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Preprint REVIEW | doi:10.20944/preprints202409.1913.v1

From Single Shot to Structure: End-to-End Network based Deflectometry for Specular Free-Form Surface Reconstruction

Kwanele Ngcobo, Sandiswa Bhengu, Ambani Mudau, Bonginkosi Thango (Y2-rated Researcher), Lerato Matshaka

Subject: Business And Management, Business, Economics And Management Keywords: deflectometry; specular surface reconstruction; deep neural networks; single-shot measurement; data simulation; variational autoencoder (VAE)

Online: 25 September 2024 (11:32:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1882.v1

Cyber Harassment in the Digital Age: Trends, Challenges, and Countermeasures

Rashed Ahmed

Subject: Computer Science And Mathematics, Security Systems Keywords: cyber harassment digital age online abuse psychological impact victims emotional consequences mental health social media platforms facilitation of harassment intervention strategies legal frameworks cyberstalking online bullying trolling harmful content trends in cyber harassment frequency of incidents severity of harassment anonymity online privacy invasion reputational damage jurisdiction challenges technological solutions educational initiatives advanced algorithms content filtering cyber laws awareness

Online: 25 September 2024 (11:29:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1865.v1

Multimodal Investigation of Metabolism in Murine Breast Cancer Cell Lines Using Fluorescence Lifetime Microscopy and Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopy

Sarah Erickson-Bhatt, Benjamin L. Cox, Erin Macdonald, Jenu V Chacko, Paul Begovatz, Patricia Keely, Suzanne M Ponik, Kevin W Eliceiri, Sean B Fain

Subject: Endocrinology And Metabolism, Biology And Life Sciences Keywords: breast cancer; metastatic potential; metabolism; FLIM; MRSI; hyperpolarized; carbon-13

Online: 25 September 2024 (11:17:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1864.v1

Bad Company: Daewoo and France, 1987–2003

Jill Harsin

Subject: Government, Social Sciences Keywords: globalization; France; Daewoo; Thomson; unemployment

Online: 25 September 2024 (11:06:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1907.v1

Histopathological Insights and Therapeutic Prospects of MCC950 in Diabetic Cardiac Autonomic Neuropathy in a Type 1 Diabetes Wistar Rat Model

Shamala Devi Subramaniam, Juita Chupri, Zamzarina Ahmad Bajari, Kah Hui Wong, Mohd Amir Kamaruzzaman, Razif Abas

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: Diabetic Cardiac Autonomic Neuropathy (DCAN); Type 1 Diabetes Mellitus (T1DM); MCC950; NLRP3 Inflammasome; Histopathology

Online: 25 September 2024 (11:00:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1942.v1

COMPRESSIVE STRENGTH VARIATION OF CONCRETE WITH COCONUT SHELL & BAMBOO STRIPS.

Mary Vithiya Vithiyananthanesan, Sharminy P

Subject: Civil Engineering, Engineering Keywords: coconut shell; bamboo strips; compressive strength; Replacement; cube samples

Online: 25 September 2024 (10:58:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1940.v1

Severe Obesity Defined by Percentiles of WHO and Cardiometabolic Risk in Youth with Obesity

Giuliana Valerio, Procolo Di Bonito, Anna Di Sessa, Giada Ballarin, Valeria Calcaterra, Domenico Corica, Maria Felicia Faienza, Francesca Franco, Maria Rosaria Licenziati, Claudio Maffeis, Giulio Maltoni, Emanuele Miraglia del Giudice, Anita Morandi, Enza Mozzillo, and Malgorzata Wasniewska

Subject: Other, Public Health And Healthcare Keywords: Body mass index Z-score; cardiometabolic risk; severe obesity; World Health Organization.

Online: 25 September 2024 (10:25:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1939.v1

Enhanced Ocular Drug Delivery of Dexamethasone Using Chitosan-Coated Soluplus® Based Mixed Micellar System

Samer Adwan, Faisal Al-Akayleh, Madeha Qasmieh, Teiba Obeidi

Subject: Pharmacy, Medicine And Pharmacology Keywords: Soluplus®; Pluronic F-127; Dexamethasone; Mixed micelle; Chitosan coat

Online: 25 September 2024 (10:25:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1953.v1

AI-powered Biodiversity Assessment: Species Classification via DNA Barcoding and Deep Learning

Loris Nanni, Daniela Cuza, Sheryl Brahnam

Subject: Mathematical And Computational Biology, Computer Science And Mathematics Keywords: DNA barcoding; ensemble; convolutional neural networks

Online: 25 September 2024 (10:22:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1966.v1

Fragility Analysis of Buried Operating Steel Pipeline Under Longitudinal Permanent Ground Deformation

Gersena Banushi

Subject: Engineering, Civil Engineering Keywords: Steel pipeline; longitudinal ground movement; fragility surfaces; Monte Carlo Simulation (MCS); Global Sensitivity Analysis (GSA); uncertainty quantification; operational loads

Online: 25 September 2024 (09:01:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1960.v1

Antibody-Drug Conjugates and Their Potential in the Treatment of Patients with Biliary Tract Cancer

Shaun Alexander, Umair Aleem, Timothy Jacobs, Melissa Frizziero, Victoria Foy, Richard A Hubner, Mairéad G McNamara

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Antibody drug-conjugate; biliary tract cancer; anti-HER2; payload; targeted therapy

Online: 25 September 2024 (09:00:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1965.v1

Resveratrol and Exercise Produce a Recovery Ankle and Metatarsus Joint Movements After a Penetrating Lesion in the Hippocampus in Male Rats

Irene Guadalupe Aguilar-Garcia, Jonatan Alpirez, Rolando Castañeda-Arellano, Judith Marcela Dueñas-Jiménez, Maria del Carmen Toro-Castillo, Lilia Carolina León-Moreno, Laura Paulina Osuna-Carrasco, Sergio Horacio Dueñas-Jiménez

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: Locomotion; Kinematics; Resveratrol; exercise

Online: 25 September 2024 (09:00:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1974.v1

Bridging the Gap Between Black Box AI and Clinical Practice: Advancing Explainable AI for Trust, Ethics, and Personalized Healthcare Diagnostics

Dang Anh Tuan

Subject: Computer Science And Mathematics, Computer Science Keywords: Explainable AI (XAI); Healthcare diagnostics; Grad-CAM; SHAP; LIME; Trust in AI; Ethical AI; Bias mitigation; Regulatory compliance; Personalized care; AI interpretability; Clinical decision-making

Online: 25 September 2024 (08:59:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1963.v1

Protonation Is Part of Dielectric Relaxation upon Reduction of Bacteriopheophytin in Reaction Center of Photosynthetic Bacterium Rhodobacter sphaeroides

Gábor Sipka, Péter Maróti

Subject: Biology And Life Sciences, Biophysics Keywords: Rhodobacter sphaeroides; reaction center; bacteriophyeophytin; quinone substitution; acidic cluster; thermodynamics; delayed fluorescence

Online: 25 September 2024 (08:59:03 CEST)

