Background: Heart disease is the leading cause of death worldwide. Heart failure patients have fears and spiritual challenges.

Objective: This literature aims to examine the philosophy of spirituality in heart disease patients from three philosophical perspectives, namely ontology, epistemology, and axiology.

Methods: Search articles were obtained from several databases: Science Direct, Springer Nature, ProQuest, SAGE Journal, Cochran, and Scopus. The articles accepted were limited by the population of heart disease and its spiritual aspects from 2019-2024.

Results: Spirituality is important for nurses to understand in carrying out care for heart failure patients, seeing the ontology of spirituality allows nurses and patients to be able to handle the suffering, guilt, and death of heart failure patients. The epistemological concept views spirituality as being able to manage blood pressure, reduce depression, and improve the quality of life of heart disease patients. The axiological concept helps nurses provide spiritual support to heart disease patients through the patient's spiritual values ​​and beliefs.

Conclusion: Spirituality plays an important role in improving nursing care from the spiritual dimension of heart failure patients. This study recommends that nurses understand the aspects of spiritual philosophy in spiritual nursing care for heart disease patients.