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Preprint ARTICLE | doi:10.20944/preprints202405.0251.v1

Diversity and Conservation of Rodents in Saudi Arabia

Khaled Ahmad Al Malki, Abdul Rahman Al Ghamdi, Faisal Shuraim, Farah Neyaz, Ahmad Al Boug, Sharif Al Jbour, Francesco Maria Angelici, Zuhair Sami Amr

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Rodentia; Saudi Arabia; distribution; conservation; zoogeography

Online: 6 May 2024 (07:39:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0751.v1

Meshless Analysis of Nonlocal Boundary Value Problems in Anisotropic and Inhomogeneous Media

Zaheer-ud-Din Muhammad, Muhammad Ahsan, Masood Ahmad, Wajid Khan, Emad E. Mahmoud, Abdel-Haleem Abdel-Aty

Subject: Physical Sciences, Acoustics Keywords: Meshless method; Integrated MQ RBF; Steady-state heat conduction equation

Online: 30 September 2020 (14:31:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0834.v1

A Roadmap for NF ISAC in 6G: A Comprehensive Overview and Tutorial

Azar Hakimi, Diluka Galappaththige, And Chintha Tellambura

Subject: Engineering, Telecommunications Keywords: Near-filed communications; Integrated sensing and communication; Channel modeling; Optimization problem

Online: 12 August 2024 (14:51:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2118.v1

A Tool for a Fast and Accurate Evaluation of the Energy Production of Bifacial PV Modules

Vincenzo D’Alessandro, Santolo Daliento, Mahmoud Dhimish, Pierluigi Guerriero

Subject: Engineering, Electrical And Electronic Engineering Keywords: albedo, bifacial module; monofacial module; orientation; photovoltaic (PV); tilt

Online: 26 July 2024 (10:25:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0390.v1

BSA Binding and Aggregate Formation of a Synthetic Amino Acid with Potential for Promoting Fibroblast Proliferation: An In Silico, CD Spectroscopic, DLS, and Cellular Study

Hayarpi M Simonyan, Rosanna Palumbo, Satenik Petrosyan, Anna F Mkrtchyan, Armen Galstyan, Ashot S. Saghyan, Pasqualina Liana Scognamiglio, Caterina Vicidomini, Marta Fik-Jaskółka, Giovanni N Roviello

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: in silico; protein binding; self-assembling system; synthetic amino acid; fibroblast growth enhancement; tissue regeneration

Online: 7 May 2024 (15:41:49 CEST)

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This study presents the chemical synthesis, purification, and characterization of a novel non-natural synthetic amino acid. The compound was synthesized in solution, purified, and characterized using NMR spectroscopy, polarimetry, and melting point determination. Dynamic Light 22 Scattering (DLS) analysis demonstrated its ability to form aggregates with an average size of 391 nm, extending to low micrometric sizes. Furthermore, cellular biological assays revealed its ability to enhance fibroblast cell growth, highlighting its potential for tissue regenerative applications. Circular dichroism (CD) spectroscopy showed the ability of the synthetic amino acid to bind serum albumins (using bovine serum albumin (BSA) as a model), and CD deconvolution provided insights into the changes in secondary structures of BSA upon interaction with the amino acid ligand. Additionally, molecular docking using HDOCK software elucidated the most likely binding mode of the ligand inside the BSA structure. We also performed in silico oligomerization of the synthetic compound in order to obtain a model of aggregate to investigate computationally. More in detail, in the dimer formation achieved by molecular self-docking, two distinct poses were observed, corresponding to the lowest and comparable energies, with one pose exhibiting a quasi-coplanar arrangement characterized by a close alignment of two aromatic rings from the synthetic amino acids within the dimer, suggesting the presence of π-π stacking interactions. In contrast, the second pose displayed a non-coplanar configuration, with the aromatic rings oriented in a staggered arrangement, indicating distinct modes of interaction. Both poses were further utilized in the self-docking procedure. Notably, iterative molecular docking of amino acid structures resulted in the formation of higher-order aggregates, with a model of a 512-mer aggregate obtained through self-docking procedures. This model of aggregate presented a cavity capable of hosting therapeutic cargoes and biomolecules, rendering it a potential scaffold for cell adhesion and growth in tissue regenerative applications. Overall, our findings highlight the potential of this synthetic amino acid for tissue regenerative therapeutics and provide valuable insights into its molecular interactions and aggregation behavior.

Preprint ARTICLE | doi:10.20944/preprints202404.0371.v1

Impact Of SARS-CoV-2 Pandemic On The Diagnosis Of Cervical Cancer And Precursor Lesions - A Single Center Retrospective Study

Lavinia Balan, Cristina Secosan, Virgiliu-Bogdan Sorop, Marilena Pirtea, ANCA MARIA CIMPEAN, Daniela Chiriac, Catalin Balan, Ema Borsi, Ariana Iorga, Laurentiu Pirtea

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: covid-19; sars-cov-2; cancer diagnosis; conization; cervical cancer; colposcopy; dysplasia; biopsy

Online: 4 April 2024 (10:59:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2316.v1

Innovation in Skills and Sustainable Development in Italian Upper Secondary Technical Education and the Professional Role of Construction, Environment, and Territory Technicians

Andrea Pompigna, Gianluigi Ferrario

Subject: Social Sciences, Education Keywords: Education for Sustainable Development (ESD); Technical and Vocational Education; Curriculum Innovation; Professional Competencies; Sustainable Mobility

Online: 30 July 2024 (00:14:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0829.v1

GRK5KO Mouse Mirrors Mild Cognitive Impairment due to Alzheimer’s Disease

William Z. Suo

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimer’s disease; Mild cognitive impairment due to Alzheimer’s disease; aging; animal model; GRK5 deficiency; GRK5 knockout mouse.

Online: 12 April 2024 (08:03:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.2016.v1

Variations & Claims in International Construction Contracts (FIDIC) from Statistical Perspective in MENA Region for the Last Decade

Ahmed Mohammed Abdelalim, Mohamed Ramadan Ezz Al Regal, AlJawharah A. AL Nasser, Rawan Alwahaibi, Mohamed Tantawy

Subject: Engineering, Architecture, Building And Construction Keywords: construction industry; international contracts; FIDIC 1999 Red Book; variations; claims; scientometric analysis; statistical analysis; relative importance index (RII); K-means clustering

Online: 1 May 2024 (04:04:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0917.v1

Comparative Analysis of Vascular Calcification Risk Factors in Pre-hemodialysis and Prevalent Hemodialysis Adult Patients: Insights into Calcification Biomarker Associations and Implications for Intervention Strategies in Chronic Kidney Disease

Marko Petrović, Voin Brković, Marko Baralić, Ivko Marić, Nenad Petković, Sanja Stanković, Nataša Lalić, Danijela Stanisavljević, Ljubica Đukanović, Višnja Ležaić

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; vascular calcifications; FGF-23; Fetuin-A; sclerostin; iPTH; Adragao score

Online: 17 February 2024 (09:04:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2122.v1

Association between Maternal Birth Weight and Prevalence of Congenital Malformations in Their offspring：The Japan Environment and Children’s Study

Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Masatoshi Saito, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

Subject: Biology And Life Sciences, Life Sciences Keywords: Birth cohort; Congenital malformations; Maternal birth weight

Online: 31 January 2024 (02:58:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1730.v1

A Thermoelectric Polymer Field-effect Transistor via Iodine-doped P3HT

Joseph Norman, Sam-Shajing Sun

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Field effect transistors FET; thermoelectric; power factor; polymers; doping

Online: 22 December 2023 (12:32:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0140.v2

Mushrooming Communities: A Field Guide to Mycology in the Community Forests of Portugal

Rita Serra, Eugénia Rodrigues, Raúl García-Barrios

Subject: Biology And Life Sciences, Forestry Keywords: common lands; baldios; wild mushrooms; non-timber forest products; Portugal; community; community forestry; forest governance

Online: 24 May 2017 (17:01:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0531.v1

Upgrading/Deacidification of Organic Liquid Phase by Liquid-Liquid Extraction Using Methanol/Water as Solvent

Nélio Teixeira Machado, Silvio Alex Pereira da Mota, Raquel Ana Capela Leão, Rodrigo O. M. A. Souza, Sergio Duvoisin, Jr., Luiz Eduardo Pizarro Borges, and Andréia de Andrade Mâncio da Mota

Subject: Engineering, Energy And Fuel Technology Keywords: Solvent extraction; Biofuel; Pyrolysis oil; Carboxylic acids; Oxygenated compounds.