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The pH dependence of the free energy level of the flash induced primary charge pair P+IA– was determined by combination of the results from indirect charge recombination of P+QA– and from delayed fluorescence of the excited dimer (P*) in reaction center of photosynthetic bacterium Rhodobacter sphaeroides where the native ubiquinone at the primary quinone binding site QA was replaced by low potential anthraquinone derivatives. The following observations were made: 1) The free energy state of P+IA– was pH independent below pH 10 (–370 ± 10 meV relative to that of the excited dimer P*) and showed remarkable decrease (about 20 meV/pH unit) above pH 10. A not insignificant part of the dielectric relaxation of the P+IA– charge pair (about 120 meV) should come from protonation related changes. 2) The single exponential decay character of the kinetics proves that the protonated/unprotonated P+IA– and P+QA– states are in equilibria and the rate constants of protonation konH +koffH is much larger than that of the charge back reaction kback ~103 s-1. 3) Highly similar pH profiles were measured for the free energy states of P+QA– and P+IA–, indicating that the same acidic cluster around QB should response to both anionic species. This was supported by model calculations based on anticooperative proton distribution in the cluster with key residues of GluL212, AspL213, AspM17 and GluH173 and on effect of polarization of the aqueous phase on the electrostatic interaction. The larger distance of IA– from the cluster (25.2 Å) than that of QA‒ (14.5 Å) is compensated by smaller effective dielectric constant (6.5 ± 0.5 and 10.0 ± 0.5, respectively). 4) The P* → P+QA− and IA‒QA → IAQA− electron transfers are enthalpy driven reactions with exemption of very large (>60%) or negligible entropic contributions in cases of substitution by 2,3-dimethyl-AQ or 1-chloro-AQ, respectively. The possible structural consequences are discussed.

Preprint REVIEW | doi:10.20944/preprints202409.1970.v1

Prognostication Opportunity of Future STEM Education and 4IR for Africa: Uphill Massif

Tola Bekene

Subject: Computer Science And Mathematics, Other Keywords: Africa; Archival research study; STEM education; 4IR; Trends and challenges of Africa

Online: 25 September 2024 (08:58:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1958.v1

Genetic Engineering in Bacteria, Fungi, and Oomycetes

Piao Yang, Abraham Condrich, Ling Lu, Sean Scranton, Camina Hebner, Mohsen Sheykhhasan, Muhammad Azam Ali

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Genetic engineering; CRISPR; Bacteria; Fungi; Oomycetes; GEMs

Online: 25 September 2024 (08:56:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1973.v1

Picornavirus Evolution: Genomes Encoding Multiple 2A^NPGP Sequences – Biomedical and Biotechnological Utility

Garry Luke, Lauren Ross, Yi-Ting Lo, Hsing-Chieh Wu, Martin Ryan

Subject: Biology And Life Sciences, Virology Keywords: Picornaviruses; Polyprotein 2A region; 2A^NPGP sequences; ribosome skipping; translation; biotechnology

Online: 25 September 2024 (08:55:48 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202409.1724.v2

The Pillars of the Societal Bioharmonism. A Conceptualist Contribution to the Evolution of the Contemporary Society

Romulus Gruia, Liviu Gaceu, Oana Bianca Oprea

Subject: Environmental And Earth Sciences, Other Keywords: bioharmonism; concept; postmodernity; systemic; societal

Online: 25 September 2024 (08:55:38 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202409.1959.v1

Library Consortia: An Overview

Chiragkumar Parmar

Subject: Social Sciences, Library And Information Sciences Keywords: Consortia; Library Consortia; Co-operation; Library Resources

Online: 25 September 2024 (08:52:59 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202409.1967.v1

Cervical Mesonephric Adenocarcinoma Treated with Neoadjuvant Chemotherapy. A Case Report and a Literature Review

Hiroaki Ishida, Megumi Manrai, Hiroki Egashira, Mizuki Nonaka, Nobuyuki Hiruta, Reiko Watanabe, Akiko Takashima

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Cervical mesonephric adenocarcinoma; Neoadjuvant chemotherapy; Adjuvant chemotherapy

Online: 25 September 2024 (08:52:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1943.v1

Blood-Brain Barrier Integrity Disruption is Associated to both Chronic Vascular Risk Factors and White Matter Hyperintensities

James Xiao Yuan Chen, Ashwati Vipin, Gurveen Kaur Sandhu, Yi Jin Leow, Fatin Zahra Zailan, Pricilia Tanoto, Ee Soo Lee, Khang Leng Lee, Christine Cheung, Negaenderan Kandiah

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebral small vessel disease; blood-brain barrier; cardiovascular risk factors; white matter hyperintensity; transendothelial electrical resistance assay

Online: 25 September 2024 (08:26:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1978.v1

Job Stress, Burnout, and Turnover Intention of Clinical Research Associates

Eunok Kwon, YoungWoo Kim

Subject: Public Health And Healthcare, Nursing Keywords: clinical research; job stress; burnout; turnover intention; nurse

Online: 25 September 2024 (07:08:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1971.v1

Nanotechnological Advances in Burn Wound Care: Chitosan-Based Nanogel Incorporating Silver Sulfadiazine-loaded Nanosuspension for Partial Thickness Burns

Harshita Barkat, Md. Abul Barkat, Raisuddin Ali, Hazrina Ab Hadi

Subject: Medicine And Pharmacology, Pharmacy Keywords: nanosuspension; topical delivery; burn wound infection; nanogel; chitosan ;

Online: 25 September 2024 (05:24:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1903.v1

Novel Acid-Assisted Polymerization Technique for Synthesis of Polyaniline Films at Room Temperature: Morphological Study and Supercapacitor Applications

Stephen Boahene, Štěpán Potocký, Kateřina Aubrechtová Dragounová, Elena Tomšík, Alexander Kromka

Subject: Chemistry And Materials Science, Electrochemistry Keywords: polyaniline (PANI); acid-assisted polymerization; glassy carbon (GC); electrochemistry

Online: 25 September 2024 (04:38:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1904.v1

Stock Price Prediction Based on Hybrid CNN-LSTM Model

Qinghe Zhao, Yue Hao, Xuechen Li

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: stock price prediction; deep learning; convolutional neural network; long short-term memory network

Online: 25 September 2024 (04:29:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1934.v1

Fluid Overload in Children Following Hematopoietic Cell Transplant: A Cause for Concern?

Lama Elbahlawan, Amr Qudeimat, Ray Morrison, Alexandra Schaller

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Fluid overload; fluid accumulation; hematopoietic cell transplant; pediatrics; critically ill; outcome; acute kidney injury

Online: 25 September 2024 (04:24:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1936.v1

Properties and Photocuring Behavior of Ceramic Polymer Composite Slurries with Varying Concentration of Silane Coupling Agent

Kook-Hyun Ryu, Ung-Soo Kim, Jin-Ho Kim, Jung-Hoon Choi, Kyu-Sung Han

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Silane coupling agent; Al2O3 slurry; Rheology; Photocuring; Internal structure analysis

Online: 25 September 2024 (04:23:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1945.v1

Perirenal Fat CT Radiomics-Based Survival Model for Upper Tract Urothelial Carcinoma: Integrating Texture Features with Clinical Predictors

Abdulrahman Nasser M Al Mopti, Abdulsalam Mohammed Alqahtani, Ali H D Alshehri, Chunhui Li, Ghulam Nabi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Upper tract urothelial carcinoma; Perirenal fat radiomics; Prognostic modelling; CT imaging; Machine learning; texture analysis; survival; prognosis

