The COVID-19 pandemic disrupted routine child immunization efforts, threatening to reverse progress in controlling vaccine-preventable diseases. We analyzed the impact of COVID-19 on DTP3 vaccination in Europe by comparing trends before and after the pandemic using time series data from 2000 to 2023. Employing Joinpoint regression, chi-square tests, and segmented regression analysis, we assessed DTP3 vaccination trends and coverage changes. The findings revealed significant regional disparities across Europe. Statistical models indicated reductions in DTP3 coverage in countries like Ireland, Sweden, and Switzerland, whereas Ukraine and San Marino showed improvements. These variations indicate the need for targeted public health strategies to address vaccine hesitancy, logistical barriers, and systemic inequities.