Online: 8 April 2024 (11:17:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0527.v1

Investigating Arctic Permafrost Dynamics Using Electrical Resistivity Imaging and Borehole measurement in Svalbard

Ding-Jiun Lin, Ping-Yu Chang, Ying-Lon Chen, Jordi Mahardika Puntu, Chuen-Fa Ni, Giletycz Jack Slawomir, Ireneusz Sobota, Kamil Czarnecki, Yu-Huan Chang

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Electrical Resistivity Imaging; borehole temperature; permafrost; Svalbard

Online: 7 August 2024 (23:11:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2096.v1

The ANSI/373 Standard: An Examination of a Voluntary Sustainability Initiative for Processing and Distributing Dimension Stone

Erin M. Ashbee, Michal J. Bardecki

Subject: Environmental And Earth Sciences, Other Keywords: dimension stone; ANSI/373 standard; voluntary sustainability initiatives; certification compliance; green building materials

Online: 29 August 2024 (08:46:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1144.v1

Linking Wetland Ecosystem Services to Fish Genetic Resources with Special Reference to Hilsa Shad (Tenualosa ilisha): A Novel Study from Northeastern Bangladesh

Atiqur Rahman Sunny, Md. Arifur Rahman, Md. Nazmul Hasan, Jeba Faizah Rahman, Sharif Ahmed Sazzad, Md. Faruque Miah, Md. Ashrafuzzaman, Shamsul Haque Prodhan

Subject: Biology And Life Sciences, Aquatic Science Keywords: Wetland; Ecosystem services; Genetic diversity; Hilsa; Bangladesh

Online: 20 February 2024 (12:44:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1612.v1

COVID-19 Disease during Pregnancy. Gestational Duration and Fetal Weight: Two Understudied Adverse Outcomes

Tirso Pérez-Medina, Fatima Garcia-Benasach, Ana Royuela, Ana Gomez-Manrique, Marta García-Cardoso, Pilar Chaves, Augusto Pereira

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: COVID-19; pregnancy; placental insufficiency, villitis; fetal weight; pregnancy length

Online: 24 June 2024 (08:43:29 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202306.1411.v1

Weight-Bias Internalization and Eating-Disorder Psycho-Pathology in Treatment-Seeking Patients With Obesity

Simona Calugi, Barbara Segattini, Gianmatteo Cattaneo, Mirko Chimini, Anna Dalle Grave, Laura Dametti, Manuela Molgora, Riccardo Dalle Grave

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: obesity; weight bias; body image; body dissatisfaction; exposure avoidance; shape dissatisfac-tion; empty stomach

Online: 21 June 2023 (03:10:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0055.v1

Numerical Simulation of Hypervelocity Impact FEM-SPH Algorithm Based on Large Deformation of Material

Aimin Yang, Jinze Li, Hengheng Qu, Yuhang Pan, Yanhong Kang, Yuzhu Zhang

Subject: Computer Science And Mathematics, Analysis Keywords: finite element method; smoothed particle method; fem-sph algorithm; large deformation; super high speed collision

Online: 14 October 2016 (11:05:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2217.v1

Lingonberry (Vaccinium vitis-idaea L.) Health Effects – a Review of In Vitro and In Vivo Human Studies

Pirjo Pärnänen, Sari Niikko, Hanna Lähteenmäki, Ismo Tapani Räisänen, Taina Tervahartiala, Timo Sorsa, Annamari Ranki

Subject: Biology And Life Sciences, Food Science And Technology Keywords: lingonberries; polyphenols; oral microbiome; Lactobacilli

Online: 29 July 2024 (10:48:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1008.v1

Evaluation of Solid-State Fermentation Conditions from Pineapple Peel Wastes to Release of Bioactive Compounds by Aspergillus niger spp.

A. Danitza Casas-Rodríguez, Juan A. Ascacio-Valdés, Miriam Desirée Dávila-Medina, Liliana Londoño-Hernández, Leonardo Sepúlveda

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: condensed tannins; hydrolyzable tannins; FRAP; ABTS; antioxidant; Plackett-Burman

Online: 18 March 2024 (10:28:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1356.v1

Comparative Analysis of Comprehensive Genomic Profile in Thymomas and Recurrent Thymomas Reveals Potentially Actionable Mutations for Target Therapies

Filippo Lococo, Elisa De Paolis, Jessica Evangelista, Andrea Dell’Amore, Diana Giannarelli, Marco Chiappetta, Annalisa Campanella, Carolina Sassorossi, Alessandra Cancellieri, Fiorella Calabrese, Emanuele Vita, Angelo Minucci, Emilio Bria, Angelo Castello, Andrea Urbani, Federico Rea, Stefano Margaritora, Giovanni Scambia

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: NGS; recurrent thymoma; surgery; CGP; gene profile; clinical trials

Online: 17 July 2024 (11:00:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0779.v1

Automatic Classification of All-sky Nighttime Cloud Images Based on Machine Learning

Xin Zhong, Fujia Du, Yi Hu, Xu Hou, Zonghong Zhu, Xiaogang Zheng, Kang Huang, Zhimin Ren, Yonghui Hou

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: nighttime cloud image; observational astronomy; all-sky cameras; PSO; XGBoost

Online: 13 March 2024 (12:40:29 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1623.v1

Lichen Amyloidosis in an Atopic Patient Treated with Dupilumab: A New Therapeutic Option

Benedetta Tirone, Gerardo Cazzato, Francesca Ambrogio, Caterina Foti, Marco Bellino

Subject: Medicine And Pharmacology, Dermatology Keywords: Lichen Amyloidosis; Atopic Dermatitis; Histopathology; Dupilumab

Online: 27 March 2024 (07:54:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.0422.v1

Review of Measuring Methods of Residual Stress in Wire Arc Additive Manufacturing Products

Fakada Dabalo Gurmesa, Hirpa Gelgele Lemu, Yosef Wakjira Adugna, Mesfin Demise Harsibo

Subject: Engineering, Mechanical Engineering Keywords: residual stress; Wire Arc Additive Manufacturing; process parameters; residual stress measurement; wire arc additive manufacturing assessment

Online: 8 May 2024 (09:42:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0462.v1

Unified Field Theory for Electromagnetic and Gravity Fields with the Introduction of Quantized Space–Time and Zero-Point Energy

Shinichi Ishiguri

Subject: Physical Sciences, Particle And Field Physics Keywords: unified field theory; zero-point energy; quantized space–time; quantized Einstein’s gravity equation; conservation of angular momentum in terms of quantized space–times

Online: 20 July 2020 (08:48:03 CEST)