Online: 25 September 2024 (04:21:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1947.v1

Framework for Integrating Large Language Models with a Ro-botic Health Attendant for Adaptive Task Execution in Patient Care

Kyungki Kim, John Windle, Melissa Christian, Tom Windle, Erica Ryherd, Pei-Chi Huang, Anthony Robinson, Reid Chapman

Subject: Computer Science And Mathematics, Robotics Keywords: medical service robot; Large Language Model (LLM); Robotic Health Attendant; healthcare robot; ChatGPT

Online: 25 September 2024 (04:19:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1929.v1

Vitamin D’s Essential Role from Natural Sources in Preventing Rhinosinusitis, Nasopharyngitis, and Otitis Media: Ensuring Optimal Care in Patients with Behavioral Disorders

Felicia Manole, Alexia Manole, Timea Claudia Ghitea

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: behavior disorders; nasopharyngitis; otitis media; rhinosinusitis; vitamin D

Online: 25 September 2024 (04:18:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1928.v1

Exploring the Potential of Agriculture Diversification as a Pathway to Improved Smallholder Livelihood Dietary System in Nepal

Bikram Nepali, Craig Johns, Tamara Jackson

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Agriculture diversification; Dietary Diversity; Smallholder farmers; cropping seasonal variation; Nepal

Online: 25 September 2024 (04:15:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1926.v1

How Agroecological Transition Frameworks Are Reshaping Agroecology: A Review

Ana Filipa Fonseca, Fabíola Polita, Lívia Madureira

Subject: Social Sciences, Geography, Planning And Development Keywords: agroecology; transition; agroecological transition; transition theory; bibliometric review

Online: 25 September 2024 (04:12:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1924.v1

On the Protocols of New Historicism and Epochal Thought: A proposition

Isaac Penzance

Subject: Arts And Humanities, Philosophy Keywords: Epochs; Marx; Engels; Socialism; Politics; Idealisation; political action; Historicism; History; Philosophy

Online: 25 September 2024 (04:10:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1932.v1

Optical Rectennas -A Review

Yuvam Bhateja

Subject: Physical Sciences, Optics And Photonics Keywords: Levelized Cost of Energy; Rectenna; Shockley-Quiesser limit; Metal-Double-Insulator-Metal diodes; CNT-Insulator-Metal diodes; Point-contact-Metal-Insulator-Metal diodes

Online: 25 September 2024 (04:00:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1938.v1

Reducing Genotype-Environment Interaction Effects in a Genetic Improvement for Liptopenaeus vannamei

Tran Thi Mai Huong, Nguyen Huu Hung, Dinh Cong Tru, Vu Dinh Ty, Nguyen Hong Nguyen

Subject: Biology And Life Sciences, Aquatic Science Keywords: Breeding program; genetic parameters; selection response; genotype and environment

Online: 25 September 2024 (02:59:53 CEST)

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Preprint ESSAY | doi:10.20944/preprints202409.1933.v1

Linguistic Cultures in Tandem to International Business Expansion

Eugene Seo

Subject: Business, Economics And Management, Economics Keywords: Economics; business; culture; linguistics

Online: 25 September 2024 (02:59:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1949.v1

Digital Methodology for Determining the Main Physical Parameters of Apple Fruits

Jakhfer Alikhanov, Aidar Moldazhanov, Akmaral Kulmakhambetova, Dimitriy Zinchenko, Alisher Nurtuleuov, Zhandos Shynybay, Tsvetelina Georgieva, Plamen Daskalov

Subject: Engineering, Control And Systems Engineering Keywords: apple; fruit; variety; apple physical parameters; methodology; digital method

Online: 24 September 2024 (17:01:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1920.v1

Sustainability Consciousness and Awareness of Sustainable Development Goals among Future Engineers

Salma Shaik, Varun A

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Engineering education; sustainable development; sustainability consciousness questionnaire; sustainable development goals; mechanical engineering; sustainability knowledge; attitude and behavior

Online: 24 September 2024 (17:00:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1948.v1

CAD Design and Modeling of a Robotic Arm for Automated Harvesting

Maxwell Salazar, Paola Portero

Subject: Engineering, Electrical And Electronic Engineering Keywords: Robotic arm; Motion simulation; CAD design

Online: 24 September 2024 (16:59:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1925.v1

Evaluation Metrics for Machine Unlearning

Cassandra Lindstrom

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: machine unlearning; privacy; finance; graph neural network

Online: 24 September 2024 (16:58:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1941.v1

Wound Healing Efficacy of Cellulose Hydrogel on ICR Mice: A Morphoanatomical, Histological and Genomic Study

Abigail Castro, Alvin Domingo, Jayson Cariaga, Francis Gamboa, Aira Cassandra Castro, Aira Nadine Pascua, Jimmbeth Zenila Fabia, Peter James Gann, Bjorn Santos, Shirley Agrupis

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: wound healing; cellulose hydrogel; probiotics; histological assessment

Online: 24 September 2024 (16:57:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1950.v1

Methane Concentration Measurements in the Longwall Area as a Data Source for the Assessment of Methane Hazard

Wacław Antoni Dziurzyński, Piotr Ostrogórski, Przemysław Skotniczny

Subject: Environmental And Earth Sciences, Environmental Science Keywords: methane concentration measurements, sectional measurements, experiment, individual methanometer, methane hazard assessment, detection of methane emission sources

Online: 24 September 2024 (15:42:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1944.v1

Future Therapeutic Strategies for Alzheimer’s Disease: Focus on Behavioral and Psychological Symptoms

Kyoung Ja Kwon, Hahn Young Kim, Seol-Heui Han, Chan Young Shin

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimer's disease; Neuropsychiatric symptoms; Psychomotor symptoms; Social function; Pharmacotherapy

Online: 24 September 2024 (14:52:39 CEST)

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Alzheimer’s disease (AD) is a progressive, degenerative brain disorder that impairs memory and thinking skills, leading to significant economic and humanistic burdens. It is associated with various neuropsychiatric symptoms (NPSs) such as anxiety, agitation, depression, aggression, apathy, and psychosis. NPSs are common in patients with AD, affecting up to 97% of individuals diagnosed with AD. The severity of NPS is linked to disease progression and cognitive decline. NPS in Alzheimer’s disease leads to increased morbidity, mortality, caregiver burden, earlier nursing home placement, and higher healthcare costs. Despite their significant impact, clinical research on NPS in AD is limited. In clinical settings, accurately distinguishing and diagnosing NPS related to AD remains a challenge. Additionally, conventional treatments for NPS in AD are often ineffective, highlighting the need for new therapies that target these specific symptoms. Understanding these comorbidities can aid in early diagnosis and better management of AD. In this review, we provide a summary of the various neurological and psychiatric symptoms (NPSs) associated with AD and new candidates under development for the treatment of NPSs based on their therapeutic targets and mechanisms. On top of the conventional NPSs studied far, this review adds recent advancements in the understanding of social functional impairment in AD. This review also provides information that can contribute to the advancement of studies and translational research in this field by emphasizing therapeutic targets and mechanism of action focused on AD-related NPS, rather than conventional mechanisms targeted in AD drug development. Above all, considering the relative lack of research in this new field despite the importance of clinical, medical, and translational research, it may increase interest in NPSs in AD, its pathophysiological mechanisms, and potential therapeutic candidates such as molecules with antioxidant potential.

