The Dead Sea region, characterized by its hypersaline conditions, significant base-level fluctuations, and active tectonic processes, presents a uniquely challenging environment for geological and geophysical studies. Recent advancements in remote sensing techniques have opened new avenues for exploring and understanding the complex subsurface dynamics. This review synthesizes findings from recent studies that employed diverse remote sensing methods to investigate the geomorphological, tectonic, and hydrological processes shaping the Dead Sea region. The studies underscore the effective use of drone-based photogrammetry, frequency domain electromagnetic methods, and integrated geophysical techniques, providing comprehensive insights into the subsurface geology and the mechanisms driving environmental changes. Additionally, the review discusses the challenges posed by sinkhole formation to major industrial operations in the region and how remote sensing has been pivotal in monitoring and mitigating these hazards. The successful integration of these methods demonstrates their potential in overcoming the limitations imposed by the extreme conditions of the Dead Sea, delivering valuable data for both scientific inquiry and environmental management.