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In our previous papers [1,3], using only the concepts of the zero-point energy and quantized space–times, all the fields including gravity were explained. However, the previous papers had the following limitations: First, the concept of the quantized space-time must be experimentally confirmed. Second, we should clarify the meaning of the quantized Einstein’s gravity equation, which is derived in [1]. Moreover, in another paper [2], we succeeded in describing the neutrinos’ self-energy and their oscillations. However, this paper assumes the rest energy of 3-leptons in advance, which is why we needed to uncover the reason why leptons have 3-generations. As mentioned, using the concepts of the zero-point energy and quantized space–times, we derived the quantized Einstein’s gravity equation in our previous paper [1]. The paper provides an analytical solution of this equalized Einstein’s equation, which implies the conservation of angular momentum in terms of quantized space–times. Employing this solution and without the standard big bang model, a unique form of acceleration equation for the acceleration-expansion universe is derived. Moreover, the temperature of the cosmic microwave background (CMB) emission is also obtained. Further, this solution results in an analytical (not numerical) derivation of the gravity wave. Moreover, based on the configuration of quantized space–times in terms of both electric and magnetic fields, we analytically attempted to calculate every equation in terms of electromagnetic and gravity fields, using the solution of the quantized Einstein’s gravity equation. As a result of this theory, first the calculated acceleration and temperature of CMB emission agree with the measurements. Furthermore, the analytical solution of the quantized Einstein’s gravity equation resulted in all the laws of electromagnetic and gravity fields in addition to the analytically derived gravity wave, which agrees well with the recent measurements. Moreover, the calculations of the energies in the basic configuration of the quantized space–times resulted in all 3-leptons’ rest energies. Considering this basic configuration is uniformly distributed everywhere in the universe, we can conclude that τ-particles or static magnetic field energy derived from the basic configuration of the quantized space–times is the identity of dark energy, which also distributes uniformly in the universe.

Preprint ARTICLE | doi:10.20944/preprints202408.0180.v1

Biologically Active Compounds of Tomato Fruits Affected by Application of Spirulina, Dunaliella and Chlorella Microalgae Extracts

Ingrīda Augšpole, Irina Sivicka, Kaspars Kampuss, Pāvels Semjonovs, Imants Missa

Subject: Biology And Life Sciences, Food Science And Technology Keywords: microalgae; Solanum lycopersicum L; chemical composition; lycopene

Online: 2 August 2024 (11:32:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0270.v1

Coupling Quantum Random Walks with Long and Short Term Memory for High Pixel Image Encryption Schemes

Junqing Liang, Zhaoyang Song, Zhongwei Sun, Mou Lv, Hongyang Ma

Subject: Computer Science And Mathematics, Information Systems Keywords: image encryption; high pixel density; neural networks; quantum random walk

Online: 15 December 2022 (06:50:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202409.0186.v1

Blood-Brain Barrier Conquest in Glioblastoma Nanomedicine: Strategies, Clinical Advances, and Emerging Challenges

Mengyun Duan, Ruina Cao, Yuan Yang, Xiaoguang Chen, Lian Liu, Boxu Ren, Lingzhi Wang, Boon-Cher Goh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Glioblastoma; Blood-brain barrier; Drug delivery; Nanomedicine delivery system; Nanoparticles

Online: 3 September 2024 (08:06:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2032.v1

Use of Microalgae-Derived Astaxanthin to Improve Cytoprotective Capacity in the Ileum of Heat-Induced Oxidative Stressed Broilers

Donna Lee Kuehu, Yuanyuan Fu, Masaki Nasu, Hua Yang, Vedbar S. Khadka, Youping Deng

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: astaxanthin; cytoprotective capacity; ileum; heat stress; oxidative stress; broilers

Online: 30 May 2024 (13:13:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0864.v1

Design of a Dispersive 1064 nm Fiber Probe Raman Imaging Spectrometer and Its Application to Human Bladder Resectates

Juan David Munoz-Bolanos, Tanveer Ahmed Shaik, Arkadiusz Miernik, Juergen Popp, Christoph Krafft

Subject: Biology And Life Sciences, Life Sciences Keywords: bladder tumor; Raman imaging; 1064 nm; cluster analysis; Python toolbox

Online: 15 April 2024 (09:07:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0032.v1

Estimating Recreational Value of Foy's Lake: An Application of Travel Cost Count Data Model for Truncated Zeros

Md. Touhidul Alam, Anis-Ul-Ekram Chowdury, Md. Sajib Hossian

Subject: Business, Economics And Management, Economics Keywords: individual travel cost method; zero truncated poisson regression model; endogenous stratification; consumer surplus

Online: 10 February 2017 (11:10:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0224.v1

Predictive Value of Der P 2-Specific IgE for Subcutaneous Immunotherapy in Children With Allergic Rhinitis

Jiayan Wang, Bohuai Xu, Xujin Jia, Yong He, Beibei Jia, Junyuan Li, Ming Xu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: allergic rhinitis; childhood; biomarkers; dermatophagoides pteronyssinus; subcutaneous immunotherapy

Online: 3 November 2023 (07:57:10 CET)

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Preprint REVIEW | doi:10.20944/preprints201707.0024.v1

In Quest for Improved Drugs against Diabetes: The Added Value of X-ray Powder Diffraction Methods

Fotini Karavassili, Alexandros Valmas, Stavroula Fili, Christos D. Georgiou, Irene Margiolaki

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: insulin; phenolic derivatives; crystallography; powder diffraction

Online: 12 July 2017 (04:11:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1095.v1

Incident Cancer Risk of Patients With Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2)

Zsolt Abonyi-Tóth, György Rokszin, Gábor Sütő, Ibolya Fábián, Zoltán Kiss, György Jermendy, Péter Kempler, Csaba Lengyel, István Wittmann, Gergő A. Molnár

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetes mellitus (Type 2); cancer; incidence; epidemiology; age; odds ratio; annual percent change

Online: 20 February 2024 (07:04:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1034.v1

Incident Cancer Risk in Patients With Incident Type 2 Diabetes Mellitus in Hungary (Part 1)

Zsolt Abonyi-Tóth, György Rokszin, Ibolya Fábián, Zoltán Kiss, György Jermendy, Péter Kempler, Csaba Lengyel, István Wittmann, Gergő A. Molnár, Gábor Sütő

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Type 2 diabetes mellitus; epidemiology; cancer; incidence; new-onset diabetes

Online: 19 February 2024 (10:20:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.1701.v1

From Bioink to Tissue: Exploring Chitosan-Agarose Composite in the Context of Printability and Cellular Behaviour

Szymon Mania, Adrianna Banach-Kopeć, Natalia Maciejewska, Katarzyna Czerwiec, Paulina Słonimska, Milena Deptuła, Jakub Baczyński-Keller, Michał Pikuła, Paweł Sachadyn, Robert Tylingo

Subject: Chemistry And Materials Science, Biomaterials Keywords: chitosan; agarose; bioprinting; natural polymers; tissue engineering; biocompatibility

Online: 23 August 2024 (08:23:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0957.v1

Petroleum System of the Middle Jurassic Khatatba Formation in the Imhotep Field, Northwestern Egypt, Based on Multi-approach Analyses

Walaa A. Ali, Amr S Deaf, Mohamed Fagelnour, Thomas Gentzis

Subject: Physical Sciences, Other Keywords: organic/inorganic geochemistry; organic petrography; petroleum system; geomechanics; burial history; Khatatba Formation; Matruh Basin; Egypt

Online: 14 May 2024 (11:09:39 CEST)

