Bimetallic PdCu nanoparticles with different Pd:Cu ratios and morphologies can be synthesized and immobilized on a variety of support materials. Accordingly, PdCu nanoparticles can be efficiently applied as heterogeneous catalysts in a large number of organic transformations including C-C coupling and cross-coupling reactions. As related to their favorable electronic and structural interactions, the catalytic performance of PdCu bimetallic nanoparticles may be superior to the monometallic species. The heterogeneous catalysts can be recovered and reused and the presence of copper tends to reduce the cost of the expensive Pd catalyst, which would be beneficial for industrial applications.