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Mutation Sites Increase over Time in SARS-CoV-2 Variants

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Liaofu Luo  *
,
Jun Lv  *

This version is not peer-reviewed

Submitted:

12 November 2024

Posted:

14 November 2024

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Abstract
The evolution timeline of SARS-CoV-2 is examined. We found an approximately linear relationship between the number of mutated sites (x) on the spike protein of a variant and its first global sample collection time. By combining the emergence of novel strains at a given x with this linear relationship, we can predict the emergence time of macro-lineages. It is forecasted that macro-lineage Q will emerge shortly after the emergence of lineage P.
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Subject: Biology and Life Sciences  -   Virology
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
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