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This study investigates the petroleum potential of the Middle Jurassic Khatatba Formation (Fm) in the Matruh Basin, northwestern Egypt. This formation shows in situ dual source and reservoir characteristics, where alternations of fine and coarse clastics were deposited during semi-arid and semi-humid conditions due to climate changes and Tethyan sea level fluctuations. The organic-rich shales and argillaceous siltstones are fair to very good/excellent (TOCm wt%: 0.91–3.07) source rocks. They are rich in late mature to early postmature mostly gas-prone organic facies C, which sourced the juxtaposing intraformational coarse clastics of the Lower Safa Member with gas and condensates. The source rocks show poor to fair gas generation potential (S2: 0.38–1.96, mg HC/g rock). The middle part of the Lower Safa Member shows excellent organic richness (TOCm wt%: 5.39 and 22.90) of early postmature gas-prone carbonaceous material and coal deposits. These coaly shale layers exhibit fair to excellent wet gas and condensate generation potential (S2: 4.51–27.43, mg HC/g rock). Maturation of the source rocks was related to the Late Jurassic–Early Cretaceous Tethyan rifting. The onset of oil generation occurred in the Early Cretaceous (~ 116 Ma ago), while the onset of gas generation occurred in the Oligocene (~ 24 Ma ago). Shales of the Lower Cretaceous Alam El Bueib Fm are primary sealing rocks, while carbonates and shales of the Khatatba Fm are secondary sealing rocks. Trap types are structural, formed during the Late Jurassic and Early Cretaceous rifting of the Matruh Basin. Sandstones of the Upper Safa Member show upward increases in kaolinite and exhibit low-quality tight sandstone reservoirs. The Lower Safa Member sandstones show better gas reservoir quality with lower shale volumes. Operationally, the Lower Safa sandstone reservoirs in the Imhotep W-1X well are not suitable for gas production because they are ductile and show a high decline in production and pressure. Overall, the petroleum system of the Khatatba Fm shows mainly fair hydrocarbon potential in the study area.

Preprint ARTICLE | doi:10.20944/preprints201612.0065.v1

Synthesis of Reusable Silica Nanosphere-Supported Pt(IV) Complex for Formation of Disulfide Bonds in Peptides

Xiaonan Hou, Xiaowei Zhao, Yamei Zhang, Aiying Han, Shuying Huo, Shigang Shen

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: monodisperse silica nanospheres; supported platinum(IV) complex; peptide; intramolecular disulfide; reusability

Online: 12 December 2016 (17:54:08 CET)

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Preprint ESSAY | doi:10.20944/preprints201703.0064.v1

Moss Bag Preparation: A Low-Cost Technique in Monitoring Airborne Particulate and Toxic Elements

Francis Olawale Abulude, Jamok Jacob Elisha

Subject: Environmental And Earth Sciences, Environmental Science Keywords: air pollution; mosses; low-cost; equipment; time-consuming

Online: 13 March 2017 (09:28:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0193.v1

The Value of Day-Ahead Coordination of Power and Natural Gas Network Operations

Kwabena Addo Pambour, Rostand Tresor Sopgwi, Bri-Mathias Hodge, Carlo Brancucci

Subject: Engineering, Electrical And Electronic Engineering Keywords: energy systems integration; sector coupling; power gas simulation; day-ahead and real-time coordination; power gas interdependence

Online: 16 April 2018 (06:46:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0965.v1

Waveform Design For The Integrated Sensing, Communication and Simultaneous Wireless Information And Power Transfer System

Qilong Miao, Weimin Shi, Chenfei Xie, Yong Gao, Lu Chen

Subject: Computer Science And Mathematics, Signal Processing Keywords: simultaneous wireless information and power transfer (SWIPT); integrated sensing and communication systems (ISACS); orthogonal time frequency space (OTFS); waveform design; beamforming; semidefinite relaxation (SDR); matched filter (MF)

Online: 14 May 2024 (11:29:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1616.v1

The Gypsum Influence On The Formation Of Secondary Phases During Autoclave Leaching Of Gold-Bearing Concentrates And The Silver Recovery Using Cyanidation

Kirill Karimov, Denis Rogozhnikov, Ilia Fomenko, Alexander Zavalyuev, Maksim Tretiak, Oleg Dizer

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: autoclave leaching; gypsum; sulfuric acid; lime boiling; sulfide; silver; gold; cyanidation

Online: 20 September 2024 (11:08:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1672.v1

Design of Digital Twin Cutting Experiment System for Shearer

Bing Miao, Yunwang Li, Yinan Guo

Subject: Engineering, Mining And Mineral Processing Keywords: shearer; similarity theory; Digital Twin; Cutting Experiment System

Online: 26 April 2024 (11:27:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1337.v1

Rotating Droplet Hydrodynamic Electrochemistry for Water Toxicity Bioassay Based on an Electron-Transfer Mediator

Kazuto Sazawa, Ahanjiana Yeasna, Kazuharu Sugawara, Hideki Kuramitz

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: electrochemical bioassay; mediator; Escherichia coli; hydrodynamic voltammetry; antibiotics

Online: 20 June 2024 (04:43:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0051.v1

Search for QPOs in the Light Curve of the Blazar OJ287: Preliminary Results from 2015/16 Observing Campaign

S. Zola, M. Valtonen, G. Bhatta, A. Goyal, B. Debski, A. Baran, J. Krzesinski, M. Siwak, S. Ciprini, A. Gopakumar, H. Jermak, K. Nilsson, D. Reichart, K. Matsumoto, K. Sadakane, K. Gazeas, M. Kidger, V. Piirola, F. Alicavus, K.S. Baliyan, A. Berdyugin, D. Boyd, M. Campas Torrent, F. Campos, J. Carrillo Gomez, D.B. Caton, V. Chavushyan, J. Dalessio, D. Dimitrov, M. Drozdz, A. Erdem, A. Escartin Perez, V. Fallah Ramazani, A.V. Filippenko, F. Garcia, F. Gomez Pinilla, M. Gopinathan, J.B. Haislip, J. Harmanen, G. Hurst, K.M. Ivarsen, M. Jelinek, A. Joshi, M. Kagitani, N. Kaur, N. Karaman, W.C. Keel, A.P. LaCluyze, B.C. Lee, E. Lindfors, J. Lozano De Haro, J.P. Moore, R. Naves Nogues, A.W. Neely, R.H. Nelson, W. Ogloza, S. Okano, J.C. Pandey, M. Perri, P. Pihajoki, G. Poyner, J. Provencal, T. Pursimo, A. Raj, R. Reinthal, S. Sadegi, T. Sakanoi, J.-L. Salto Gonzales, T. Schweyer, F.C. Soldan Alfaro, E. Sonbas, I. Steele, J.T. Stocke, J. Strobl, L.O. Takalo, T. Tomov, L. Tremosa Espasa, J.R. Valdes, J. Valero Perez, F. Verrecchia, J.R. Webb, M. Yoneda, M. Zejmo, W. Zheng, J. Telting, J. Saario, T. Reynolds, A. Kvammen, E. Gafton, R. Karjalainen, P. Blay

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxies: active; BL Lacertae objects: individual (OJ 287); super massive black holes

Online: 18 July 2016 (10:46:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0092.v1

Nano-Pulse Treatment Overcomes Immunosuppressive Tumor Microenvironment to Elicit In Situ Vaccination Protection against Breast Cancer

Anthony Nanajian, Megan Scott, Niculina I. Burcus, Brittney L. Ruedlinger, Ayobami Oshin, Stephen J. Beebe, Siqi Guo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Nano-pulse treatment (NPT); in situ vaccination; breast cancer; tumor microenvironment; immunosuppression; apoptosis; memory T cells; regulatory T cells; myeloid-derived suppressor cells; tumor-associated macrophages

Online: 2 May 2024 (12:04:27 CEST)

