnadasan, R. Caught in the Crossfire: A Case of Splenic Infarction Amid G-CSF Therapy in Chronic Myelomonocytic Leukemia. Preprints2024, 2024110388. https://doi.org/10.20944/preprints202411.0388.v1
Peshin, S.; Balla, M.; Singh, S.; Dharia, A.; Kapadia, C.; Krishnadasan, R. Caught in the Crossfire: A Case of Splenic Infarction Amid G-CSF Therapy in Chronic Myelomonocytic Leukemia. Preprints 2024, 2024110388. https://doi.org/10.20944/preprints202411.0388.v1
Peshin, S.; Balla, M.; Singh, S.; Dharia, A.; Kapadia, C.; Krishnadasan, R. Caught in the Crossfire: A Case of Splenic Infarction Amid G-CSF Therapy in Chronic Myelomonocytic Leukemia. Preprints2024, 2024110388. https://doi.org/10.20944/preprints202411.0388.v1
APA Style
Peshin, S., Balla, M., Singh, S., Dharia, A., Kapadia, C., & Krishnadasan, R. (2024). Caught in the Crossfire: A Case of Splenic Infarction Amid G-CSF Therapy in Chronic Myelomonocytic Leukemia. Preprints. https://doi.org/10.20944/preprints202411.0388.v1
Chicago/Turabian Style
Peshin, S., Chirag Kapadia and Ravitharan Krishnadasan. 2024 "Caught in the Crossfire: A Case of Splenic Infarction Amid G-CSF Therapy in Chronic Myelomonocytic Leukemia" Preprints. https://doi.org/10.20944/preprints202411.0388.v1
Abstract
This case report highlights a rare but significant complication associated with the use of granulocyte-colony stimulating factor (G-CSF) therapy, specifically splenic infarction, in a 67-year-old male with chronic myelomonocytic leukemia (CMML) undergoing chemotherapy. G-CSFs, such as Neulasta (pegfilgrastim), are frequently used to prevent febrile neutropenia in cancer patients undergoing myelotoxic chemotherapy. While G-CSF is effective in reducing the risk of neutropenia, its administration has been linked to uncommon but severe complications like splenic infarction and rupture. Our patient, receiving dose-dense chemotherapy with G-CSF support, developed severe abdominal pain midway through treatment. A computed tomography (CT) scan revealed multiple splenic hypodensities consistent with splenic infarction, but no active bleeding. Conservative management was successfully employed, avoiding surgical intervention. This case underscores the need for vigilance when administering G-CSF, particularly in patients at high risk for complications, and contributes to the limited body of literature on G-CSF-induced splenic infarction.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
