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Preprint ARTICLE | doi:10.20944/preprints201904.0163.v1

Butyl Rubber-Based Composite: Thermal Degradation and Prediction of Service Life Time

Phuong Nguyen-Tri, Ennouri Triki, Tuan Anh Nguyen

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polymer aging; swelling behavior; protective glove materials; elastomers; composites; rubber

Online: 15 April 2019 (11:29:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1885.v1

Advancements in the Anti-aging Effects of Physical Activity: Bibliometric- and Meta-Analyses

Yerim Choi, Daekyoo Kim, Seung Kyum Kim

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: aging; physical activity; bibliometric analysis; meta-analysis; frailty; resistance training

Online: 30 October 2023 (10:26:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0516.v1

The Confound of Hemodynamic Response Function Variability in Resting-State Functional MRI Studies

D Rangaprakash, Robert Barry, Gopikrishna Deshpande

Subject: Biology And Life Sciences, Biophysics Keywords: BOLD fMRI; HRF; resting state connectivity; aging; sex differences; confound

Online: 28 February 2023 (09:32:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0683.v1

Effectiveness of tDCS to Improve Recognition and Reduce False Memories in Older Adults

Juan C Melendez, Encarnación Satorres, Alfonso Pitarque, Iraida Delhom, Elena Real, Joaquin Escudero

Subject: Social Sciences, Psychology Keywords: transcranial direct current stimulation; true recognition; false recognition; aging; experiment.

Online: 28 December 2020 (11:15:38 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202009.0168.v1

Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach

Md. Adnan Arefeen, Sumaiya Tabassum Nimi, M. Sohel Rahman, S. Hasan Arshad, John W. Holloway, Faisal I. Rezwan

Subject: Computer Science And Mathematics, Computer Science Keywords: lung function; epigenetic aging; machine learning; feature selection; hyperparamter tuning

Online: 8 September 2020 (03:15:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0482.v1

Potential of Cochayuyo (Durvillaea incurvata) Extract Obtained by Ultrasound Assisted Extraction Against Aging Related Diseases.

Nicolás Muñoz-Molina, Javier Parada, Mario Simirgiotis, Romina Montecinos-González

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Durvillaea incurvata; aging; enzymes inhibition; Alzheimer's, diabetes; hypertension

Online: 7 December 2023 (07:12:27 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202108.0267.v1

From Oncological Paradigms to Non-Communicable Disease Pandemic. The Need of Recovery Human Biology Evolution

Elia Biganzoli, Romano Demicheli

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer dormancy; Low-grade chronic inflammation; Healthy aging; Physical exercise

Online: 11 August 2021 (17:57:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1143.v1

Estimation of Threshold Age for Cerebral Decline Using Sigmoidal Growth Model in Cross-Sectional Imaging Study

Namhee Kim, Moonseong Heo, Roman Fleysher, Malka Z. Sears, Michael L. Lipton

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: aging; sigmoidal growth function; nonlinear regression; threshold estimation; fractional anisotropy

Online: 18 September 2023 (14:27:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0338.v2

Effect of Artificial Aging Treatment and lubrication Modes on the Machinability of A356 Cast Alloys

Mohamed Amine Alliche, Abdelhakim Djebara, Yasser Zedan, Victor Songmene

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: aluminum alloys; artificial aging; drilling; surface quality; cutting fluid; burr formation

Online: 27 March 2020 (02:54:29 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202312.1892.v1

Epigenetic Clocks and Programmatic Aging

David Gems, Roop Singh Virk, João Pedro de Magalhães

Subject: Biology And Life Sciences, Aging Keywords: aging, development, epigenetics, hyperfunction, methylation clocks, programmatic theory

Online: 26 December 2023 (11:31:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1716.v1

Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain

Sanna H. Loppi, Marco A. Tavera-Garcia, Natalie E. Scholpa, Boaz K. Maiyo, Danielle A. Becktel, Helena W. Morrison, Rick G. Schnellmann, Kristian P. Doyle

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: stroke; aging; mitochondrial biogenesis; beta-2-adrenergic activation

Online: 26 October 2023 (12:16:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1227.v1

Neurofilament Light Chain Levels Increase With Age and Are Associated With Worst Physical Function and Body Composition in Men but Not in Women

Xavier Capo, Aina Galmes-Panades, Cayetano Navas-Enamorado, Ana Ortega-Moral, Silvia Marin, Marta Cascante, Andres Sanchez-Polo, Luis Masmiquel, Margalida Torrens-Mas, Marta Gonzalez-Freire

Subject: Biology And Life Sciences, Aging Keywords: Aging; neurodegeneration; metabolomics; NFL; muscle function; gender dimorphism

Online: 18 July 2023 (14:18:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0377.v1

Calibrating A Comprehensive Immune Age Metric to Analyze the Cross Sectional Age-Related Decline in Cardiorespiratory Fitness

Peter Bröde, Maren Claus, Patrick D. Gajewski, Stephan Getzmann, Klaus Golka, Jan G. Hengstler, Edmund Wascher, Carsten Watzl

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; immunosenescence; physical fitness; physical activity; obesity; sex

Online: 26 September 2022 (05:00:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0208.v1

Lactobacillus Acidophilus DDS-1 Modulates the Gut Microbial Co-Occurrence Networks in Aging Mice

Ravichandra Vemuri, Christopher J. Martoni, Kylie Kavanagh, Rajaraman Eri

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; intestinal microbiota; dysbiosis; probiotics; microbial co-occurrences

Online: 17 February 2022 (10:59:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0542.v1

Changes in Facial Recognition and Facial Expressions with Age

Hyunwoong Ko, Kisun Kim, Minju Bae, Myo-Geong Seo, Gieun Nam, Seho Park, Soowon Park, Jungjoon Ihm, Jun-Young Lee

Subject: Social Sciences, Psychology Keywords: action unit; aging; emotion; facial expression; facial recognition

Online: 20 April 2021 (12:47:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0305.v1

Prostaglandin E2 induces Skin Aging via E-prostanoid 1 in Normal Human Dermal Fibroblasts

Joong Hyun Shim

Subject: Biology And Life Sciences, Aging Keywords: PGE2; EP1; skin-aging; ERK1/2; intracellular calcium

Online: 27 October 2019 (11:04:31 CET)

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Working Paper REVIEW

Eye Movements Actively Reinstate Spatiotemporal Mnemonic Content

Jordana Wynn, Kelly Shen, Jennifer Ryan

Subject: Social Sciences, Cognitive Science Keywords: eyetracking, eye movements, gaze, memory, retrieval, vision, aging

Online: 20 May 2019 (12:25:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0091.v1

Frailty as a Moderator of the Relationship Between Social Isolation and Health Outcomes in Community-Dwelling Older Adults

Fereshteh Mehrabi, François Béland

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Frailty; Social Isolation; Social Networks; Social Support; Social Participation; Aging

Online: 2 February 2021 (14:32:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1583.v1

The Shortening of Leukocyte Telomere Length Contributes to Alzheimer’s Disease: Further Evidence from Late-Onset Familial and Sporadic Cases

Paolina Crocco, Francesco De Rango, Serena Dato, Rossella La Grotta, Raffaele Maletta, Amalia Cecilia Bruni, Giuseppe Passarino, Giuseppina Rose

