Preprint Article Version 1 This version is not peer-reviewed

A New Approach to Non-Invasive Microcirculation Monitoring: Quantifying Capillary Refill Time Using Oximetric Pulse Waves

Version 1 : Received: 7 November 2024 / Approved: 7 November 2024 / Online: 7 November 2024 (15:13:07 CET)

How to cite: Xia, Y.; Wang, X.; Guo, Z.; Wang, X.; Wang, Z. A New Approach to Non-Invasive Microcirculation Monitoring: Quantifying Capillary Refill Time Using Oximetric Pulse Waves. Preprints 2024, 2024110568. https://doi.org/10.20944/preprints202411.0568.v1 Xia, Y.; Wang, X.; Guo, Z.; Wang, X.; Wang, Z. A New Approach to Non-Invasive Microcirculation Monitoring: Quantifying Capillary Refill Time Using Oximetric Pulse Waves. Preprints 2024, 2024110568. https://doi.org/10.20944/preprints202411.0568.v1

Abstract

(1) Background: A new type of capillary refill time measurement system is proposed to be designed to achieve non-invasive, mechanised and standardised measurement of the microcirculatory status of the human body; (2) Methods: First, a mechanical measurement device based on electromagnetic pressurisation technology was designed for the measurement of microcirculation monitoring indexes such as capillary refill time, and the measurement control logic was set based on clinical application scenarios; second, the haemoglobin content in the arterial blood flow in the distal capillary bed was continuously monitored, and a software system was designed for the automatic acquisition, transmission, analysis, computation, and storage of the raw data and noise removal algorithms were proposed for the mutational noise present in the data; finally, healthy adult subjects were recruited to carry out a preliminary clinical observational study to evaluate the reproducibility and reliability of the measured parameters; (3) Results: A capillary refill time meter test machine was developed with good CRT reproducibility, both between different observers and between different numbers of observations for a uniform observer; (4) Conclusions: Rapid non-invasive monitoring of microcirculation has been successfully achieved, making non-invasive monitoring of microcirculation further mechanised and standardised, with the advantages of simple measurement and high accuracy.

Keywords

microcirculation; capillary refill time; oxygen pulse wave; sepsis; non-invasive monitoring

Subject

Medicine and Pharmacology, Clinical Medicine

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