This study evaluates the impact of integrated nutrient management (INM) practices on potato yield and quality in the coastal regions of Bangladesh. Potatoes are a vital crop in Bangladesh, and optimizing nutrient management is crucial for enhancing productivity and ensuring sustainability. The research was conducted in multiple agro-ecological zones in Gopalganj, where field trials were established with three treatment groups: traditional fertilization practices, organic fertilizers, and a combination of organic and inorganic fertilizers (INM). The results demonstrated that INM practices significantly improved potato yield and quality compared to traditional practices. Specifically, the INM group exhibited a 20% increase in yield and enhanced tuber quality, characterized by higher nutrient content and reduced incidence of common diseases. Soil health parameters, including microbial activity, nutrient availability, and organic matter content, were also positively influenced by INM practices. Economic analysis revealed that, despite higher initial costs, INM practices were more cost-effective in the long run due to reduced fertilizer input and improved crop yield. This study highlights the importance of adopting sustainable nutrient management strategies to improve potato production in Bangladesh. The findings underscore the potential of INM practices to enhance food security and support sustainable agricultural development. By integrating organic and inorganic fertilizers, farmers can achieve higher yields, better-quality produce, and maintain soil health, making INM a viable strategy for the future of potato farming in Bangladesh.