Subject: Biology And Life Sciences, Aging Keywords: Telomere length; Telomeres; Alzheimer’s Disease; late-onset AD, Aging, Neurodegeneration

Online: 22 August 2023 (13:22:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0374.v1

Very Low and High Levels of Vitamin D are Associated with Shorter Leukocyte Telomere Length in 148,321 UK Biobank Participants

Chia-Ling Kuo, Ben Kirk, Meiruo Xiang, Luke C. Pilling, George A. Kuchel, Richard Kremer, Gustavo Duque

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Telomerase; leukocyte telomere length; vitamin D; aging; serum levels; geroscience

Online: 22 January 2023 (03:36:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0153.v2

Trends in Excess Winter Mortality (EWM) From 1900/01 to 2019/20—Evidence for a Complex System of Multiple Long-Term Trends

Rodney P. Jones, Andrey Ponomarenko

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: winter mortality; trends; season; estimated influenza mortality; pandemic influenza; aging

Online: 25 February 2022 (14:24:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0791.v1

A High-Speed Multichannel Electrochemical Impedance Spectroscopy System Using Broadband Multi-Sine Binary Perturbation for Retired Li-Ion Batteries of EVs

Muhammad Sheraz, Woojin Choi

Subject: Engineering, Electrical And Electronic Engineering Keywords: Electrochemical Impedance Spectroscopy (EIS); Battery Aging; Retired EVs Battery; Battery Grading; Broadband Perturbation; Combined Multi-sine Binary Signal (MSBS); Digital Lock-in Amplifier (DLIA); Kronig Kramer (KK) Transform

Online: 11 April 2024 (10:04:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1294.v1

The Mediating Effects of Social Networks and Wisdom on the Relationship between Lifestyle Habits and Healthy Aging in Older Adults with Chronic Diseases

Hee-Kyung Kim, Hye-Suk Oh, Cheol-Hee Park

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: elderly; healthy aging; lifestyle habits; social networks; wisdom; chronic disease

Online: 19 July 2023 (09:53:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0246.v1

On the Safety of Implanted Breast Prostheses in Accidental Impacts

Gerardus Janszen, Michela Arnoldi, Valeriano Vinci, Marco Klinger, Luca Di landro

Subject: Chemistry And Materials Science, Biomaterials Keywords: breast implants; silicone prosthesis aging; accidental impacts; crash test; compression tests

Online: 5 June 2023 (05:38:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0255.v3

How Much of Aging Is Simply a Trash Collection Problem?

Michael Renteln

Subject: Biology And Life Sciences, Aging Keywords: Anti-aging therapy; lipofuscin; SENS; oncolytic vector; telomerase; TFEB; intracellular microbe

Online: 22 February 2023 (15:24:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202204.0055.v1

Activity-Dependent Induction of Younger Molecular, Cellular and Organism Phenotypes

Thomas Lissek

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cell; biology; aging; medicine; transcription; activity; neurons; brain; immune system; muscle

Online: 7 April 2022 (04:24:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1990.v1

The Central Role of the Kynurenine Pathway of Tryptophan Metabolism in the Pathophysiology of Frailty, Sarcopenia and Osteoporosis

Juan Ballesteros, Daniel Rivas, Gustavo Duque

Subject: Biology And Life Sciences, Aging Keywords: Tryptophan; Kynurenine pathway; Aging; older adults; Inflammation; Osteoporosis; Sarcopenia; Frailty; Biomarkers; Osteosarcopenia

Online: 29 May 2023 (07:32:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0135.v1

MRI Study of the Influence of Surface Coating Aging on the In Vivo Biodistribution of Iron Oxide Nanoparticles

Susana Carregal-Romero, Sandra Plaza-Carcía, Rafael Piñol, Losé Luís Murillo, Jesús Ruiz-Cabello, Daniel Padro, Ángel Millán, Pedro Ramos-Cabrer

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: iron oxide nanoparticles; multimodal nanoparticles; biodistribution; magnetic resonance imaging; aging; coating degradation

Online: 6 November 2018 (10:37:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.0213.v1

Nitric Oxide as a Determinant of Human Longevity and Health Span

Burkhard Poeggeler, Kumar Sandeep Singh, Kumar Sambamurti, Miguel A. Pappolla

Subject: Biology And Life Sciences, Aging Keywords: aging; amino acids; antioxidant; arginine; nitric oxide; oxidative stress; protein; peptide

Online: 6 September 2023 (14:47:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0090.v1

Nitric Oxide as a Determinant of Human Longevity and Health Span

Burkhard Poeggeler, Sandeep Kumar Singh, Kumar Sambamurti, Miguel A. Pappolla

Subject: Biology And Life Sciences, Aging Keywords: aging; amino acids; antioxidant; arginine; nitric oxide; oxidative stress; protein; peptide

Online: 1 September 2023 (16:25:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0061.v1

Sustainable Transformation of Digital Health Services- A Stakeholder Exploratory Case Study

Siyu Zhou, Ziling Ni, Atsushi Ogihara, Xiaohe Wang

Subject: Public Health And Healthcare, Health Policy And Services Keywords: sustainability; digital transformation; suitable for aging; service ecological theory; health service

Online: 6 May 2022 (07:45:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1242.v1

Effects of Lignin on the Thermal and Morphological Properties and Damages Mechanisms after UV Irradiation of Polypropylene Biocomposites Reinforced with Flax and Pine Fibres: Acoustic Emission Analysis

Zouheyr Belouadah, Khaled Nasri, Lotfi Toubal

Subject: Engineering, Mechanical Engineering Keywords: biocomposites; UV aging; acoustic emission; damage mechanisms; environmental degradation; thermogravimetric analysis

Online: 20 March 2024 (17:03:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0043.v1

Managing Skin Ageing as a Modifiable Disorder – The Clinical Application of Nourella® Dual Approach Comprising a Nano-encapsulated Retinoid, Retilex-A® and a Skin Proteoglycan Replacement Therapy, Vercilex®

Jan Wadstein, Israel Sánchez Alvarez, Erling Thom, Lidia Bernal López

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin Aging; Rejuvenation; Skin Cream; Retinoid formulation; RetileX-A; Vercilex

Online: 2 November 2021 (10:55:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1288.v1

The Prevalence and Risk Factors of Low Bone Mineral Density in the Population of the Abay Region of Kazakhstan

Madina Madiyeva, Tamara Rymbaeva, Alida Kaskabayeva, Gulzhan Bersimbekova, Gulnur Kanapiyanova, Marya Prilutskaya, Dinara Akhmetzhanova, Aliya Alimbaeva, Nazarbek Omarov

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: bone mineral density; osteoporosis; dual energy X-ray absorptiometry; dietary patterns; aging

Online: 18 April 2024 (15:54:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0088.v1

IoT-based Technologies for Addressing the Unique Healthcare Needs of the Elderly Population

Syed Adnan Ali, Rehan Khan

Subject: Computer Science And Mathematics, Information Systems Keywords: IoT; geriatric healthcare; IoMT; biomedical devices; telemedicine; remote monitoring; aging population

Online: 6 March 2023 (04:20:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202304.0622.v1

A Systematic Review of Qualitative Research Literature and a Thematic Synthesis of Older LGBTQ People’s Experiences of Quality of Life, Minority Joy, Resilience, Minority Stress, Discrimination, and Stigmatization in Japan and Sweden

