(1) Background: Notio calculates coefficient of drag area (CDA) considering dynamic pressure data calculated by an integrated Pitot-static tube. Therefore, this study aimed to evaluate the validity and reliability of Pitot-static tube calculations through wind speed (WS) data, against a hot-wire anemometer (HWA). (2) A total of 60 recordings were made, lasting 30 seconds each, in a closed-circuit wind tunnel at 4 different WS (≈30 to ≈60km/h), and at five different yaw angles (0º to 20º). (3) Results: Notio showed WS 6.44% higher than HWA. The calibration process recommended by the Notio manufacturer reduced the differences to a non-significant 0.76%. Comparison of the WS of Notio calibrated and HWA only showed significant differences in the WS group of ≈60 km/h. There were no significant differences in the comparison of yaw angles groups. The reliability of Notio was worse than that of the HWA. (4) Conclusions: Notio calibrated at a speed close to its use, allows reliable and accurate calculation of WS over a wide range of yaw angles under controlled wind tunnel conditions without the presence of a cyclist and bike. However, due to the influence of WS on aerodynamic drag, small errors in WS could translate into considerable values of CDA for cycling performance.

Growing evidence has revealed the implication of germline variation in cancer predisposition and prognostication. Here, we describe an analysis of putatively disruptive rare variants across the genomes of 726 patients with B-cell lymphoid neoplasms. We discovered a significant enrichment of 26 genes in germline protein truncating variants (PTVs), affecting cell signaling (MET, JAK2, ANGPT2), energy metabolism (ACO1) and nucleic acid metabolism and repair pathways (NT5E, DCK). Interestingly, some of these variants were restricted to either chronic lymphocytic leukemia (CLL) (i.e., ANGPT2 and AKR1C3) or B-cell lymphoma cases (PNMT, TPT1 and IGHMBP2). Additionally, we detected 1,675 likely disrupting variants in genes associated with cancer, of which 44.75% were novel events and 7.88% were PTVs. Among these, the most frequently affected genes were ATM, BIRC6, CLTCL1A and TSC2. Homozygous or compound heterozygous variants were detected in 28 cases; and coexisting somatic events were observed in 17 patients, some of which affected key lymphoma drivers such as ATM, KMT2D and MYC. Finally, we observed that variants in the helicase gene WRN were independently associated with shorter survival in CLL. Our study results support an important role for rare germline variation in the pathogenesis, clinical presentation and disease outcome of B-cell lymphoid neoplasms.