The complement system include soluble and cell surface proteins and it is an important arm of the innate immune system. Once activated, the complement system rapidly gener-ates proteins with inflammatory and vasoactive activities. Although complement is crucial to host defense and homeostasis, its inappropriate or uncontrolled activation can also drive tissue injury. Glomerulopathy encompasses a spectrum of diseases with diverse eti-ologies, clinical presentations, and outcomes. Among the intricate web of factors contrib-uting to glomerulopathies pathogenesis, the role of complement activation has emerged as a focal point of research interest and therapeutic intervention. The pioneer drug was eculizumab, which made it possible to drastically change the prognosis of atypical hemo-lytic uremic syndrome, an otherwise fatal disease. This comprehensive review aims to elu-cidate the multifaceted interplay between complement pathways and glomerulopathy, shedding light on potential pathway for targeted therapies and improved patient care.