Background: Uterus transplantation represents a revolutionary breakthrough for women with absolute infertility of uterine origin, offering them the possibility of realizing the dream of motherhood. This complex procedure has profound medical, ethical and psychological implications. The aim of our study was to analyze the psychological distress caused by infertility and the experience of trying to get pregnant through uterus transplantation in a 29-year-old woman. Methods: The case report follows the Case Reporting (CARE) guidelines. In the pre-transplant evaluation, Giorgia was administered the Machover Test, the Bauman Test, the Million Clinical Multiaxial Inventory- III (MCMI-III), the Short Form Health Survey-36 (F-36), the Patient Health Questionnaire-9 (PHQ-9), and the General Anxiety Disorder-7 (GAD-7). The same instruments were re-administered 1 year and 2 years after the transplant and the birth of the baby girl. Results: The projective graphic tests highlighted some significant aspects: the facial expression of the female figure became more restless in subsequent evaluations, until aggressiveness emerged (clenched fists) in the last evaluation. The tree will also be drawn on a flowerbed in the last evaluations, indicating a sense of loneliness and abandonment. Conclusions: Overall, uterus transplantation appears to be psychologically well-tolerated, but ongoing evaluation and psychological support are essential.