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We previously reported nano-pulse treatment (NPT), a pulsed power technology, resulted in 4T1-luc mammary tumor elimination and a strong in situ vaccination, thereby completely protecting tumor-free animals against a second live tumor challenge. The mechanism whereby NPT mounts effective antitumor immune responses in the 4T1 breast cancer predominantly immunosuppressive tumor microenvironment (TME) remains unanswered. In this study, orthotopic 4T1 mouse breast tumors were treated with NPT (100 ns, 50 kV/cm, 1000 pulses, 3 Hz). Blood, spleen, draining lymph nodes and tumors were harvested at 4-hour, 8-hour, 1-, 3-, 7-day. Additional studies were conducted over 3-month posttreatment intervals for the analysis of frequencies, death and functional markers of various immune cells in addition to suppressor function of regulatory T cells (Tregs). NPT was verified to elicit strong in situ vaccination (ISV) against breast cancer and promoted both acute and long-term T cell memory. NPT abolished immunosuppressive dominance systemically and in the TME by substantially reducing Tregs, myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs). NPT induced apoptosis in Tregs and TAMs. It also functionally diminished the Treg suppression capacity, likely explained by the downregulation of activation markers, particularly 4-1BB and TGFβ, and a phenotypic shift from predominantly activated (CD44+CD62L-) to naïve (CD44-CD62L+) Tregs. Importantly, NPT selectively induced apoptosis in activated Tregs and spared effector CD4+ and CD8+ T cells. These changes were followed by a concomitant rise in CD8+CD103+ tissue-resident memory T cells and TAM M1 polarization. These findings indicate that NPT effectively switches the TME and secondary lymphatic systems from an immunosuppressive to an immunostimulatory state allowing cytotoxic T-cell function and immune memory formation to eliminate cancer cells and account for the NPT in situ vaccination.

Preprint ARTICLE | doi:10.20944/preprints202406.0742.v1

Morphological Patterns and Drivers of Urban Growth on Africa’s Wetland Landscapes: Insights from the Densu Delta Ramsar Site, Ghana

Charles Yaw Oduro, Prince Aboagye Anokye, Michael Ayertey Nanor

Subject: Social Sciences, Urban Studies And Planning Keywords: Urban growth; spreading pancake; ribbon development; village magnet; wetland; Densu Delta Ramsar site

Online: 11 June 2024 (18:32:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1749.v1

Study on Long-Term Care Service Awareness, Needs, and Usage Intention of Elderly Male Homosexuals in Taiwan and Their Ideal Long-Term Care Service Model

Hong Hong

Subject: Social Sciences, Gender And Sexuality Studies Keywords: homosexual long-term care; elderly male homosexuals; long-term care services

Online: 29 November 2023 (09:38:21 CET)

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The present study examines the long-term care service awareness, needs, and usage intention of elderly male homosexuals in Taiwan and their ideal long-term care service model. This study of five elderly male homosexual subjects aged 66 to 73 years was intended as a preliminary exploration. Interviews were used to collect data. The study determined that the five subjects had high awareness of long-term care services, as they had actual experience of long-term care services or even participated in care service staff training to obtain certificates. Some even had experience in applying for home care services and experienced problems during use. The subjects perceived that they were very likely to require long-term care services in the future and tended to use home care services if they required long-term care services. Due to their personal experiences, the subjects had negative awareness of long-term care services and worried that long-term care service staff had poor attitudes toward homosexuals. The subjects considered the most important aspects of long-term care to be basic medical care and lifestyle care. However, they worried that long-term care staff would delay or refuse to provide such services due to the subjects’ sexual orientation or stereotypes, and they were concerned above all about the “friendly attitude” of long-term care staff. They hoped that long-term care staff were friendly toward homosexuals and did not discriminate against them, and they felt that it would be more appropriate for homosexual long-term care staff to provide assistance. In terms of vision, while preferring organizations with homosexual employees, the subjects worried that they would be stigmatized and discriminated against . With regard to ideal long-term care services, while considering institutions with homosexual staff to be ideal, the subjects also worried that these would be labeled as institutions that were dedicated to homosexuals, potentially resulting in discrimination. Therefore, they hoped that the sexuality sensitivity of long-term care staff could be improved and that they would undergo professional continuing education to learn about homosexuals, the situation and care needs of homosexuals, and care techniques for homosexuals.

Preprint ARTICLE | doi:10.20944/preprints202403.1021.v1

Introduction of a Novel Structure for Light Unmanned Balloon’s Payload: A Comprehensive Hybrid Study

Norbert Hegyi, Gusztáv Fekete, János Jósvai

Subject: Engineering, Aerospace Engineering Keywords: novel payload structure; dodecahedron; PLA; low air pressure test; drop test; flight test

Online: 18 March 2024 (10:44:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0141.v1

Isolation and Propagation of Laboratory Strains and a Novel Flea-Derived Field Strain of Wolbachia in Tick Cell Lines

Jing Jing Khoo, Timothy Kurtti, Nurul Aini Husin, Alexandra Beliavskaia, Fang Shiang Lim, Mulya Mustika Sari Zulkifli, Alaa Al-Khafaji, Catherine Hartley, Alistair Darby, Grant Hughes, Sazaly AbuBakar, Benjamin Makepeace, Lesley Bell-Sakyi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Wolbachia; tick cell line; Ctenocephalides; flea; Malaysia; in vitro culture; phylogeny

Online: 12 June 2020 (04:51:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0254.v1

Ultrafiltration Harvesting of Microalgae Culture Cultivated in a WRRF: Long-Term Performance and Techno-Economic and Carbon Footprint Assessment

Juan Francisco Mora-Sánchez, Josué González-Camejo, Guillermo Noriega-Hevia, Aurora Seco, Maria Victoria Ruano

Subject: Engineering, Chemical Engineering Keywords: Anaerobic digestion (AD); cross-flow; greenhouse gas (GHG) emissions; harvesting; Membrane photobioreactor (MPBR); microalgae; ultrafiltration (UF); water resource recovery facility (WRRF).

Online: 5 December 2023 (15:09:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1088.v1

Hematodinium perezi (Dinophyceae: Syndiniales) in Morocco: First Record on the African Atlantic Coast, and First Country Record of a Parasite of the Invasive Blue Crab Callinectes sapidus

Amal Lamkhalkhal, Imane Rahmouni, Mohamed Selfati, Aicha Hamid, Nikol Kmentová, Maarten P.M. Vanhove, Hocein Bazairi

Subject: Biology And Life Sciences, Parasitology Keywords: bioinvasion; parasites; ITS1 rDNA; coastal lagoon; North Africa

Online: 16 May 2024 (10:04:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0359.v1

Malaria Vaccine Introduction in Cameroon: Early Results 30 Days into the Rollout

Shalom Tchofke Ndoula, Franck Mboussou, Andreas Ateke Njoh, Raoul Nembot, Simon Franky Baonga, Arnaud Njinkeu, Joseph Biey, Mohamed Kaba, Adidja Amani, Bridget Farham, Jean-Christian Kouontchou, Christian Armel Kouakam, Konstantin Volkmann, Hilaire Dadjo, Phanuel Habimana, Benido Impouma

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Malaria vaccine; Cameroon; new vaccine introduction; Africa.