Anna Sofia Bratt, Ann-Christine Petersson Hjelm, Matilda Wurm, Richard Huntley, Yoshihisa Hirakawa, Tsukasa Muraya

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: aging; aged; sexual and gender minorities; quality of life; stereotyping; social discrimination

Online: 20 April 2023 (07:49:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0082.v1

Dose-Dependent Effects of Oral Tyrosine Administration on Plasma Tyrosine Levels and Cognition in Aging

Ondine van de Rest, Mirjam Bloemendaal, Rianne de Heus, Esther Aarts

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: tyrosine; dose-response; aging; working memory; plasma amino acids; catecholamines; dopamine

Online: 18 September 2017 (15:48:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0027.v1

Influence of Environmental Parameters and Fiber Orientation on Dissolution Kinetics of Glass Fibers in Polymer Composites

Andrey E. Krauklis, Hani Amir Aouissi, Selma Bencedira, Juris Burlakovs, Ivar Zekker, Irina Bute, Maris Klavins

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: glass fibers; composites; environmental aging; modeling; kinetics; water; pH; temperature; orientation; durability

Online: 4 July 2022 (03:44:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0401.v1

Definition of the Sensory and Aesthetic Spaces of Dry White Wines with Aging Ability by Experienced Tasters

Marta Esteves, Mariana Sequeira, Manuel Malfeito Ferreira

Subject: Biology And Life Sciences, Food Science And Technology Keywords: white wines, fine wines, aging potential, appreciation, age prediction, browning, complexity, quality.

Online: 7 May 2024 (13:52:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1131.v1

Online Determination of State of Charge in Lithium-Ion Batteries: Influence of the State of Health

Carlos Armenta-Déu

Subject: Physical Sciences, Chemical Physics Keywords: Lithium-ion batteries; State of Charge; State of Health; Aging Effects; Simulation process

Online: 17 June 2024 (11:16:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2235.v1

New Insights into the Enhancement Effect of Exogenous Calcium on Biochar Stability during Its Aging in Farmland Soil

Hongyan Nan, Yunqiu Jiang, Weiqi Zhou, Ling Zhao, Fan Yang

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: Biochar aging; Ca-rich biochar; Carbon stability; Farmland soil; Carbon sequestration

Online: 31 May 2023 (11:18:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0360.v2

Rice Husk Shredding as a Means of Increasing the Long-Term Mechanical Properties of Earthen Mixtures for 3D Printing

Elena Ferretti, Massimo Moretti, Alberto Chiusoli, Lapo Naldoni, Francesco De Fabritiis, Massimo Visonà

Subject: Engineering, Civil Engineering Keywords: earthen buildings; 3D printing; sustainability; biocomposites; aging; mechanical properties; lime carbonation; vulcanization

Online: 11 January 2022 (12:14:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0133.v2

Age- and Genotype-Specific Effects of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Mitochondrial and Metabolic Parameters in Drosophila melanogaster

Karis A. Ederer, Kelly Jin, Sarah Bouslog, Lu Wang, Greg S. Gorman, Glenn C. Rowe, Peter Abadir, Daniel Raftery, Douglas Moellering, Daniel Promislow, Patricia Jumbo-Lucioni, Maria De Luca

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aging; angiotensin-converting enzyme inhibitors; nutrient metabolism; genetic background; nutritional stress

Online: 29 October 2018 (10:33:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0202.v1

Anisotropic Tensile and Compressive Strengths of Al–4wt.%Cu Alloy Powder: Part 1—Effects of Compaction Loads and Heat Treatments

Rodrigo Silva Bonatti, Ausdinir D. Bortolozo, Rodrigo F.G. Baldo, Erik Poloni, Wislei R. Osório

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: aluminum composite; Al–Cu alloys; natural aging; annealing; mechanical properties; environmental aspects

Online: 5 September 2023 (05:22:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2091.v1

Solsol Seo, Tae-Seok Kim, Yeon-Hee Lee

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: aging; oral health; saliva; halitosis; systemic disease; systemic medication

Online: 28 August 2024 (16:36:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0862.v1

Nutrient Intake and its Association with Appendicular Total Lean Mass, Function and Strength in Older Adults: A Population-Based Study

Miguel Germán Borda, Jessica Samuelsson, Tommy Cederholm, Jonathan Patricio Baldera, Mario Ulises Perez-Zepeda, George E. Barreto, Anna Zettergren, Silke Kern, Rydén Lina, Mariana Gonzalez-Lara, Salomón Salazar-Londoño, Gustavo Duque, Ingmar Skoog, Dag Aarsland

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Sarcopenia; Body Composition; Aging; Diet; Walking Speed; Muscle Strength

Online: 11 January 2024 (10:21:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1932.v1

DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging

Jawad Nadeem, Amna Parveen, Sun Yeou Kim

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Anti-aging, DNA damage response, senescence-associated secretory phenotype

Online: 28 September 2023 (04:56:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1322.v1

Age and Task Modulate Olfactory Sensitivity in the Florida Carpenter Ant Camponotus floridanus

Stephen T Ferguson, Isaac Bakis, Nicholas D Edwards, Laurence J Zwiebel

Subject: Biology And Life Sciences, Insect Science Keywords: hymenoptera; olfaction; odor coding; task allocation; age polyethism; aging

Online: 19 July 2023 (10:03:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1701.v1

Evaluating Sarcopenia Using Bioelectrical Impedance Vector Analysis and Phase Angle

Saizhao Tang, Fang Lin Jiang, Seon-Ho Eom, Jae-Young Lee, Ji Heon Chae, Chul-Hyun Kim

Subject: Public Health And Healthcare, Primary Health Care Keywords: bioelectrical impedance vector analysis; phase angle; aging; diagnosis; noninvasive

Online: 25 June 2023 (03:09:52 CEST)

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Sarcopenia becomes more common with age, being most prevalent among elderly individuals. According to the EWGSOP, muscle mass is one of the criteria for the evaluation of sarcopenia. The main methods for evaluating muscle mass are CT, MRI, and DXA, but these methods are difficult to apply in the field due to equipment costs, radioactivity, and lack of portability. BIVA and PhA are alternative approaches for assessing somatic cell mass and volume and do not require predictive equations. These variables are clinically relevant parameters that indicate cell health, especially cell membrane integrity and cell function. This study in sarcopenic and nonsarcopenic elderly volunteers aimed to determine the BIVA distribution pattern among individual sarcopenia patients; to evaluate the relationship between PhA and muscle strength, muscle quality, and physical function; and to find any correlates of PhA. The sample comprised 134 free-living elderly individuals of both sexes aged 69–91 years. Anthropometric parameters, grip strength, DXA findings, BIA results, and physical performance (the 6-meter walk test) were measured. Impedance vector distributions were evaluated in sarcopenia patients and healthy elderly individuals using BIVA. According to the AWGS criteria, sarcopenia was diagnosed according to DXA findings, grip strength and physical performance test results. Group differences were evaluated using the t test, Mann‒Whitney U test, and Hotelling's T2 test. Correlation analysis was performed to identify variables significantly associated with PhA. Linear regression analysis was performed to determine whether PhA was associated with muscle strength, muscle quality and physical function. BIVA detected a significant difference between the sarcopenia and non-sarcopenia groups (both sexes) due to higher R/H values and lower phase angles in a few individuals, whereas Xc/Ht values did not differ between the two groups. The sarcopenia group had a significantly lower PhA than the non-sarcopenia group among both males (p<0.01) and females (p<0.05). PhA was significantly correlated with age, ASM, HGS, and muscle quality in both sexes and significantly correlated with ASM/Ht2 and physical performance in males. PhA was a significant indicator of muscle strength in both males (β = 2.6; p<0.01) and females (β = 3.4; p<0.01), a significant indicator of muscle quality in both males (β = 0.07; p<0.05) and females (β = 0.17; p<0.01), and a significant indicator of physical performance in males (β = 0.3; p<0.01). BIVA can detect changes in muscle mass in individuals with sarcopenia and is a practical method for the assessment of sarcopenia in the field. PhA is a good indicator of muscle strength, muscle quality and physical performance (in males). These methods can help diagnose sarcopenia in elderly individuals with reduced mobility.

