Background/Objectives: To examine the relationship between quality of life and oral health in adolescents and young adults in the area of the city of Zagreb. Methods: 250 examinees, in the area of the city of Zagreb, between the ages of 14 and 25 participated in this research. All examinees were examined by a doctor of oral medicine with a probe and mirror in a dental unit and their DMFT status has been determined. All examinees filled out a specially crafted questionnaire about their socioeconomic status (SES) as well as a questionnaire about the influence of their life quality on dental health (OHIP-14). Results: Caries is the most common dental issue among adolescents (2.23±2.58) and restoration (54%) is the most common treatment performed by dentist. Endodontic treatment and tooth extraction are more common among people with a lower socioeconomic status (24.1%) and their DMFT scores are worse (8.09±5.56). Prophylaxis is equally distributed based on socioeconomic status and gender. Male patients have more carious teeth (2.75±3.07) than female patients (1.85 ±2.08), while the female patients show poorer scores on the OHIP-14 (10.97±8.77) scale in comparison to men (8.81±8.11). Age positively correlates with both OHIP-14 and DMFT scales. Conclusion: DMFT scores of adolescents and young adults in the area of the city of Zagreb are very poor. OHIP-14 scores are also worse. It could be concluded that young people in the area of the city of Zagreb have a poorer DMFT status and poorer life quality in regards to their oral health. Considering that DMFT and OHIP-14 scores get higher with age, the importance of oral health should be emphasized more among this population. The acquired results showcase the importance and need of implementing preventative measures for adolescents.