Version 1
: Received: 4 November 2024 / Approved: 6 November 2024 / Online: 6 November 2024 (12:15:23 CET)
How to cite:
Bai, S.; Zhang, M.; Tang, S.; Li, M.; Wu, R.; Wan, S.; Chen, L.; Wei, X.; Feng, S. Effects and Impact of Selenium on Human Health, A Review. Preprints2024, 2024110435. https://doi.org/10.20944/preprints202411.0435.v1
Bai, S.; Zhang, M.; Tang, S.; Li, M.; Wu, R.; Wan, S.; Chen, L.; Wei, X.; Feng, S. Effects and Impact of Selenium on Human Health, A Review. Preprints 2024, 2024110435. https://doi.org/10.20944/preprints202411.0435.v1
Bai, S.; Zhang, M.; Tang, S.; Li, M.; Wu, R.; Wan, S.; Chen, L.; Wei, X.; Feng, S. Effects and Impact of Selenium on Human Health, A Review. Preprints2024, 2024110435. https://doi.org/10.20944/preprints202411.0435.v1
APA Style
Bai, S., Zhang, M., Tang, S., Li, M., Wu, R., Wan, S., Chen, L., Wei, X., & Feng, S. (2024). Effects and Impact of Selenium on Human Health, A Review. Preprints. https://doi.org/10.20944/preprints202411.0435.v1
Chicago/Turabian Style
Bai, S., Xian Wei and Shuang Feng. 2024 "Effects and Impact of Selenium on Human Health, A Review" Preprints. https://doi.org/10.20944/preprints202411.0435.v1
Abstract
Selenium (Se) is an essential trace element that is crucial for human health. As a key component of various enzymes and proteins, selenium primarily exerts its biological functions in the form of selenoproteins within the body. Currently, over 30 types of selenoproteins have been identified, with more than 20 of them containing selenocysteine residues. Among these, glutathione peroxidases (GPXs), thioredoxin reductases (TrxRs), and iodothyronine deiodinases (DIOs) have been widely studied. Selenium boasts numerous biological functions, including antioxidant properties, immune system enhancement, thyroid function regulation, anti-cancer effects, cardiovascular protection, reproductive capability improvement, and anti-inflammatory activity. Despite its critical importance to human health, the range between selenium's nutritional and toxic doses is very narrow. Insufficient daily selenium intake can lead to selenium deficiency, while excessive intake carries the risk of selenium toxicity. Therefore, selenium intake must be controlled within a relatively precise range. This article reviews the distribution and intake of selenium, as well as its absorption and metabolism mechanisms in the human body. It also explores the multiple biological functions and mechanisms of selenium in maintaining human health. The aim is to provide new insights and evidence for further elucidating the role of selenium and selenoproteins in health maintenance, as well as for future nutritional guidelines and public health policies.
Keywords
selenium; selenoproteomics; glutathione peroxidases; thioredoxin reductases, iodothyronine deiodinases; human health
Subject
Chemistry and Materials Science, Analytical Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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