Preprint ARTICLE | doi:10.20944/preprints202409.1931.v1

Extracorporeal Photopheresis of Patients with Crohn’s Disease Using 5-Aminolevulinic Acid – a First-in-Human Phase I/II Study

Kristian Espeland, Eidi Christensen, Astrid Aandahl, Andreas Ulvær, Trond Warloe, Andrius Kleinauskas, Sagar Darvekar, Petras Juzenas, Vlada Vasovic, Qian Peng, Jørgen Jahnsen

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Crohns disease, extracorporeal photopheresis, ECP, 8-MOP, UV-A, blue light.

Online: 24 September 2024 (14:21:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1935.v1

Research on a Key Method for the Optimization of Port Vessel Detection Based on an Improved Multi-Structural Morphology Approach

Bernard Marie Tabi Fouda, Wenjun Zhang, Jacques Atangana, Hélène Carole Edima-Durand

Subject: Engineering, Marine Engineering Keywords: Port vessel detection; weighted morphological filtering; adaptive fast median filtering; connected domain computing; multi-structure morphology; sea surface congestion

Online: 24 September 2024 (14:09:10 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202409.1899.v1

The Impact of Aerobic Exercise on a Novice Athlete with Crohn's Disease: A Case Study from Greece

Eleftherios Paraskevopoulos

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Inflammatory Bowel Disease; Crohn's Disease; Therapeutic Exercise

Online: 24 September 2024 (14:07:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1912.v1

Impact of Severe Obesity on Outcomes in Single-Level Anterior Cervical Discectomy and Fusion (ACDF): A Large-Scale Comparative Study

David Maman, Ofek Bar, Yaniv Steinfeld, Ali Sliman, Arsen Shpigelman, Lior Ben-Zvi, Yaron Berkovich

Subject: Public Health And Healthcare, Primary Health Care Keywords: Anterior Cervical Discectomy; Severe Obesity; BMI; Postoperative Complications; ACDF

Online: 24 September 2024 (14:06:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1918.v1

Stable Microclimates and Autonomic Modulation in Horses Sin-Gle-Stall Housed in Different Stable Architectures During Mon-Soon in a Tropical Savannah Environment

Chanoknun Poochipakorn, Kanokpan Sanigavatee, Kansuda Leelehapongsathon, Thita Wonghanchao, Metha Chanda

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Air velocity; Humidity; Interior environment; Monsoon; Noxious gases; Single-stall housing; Stress responses; Temperature; Tropical savannah climate; Welfare

Online: 24 September 2024 (14:06:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1905.v1

An Open Frame Loading Stage for High-Resolution Microtomography

David Plappert, Georg C. Ganzenmüller

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: in-situ; computed tomography; CT; loading frame; fibre reinforced composites

Online: 24 September 2024 (14:05:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1930.v1

Circular Design for Natural Fibers: A Literature Review on Life Cycle Evaluation Approaches for Environmental, Social and Economic Sustainability

Francesca Thiebat, Elena Fregonara, Alice Masoero, Fiamma Morselli, Chiara Senatore, Roberto Giordano

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: LCA; LCC; S-LCA; LCSA; circular design; natural fibers; environmental sustainability; social sustainability; economic sustainability; evaluation approaches; life cycle

Online: 24 September 2024 (14:04:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1900.v1

Prognostic Value of Separate Extramural Vascular Invasion Reporting in Operative Samples of Rectal Cancer: Single-Institutional Experience

Mladen Đurić, Bojana Kožik, Tijana Vasiljević, Aleksandar Đermanović, Nevena Stanulović, Marina Đurić

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Rectal cancer (RC); Extramural venous invasion (EMVI); Predictive Medicine

Online: 24 September 2024 (14:04:05 CEST)

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Background/Objectives: Vascular invasion, especially extramural vascular invasion (EMVI) has emerged as prognostic parameter for rectal cancer (RC) in recent years. Prediction of reccurence and metastases development poses a significant challenge for oncologists, needing markers for prediction of adverse outcome. The aim of this study was to examine the prognostic significance of pathohistologically detected EMVI in untreated rectal cancer and its implications in separate reporting. Methods: We examined 100 untreated RC patients who underwent curative resection from January 2016 to June 2018 with follow up of 5 years. Patients were divided in equal EMVI- and EMVI+ groups based on histological re-examination of H&E stained postoperative surgical samples. Results: The presence of EMVI within the selected cohort was significantly associated with female gender, T3/T4 and N1/N2 post-operative stages, positive lymph nodes, lymph node ratio LNR2 and LNR3 groups, abundant tumor-infiltrating lymphocytes, positive lympho-vascular invasion (LVI), perineural (PNI), and circumferential resection margin (CRM) (p<0.05 in all tests). Within EMVI+ patients, local recurrences and/or metastases, and death outcomes were more frequent events (p=0.029 and p=0.035, respectively), while survival analyses revealed that EMVI+ patients had significantly shorter overall survival (OS, p=0.040) and disease-free survival (DFS, p=0.028). Concerning LVI, differences in OS between LVI+ and LVI- patients were not statistically significant (p=0.068), while LVI+ patients had significantly shorter DFS (p=0.024). Moreover, univariate COX regression analysis demonstrated the negative impact of EMVI on OS (HR: 2.053, 95% CI: 1.015-4.152; p=0.045) and DFS (HR: 2.106, 95% CI: 1.066-4.870; p=0.038), which was not the case for LVI+ RC patients. Conclusions: Obtained results strongly suggest significance of separate reporting of EMVI from lympho-vascular invasion, as it is potentially a surogate marker for adverse prognosis and outcome.

Preprint ARTICLE | doi:10.20944/preprints202409.1923.v1

Challenges and Solutions for Leave-One-Out Biosensor Design in the Context of a Rugged Fitness Landscape

Shounak Banerjee, Keith Fraser, Donna E Crone, Jinal C Patel, Sarah Bondos, Christopher Bystroff

Subject: Biology And Life Sciences, Biophysics Keywords: green fluorescent protein; biosensors; folding; library screening; biosensor materials; computational design; folding energy landscape; chromophore; ultrabithorax fibers

Online: 24 September 2024 (14:04:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1916.v1

Tricoma (Tricoma) disparseta sp. nov. (Nematoda: Desmoscolecidae), a New Free-Living Marine Nematode from a Seamount in the Northwest Pacific Ocean, with a New Record of T. (T.) longirostris (Southern, 1914)

Hyo Jin Lee, Heegab Lee, Ji-Hoon Kihm, Hyun Soo Rho

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: marine nematodes; Tricoma; morphometrics; taxonomy; Northwest Pacific Ocean

Online: 24 September 2024 (14:02:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1927.v1

Methodology for the Development of Blended Learning Support Virtual Courses

Ricardo Patricio Medina-Chicaiza, Walfredo González Hernández, Lorena Chiliquinga-Véjar

Subject: Social Sciences, Education Keywords: blended learning; e‐learning; virtual course; e‐learning

Online: 24 September 2024 (14:02:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1922.v1