Preprint ARTICLE | doi:10.20944/preprints202305.1638.v1

Population Aging and Household Tourism Consumption——An Empirical Study Based on China Family Panel Studies (CFPS) Data

Xing Cai, Yinhe Zhang

Subject: Social Sciences, Tourism, Leisure, Sport And Hospitality Keywords: population aging; household tourism consumption; intergenerational care; Internet use

Online: 23 May 2023 (10:26:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0598.v1

Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria

Wei Xu, Xiaodong Li

Subject: Biology And Life Sciences, Aging Keywords: circadian rhythms; aging; suprachiasmatic nucleus; peripheral clock; inflammatory response

Online: 9 May 2023 (08:19:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0158.v1

Maria Casagrande, Francesca Agostini, Francesca Favieri, Giuseppe Forte, Jasmine Giovannoli, Angela Guarino, Andrea Marotta, Fabrizio Doricchi, Diana Martella

Subject: Social Sciences, Psychology Keywords: Attention; Attentional Networks; Alerting; Orienting; Executive Control; Aging; Lateralization

Online: 6 July 2021 (14:52:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0115.v1

Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations Under Maternal High-Fat Diet Intake: Multigenerational Epigenetic Inheritance.

Vanesa Izquierdo, Verónica Palomera-Ávalos, Mercè Pallàs, Christian Griñán-Ferré

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cognitive decline; epigenetics; HFD; aging; SAM0P8; m6A, multigenerational inheritance.

Online: 4 December 2020 (14:54:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0240.v1

Sarcopenia is Associated Cognitive Impairment Mainly Due to Slow Gait Speed: Results from the Korean Frailty and Aging Cohort Study (KFACS)

Miji Kim, Chang Won Won

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: sarcopenia; slow gait speed; cognitive impairment; older adult; aging

Online: 22 April 2019 (11:28:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0563.v1

Omega-3 Monoacylglyceride Effects on Longevity, Mitochondrial Metabolism and Oxidative Stress: Insights from Drosophila melanogaster

Camille M. Champigny, Robert P.J. Cormier, Chloé J. Simard, Patrick-Denis St-Coeur, Samuel Fortin, Nicolas Pichaud

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mitochondrial metabolism; aging; monoacylglyceride; polyunsaturated fatty acids; oxidative stress

Online: 24 October 2018 (09:40:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0123.v1

Multi-Azimuth Failure Mechanisms in Phosphor-Coated White LEDs by Current Aging Stresses

Zhangbao Peng, Ziquan Guo, Tingzhu Wu, Peng Zhuang, Yuan Shi, Tien-Mo Shih, Yijun Lu, Hao-Chung Kuo, Zhong Chen

Subject: Engineering, Electrical And Electronic Engineering Keywords: light-emitting diodes; failure mechanisms; current-stress aging; reliability

Online: 15 March 2018 (16:32:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201802.0048.v1

Body Weight Loss, Tissue Wasting and Shortened Lifespan in Late Middle-aged Mice on Imbalanced Essential/Non-essential Amino Acids Diet

Giovanni Corsetti, Evasio Pasini, Claudia Romano, Riccardo Calvani, Anna Picca, Emanuele Marzetti, Vincenzo Flati, Francesco S. Dioguardi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Aging, Nutrition, Diet, Muscle atrophy, Body wasting, Food choice

Online: 5 February 2018 (23:43:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0364.v1

Efﬁcacy and Safety of Phaseolus angularis L for. as Anti-aging Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

Sarang Oh, Jeehaeng Jeong, Xiangji Jin, Myeongju Kim, Shengdao Zheng, Tae-Hoo Yi

Subject: Medicine And Pharmacology, Dermatology Keywords: Phaseolus angularis seed extract (PASE); anti-aging; health skin, cosmetic products

Online: 20 December 2022 (09:03:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1619.v1

Epigenetic Reprogramming of Aging: Reversing the Clock for Regenerative Medicine

Mohammad Odah

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Epigenetic Reprogramming; Aging; Regenerative Medicine; DNA Methylation; Cellular Rejuvenation; CRISPR-Cas9; Senescence

Online: 22 August 2024 (06:02:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0032.v1

Aging Triggers H3K27 Trimethylation Hoarding in the Chromatin of Nothobranchius Furzeri Skeletal Muscle

Chiara Cencioni, Johanna Heid, Anna Keprelova, Seyed Mohammad Mahdi Rasa, Carsten Kuenne, Stefan Guenther, Mario Baumgart, Alessandro Cellerino, Francesco Neri, Francesco Spallotta, Carlo Gaetano

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; skeletal muscle; sarcopenia; frailty; chromatin; epigenetic changes; histone modifications; Nothobranchius furzeri

Online: 2 August 2019 (12:17:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0094.v1

Modeling Time-Dependent Behavior of Concrete Affected by Alkali Silica Reaction in Variable Environmental Conditions

Mohammed Alnaggar, Giovanni Di Luzio, Gianluca Cusatis

Subject: Engineering, Civil Engineering Keywords: alkali silica reaction; lattice discrete particle model; concrete; creep; shrinkage; aging; deterioration

Online: 17 April 2017 (06:12:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0028.v3

Anti Cutaneous Aging Effect of Red Djulis (Chenopodium formosanum) Extract on Gene Expression of Human Dermal Fibroblast

Yung-Hsiang Lin, Yung-Kai Lin, Shu-Ting Chan, Yu-Ming Chun, Yu-Ting Lin, Kai-Wen Kan, Chin-Hsiu Yu

Subject: Biology And Life Sciences, Aging Keywords: Chenopodium formosanum; human dermal fibroblast; UV exposure; antioxidant activity; anti-aging; red djulis

Online: 13 November 2019 (11:02:35 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202303.0017.v1

Characteristics of Sleep and Autonomic Activity in Active Older Adults Based on Metabolic Age: A Case Report

Miki Sato, Ryuichi Tanioka, Feni Betriana, Kyoko Osaka, Yueren Zhao, Tetsuya Tanioka, Akira Takahashi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: healthy aging; autonomic nervous activities; heart rate variability; sleep status; well-being

Online: 1 March 2023 (09:12:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2276.v1

Understanding the Mellowing Effect of Bottle Aging on the Sensory and Aesthetic Perceptions of Varietal Dry White Wines

Giovanni Marasà, Joana Ferreira, Mariana Mota, Manuel Malfeito-Ferreira

Subject: Biology And Life Sciences, Food Science And Technology Keywords: fine wines; aging bouquet; vertical tasting; maturation; quality; complexity; sensory space; aroma; mouthfeel

