Implant-associated infections and aseptic loosening of prosthesis due to insufficient secondary stability continue to present a challenging issue in arthroplasty. Potential solutions include bioactive coatings to promote osseointegration. With this in mind, this project aims to investigate and compare thin bioactive and bioresorbable β-tricalcium phosphate and calcium alkaliphosphate coatings, both produced via High Velocity Suspension Flame Spraying. To achieve an additional antibacterial effect, Cu-doped TCP supraparticles are incorporated into the coatings. β-TCP and GB14 coatings with 0.5 wt.% Cu-doped TCP supraparticles each were investigated. According to ISO EN 10993-14, a degradation test was performed in TRIS-buffer at pH 7.4 over 120 hours. Biocompatibility tests were performed on human osteoblasts. Live/Dead staining was performed on day 1, 3 and 7 to visualize live and dead cells. Furthermore, cytotoxicity was evaluated over 3 days using the LDH assay. To determine the antibacterial efficacy Safe Airborne Antibacterial Assays using Staphylococcus aureus and Escherichia coli were performed. Our investigations demonstrate that copper is released from the coatings over a period of 120 hours. Both coatings exhibit good biocompatibility, with cell counts varying depending on the amount of Cu released. Cytotoxicity testing showed no cytotoxic effects for the samples examined. Cu-doping of the coatings achieved a significant reduction in colony-forming units across all coatings.