Impact of Daratumumab in Transplant Eligible/Ineligible Patients with Newly Diagnosed Multiple Myeloma: An Updated Meta-Analysis of Phase- III Trials

Bolivia Crocete Aloysia Fernandes, Vedant Shah, Muhammad Ashar Ali, Rahul Mehta, Prakash Chano Mal, Jannat Sardar Sheikh, Sulochana Gnanasekaran, Makarand Madine, Arya Alla, Sucharitha Pandeti, Jamarc Simon, Vinod Nookala

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: daratumumab; multiple myeloma; meta-analysis

Online: 24 September 2024 (14:01:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1906.v1

Links Between Attention-Deficit/Hyperactivity Disorder Symptoms, Peer Relationships and Mental Health Outcomes in Western Australian Youth

Carolyn Maxwell, Stephen Houghton, Elaine Chapman

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Peer relationships; attention-deficit/hyperactivity; mental health; adolescents

Online: 24 September 2024 (14:01:04 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202409.1921.v1

Prolonged Neurological and Musculoskeletal Symptoms Following Shingrix Vaccination

Sabrina Christine Hollar, Amna Khalid, Benjamin D. Brooks, Michael Wons

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Shingrix vaccine; adverse reaction; joint pain; neurological symptoms; long-term symptoms; vaccine safety

Online: 24 September 2024 (14:00:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1914.v1

The Effect of Stress on the Skin Welfare in Lumpfish (Cyclopterus lumpus) Broodstock

Thor Magne Jonassen, Albert Kjartan Dagbjartarson Imsland, Karin Anna Pittman

Subject: Biology And Life Sciences, Aquatic Science Keywords: Reproduction; stress; skin health; Q-cells; lumpfish

Online: 24 September 2024 (14:00:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1919.v1

Whole Genome Sequencing of the Entomopathogenic Fungus Fusarium solani KMZW-1 and Its Efficacy Against Bactrocera dorsalis

Junfu Yu, Mehboob Hussain, Mingqi Wu, Chunlan Shi, Shini Li, Yuanxia Ji, Sikandar Hussain, Deqiang Qin, Chun Xiao, Guoxing Wu

Subject: Biology And Life Sciences, Insect Science Keywords: Fusarium solani KMZW-1; whole genome sequencing; entomopathogenic fungus; Bactrocera dorsa-lis

Online: 24 September 2024 (13:59:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1909.v1

Electronic Nursing Record - Importance for Nursing and Benefits of Implementing it in Health Information Systems

Daniela Ivova Taneva, Vasilka Todorova Gyurova-Kancheva, Angelina Georgieva Kirkova-Bogdanova, Diana Angelova Paskaleva, Yovka Tinkova Zlatanova

Subject: Public Health And Healthcare, Nursing Keywords: Electronic nursing record; electronic health record; nursing care; nursing practice; nursing documentation

Online: 24 September 2024 (13:58:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1871.v1

Selecting Optimal Printing Parameters for 3D Printed Parts in Haptic Machine Interface Prototyping

Oluwaseun Kayode Ajayi, Shenghzi Du, Tolulope Adebukola Odekomaya, Olaoluwa Bayonle

Subject: Engineering, Other Keywords: Print speed; infill density; layer thickness; Regression; chart

Online: 24 September 2024 (12:38:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1861.v1

Physics-Informed Neural Network for Solving a 1-Dimensional Solid Mechanics Problem

Vishal Singh, Rajnish Mallick, Sahaj Saxena, Sharanjeet Dhawan, Manoj Sahni, Dineshkumar Harursampath

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Physics-informed Neural Network; Deep Neural Network; Artificial Neural Network; Computational Solid Mechanics; Partial Differential Equation

Online: 24 September 2024 (12:36:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1868.v1

Adaptive Strategies and Sustainable Innovations of Chinese Contractors in the Belt and Road Initiative: A Social Network and Supply Chain Integration Perspective

Jiaxin Huang, Shui Ming Li

Subject: Business, Economics And Management, Business And Management Keywords: Supply Chain Integration; Social Network Analysis; International Engineering Projects and Sustainability; Sustainable Procurement Management; Stakeholder Engagement and Relationships; EPC Model for Sustainable Development

Online: 24 September 2024 (12:34:29 CEST)

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As global economic integration and rapid technological advancements transform international business, international engineering contracting has become essential for achieving sustainable development goals (SDGs). This paper investigates the significant impact of China’s strategic initiatives, notably the "Going Global" strategy and the Belt and Road Initiative (BRI), on the operational practices of Chinese enterprises involved in overseas investments. Central to this transformation is the Engineering, Procurement, and Construction (EPC) model, which emphasizes the integration of supply chain management and stakeholder collaboration to enhance performance in international EPC projects and underscores the crucial role of these elements in promoting sustainability. Incorporating insights from social network data analysis, this study reveals that contractors collaborating with various stakeholders—such as owners/consulting engineers, domestic and foreign customs departments, and group headquarters/design parties—exhibit a high degree of similarity in personnel profiles. This suggests that the internal organizational structure and personnel allocation of contractors could be optimized to enhance operational efficiency, aligning with the collaborative patterns identified. This study addresses a critical research gap by exploring how effective supply chain management and collaborative stakeholder engagement within multinational EPC projects contribute to sustainable outcomes. Employing advanced social network analysis software, the research examines the complex interactions among stakeholders and their influence on procurement dynamics. Findings indicate that strong relational networks and strategic collaborations significantly enhance procurement efficiency and project success, underscoring the importance of supply chain integration. Ultimately, integrating supply chain management principles into the EPC model not only offers innovative perspectives for advancing sustainability in international projects but also provides actionable insights for improving project outcomes within the BRI framework. This research underscores the pivotal role of supply chain organization and stakeholder cooperation in achieving sustainability objectives, thereby enriching the discourse on sustainable enterprise operation and supply chain management in the context of global initiatives.

Preprint ARTICLE | doi:10.20944/preprints202409.1872.v1

Antifungal Activity and Mycotoxin Degradation Potential of Bioprotective Microorganisms to Application in Animal Food Production Chain

Alberto Gonçalves Evangelista, Tiago de Melo Nazareth, Carlos Luz, Victor Dopazo, Ana Moreno, Mario Riolo, Giuseppe Meca, Fernando Bittencourt Luciano

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Animal production; Bacillus; Streptomyces; Zearalenone

Online: 24 September 2024 (12:33:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1917.v1

Multimodal Information Fusion with Neural Gating

Olivia Smith, Ava Martinez, Noah Brown

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: multimodal learning; neural networks; genre classification; information fusion; gated mechanisms

Online: 24 September 2024 (12:32:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1855.v1

Antimicrobial Susceptibility of Uropathogenic Escherichia coli with Analysis of Impact of Socio-Economic Factors in Low, Medium and High-Income Countries