Online: 6 March 2024 (12:07:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0096.v1

Biomineralization of Calcium and Magnesium Carbonate Minerals Induced by Bacillus licheniformis and Its Application in Water Softening

Yanyang Zhao, Hui Zhao

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: biomineralization; calcium ions; magnesium ions; Bacillus lichemiformis; carbonates

Online: 22 January 2017 (04:58:39 CET)

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Reducing the hardness of hard water is of great concern nowadays due to some adverse effects on water pipes, boilers and soap consumption. Using the method of biomineralization to precipitate calcium and magnesium ions to become carbonate minerals was one of the most important innovations for reducing the hardness of hard water. The present study sought to explore the physical and chemical conditions of carbonates bio-precipitation and the potential use of Bacillus licheniformis SRB2 strain (GenBank: KM884945.1) isolated from sludge sample of Moshui River (Shandong University of Science and Technology, Qingdao, China) in reducing the hardness of hard waters by the induction of carbonate minerals. In this study, B. licheniformis SRB2 strain was identified based on the morphological, biochemical and 16S rDNA gene sequence homology analysis. The carbonate minerals induced by B. licheniformis bacteria in the liquid culture medium with 3% NaCl and Mg/Ca molar ratio of 0, 6, 8, 10 and 12 were investigated. The culture medium was inoculated with the bacterial liquid seed was set as the experimental group and the other culture medium was inoculated with the same volume of distilled water was set as the control group. The mineral phases, micromorphologies, and crystal structures were analyzed using X-ray powder diffraction, scanning electron microscope, energy dispersive X-ray detector, high resolution transmission electron microscopy and selected area electron diffraction. The bacterial concentrations and pH values of the solution were measured by a spectrophotometer and a pH meter, respectively. The urease secreted by B. licheniformis SRB2 was found to greatly increase the pH values of the liquid medium, which favored the formation of calcium carbonate.As a result, Mg²⁺ and Ca²⁺ ion concentrations decreased greatly due to the biomineralization of calcium carbonate and nesquehonite minerals in the presence of B. licheniformis SRB2 bacterium. There were only few calcium carbonates and no nesquehonite minerals in the control groups. It was also found that the minerals of nesquehonite induced by B. licheniformis SRB2 had a phenomenon of preferred orientation. What was more, even though Mg²⁺ ions inhibited the precipitation of Ca²⁺ ions, but under the action of B. licheniformis SRB2 bacteria, the inhibition effect was significantly declined. The bio-precipitation of calcium carbonate and nesquehonite minerals may represent a new method of pretreatment for the hardness reduction of hard water. The accomplished study is of certain interest for interpretation of the carbonates biomineralization in natural environment, and maybe also has a certain application value in the former processing of hard water

Preprint ARTICLE | doi:10.20944/preprints202407.2108.v1

Combined Effect of tDCS and Motor or Cognitive Activity in Patients with Alzheimer’s Disease: A Proof-of-Concept Pilot Study

Cristina Fonte, Valentina Varalta, Giorgia Rotundo, Angelica Filosa, Ettore Muti, Cosimo Barletta, Elisa Evangelista, Alessandro Picelli, Nicola Smania

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Transcranial Direct Current Stimulation; Motor Activity; Cognitive Stimulation Alzheimer’ s disease

Online: 26 July 2024 (09:15:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0014.v1

Agro-Meteorological Monitoring: A Study Based on Observations from Akure, Ondo State, Nigeria

F.O Abulude, S.D Fagbayide, A.S Efunboade

Subject: Environmental And Earth Sciences, Environmental Science Keywords: rainwater; weather; windbreaker; cup anemometer; dry and wet bulb thermometers

Online: 4 January 2017 (07:27:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1585.v1

Development Strategy Based on Combination of Carbon Emission and Vibrancy Typology — a Multi-sourced Data-Driven Approach in Beijing, China

Jingyi Xia, Jiali Wang, Yuan Lai

Subject: Social Sciences, Urban Studies And Planning Keywords: Carbon emissions; Urban vibrancy; Development strategy

Online: 24 May 2024 (10:15:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0053.v1

Deciding on Optical Illusions: Reduced Alpha Power in Body Dysmorphic Disorder

Anastasios E. Giannopoulos, Ioanna Zioga, Konstantinos Kontoangelos, Panos Papageorgiou, Fotini Kapsali, Christos Ν. Capsalis, Charalabos Papageorgiou

Subject: Social Sciences, Behavior Sciences Keywords: body dysmorphic disorder; EEG; optical illusions; alpha oscillations

Online: 6 January 2022 (09:44:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0239.v1

Fundamental Constants in Time from the Big-Bang

Heikki Sipilä, Ari Lehto

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Fine structure constant; period doubling; alpha; natural constants

Online: 11 July 2020 (10:23:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1127.v1

Predicting the Effect of miRNA on Gene Regulation to Foster Translational Multiomics Research – A Thorough Review on the Role of ChIP-Seq Data

Sarmistha Das, Shesh N Rai

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Super-enhancer; miRNA; ChIP-Seq; Gene regulatory network; Transcription factor; Multi-omics

Online: 22 March 2024 (07:38:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.2156.v1

The Spatial Effects Study of the Digitization Level on the Deepening of National Value Chain in China:Based on the panel data of 263 cities

Guoguang Liu, Jing Liu, Jing Gao

Subject: Business, Economics And Management, Economics Keywords: digitization level; National Value Chain; cost reduction; consumption upgrading; spatial spillovers

Online: 29 August 2024 (11:34:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0990.v1

Polyethylene Terephthalate Waste Forms: Going beyond Flakes and Fibers

Kirill A. Kirshanov, Roman V. Toms, Gadir Sh. Aliev, Daniil A. Ismaylov, Andrew E. Mokhorev, Alexander Yu. Gervald

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: PET; polyethylene terephthalate; oligoethylene terephthalates; bis(2-hydroxyethyl) terephthalate; ethylene glycol; waste management; recycling

Online: 15 May 2024 (10:19:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1891.v1

Quantitative Analysis and Molecular Docking Simulation of Flavonols from Eruca sativa Mill. And Their Effect on Skin Barrier Function

Jihye Park, Wonchul Choi, Jayoung Kim, Hye Won Kim, Jee-Young Lee, Jongsung Lee, Bora Kim

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Eruca sativa; Skin barrier function; Peroxisome proliferator activated receptor-α ; Anti-inflammation; Docking simulation

Online: 29 November 2023 (12:16:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1385.v1

Brevundimonas aurifodinae, sp. nov., an Aerobic Anoxygenic Phototroph Resistant to Metalloid Oxyanions Isolated from Gold Mine Tailings

Chris Maltman, Katia Messner, John A. Kyndt, Vladimir Yurkov

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Aerbic anoxygenic phototroph; Brevundimonas; Brevundimonas aurifodinae; Bacteriochlorophyll a; Mine tailings; Metalloid oxide resistance; Tellurium; Selenium; Vanadium

Online: 20 September 2024 (03:10:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0292.v1

The Retinal Pigment Epithelium Pigment Granules: Norm, Age-related and Pathology

Alexander E Dontsov, Mikhail A Ostrovsky

Subject: Biology And Life Sciences, Aging Keywords: Retinal Pigment Epithelium; Reactive Oxygen Species; Lipofuscin, Bisretinoids; Oxidative stress; Melanin; Melanolipofuscin; Aging

Online: 6 March 2024 (10:06:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0605.v1

Relationship of Metabolic Dysfunction-associated Steatohepatitis-related Hepatocellular Carcinoma with Oral and Intestinal Microbiota: A Cross-Sectional Pilot Study

Takaaki Matsui, Toshiya Morozumi, Yuko Yamamoto, Takashi Kobayashi, Ryo Takuma, Masato Yoneda, Asako Nogami, Takaomi Kessoku, Muneaki Tamura, Yoshiaki Nomura, Toru Takahashi, Yohei Kamata, Shuntaro Sugihara, Kyoko Arai, Masato Minabe, Norio Aoyama, Kenji Mitsudo, Atsushi Nakajima, Motohiro Komaki

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: microbiota; oral bacteria; intestinal bacteria; hepatocellular cancer; metabolic dysfunction-associated steatohepatitis; Porphyromonas gingivalis

