In its broadest meaning, salutogenesis denotes an orientation toward the origins and assets for positive health, as opposed to the origins and risk factors associated with disease (which is termed pathogenesis). While salutogenesis continues to inspire health promotion, it has been noted that qualitative studies can further its understanding and broaden its use in research, clinical practice, and policies. The present study is based on an analysis of more than 7.5 hours of structured and unstructured recorded interviews with six refugee musicians. Applying interpretive phenomenological analysis, we comparatively explored the factors contributing to persistence in music between participants. Five factors were found: a) long-term participation and identity as musicians; b) desirable effects of music performance; c) competence, talent, and social recognition; d) management of social and cultural differences; and e) locally organized refugee events. The links between music performance and salutogenesis include: 1) inclusion of salutogenic orientation (in addition to pathogenic orientation) toward health; 2) that music invigorated generalized resistance resources so that their expression was augmented, steady, and enduring; and 3) that a high sense of coherence was demonstrated. Music had a major role in fostering sense of coherence and promoting health and well-being.