Meher Rizvi, Maria Khan, Amina AL Jardani, Ujjala Ghoshal, Zaaima AL Jabri, Mohammad Ahanjan, Azza AL Mamari, Nawal AL Shizawi, Hiba Sami, Abdullah Balkhair, Adila Shaukat, Alwarith Nasser Salem Alkharusi, Abdulrahman Almahrouqi, Afreenish Hassan, Ajay Kumar, Amal Malehi, Amina Gul, Ashima Singh, Asma Said Hamed AL Shidhani, Areena Hoda Siddiqui, Aruna Poojary, Azza AL Rashdi, Bradley Langford, Dmytro Stepanskyi, Abbas Dolatabadi, Aisha Al Mufraji AL Mufraji, Elham Said Ahmed AL Risi, Garima Kapoor, Isabella Princess, Hatim Ali Eltahir, Hilal Al Sidairi, Kaitlyn Dougherty, Katia Iskandar, Ken Masters, Ibrahim Khalaf Hamdan AL Busaidi, Laila AL Yazidi, Mahfuza Nasrin, Mahmood Salim AL Subhi, Mallika Sengupta Mallika Sengupta, Manisha Khandait, Nada Khalfan AL Tamtami, Nada Khafan Alsiyabi, Nawal AL Kindi, Nazla Musthafa Luthfee, Neha Shreshtha, Nihal Mohamed Amur AL Riyami, Noora Hilal Ali AL Busaidi, Nupur Goel, Oksana Ishchenko, Omnia Mohamed Elnabawy Ahmed Taher, Pragnya Paramita Jena, Rajni Ekadashi, Razan Zadjali, Reba Kanungo, Sara Abolghasemi, Salima Al-maqbali, Sanjay Jaju, Sayantan Banerjee, Shadma Yaqoob, Shahnaz Sali, Shafqat Husnain Khan, Shalini Malhotra, Stephen Hughes, Sundas Shaukat, Syed Mohammed Atif, Vrushali Vishwas Patwardhan, Victorien Dougnon, Wahid Khan, Walid Wali, Zakariya AL Muharrmi, Zeeshana Basit, Jasashree Choudhury, Rachita Pravalina, Sanjeev Singh, Sarman Singh, Neelam Taneja, Raman Sardana, Pawan Kapoor, Rajeev Soman, Rashid Al Abri

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: community acquired UTI; Escherichia coli; antimicrobial susceptibility; Indian subcontinent; MENA; GDP; temperature

Online: 24 September 2024 (12:32:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2238.v3

Challenges and Advances in Cervical Cancer Prevention for HIV-Positive Individuals

Angel Justiz-Vaillant, Darren Gopaul, Odalis Asin-Milan, Rodolfo Arrozarena-Fundora, Reinand Thompson, Sachin Soodeen, Patrick Eberechi Akpaka, Chandrashekhar Unakal

Subject: Biology And Life Sciences, Virology Keywords: HIV; HPV; Prevalence; Vaccination strategy; HPV screening; Cervical intraepithelial neoplasia

Online: 24 September 2024 (12:30:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1854.v1

A Ceramide Theory of Multiple Sclerosis

Ari Rappoport

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: multiple sclerosis; demyelination; ceramide; sphingomyelin; galactosylceramide

Online: 24 September 2024 (12:28:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1910.v1

Synthetic Biology Approaches for Engineering of Secondary Metabolism in Streptomyces: Manipulation of Crosstalk between Primary and Secondary Metabolism

Sergii Krysenko

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: synthetic biology, Streptomyces, biotechnology, primary metabolism, secondary metabolism

Online: 24 September 2024 (12:26:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1869.v1

A Decision Support Tool Integrating Data and Advanced Modeling

Shaul Arieli, Ron Ben Jacob, Gilad Hirschberger, Sivan Hirsch-Hoefler, Ariel Kenett, Ron S. Kenett

Subject: Business, Economics And Management, Other Keywords: decision support tool; indicators; multivariate analysis; composite indicators; random forrests; Bayesian networks

Online: 24 September 2024 (11:59:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1852.v1

Symmetric Reverse $n$-Derivations on Ideals of Semiprime Rings

Shakir Ali, Ali Y. Hummdi, Naira N. Rafiquee, Vaishali Varshney, KokBin Wong

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Semiprime ring; ideal; symmetric $n$-derivation; symmetric reverse $n$-derivation; derivation; trace of symmetric map

Online: 24 September 2024 (11:59:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1876.v1

Spoken Kashmiri Recognition with Dual Feature Extraction and Spectrogram Augmentation Using a CNN-gMLP Hybrid Model

Umer Ayub Hajam, Syed Tanzeel Rabani, Akib Mohi Ud Din Khanday, Mehdi Neshat

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Automatic Speech recognition; Hybrid convolutional neural networks; Kashmiri Language; Spectrogram; Classification

Online: 24 September 2024 (11:58:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1644.v2

RNA Interference of Cytochrome P450s, CYP321A7 and CYP321A8, in Fall Armyworm Spodoptera frugiperda (J.E. Smith, 1797) (Lepidoptera: Noctuidae) Enhances Susceptibility to Chlorantraniliprole and Thiamethoxam

Raymund Kim D. dela Cruz, Karen B. Alviar

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Cytochrome P450; dsRNA; RNAi; Spodoptera frugiperda

Online: 24 September 2024 (11:58:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1875.v1

Strategic Deductive Reasoning in Large Language Models: A Dual-Agent Approach

Siyue Li, Xiaofan Zhou, Zhizhong Wu, Yujian Long, Yanxin Shen

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Language Models; Deductive Reasoning; Information Collection; Pre-trained Models; Strategic Reasoning

Online: 24 September 2024 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1859.v1

Meta-Analysis of the Fisheries, and Life History for Trichiurus. Japonicas, T. brevis and T. nanhaiensis, in the Northwest of Pacific Ocean

Baochao LIAO, Can Zhou, Jianpeng Yu, Kui Zhang, Abdul Baset, Xiujuan Shan, Longchuan Zhuang

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Trichiurus spp.; spatiotemporal heterogeneity; population dynamics; meta-analysis; the northwest Pacific Ocean

Online: 24 September 2024 (11:58:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1908.v1

Predicting Shot Accuracy in Badminton Using Quiet Eye Metrics and Neural Networks

Samson Tan, Teoh Teik Toe

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Quiet Eye (QE); baminton; shot accuracy; neural networks; eye-tracking; biomechanics; sports performance; predictive modeling; gaze dynamics; performance analysis; motor learning; perception in sports

Online: 24 September 2024 (11:57:56 CEST)

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This paper presents a novel approach to predicting shot accuracy in badminton by analyzing Quiet Eye (QE) metrics such as QE duration, fixation points, and gaze dynamics. We develop a neural network model that combines visual data from eye-tracking devices with biomechanical data such as body posture and shuttlecock trajectory. Our model is designed to predict shot accuracy, providing insights into the role of QE in performance. The study involved 30 badminton players of varying skill levels from the Singapore Swimming Club. Using a combination of eye-tracking technology and motion capture systems, we collected data on QE metrics and biomechanical factors during a series of badminton shots. Key results include: 1. The neural network model achieved 85% accuracy in predicting shot outcomes, demonstrating the potential of integrating QE metrics with biomechanical data. 2. QE duration and onset were identified as the most significant predictors of shot accuracy, followed by racket speed and wrist angle at impact. 3. Elite players exhibited significantly longer QE durations (M = 289.5 ms) compared to intermediate (M = 213.7 ms) and novice players (M = 168.3 ms). 4. A strong positive correlation (r = 0.72) was found between QE duration and shot accuracy across all skill levels. These findings have important implications for badminton training and performance evaluation. The study suggests that QE-based training programs could significantly enhance players' shot accuracy. Furthermore, the predictive model developed in this study offers a framework for real-time performance analysis and personalized training regimens in badminton. By bridging cognitive neuroscience and sports performance through advanced data analytics, this research paves the way for more sophisticated, individualized training approaches in badminton and potentially other fast-paced sports. Future research directions include exploring the temporal dynamics of QE during matches and developing real-time feedback systems based on QE metrics.