Online: 11 June 2024 (08:42:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0151.v1

Feasibility and Efficacy of Prenatal Ultrasonic Screening for Developmental Dysplasia of the Hip

Claudia Bevilacqua, Virginia Boscarato, Giovanni Pieroni, Eva Fraternali, Giuliano Lattanzi, Simone D. Aspriello, Antonio P. Gigante, Alessandro Cecchi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: developmental dysplasia of the hip; DDH; congenital dislocation of the hip; prenatal ultrasound screening of the hip; Graf technique; alpha angle; beta angle; newborn hip screening ;

Online: 4 June 2024 (10:37:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0988.v1

The Antidepressant Drug Amitriptyline Affects Human SH-SY5Y Neuroblastoma Cell Proliferation and Modulates Autophagy

Annagrazia Adornetto, Maria Luisa Laganà, Andrea Satriano, Ester Licastro, Maria Tiziana Corasaniti, Giacinto Bagetta, Rossella Russo

Subject: Biology And Life Sciences, Life Sciences Keywords: amitriptyline; antidepressant; autophagy; cell proliferation; neuroblastoma; SH-SY5Y

Online: 14 May 2024 (23:32:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1296.v1

Causal Meta-Reinforcement Learning for Multimodal Remote Sensing Data Classification

Wei Zhang, Xuesong Wang, Haoyu Wang, Yuhu Cheng

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Multimodal data; remote sensing; reinforcement learning; meta-learning; causal learning

Online: 22 February 2024 (15:30:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0094.v1

A BIM Based Framework for Damage Segmentation, Storage, and Visualization

Mathias Artus, Mohamed Alabassy, Christian Koch

Subject: Engineering, Civil Engineering Keywords: Building Information Modeling; defects; damage information modeling; life cycle; bridges; inspection; maintenance

Online: 6 January 2022 (17:45:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.0775.v1

Smart Composite Materials with Self-Healing Properties: A Review on Design and Applications

Artemis Kontiza, Ioannis A. Kartsonakis

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: microcapsules; self-healing; thermoplastic polymers

Online: 12 June 2024 (14:49:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0594.v1

Compensatory Modulation of Seed Storage Protein Synthesis and Starch Accumulation by Selective Editing of 13 kDa Prolamin Genes in Rice

Hue Anh Pham, Kyoungwon Cho, Anh Duc Tran, Deepanwita Chandra, Jinpyo So, Hanh Thi Thuy Nguyen, Hyunkyu Sang, Jong-Yeol Lee, Oksoo Han

Subject: Biology And Life Sciences, Plant Sciences Keywords: prolamin; 13 kDa prolamin; glutelin; seed storage protein; CRISPR-Cas9; protein body; starch; rice seed; ER stress; differentially expressed genes

Online: 9 May 2024 (11:58:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1266.v1

Pulmonary Hypertension: Pharmacological and Non-Pharmacological Therapies

Jason Tsai, Shaista Malik, Stephanie C. Tjen-A-Looi

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: pulmonary hypertension (PH); pulmonary arterial hypertension (PAH); chronic thromboembolic pulmonary hypertension (CTEPH); cardiac dysfunction; neurostimulation and electroacupuncture; vascular remodeling; alveolar hypoxia

Online: 20 May 2024 (12:16:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0311.v1

The Replicability Crisis and the p-Value Debate – what Are the Consequences for the Agricultural and Food Economics Community?

Thomas Heckelei, Silke Hüttel, Martin Odening, Jens Rommel

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: Statistical inference; p-hacking; pre-registration; publication bias; replication crisis

Online: 20 January 2022 (15:32:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1093.v1

IoT Wearable Sensors for Automatic Boxing Punch Recognition and Classification Based on Upper Limb Biomechanics

Saravanan Manoharan, John Warburton, Ravi Sadananda Hegde, Ranganathan Srinivasan, Babji Srinivasan

Subject: Engineering, Bioengineering Keywords: IoT Wearables; punch Detection and Classification; Computer Vision; Punch Key Performance Indicator (KPI)

Online: 14 July 2024 (03:11:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0201.v1

Interscapular and Perivascular Brown Adipose Tissue Respond Differently to a Short-Term High-Fat Diet

Peter Aldiss, Jo Lewis, David Boocock, Amanda Miles, Ian Bloor, Francis Ebling, Helen Budge, Michael Symonds

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: brown fat; white fat; proteome; nutrient excess

Online: 21 February 2019 (10:01:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.0062.v1

A Survey of Quantitative Techniques in Electricity Consumption – A Global Perspective

Atif Maqbool Khan, Artur Wyrwa

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: Survey; Quantitative Methods; Energy Consumption

Online: 1 August 2024 (11:55:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0110.v1

Hydrogen Generation from Catalytic Steam Reforming Bio-Oil Model Compound—Acetic Acid Employing Ni/attapulgite Catalysts Prepared with Different Preparation Methods

Yishuang Wang, Mingqiang Chen, Tian Liang, Jie Yang, Zhonglian Yang, Shaomin Liu

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: hydrogen production; steam reforming; Ni/attapulgite; catalysts deactivation; agglomeration and sintering

Online: 28 September 2016 (10:14:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1655.v1

Under Normoxia Simvastatin Shifts Lipid Metabolism of B16.F10 Melanoma Cells to Support Their Aggressiveness

Giorgiana Gabriela Negrea, Loredana Balacescu, Alina Sesarman, Manuela Banciu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: simvastatin; normoxia; hipoxia inducible factor 1; transcriptomics; unsaturated fatty acids; prostaglandins

Online: 23 September 2024 (08:45:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0055.v1

The Educational Value of Artificial Intelligence in Higher Education: A Ten-Year Systematic Literature Review

Agostino Marengo, Alessandro Pagano, Kamal Soomro, Jenny Pange

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: AI; artificial intelligence; higher education; learning; teaching; systematic review

Online: 2 November 2023 (00:04:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0572.v1

How to Evaluate the Brand Value of Exhibitions? A AHP Model Construction from Shanghai China

Mingguang Liu, Fangping Yang, Chunlei Wang

Subject: Business, Economics And Management, Business And Management Keywords: Exhibitions; Brand Value; Evaluation; AHP Model

Online: 9 May 2023 (05:13:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0306.v1

Productivity Improvement using Simulated Value Stream Mapping: A Case Study of the Truck Manufacturing Industry

Fikile Poswa, Khumbulani Mpofu, Olukorede Tijani Adenuga

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: simulated value stream mapping; small and medium enterprise

Online: 17 August 2022 (08:19:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1413.v1

High Dose Neutrophil Depleted Platelet-Rich Plasma Therapy for Knee Osteoarthritis: A Retrospective Study

Andrea De Matthaeis, Maria Bianchi, Rossana Putzulu, Giulio Maccauro

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: High dose PRP; Knee Osteoarthritis; neutrophil- depleted; Leukocyte Poor PRP

Online: 17 July 2024 (10:54:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1260.v1

Banana Classification Using Sanger Sequencing of the Ribosomal DNA Internal Transcribed Spacers (ITS)

Hongyun Zeng, Bingzhi Huang, Linbing XU, Yuanli Wu

Subject: Biology And Life Sciences, Plant Sciences Keywords: Musa; germplasm resources; genotypes; ITS

Online: 22 February 2024 (07:49:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1534.v1

THz Wave Power Enhancement Using a Microstrip Line-based Combiner Integrated with Arrayed UTC-PDs

Hussein Ssali, Yoshiki Kamiura, Ryo Doi, Hiroki Agemori, Ming Che, Yuya Mikami, Kazutoshi Kato

