Version 1
: Received: 7 November 2024 / Approved: 7 November 2024 / Online: 7 November 2024 (16:42:55 CET)
How to cite:
Dobritoiu-Grigore, A.; Stoleru, S.; Costescu, M.; Vatasescu-Balcan, A.; Coman, O. A.; Zugravu, A.; Fulga, I. Experimental Research on Influence of Calcium Channels on the Healing of Skin Wounds in Rats. Preprints2024, 2024110550. https://doi.org/10.20944/preprints202411.0550.v1
Dobritoiu-Grigore, A.; Stoleru, S.; Costescu, M.; Vatasescu-Balcan, A.; Coman, O. A.; Zugravu, A.; Fulga, I. Experimental Research on Influence of Calcium Channels on the Healing of Skin Wounds in Rats. Preprints 2024, 2024110550. https://doi.org/10.20944/preprints202411.0550.v1
Dobritoiu-Grigore, A.; Stoleru, S.; Costescu, M.; Vatasescu-Balcan, A.; Coman, O. A.; Zugravu, A.; Fulga, I. Experimental Research on Influence of Calcium Channels on the Healing of Skin Wounds in Rats. Preprints2024, 2024110550. https://doi.org/10.20944/preprints202411.0550.v1
APA Style
Dobritoiu-Grigore, A., Stoleru, S., Costescu, M., Vatasescu-Balcan, A., Coman, O. A., Zugravu, A., & Fulga, I. (2024). Experimental Research on Influence of Calcium Channels on the Healing of Skin Wounds in Rats. Preprints. https://doi.org/10.20944/preprints202411.0550.v1
Chicago/Turabian Style
Dobritoiu-Grigore, A., Aurelian Zugravu and Ion Fulga. 2024 "Experimental Research on Influence of Calcium Channels on the Healing of Skin Wounds in Rats" Preprints. https://doi.org/10.20944/preprints202411.0550.v1
Abstract
The migration of cells during the healing process is supported by an electrical potential difference that develops between the edges of skin wounds and the center of the wound. The electrical potential in cells' membranes is responsible for their migration in an electric field. The transmembrane electrochemical gradient differences cause this potential., Concomitant blockade of potassium and calcium channels by amiodarone at a medium dosage favored wound healing [1,2], but the effect was less intense than in the case of selective blocking of potassium channels. This suggested that blocking calcium channels partially antagonizes the effect of blocking potassium channels [8,9]. Since nimodipine blocks both L-type and T-type calcium channels, we decided to study which of these calcium channels are involved in wound healing. Hence, we performed an experimental study in which nimodipine was used in 3 concentrations: 200nM, which block only L-type calcium channels, 1000nM that block both L-type and T-type calcium channels and 10,000 nM, respectively, that block calcium channels and activate CB1 cannabinoid receptors. Blocking of calcium channels favored wound healing under our experimental conditions, but this happened only by simultaneously blocking of the L-type and T-type calcium channels, because only the medium nimodipine concentration had a statistically significant effect.
Keywords
wound healing; calcium channels; nimodipine
Subject
Medicine and Pharmacology, Dermatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
