Agro-industrial activities generate significant amounts of organic waste and a variety of effluents, thus posing environmental challenges. Viticulture in Argentina, covering 204,847 ha in 2023, faces water scarcity as a limiting factor conditioning its production. This industry produces large volumes of grape marc, sediments, and stalks, which can be valorized into products like alcohol, tartaric acid, and compost. However, these valorization processes generate effluents with high organic load and salinity, further stressing water resources. This study explores the potential of utilizing these effluents to cultivate plant biomass in arid regions (sorghum or perennial pasture), which could serve as bioenergy, animal feed, or composting co-substrates, contributing to circular bioeconomy principles. Sorghum plots showed better establishment and higher dry biomass yield (32.6 Tn/ha) compared to pasture (6.5 Tn/ha). Sorghum demonstrated better tolerance to saline soils and high salinity effluents, aligning with previous studies. Although pasture had lower biomass yield, it was more efficient in nutrient uptake, concentrating more NPK, ash, and soluble salts. Sorghum's higher yield compensates for its lower nutrient concentration. For biomass production, sorghum is preferable, but if nutrient capture from effluents is prioritized, summer polyphytic pastures are more suitable. These results suggest that the final selection between plant biomass alternatives highly depends on whether the goal is biomass generation or nutrient capture.