Objectives. This study examined how self-compassion and emotion regulation strategies have influenced perinatal anxiety, depression, and social anxiety during COVID-19. Methods. A sample of 265 Australian perinatal women completed an online survey containing measures of depression, anxiety, social anxiety, COVID-19 experiences, self-compassion, and emotion regulation strategies. Results. As hypothesised, correlation analyses showed that self-compassion and adaptive emo-tion regulation strategies were negatively related to anxiety, depression and social anxiety, and maladaptive strategies were positively related. Contrary to predictions, COVID-19 related experience showed little relationship with mental health outcomes. Parallel mediation analyses showed that self-compassion negatively predicted depression and anxiety and was partially mediated by specific emotion regulation strategies. For social anxiety, self-compassion was fully mediated by emotion regulation strategies. Different emotion regulation strategies were significant mediators of the relationship between self-compassion and each mental health outcome. Conclusions. Findings suggest that reinforcing self-compassion and addressing certain emotion regulation deficits is important in alleviating mental health symptoms among perinatal women.