Abstract: Climate change is one of the main barriers for agricultural production and productivity globally. Hence, understanding farmers’ adoption level of CSA practices and determinants is of highly important for policy decisions. Consequently, the study's purpose was to assess adoption level of multiple CSA practices and determinants of climate-smart agriculture practices in the study area. The study was conducted in Welmera Woreda, Oromia Region, Ethiopia. From the Woreda, three kebeles were identified, and 306 respondent farmers were selected. A cross-sectional household survey, focus group discussion, and key informant interviews were used. Multivariate probit model was used to examine adoption determinants of multiple climate-smart agriculture practices. According to the result, Conservation agriculture, integrated soil fertility management, and crop diversification are the most commonly practiced CSA techniques in the study area. Demographic factors result indicated that being male as compared with female farmers, has positive and significant effect on crop diversification and improved livestock feed and feeding practices. Age of farmers significantly and negatively affecting the probability of adoption of improved soil fertility management practices and crop diversification. However, it affects the adoption of agroforestry practices positively and significantly. Based on the result of economic factors, having relatively large farm land size significantly increases the adoption of conservation agriculture, improved soil fertility management, crop diversification, improved livestock feed and feeding practices, and postharvest technology practice. Better farm income increases the likelihood of uptake of improved livestock feed and feeding. Having a large number of livestock positively influences adoption of conservation agriculture and having access to credit services positively influences the implementation of agroforestry, crop diversification, and postharvest technology. In addition, institutional factors such as access to agricultural extension service and training found that significantly and positively influences the adoption of crop diversification; access to participation on farmers’ field day similarly significantly and positively influence the adoption of both conservation agriculture and improved soil fertility management practice. Awareness creation for farmers and experts about climate change and including location specific CSA practices in to agricultural program is crucial.