Online: 29 July 2024 (10:07:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0412.v1

Synthesis of Hydronium-Potassium Jarosite; Effect of pH and Aging Time on their Structural, Morphological and Electrical Properties

Elías Hernández-Lazcano, E. Cerecedo-Sáenz, J. Hernández-Ávila, Norman Toro, T.V.K. Karthik, D. Mendoza-Anaya, M. E. Fernández-García, V. Rodríguez-Lugo, E. Salinas-Rodríguez

Subject: Chemistry And Materials Science, Biomaterials Keywords: Hydronium jarosite; potassium jarosite; micro particles; pH; aging time; energy storage; euhedral morphology

Online: 16 December 2020 (13:41:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0224.v1

A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia: Preliminary Results from the BIOSPHERE Study

Riccardo Calvani, Anna Picca, Federico Marini, Alessandra Biancolillo, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Helio Coelho-Junior, Maurizio Bossola, Andrea Urbani, Francesco Landi, Roberto Bernabei, Emanuele Marzetti

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; muscle; protein; metabolism; metabolomics; profiling; biomarkers; multi-marker; physical performance; multivariate

Online: 12 September 2018 (17:11:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.2087.v1

From Chronodisruption to Sarcopenia: The Therapeutic Potential of Melatonin

José Fernández-Martínez, Yolanda Ramírez-Casas, Yang Yang, Paula Aranda-Martínez, Laura Martínez-Ruiz, Germaine Escames, And Darío Acuña-Castroviejo

Subject: Biology And Life Sciences, Aging Keywords: aging; chronodisruption; clock genes; Bmal1; inflammaging; oxidative stress; mitochondria; skeletal muscle; sarcopenia; melatonin

Online: 1 November 2023 (03:02:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0457.v1

Influence of Cross Section Thickness and Aspect Ratio on Deformation during Diffusion Bonding and Impact of Metal Diffusion and Evaporation on Temperature Measurement Accuracy

Thomas Gietzelt, Volker Toth, Manfred Kraut, Uta Gerhards, Robin Duerrschnabel

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: diffusion welding; diffusion bonding; cross section width; aspect ratio; material thickness; thermocouple aging

Online: 29 February 2020 (09:01:14 CET)

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Diffusion bonding is often used on pre-machined parts to generate internal cavities, e.g. for cooling injection molding tools close to the mold cavity. Only then, the workpieces are finished to their final dimensions. In the case of micro-process devices, however, it is essential to precisely control the deformation, as otherwise uncontrollable pressure losses will occur with channel cross-sections in the sub-millimeter range. Post-processing is not possible. The most important process parameters for diffusion bonding are temperature, dwell time and contact pressure, with the bonding temperature and contact pressure acting in opposite directions and showing a strong non-linear dependence on deformation. In addition, the deformation is influenced by a number of other factors such as the absolute size of the cross-section and the aspect ratio of the parts, the dimensions and distribution of the internal cross sections and the overall percentage of the cross-section to be bonded. In micro process engineering, small material cross-sections in the range of the materials microstructure can facilitate additional deformation mechanisms such as grain boundary sliding, which are not relevant at all for larger structures. For parts consisting of multiple layers, tolerances in thickness and roughness of multiple surfaces must be levelled, contributing to the percentaged deformation. This makes it difficult, especially in micro process engineering and in single or small series production, to determine suitable joining parameters in advance, which on the one hand do not cause unforeseen large deformations, but on the other hand reliably produce highly vacuum-tight components. Hence, a definition of a fixed percentaged deformation does not work for all kinds of components. This makes it difficult to specify parameters for surely obtain high-vacuum tight parts. For successful diffusion bonding, atoms must diffuse over the bonding planes, forming a monolithic part in which the original layers are no longer visible. Only then, mechanical properties identical to those of the base material, which has been subjected to identical heat treatment, can be achieved. In this paper, the impacts of different material cross section widths as well as of the aspect ratio on deformation were investigated. By accident, it was found that also accuracy of the temperature measurement may have a serious impact in terms of deformation.

Preprint ARTICLE | doi:10.20944/preprints202308.0824.v1

A Biopsychosocial Model Predicting Myocardial Infarction

José M. Tomás, Amparo Oliver, Zaira Torres, Janhavi Parker, Elena Marques, Trinidad Sentandreu-Mañó

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: biopsychosocial approach; coronary artery disease; cardiovascular disease; SHARE survey; aging

Online: 10 August 2023 (08:14:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0306.v1

Vision impairments in young adults with Down syndrome

Yolanda Martin-Perez, Guadalupe Gonalez-Montero, Angel Luis Gutierrez-Hernandez, Vanesa Blázquez-Sánchez, Celia Sánchez-Ramos

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: aging; Down syndrome; quality of life; refractive error; visual impairments

Online: 3 August 2023 (10:27:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1589.v1

Replicative Senescence in Vascular Smooth Muscle Cells: PURPL and NEAT1 Long Non-Coding RNAs as New Senescence-Associated Biomarkers

Clara Rossi, Marco Venturin, Jakub Gubala, Angelisa Frasca, Alberto Corsini, Cristina Battaglia, Stefano Bellosta

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: aging; biomarkers; lncRNA; NEAT1; PURPL; RRAD; senescence; smooth muscle cells

Online: 24 July 2023 (10:02:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1412.v1

Hydrogen Assisted Aging to Storage & Sealing Materials: A Comprehensive Review

A.K.M. Ahsanul Habib, Ahmed Nazmus Sakib, Zarin Tasnim Mona, Md Monjur Hossain Bhuiyan, Pejman Kazempoor, Zahed Siddique

Subject: Engineering, Chemical Engineering Keywords: hydrogen; aging; polymer; storage and sealing materials; sustainability; pipeline; leak

Online: 20 July 2023 (10:11:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1728.v1

Nicotinamide Riboside, a Promising Vitamin B₃ Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Andrei Biţă, Ion Romulus Scorei, Maria Viorica Ciocîlteu, Oana Elena Nicolaescu, Andreea Silvia Pîrvu, Ludovic Everard Bejenaru, Gabriela Rău, Cornelia Bejenaru, Antonia Radu, Johny Neamţu, George Dan Mogoşanu, Steven A. Benner

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: nicotinamide riboside; vitamin B3 derivative; efficacy; safety; healthy aging; longevity

Online: 25 June 2023 (10:43:10 CEST)

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NAD⁺ is known classically as a metabolite that participates in catabolic and anabolic pathways throughout the metabolism that is taught to students in introductory biochemistry courses. However, non-classical studies starting over a decade ago found that NAD⁺ is also involved in higher order functions, in part because of its involvement in the activation of SIRTs and the support of the mitochondrial unfolded protein response. Many studies since have suggested that NAD⁺ is involved in an extensive spectrum of human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes, Further, healthy aging and longevity appear to be closely related to NAD⁺ and its related metabolites, including NAR and NMN. Together, these studies show that this system has value as a dietary supplement to improve general health overall, as well as mitigating specific disease conditions. Accordingly, many are now recommending the consumption of materials in this system as dietary supplements. Nicotinamide riboside (NAR) appears to have special value in this regard. It appears to be better tolerated than other molecules in this system, as well as better pharmacodynamics and greater potency. Unfortunately, NAR is a reactive molecule, often unstable during its manufacturing, transport, and storage. Indeed, HPLC analyses of many commercial samples of NAR shows that they contain substantial amounts of material that are not, in fact, NAR. In some of these commercial preparations, NAR is a minority component. Therefore, more stable derivatives of NAR that are easily converted upon consumption into NAR are therefore desired. Recently work related to prebiotic chemistry provided the borate derivative of NAR. NARB is considerably more stable than NAR itself. However, immediately upon consumption, the borate dissociates from NARB, and is lost in the body through dilution and binding to other species, notably carbohydrates such as fructose and glucose. The NAR left behind is expected to behave pharmacologically in ways identical to NAR itself. This review provides a comprehensive summary (through Q1 of 2023) of literature that makes the case for the consumption of NAR as a dietary supplement. It then summarizes the challenges of delivering quality NAR to consumers using standard synthesis, manufacture, shipping, and storage approaches. It concludes by outlining the advantages of NAR-borate in these processes.