Subject: Engineering, Electrical And Electronic Engineering Keywords: Microstrip line; patch antenna; terahertz wave; uni-travelling carrier photodiode; Wilkinson power combiner

Online: 23 April 2024 (17:18:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1238.v1

The Museums of Geology and Paleontology as Geoeducational Learning Environments for Raising Climate Change Awareness

Christina Kondyli, Maria Psychogiou, Hara Drinia

Subject: Social Sciences, Education Keywords: climate change; museum education; AR in museums; geoheritage; geoconservation

Online: 18 April 2024 (14:03:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0067.v1

Global Existence, Exponential Decay and Finite Time Blow-up of Solutions for a Class of Semilinear Pseudo-parabolic Equations with Conical Degeneration

Gang Li, Jiangyong Yu, Wenjun Liu

Subject: Computer Science And Mathematics, Analysis Keywords: blow-up; semilinear pseudo-parabolic equations; critical initial energy; conical degeneration

Online: 13 March 2017 (09:56:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0094.v1

Spatiotemporal Information Extraction from a Historic Expedition Gazetteer

Mafkereseb Kassahun Bekele, Rolf A. De By, Gaurav Singh

Subject: Computer Science And Mathematics, Information Systems Keywords: GIR; TIR; NLP; spatiotemporal information; temporal inference

Online: 22 October 2016 (10:55:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1209.v1

Linezolid Adsorption on the Filters during Continuous Renal Replacement Therapy: In Vitro Study

Krzysztof Nosek, Milena Samiec, Hubert Ziółkowski, Paulina Markowska-Buńka, Mirosław Czuczwar, Michał Borys, Dariusz Onichimowski

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: adsoprtion; linezolid; continous renal replacement therapy; dialysis filter

Online: 16 August 2024 (07:14:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0507.v1

The Effect of Orally Administered Multi-Strain Probiotic Formulation (Lactobacillus, Bifidobacterium) on the Phagocytic Activity and Oxidative Metabolism of Peripheral Blood Granulocytes and Monocytes in Lambs

Roman Wójcik, Joanna Małaczewska, Dawid Tobolski, Jan Miciński, Edyta Kaczorek-Łukowska, Grzegorz Zwierzchowski

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: lambs; phagocytosis; oxidative burst; granulocytes; monocytes; probiotic.

Online: 8 April 2024 (08:41:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0583.v1

Ultrasound Assisted Alkaline Pretreatment of Biomass to Enhance the Extraction Yield of Valuable Chemicals

Adina I. Gavrila, Anamaria Vartolomei, Ioan Calinescu, Mircea Vinatoru, Oana C. Parvulescu, Grigore Psenovschi, Petre Chipurici, Adrian Trifan

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: ultrasound; lignin; wood residue; enzymatic hydrolysis

Online: 8 April 2024 (15:38:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1129.v1

Impacts of a Moderate-Sized Earthquake: The 2023 Magnitude (Mw) 4.7 Leyte, Leyte Earthquake, Philippines

Jeffrey S. Perez, Deo Carlo E. Llamas, Daniel Jose L. Buhay, Ryan Christian Constantino, Crystel Jade M. Legaspi, Kristine Dionne B. Lagunsad, Rhommel N. Grutas, Marc Marion Y. Quimson

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: Philippine fault – Leyte segment; PHIVOLCS Earthquake Intensity Scale (PEIS); surface rupture; liquefaction, landslide, site amplification; disaster risk reduction

Online: 21 February 2024 (03:49:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0998.v1

Investigation of CFRP Concrete Reinforcement Ageing Using Microwave Infrared Thermography Method (MIRT)

Barbara Szymanik, Sam Ang Keo, Franck Brachelet, Didier Defer

Subject: Engineering, Civil Engineering Keywords: Microwave thermography; carbon-fiber-reinforced polymer (CFRP); defect; ageing; modeling with COMSOL

Online: 16 April 2024 (07:36:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0364.v1

An Explainable AI-based Machine Learning Approach for Predicting Diabetes in the Early Stage Using the Influential Features

Utsha Das, Boshir Ahmed

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: communicable disease; diabetes; feature selection; imbalanced dataset; insulin; kernel function; outlier
samples

Online: 12 June 2024 (14:16:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2219.v1

Adjusted versus Targeted Fortification in Extremely Low Birth Weight Preterm Infants: Fortin Study. A Randomized Clinical Trial.

Maria Sanchez-Holgado, Miguel Saenz de Pipaon, Concepción Jiménez-González, María Gema Crespo Sánchez, Marta Molero-Luis, Maria Teresa Montes, Cristina Segovia, Itsaso Losantos-García, María Jiménez-González, Esperanza Escribano-Palomino, Marta Cabrera-Lafuente

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: preterm infants; neonatal nutrition; growth; human milk; human milk fortification; blood urea nitrogen; individualized fortification

Online: 29 July 2024 (10:50:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0490.v1

Shor-Term Forecasting of Photovoltaic Power Using MLPNN, CNN AND kNN

Kelachukwu Iheanetu, KeChrist Obileke

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: renewable energy; solar; photovoltaic; forecasting; data-driven; machine learning; modelling

Online: 8 May 2024 (15:29:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0084.v1

Long-Term Tree Survival and Diversity of Highway Tree Planting Projects

Allyson B. Salisbury, Jason W. Miesbauer, Andrew K. Koeser

Subject: Biology And Life Sciences, Plant Sciences Keywords: drought tolerance; roadside woody vegetation; Simpson diversity; site conditions; tree mortality; tree planting initiatives

Online: 4 March 2022 (17:04:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1647.v1

Drought Risk Assessment for the Agriculture System in Afghanistan: A Spatial Analysis of Hazard, Exposure and Vulnerability

Abdur Rashid Jamalzi, Fernando Jaramillo, Qiyamud Din Ikram, Fazlullah Akhtar, Tesse de Boer

Subject: Environmental And Earth Sciences, Geography Keywords: drought; risk; vulnerability; agriculture; vegetation condition index; Afghanistan

Online: 22 July 2024 (09:59:04 CEST)

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Despite decades of conflict and political instability, drought has also severely affected Afghanistan’s rural population and agriculture sector. Agriculture is a primary livelihood source in the country, and recurring droughts have put cascading pressures on the agricultural economy and food security. Therefore, understanding the key drivers of all risk components through a comprehensive risk assessment is critical for proactive drought risk management. This study assesses agricultural drought risk from an integrated perspective, emphasizing the combined effects of drought hazard, exposure, and vulnerability. Multi-methods research was conducted, employing remote-sensing-based analysis covering a period from 2001 to 2023. We used the Vegetation Condition Index (VCI) to analyze the drought hazard for the agricultural system during the winter growing season. The vulnerability indicators and exposure levels of the agricultural system were determined through spatial analysis combined with a literature review and expert consultation. An adapted conceptual framework of the Intergovernmental Panel on Climate Change (IPCC) was utilized, which incorporates hazard, exposure, and vulnerability to define risk. The results revealed that droughts occur frequently and in changing patterns throughout the country. All provinces have experienced drought over the past two decades, albeit with varying severities and frequencies. Severe droughts were observed in 2001-2002, 2008, 2011, 2018, and consecutively in 2021-2022-2023. Drought vulnerability and exposure vary widely across the country, particularly in the northern, western, and southern provinces. The final calculated risk shows that most provinces in southern and southwestern zones face a high risk of recurrent droughts, further exacerbating agricultural challenges in these regions. Such analyses under a multimethod approach provide information on spatial patterns of drought risk and drivers of agricultural systems that can support decision-makers and policymakers in formulating strategies to reduce drought risk and adapt to the agricultural sector.

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