Version 1
: Received: 6 November 2024 / Approved: 7 November 2024 / Online: 8 November 2024 (16:51:22 CET)
How to cite:
Rehnke, R. D. The “Culture” of Organs: A Holistic Theory on the Origins of the Cancer Tissue Environment. Preprints2024, 2024110561. https://doi.org/10.20944/preprints202411.0561.v1
Rehnke, R. D. The “Culture” of Organs: A Holistic Theory on the Origins of the Cancer Tissue Environment. Preprints 2024, 2024110561. https://doi.org/10.20944/preprints202411.0561.v1
Rehnke, R. D. The “Culture” of Organs: A Holistic Theory on the Origins of the Cancer Tissue Environment. Preprints2024, 2024110561. https://doi.org/10.20944/preprints202411.0561.v1
APA Style
Rehnke, R. D. (2024). The “Culture” of Organs: A Holistic Theory on the Origins of the Cancer Tissue Environment. Preprints. https://doi.org/10.20944/preprints202411.0561.v1
Chicago/Turabian Style
Rehnke, R. D. 2024 "The “Culture” of Organs: A Holistic Theory on the Origins of the Cancer Tissue Environment" Preprints. https://doi.org/10.20944/preprints202411.0561.v1
Abstract
Abstract
For over a century the somatic gene mutation theory of cancer has been a scientific orthodoxy. Recent failures of causal explanations using this theory and lack of significant progress in addressing the cancer problem medically have led to a new competition of ideas about just what cancer is. This essay presents an alternative view of cancer as a developmental process gone wrong. More particularly, cancer is a break down in the autopoietic process of organ maintenance and the multi-cellular coordination of tissues. Breast cancer is viewed through a systems science perspective as an example of the importance of framing one’s theoretical assumptions before making empirical judgments. Finally, new understanding of the histoarchitecture of the interstitium is presented as a first principle of cancer: a process of cells coming from cells, invading the space between cells.
Keywords
cancer; epithelial parenchyma; interstitium; developmental autopoiesis; breast cancer; reticular fascial network; mesenchyme; intra-organic spaces; ontogenesis; cancer tissue environment
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