Preprint REVIEW | doi:10.20944/preprints202011.0019.v1

Semelparity and Reproductive Death in Caenorhabditis elegans

David Gems, Carina Kern, Joseph Nour, Marina Ezcurra

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; biomass conversion; C. elegans; reproductive death; semelparity; senescent pathology

Online: 2 November 2020 (10:45:56 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202004.0158.v1

How studies on inflamm-aging may help to understand and combat COVID-19 pandemic.

Gianluca Storci

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Covid-19; SARS-CoV-2; Inflamm-aging; mtDNA; Telomere; Inflammation

Online: 9 April 2020 (14:43:41 CEST)

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More than 1,000,000 confirmed cases of COVID-19 have been registered worldwide since the beginning of the pandemic in Wuhan on December 2019. The high mortality rate of COVID-19 is associated with age, gender and the presence of comorbidities. Biochemical data have shown that COVID-19 patients develop a local and systemic hyper-inflammatory response associated with poor outcome. Therefore, the understanding of the biological mechanisms underlying SARS-CoV-2-induced inflammation is a compelling need. Following this reasoning, here we will focus on the importance of the progressive age-related development of a pro-inflammatory state (aka inflamm-aging) in the understanding of the unbalanced inflammatory response against SARS-CoV-2 in aged people. In particular, we underpin the role of mitochondrial DNA and genomic DNA telomeric sequences in local and systemic mechanisms of inflammation. Indeed, the leakage of mtDNA out of its natural compartment (i.e. the mitochondrion), into the cytoplasm and in the extracellular environment is a powerful trigger of innate immunity and inflammation, as part of an evolutionary-conserved signaling mechanism of cellular damage (e.g. viral infection). High levels of circulating mtDNA are increased in aged people and set up as inflammatory markers of poor prognosis in intensive care unit patients. In turn, telomeric DNA, which can be released into the cytoplasm and in the extracellular environment upon cell damage, has been proven to exert potent anti-inflammatory activity. Since that aged people (particularly those affected by co-morbidity) are equipped with shortened telomeres, we posit that, in aged people affected by COVID-19 the release of mtDNA, coupled with insufficient telomeric DNA favors the onset of a detrimental inflammatory response. In this regard, we highlight that the mechanism of action of some currently used drugs, as well as potential new ones may be better understood under the light of the above-depicted theoretical framework thus explaining how studies on inflamm-aging may help to understand and combat COVID-19 pandemic.

Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0110.v1

Prediction Models to Control Aging Time in Red Wine

G Astray, JC Mejuto, V Martinez-Martinez, I Nevares, M Alamo-Sanza, Jesus Simal-Gandara

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Food authenticity; Toro appellation of origin; Prediction Models; Wine; Aging.

Online: 11 January 2019 (10:50:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0149.v1

Long Term Aging Treatment Impact on Ultralow Iron Alloy 625 Intergranular Corrosion Property

Zhi-yuan Zhu, Yi Sui, An-lun Dai, Yuan-fei Cai, Ling-li Xu, Ze-xin Wang, Hong-mei Chen, Xing-ming Shao, Wei Liu

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Alloy 625; aging sensitization treatment; intergranular corrosion; ASTM G28A methods

Online: 29 September 2017 (04:13:44 CEST)

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This paper investigates the evolution of microstructures and precipitations of an ultra-low iron alloy 625 subjected to long term aging treatment by scanning electron microscope (SEM) and X-ray diffraction(XRD). Use ASTM G28A acid Fe3(SO4)2 erosion to represent intergranular corrosion weightlessness and corrosive morphology. The result shows that alloy at 750C by aging treatment for 40h, precipitated γ'' phase in the grain boundary. In high density area of γ'' phase, occurs γ'' phase to δ phase degeneration transformation by aging treatment for 200h and the needle-like δ phase becomes more with time prolonged. And γ'' phase degenerated to δ phase completely until treated for 1000h. The sample which has aging treatment tends to have intergranular corrosion and mainly because alloy element spreading leads to dilution area and grain boundary precipitated phase, plus interlaced δ phase’s dissolving, which makes sample grain particle fall off and this results in apparent weightlessness. The weightlessness rate(WLR) is related with precipitated volume score. With aging sensitization time change, can be described by Johnson-Mehl-Avrami equation, i.e.:

W L R = 44.32 [1 - exp (- \frac{t}{10.99})] + 44.62 [1 - exp (- \frac{t}{327.8})] + 1.267 (m m / a)

Preprint ARTICLE | doi:10.20944/preprints201610.0003.v1

2nd life batteries on a gas turbine power plant to provide area regulation services.

Lluc Canals Casals, Beatriz Amante García

Subject: Engineering, Energy And Fuel Technology Keywords: Aging model; Lithium ion batteries; Second life applications, Area regulation

Online: 3 October 2016 (16:33:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0899.v1

The Relationship between Oral Health‐Related Quality of Life and Body Mass Index in an Older Population from Southern Italy: The Salus in Apulia Study

Vittorio Dibello, Frank Lobbezoo, Rodolfo Sardone, Madia Lozupone, Fabio Castellana, Roberta Zupo, Alberto Pilotto, Antonio Daniele, Vincenzo Solfrizzi, Daniele Manfredini, Francesco Panza

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: oral health; body mass index; obesity; OHRQoL; OHIP-14; aging; older people

Online: 11 August 2023 (07:51:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.2245.v1

Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer’s Disease

Geidy E. Serrano, Jessica Walker, Courtney Nelson, Michael Glass, Richard Arce, Anthony Intorcia, Madison P. Cline, Natalie Lana Nabaty, Amanda Acuña, Ashton Huppert Steed, Lucia Sue, Christine Belden, Parichita Choudhury, Eric Reiman, Alireza Atri, Thomas G Beach

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: aging; SNAP25; PSD95; neurofibrillary tangles; amyloid plaques; Braak stage; cerebral cortex; PET imaging

Online: 29 December 2023 (11:29:36 CET)