Preprint ARTICLE | doi:10.20944/preprints202409.1873.v1

Correlation Between IgA Levels in Henoch–Schönlein Purpura and a Medical History of Infectious Disease in the Pediatric Population: A Five-Year Retrospective Analysis

Sînziana Oprițescu, Gabriela Viorela Nițescu, Mihaela Golumbeanu, Dora Boghițoiu, Elena Iuliana Ioniță, Diana-Andreea Ușurelu, Cristian Lucaci, Adriana Negoiță, Elena Moroșan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Henoch–Schönlein purpura; IgA vasculitis; allergic vasculitis; infectious diseases

Online: 24 September 2024 (11:57:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1847.v1

Exploring the Potential of Salicylic Acid and Arbuscular Mycorrhizae in Boosting the Growth and Flowering Response of Statice (Limonium sinuatum [L.] Mill.)

Shriya Gupta, Nomita Laishram, Arvinder Singh, Ritika Manhas, Kedar Mahadev Gheware, Gurdev Chand, Rajesh Kumar Pandey

Subject: Biology And Life Sciences, Horticulture Keywords: Statice; salicylic acid; arbuscular mycorrhiza; growth; flowering

Online: 24 September 2024 (11:57:08 CEST)

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In sustainable floriculture, the integration of arbuscular mycorrhizal fungi (AMF) and salicylic acid (SA) in the cultivation of statice flowers presents a promising ecofriendly approach to enhancing crop health and productivity. AMF improve nutrient uptake, particularly phosphorus, in plants, leading to stronger growth and abundant flowering while reducing the reliance on chemical fertilizers. Additionally, AMF enhance soil structure and water retention, fostering robust root systems and increasing the plant's resilience to drought and soil-borne pathogens thus improving soil health and minimizing environmental impact. Complementarily, the application of salicylic acid boosts the plant’s innate defense mechanisms, elevating its resistance to diseases, enhancing stress tolerance, helping statice flowers withstand adverse conditions such as drought and salinity, and promotes vigorous root development for better nutrient absorption. Hence, this study evaluates the effect of mycorrhizal inoculation and salicylic acid treatment on ornamental statice (Limonium sinuatum [L.] Mill.) cv. Qis White. The investigation involves two primary factors: mycorrhizal inoculation and salicylic acid concentration. For mycorrhizal inoculation, the study compares the untreated control with treatments including Glomus mossae, Gigaspora margarita, and a mixture of both fungi (applied as basal during transplanting). For salicylic acid, the study assesses the untreated control alongside treatments with Salicylic Acid at 100 mg L-1, 150 mg L-1, and 200 mg L-1 (applied as foliar spray at 45 and 90 days after transplanting) in a factorial RCBD experiment with three replications. Growth, flowering, yield and biomass parameters were assessed in this study. The results indicated that statice plants benefited from mycorrhizal inoculation, particularly with Glomus mosseae, when paired with salicylic acid @ 200 mg L-1. This was further validated by principal component analysis. AMF inoculated plants showed improved growth, and superior flower qualities compared to non-inoculated plants. Additionally, the application of salicylic acid demonstrated positive effects across various parameters. Notably mycorrhization led to a delay of 4 to 9 days in the flowering time of statice. In conclusion, mycorrhizal inoculation and salicylic acid can enhance the growth and flowering attributes of statice by choosing the appropriate mycorrhizal inoculum and optimal salicylic acid concentrations. In the future they can contribute to more sustainable and productive statice cultivation by reducing the need for chemical inputs and supporting overall plant health.

Preprint ARTICLE | doi:10.20944/preprints202409.1858.v1

Reproductive Biology of the Invasive Blue Crab Callinectes sapidus in the Thermaikos Gulf (Northwest Aegean Sea, Eastern Mediterranean): Identifying Key Information for an Effective Population Management Policy

KOSMAS KEVREKIDIS, THEODOROS KEVREKIDIS, CHARITON CHARLES CHINTIROGLOU, KYRIAKI AVRAMOGLOU, SOFOKLIS KEISARIS, KOSTAS FRYGANIOTIS, CHRISOULA APOSTOLOGAMVROU, Kyriakoula Roditi, Konstantinos Voulgaris, Anastasios Varkoulis, IRENE DALMIRA, Katerina Charitonidou, VIVIAN MALEA, DIMITRIS VAFIDIS

Subject: Biology And Life Sciences, Aquatic Science Keywords: invasive blue crab; Callinectes sapidus; Thermaikos Gulf; Aegean Sea; reproductive biology; ovigerous females; depth gradient; size at first maturity; fecundity; population management policy

Online: 24 September 2024 (11:56:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1911.v1

Uric Acid Transporter Gene SLC22A12 is a Chimera of Multiple Ancestral Genes

Kazuharu Misawa

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Uric acid transporter; Gout; Hyperuricemia; Gene fusion; Molecular Evolution; Mammal

Online: 24 September 2024 (11:56:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1846.v1

Class Incremental Learning for Financial Data Streams and Two Classes of Methodologies

Larry Milner

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Class-incremental Learning; Financial Learning; Machine Learning; Optimization

Online: 24 September 2024 (11:51:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1866.v1

Floater Assembly and Turbine Integration Strategy for Floating Offshore Wind Energy: Considerations and Recommendations

Glib Ivanov, Kai-Tung Ma

Subject: Engineering, Marine Engineering Keywords: offshore wind; floater assembly; port infrastructure; turbine integration; installation strategy

Online: 24 September 2024 (11:49:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1844.v1

Potential of Anxiety and Fear in Indonesia’s and Taiwan’s Online News regarding COVID-19 Pandemic: Sentiment Analysis

Meiselina Irmayanti, Li Fang Chou, Nur Najla binti Zainal Anuar

Subject: Social Sciences, Psychology Keywords: anxiety; fear; sentiment analysis; online news; LIWC; seance

Online: 24 September 2024 (11:49:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1853.v1

Construction of a DNA Fingerprinting of Improved Varieties of Slash Pines in China Based on 51K Liquid-Phased Probes

Yadi Wu, Shu Diao, Xianyin Ding, Qinyun Huang, Qifu Luan

Subject: Biology And Life Sciences, Forestry Keywords: DNA fingerprinting; Improved variety identification; liquid-phased probes; Pinus elliottii

Online: 24 September 2024 (11:48:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1783.v1

Investigation on Hydrodynamic Performance and Wall Temperature of Water-cooled Wall in a 1000 MW Boiler under Low-load Conditions

Peian Chong, Xiaolei Zhu, Jianning Li, Xiao Li, Lei Deng

Subject: Engineering, Energy And Fuel Technology Keywords: Supercritical boiler; Water-cooled wall; Hydrodynamic performance; Wall temperature characteristics; Deep peak shaving