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Synaptic transmission is essential for nervous system function and the loss of synapses is a known major contributor to dementia. Alzheimer’s disease dementia (ADD) is characterized by synaptic loss in the mesial temporal lobe and cerebral neocortex, brain areas associated with memory and cognition. The association of synaptic loss and ADD was established in the late 1980s and it has been estimated that 30-50% of neocortical synaptic protein is lost in ADD, but there has not yet been a quantitative profiling of different synaptic proteins in different brain regions in ADD from the same individuals. Very recently, PET imaging of synapses is being developed, accelerating the focus on the role of synaptic loss in ADD and other conditions. In this study, we quantified densities of two synaptic proteins, the presynaptic protein SNAP25 and the postsynaptic protein PSD95 in human brain using enzyme-linked immunosorbent assays (ELISA). Protein was extracted from the cingulate, hippocampus, frontal, visual, and entorhinal cortex from cognitively unimpaired controls, subjects with mild cognitive impairment (MCI) and demented subjects with different levels of Alzheimer’s pathology. SNAP25 is significantly reduced in ADD when compared to controls in frontal cortex, visual cortex and cingulate; while hippocampus showed a smaller, non-significant reduction and entorhinal cortex concentrations were not different. In contrast, all brain areas showed lower PSD95 concentrations in ADD when compared to non-demented controls, although in hippocampus this failed to reach significance. Interestingly, cognitively unimpaired cases with high levels of AD pathology had higher levels of both synaptic proteins in all brain regions. SNAP25 and PSD95 concentrations significantly correlated with densities of neurofibrillary tangles, amyloid plaques and Mini Mental State Examination scores. Our results suggest that synaptic transmission is affected by ADD in multiple brain regions. Differences were less marked in entorhinal cortex and hippocampus, most likely due to a ceiling effect imposed by the very early development of neurofibrillary tangles in older people in these brain regions.

Preprint REVIEW | doi:10.20944/preprints202305.0028.v1

The Role of Oxidative Stress and Antioxidants in Cardiovascular Comorbidities in COPD

Zsuzsanna Miklós, Ildikó Horváth

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: antioxidants; arterial aging; airway inflammation; -Klotho; ROS; hydrogen peroxide; SOD; heart rate variability

Online: 1 May 2023 (11:23:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0149.v1

Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort

Ailsa A. Welch, Jane Skinner, Mary Hickson

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: aging; skeletal muscle; grip strength; sarcopenia; physical function; bone mineral density; magnesium

Online: 23 October 2017 (11:26:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0406.v1

Dietary Tyrosine Intake Is Associated with Locus Coeruleus Integrity, Attentive Cognitive Control and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II

Emanuele Raffaele Giuliano Plini, Michael Christopher Melnychuk, Andrew Harkin, Martin J Dahl, Matthew McAuslam, Simone Kühn, Rory Thomas Boyle, Robert Whelan, Ralph Andrews, Sandra Duzel, Johanna Drewelies, Gert G Wagner, Ulman Lindenberger, Kristina Norman, Ian Hamilton Robertson, Paul Michael Dockree

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: tyrosine; Locus Coeruleus; protein intake; attention; grey matter; neuroimaging; diet; healthy aging

Online: 17 April 2023 (05:00:06 CEST)

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Background & aims It is documented that low protein and amino-acid dietary intake is related to poorer cognitive health and increased risk of dementia. Degradation of the neuromodulatory pathways, (comprising the cholinergic, dopaminergic, serotoninergic and noradrenergic systems) is observed in neurodegenerative diseases and impairs the proper biosynthesis of key neuromodulators from micro-nutrients and amino acids. How these micro-nutrients are linked to neuromodulatory pathways in healthy adults is less studied. The Locus Coeruleus–Noradrenergic System (LC-NA) is the earliest subcortical structure affected in Alzheimer’s disease, showing marked neurodegeneration, but is also sensitive for age-related changes. The LC-NA system is critical for supporting attention and cognitive control, functions that are enhanced both by tyrosine administration and chronic tyrosine intake. The purpose of this study was to 1) investigate whether the dietary intake of tyrosine, the key precursor for noradrenaline (NA), is related to LC integrity 2) whether LC integrity mediates the reported association between tyrosine intake and higher cognitive performance (measured with Trail Making Test – TMT), and 3) whether LC integrity relates to an objective measure of brain maintenance (BrainPAD). Methods The analyses included 398 3T MRIs of healthy participants from the Berlin Aging Study II to investigate the relationship between LC integrity and habitual dietary tyrosine intake-daily average (HD-Tyr-IDA). As a control procedure, the same analyses were repeated on other main seeds of the neuromdulatory subcortical system (Dorsal and Medial Raphe, Ventral Tegmental Area and Nucleus Basalis of Meynert). In the same way, the relationships between the five nuclei and BrainPAD were tested. Results Results show that HD-Tyr-IDA is positively associated with LC integrity. Similarly, LC integrity disproportionally relates to better brain maintenance (BrainPAD). Mediation analyses reveal that only LC, relative to the other nuclei tested, mediates the relationship between HD-Tyr-IDA I and performance in the TMT and between HD-Tyr-IDA and BrainPAD. Conclusions These findings provide the first evidence linking tyrosine intake with LC-NA system integrity and its correlation with neuropsychological performance. This study strengthens the role of diet for maintaining brain and cognitive health and supports the noradrenergic theory of cognitive reserve. Within this framework, adequate tyrosine intake might increase the resilience of LC-NA system functioning, by preventing degeneration and supporting noradrenergic metabolism required for LC function and neuropsychological performance.

Preprint ARTICLE | doi:10.20944/preprints202305.1872.v1

Reproducibility in Radiomics: A Comparison of Feature Extraction Methods and Two Independent Datasets

Hannah Mary Thomas, Helen YC Wang, Amal Joseph Varghese, Ellen M Donovan, Chris P South, Helen Saxby, Andrew Nisbet, Vineet Prakash, Sasidharan Balu Krishna, Simon Pradeep Pavamani, Devakumar D, Manu Mathew, Rajesh Isiah, Philip M Evans

Subject: Public Health And Healthcare, Other Keywords: radiomics; reproducibility; repeatability; validation; lung cancer; head and neck cancer; CT im-aging

Online: 26 May 2023 (07:15:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1910.v1

Revisiting Pseudo-OCV Pulse-Based Incremental Capacity Analysis for Diagnostics of Li-Ion Batteries

Julia Wind, Preben J. S. Vie

Subject: Engineering, Energy And Fuel Technology Keywords: Li-ion battery; diagnostics; ICA; dQ/dV; OCV; battery system; aging; SoH; SoS

Online: 27 June 2024 (11:37:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1890.v1

Gratitude and Life Satisfaction among older adults in Saudi Arabia: Social Support and Enjoyment of Life as Mediators

Mogeda El Sayed El Keshky, Shatha Jamil Khusaifan, Feng Kong

Subject: Social Sciences, Psychology Keywords: gratitude, enjoyment of life, life satisfaction, social support, aging, older adults, Saudi Arabia

Online: 26 May 2023 (08:19:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2021.v1

Spatial Analysis and Evaluation Aging-Friendly City Indicators Using GIS: Study in 8 Districts of Ahwaz City, Southwestern Iran

Vafa Musavi, Tayebeh Rakhshani, Somayeh Fathtabar Firozjaee, Abdolrahim Asadollahi

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Aging-friendly city; Ahwaz; Spatial analysis; Hot spots indicator; Geographic information system (GIS)

Online: 29 June 2023 (03:30:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0351.v1

Low-Temperature Aged Synthesis of CeO₂-coated Li-rich Oxide as Cathode for Low Cost High Energy Density Li-ion Batteries

Yanlin Liu, Bin Li, Min Chen, Weishan Li

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Li-rich oxide; surface coating; cerium oxide; low temperature aging; lithium-ion battery

Online: 14 April 2023 (04:47:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0081.v3

Developing and Validating an Age-Independent Equation Using Multi-Frequency Bioelectrical Impedance Analysis for Estimation of Appendicular Skeletal Muscle Mass and Establishing a Cutoff for Sarcopenia

Yosuke Yamada, Miyuki Nishizawa, Tomoka Uchiyama, Yasuhiro Kasahara, Mikio Shindo, Motohiko Miyachi, Shigeho Tanaka

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: age-related skeletal muscle loss; sarcopenia; malnutrition risk assessment; DXA; multi-frequency BIA; aging

Online: 23 August 2017 (17:57:14 CEST)

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Background: Appendicular skeletal muscle (or lean) mass (ALM) estimated using dual-energy X-ray absorptiometry (DXA) is considered to be a preferred method for sarcopenia studies. However, DXA is expensive, has limited portability, and requires radiation exposure. Bioelectrical impedance analysis (BIA) is inexpensive, easy to use, and portable; thus BIA might be useful in sarcopenia investigations. However, a large variety of models have been commercially supplied by different companies, and for most consumer products, the equations estimating ALM are not disclosed. It is therefore difficult to use these equations for research purposes. In particular, the BIA equation is often age-dependent, which leads to fundamental difficulty in examining age-related ALM loss. The aims of the current study were as follows: (1) to develop and validate an equation to estimate ALM using multi-frequency BIA (MF-BIA) based on theoretical models, and (2) to establish sarcopenia cutoff values using the equation for the Japanese population. Methods: We measured height (Ht), weight, and ALM obtained using DXA and a standing-posture 8-electrode MF-BIA (5, 50, 250 kHz) in 756 Japanese individuals aged 18 to 86-years-old (222 men and 301 women as developing equation group and 97 men and 136 women as a cross validation group). The traditional impedance index (Ht²/Z₅₀) and impedance ratio of high and low frequency (Z₂₅₀/Z₅) of hand to foot values were calculated. Multiple regression analyses were conducted with ALM as dependent variable in men and women separately. Results: We created the following equations: ALM = (0.6947 × (Ht²/Z₅₀)) + (−55.24 × (Z₂₅₀/Z₅)) + (−10,940 × (1/Z₅₀)) + 51.33 for men, and ALM = (0.6144 × (Ht²/Z₅₀)) + (−36.61 × (Z₂₅₀/Z₅)) + (−9332 × (1/Z₅₀)) + 37.91 for women. Additionally, we conducted measurements in 1624 men and 1368 women aged 18 to 40 years to establish sarcopenia cutoff values in the Japanese population. The mean values minus 2 standard deviations of the skeletal muscle mass index (ALM/Ht²) in these participants were 6.8 and 5.7 kg/m² in men and women, respectively. Conclusion: The current study established and validated a theoretical and age-independent equation using MF-BIA to estimate ALM and provided reasonable sarcopenia cutoff values.

Preprint REVIEW | doi:10.20944/preprints202403.0545.v1

Telomere Length as a Biomarker of Smoking-Induced Cellular Damage

Mohammad Odah

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Smoking; telomere atrophy; cellular aging; disease risk; molecular mechanisms; gender disparities; age disparities. ;

Online: 10 March 2024 (16:55:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1134.v1

On Structural Sensitivity Of Young’s Modulus Of Ni-Rich Ti-Ni Alloy

Elena Ryklina, Semen Murygin, Victor Komarov, Kristina Polyakova, Natalia Resnina, Vladimir Andreev

Subject: Engineering, Other Keywords: Ni-rich Ti-Ni alloy; grain-subgrain size; aging-induced microstructure; martensitic transformations; Young’s modulus

Online: 18 July 2023 (08:36:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0742.v1

A Network Comprised of miR-15b and miR-29a is Involved in VEGFA Pathway Regulation in Thymus Adipose Tissue from Elderly Ischemic Cardiomyopathy Subjects

Adriana-Mariel Gentile, Said Lhamyani, Maria Mengual Mesa, Francisco Javier Pavón-Morón, John R Pearson, Julian Salas, Mercedes Clemente-Postigo, Lucia Perez Costillas, Gabriel Olveira, Rajaa El Bekay

Subject: Biology And Life Sciences, Aging Keywords: aging; angiogenesis; elderly; ischemia; microRNA; myocardial infarction; thymus adipose tissue; subcutaneous adipose tissue

Online: 12 September 2023 (07:09:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0252.v1

A Green Ultrasound-Assisted Extraction Optimization of the Natural Antioxidant and Anti-aging Flavonolignans from Milk Thistle Silybum marianum (L.) Gaertn. Fruits for Cosmetic Applications

Samantha Drouet, Emilie Leclerc, Laurine Garros, Duangjai Tungmunnithum, Atul Kabra, Bilal Haider Abbasi, Eric Lainé, Christophe Hano

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Silybum marianum; silymarin; flavonolignans; ultrasound-assisted extraction; design of experiement; antioxidant; anti-aging

Online: 23 July 2019 (09:51:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0211.v1

Tobacco Smoking as an EDC in Aging

Ho-Sun Lee, Hyun-Kyung Na, Seong-Sil Chang, Soo-Young Kim, Chang Seong Kim, Yoonjeong Song, Mihi Yang

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: tobacco smoking; biological monitoring; adolescent; genetic polymorphism; addiction; mtDNA alteration; aging

Online: 4 January 2024 (03:43:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1738.v1

Zebrafish as an Emerging Model for Sarcopenia: Considerations, Current Insights, and Future Directions

Santiago Callegari, Foad Mirzaei, Lila Agbaria, Sanobar Shariff, Burhan Kantawala, Desmond Moronge, Brian M. O. Ogendi

Subject: Biology And Life Sciences, Aging Keywords: Sarcopenia; Zebrafish; Age-related muscle deficits; Aging; Biomarkers; Electrical Impedance Myography

Online: 26 September 2023 (13:38:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1184.v1

Diagnosing Alzheimer's Disease Levels Using Machine Learning and MRI: A Novel Approach

Reza Bahadori, Ali Akbar Kiaei, Hourieh Malek Zadeh, Mahnaz Boush, Sadegh Abadijou, Danial Safaei, Amir Hossein Mehdikhani

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Alzheimer's disease; neurological illness; dementia; machine learning; Magnetic Resonance Im-aging

Online: 16 June 2023 (07:28:28 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202301.0334.v1

Serotonin Impact on Lifespan Longevity in Marine Annelid D.gyrociliatus

Elizaveta Fofanova

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: serotonin; pcpa; cystamine; dinophilida; invertebate models; aging; maternal serotonin; lifespan longevity

Online: 18 January 2023 (10:22:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0011.v1

Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Olajuwon Okubena, Adaeze Adebesin, Adrian Omogbiya, Oluwafemi Oluwole, Rita Asomadu, Michael Afolabi, Samira Makanjuola, Louis Ajonuma, Adedoyin Dosunmu, Ololade Otitoloju, Solomon Umukoro

Subject: Biology And Life Sciences, Food Science And Technology Keywords: SBSJ; polyphenolic constituents; antioxidants; anti-inflammatory, chemoprevention; immunomodulation; anti-aging; adaptogen

Online: 1 August 2022 (08:06:10 CEST)

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