Online: 24 September 2024 (11:33:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1785.v1

Physical Health and Welfare States of Fin (Balaenoptera physalus) and Humpback Whales (Megaptera novangliae) in an Anthropized Environment: Validation of a First Animal-Based Welfare Assessment Protocol for Wild Cetaceans

Anik Boileau, Jonathan Blais, Marie-Francoise Van Bressem, Kathleen Ellen Hunt, Jamie Ahloy-Dallaire

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Humpback Whales; Fin Whales; Welfare Assessment; Anthropized environment; Chronic Stress; Entanglement; Physical health; Body condition; Cutaneous lesions

Online: 24 September 2024 (11:32:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1772.v1

Chaotic Dynamics, Sequence Density, and Chaos Suppression: A Study in Euclidean and Riemannian Spaces Inspired by Collatz-like Problems

Rafik zeraoulia

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: ; Collatze like problem; irrationality; sequences; Riemannian metri

Online: 24 September 2024 (11:30:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1797.v1

The ESG Criteria Impact on Taxation

Marco Greggi

Subject: Social Sciences, Law Keywords: ESG; Direct taxation; Business Income; Transfer Pricing; GAAR: Business Purpose Test; Market Economy; UN; EU; Interpretation of the Law

Online: 24 September 2024 (11:28:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1771.v1

Sputum Induction in Pediatric Lung Disease: Are We There Yet?

Tuba Kockar Kizilirmak, Emanuela M Bruscia, Clemente J Britto, Marie E Egan

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Induced sputum; airway inflammation; respiratory; children

Online: 24 September 2024 (11:26:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1835.v1

Fungi as Indicators of Indoor Air Quality: Their Effects on Human Health and Treatment

Azhar Abdullah Najjar

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Fungi; Indoor air quality; Contamination; Human Health risk; Treatment

Online: 24 September 2024 (11:22:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1843.v1

Association Between Temperature and Sunlight Hours with Daily Steps in School-Aged Children over 35 Weeks: Findings from the E-MOVI Study

Eva Rodríguez-Gutiérrez, Ana Torres-Costoso, Estela Jiménez-López, Arthur Eumann Mesas, Valentina Díaz-Goñi, María José Guzmán‐Pavón, Nuria Beneit, Vicente Martínez-Vizcaíno

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: children; sunlight; temperature; daily steps; physical activity; dose-response analysis

Online: 24 September 2024 (11:21:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1898.v1

Mild Traumatic Brain Injury in Yucatan Minipigs: Assessing Changes in Approachability/Sociability and Mechanical Nociception Following Central Fluid Percussion Injury

Mark Pavlichenko, Radina Lilova, Amanda Logan-Wesley, Karen Gorse, Audrey D. Lafrenaye

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: mild traumatic brain injury; minipig; central fluid percussion injury; social behavior; mechanical nociception; human approach task; von Frey

Online: 24 September 2024 (11:16:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1901.v1

The Impact of Data Packet Loss on Neural Decoding

Jiaqi Zheng, Yuan Li, Liangliang Chen, Fei Wang, Boxuan Gu, Qixiang Sun, Xiang Gao, Fan Zhou

Subject: Engineering, Bioengineering Keywords: Neural Decoding; Packet Loss; Gilbert-Elliott Model

Online: 24 September 2024 (11:15:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1895.v1

Theory of Food: The Relationship between Childhood Eating Habits to Implicit Attitudes towards Food in Adulthood

Omer Horovitz

Subject: Social Sciences, Psychology Keywords: nutritional psychology; theory of food; childhood eating habits; implicit attitudes; food choices

Online: 24 September 2024 (11:11:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1887.v1

Enhanced Modal Fusion Learning for Multimodal Sentiment Interpretation

Kayla Robinson, Ava Martinez, Ethan Turner

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: sentiment analysis; robust learning; cross-modal integration

Online: 24 September 2024 (11:09:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1890.v1

Thermal Stress and Suitability for Aquatic Species in the San Francisco Estuary

Catarina Pien, Rosemary Hartman, Eva Bush, Peggy Lehman, Brittany Davis

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: water temperature; estuary; thermal stress; habitat suitability; climate change; refugia; Sacramento-San Joaquin delta; long-term monitoring; fish

Online: 24 September 2024 (11:08:25 CEST)

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Increases in water temperature caused by climate change will challenge water and species management in the San Francisco Estuary. Our goals were to describe spatial and seasonal patterns in water temperature across the upper Estuary, and evaluate how temperature stress and suitability vary across the aquatic ecosystem. We synthesized 10 years of continuous water temperature data at 75 stations across six regions of the Estuary between 2010 and 2019. We identified stressful temperature thresholds for species of interest using published physiological limits and observed distribution, including ESA-listed native (e.g., osmerids, salmonids), non-ESA-listed native (e.g., cyprinids), non-native (e.g., centrarchids, bivalves), and nuisance species such as invasive aquatic vegetation, and harmful cyanobacteria. We then quantified thermal stress across varying spatial and temporal scales and metrics. Analyses indicated there were detectable regional temperature differences, and that Suisun Bay was the only region to provide regular thermal refuge during the warmer parts of the year, though portions of the Confluence and Suisun Marsh also provided potential thermal refuge during summer/fall and during cooler parts of the day. Meanwhile, the Central and South Delta experienced the warmest temperatures, exceeding thresholds for listed species throughout summer and early fall. We found that listed species such as juvenile salmonids and osmerids experience more thermal stress across a number of metrics. Fishes with higher heat tolerance (including non-natives and select natives), aquatic vegetation, and Microcystis (a harmful cyanobacteria) had the lowest average number of thermal stress days. This study demonstrates that the Estuary is already exhibiting stressful conditions for species of concern, and thermal stress will only increase with climate change. We identify at what times of year and where the Estuary may provide refuge from thermal stress conditions which has important implications for restoration prioritization and design and species management.

Preprint ARTICLE | doi:10.20944/preprints202409.1902.v1

Friendship Through a Narcissistic Lens: The Role of Narcissism in Perceived Humor Similarity Among Friends in Germany and the US

Tobias Altmann, Destaney Sauls

Subject: Social Sciences, Psychology Keywords: narcissism; friendship; humor styles; perceived similarity; friend-report

Online: 24 September 2024 (11:07:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1862.v1

Evaluation of Chronic Pain Development in Patients Undergoing Shoulder Arthroscopy

Teoman Etikcan, Keziban Sanem Cakar Turhan, Suheyla Karadag Erkoc, Hanzade Aybuke Unal

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; postoperative pain; arthroscopy

Online: 24 September 2024 (11:04:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1838.v1

Cutting Through History: The Evolution of Glioblastoma Surgery

Abdullah Ishaque, Sunit Das

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: glioblastoma; surgery; history

Online: 24 September 2024 (11:02:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1894.v1

Diverse Fatty Acid Profiles and Antioxidant Properties in Different Populations of Ox Tongue (Echium amoenum) Fisch. & Mey

Zohreh Emami Bistgani, Vahid Rowshan Sarvestani, Masoud Hashemi

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Ox tongue; Fatty acids; Antioxidant; α-linolenic acid

Online: 24 September 2024 (10:59:54 CEST)

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