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Preprint ARTICLE | doi:10.20944/preprints201704.0179.v1

Effects of Hydroalcoholic Extract of Celtis iguanaea on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats

Barbara Zanchet, Denise B. Gomes, Vanessa S. Corralo, Kriptsan A. P. Diel, Amanda P. Schönell, Caroline Faust, Patrícia Nicola, Liz G. Muller, Ana Paula Zanatta, Silvana M. Wildner, Fernanda Bevilaqua, Rafael Chitolina, Adrieli Sachett, Leila Zanatta, Marta M. M. F. Duarte, Greicy M. M. Conterato, Claudia Q. Rocha, Camile Peretti, Tatiane Brumelhaus, Nayara Souza Alves, Jean Carlo Olivo Menegatt, Fernanda Conte, Guilherme Serena, Adriano Tony Ramos, Francielli Cordeiro Zimermann, Walter A. Roman Junior

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: medicinal plants; flavonoids; hypoglycemic; hypolipidemic; antiatherogenic

Online: 27 April 2017 (04:13:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0098.v1

Induction of G2M Arrest by Flavokawain A, A Kava Chalcone, Increases the Responsiveness of HER2 Overexpressing Breast Cancer Cells to Herceptin

Danielle D. Jandial, Lauren S. Krill, Lixia Chen, Chunli Wu, Yu Ke, Jun Xie, Bang H. Hoang, Xiaolin Zi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Flavokawain A; HER2 overexpression; resistance to apoptosis

Online: 23 January 2017 (03:30:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1156.v1

A High-Homology Region in Bacterial β-Barrel Pore-Forming Toxins

Alexey S. Nagel, Olesya Vetrova, Natalia V. Rudenko, Anna P. Karatovskaya, Anna Zamyatina, Zhanna I. Andreeva-Kovalevskaya, Vadim Salyamov, Nadezhda Egorova, Alexander V. Siunov, Tatiana D. Ivanova, Khanafi M. Boziev, Fedor A. Brovko, Alexander S. Solonin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus α -toxin; Bacillus cereus hemolysin II; cytotoxin K2; suppression of hemolytic activity; monoclonal antibodies; enzyme immunoassay

Online: 20 March 2024 (12:23:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2128.v1

Predicting Survival of Metastatic Clear Cell Renal Cell Carcinoma Treated With Tyrosine Kinase Inhibitor Based Sequential Therapy

Javier C. Angulo, Gorka Larrinaga, David Lecumberri, Ane Miren Iturregui, Jon Danel Solano-Iturri, Charles H. Lawrie, María Armesto, Juan F. Dorado, Caroline E. Nunes-Xavier, Rafael Pulido, Claudia Manini, José I. López

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: metastatic renal cell carcinoma; tyrosine kinase inhibitor sunitinib; nomogram; cancer-specific survival; prognosis; treatment response

Online: 26 July 2024 (06:23:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1007.v1

Development and Evaluation of a Solar Milk Pasteurizer for the Savanna Ecological Zone of West Africa

Iddrisu Ibrahim, Paul Tengey, Joseph Atia Ayariga, Junhuan Xu, Boakai K. Robertson, Olufemi S. Ajayi, James Owusu-Kwarteng

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: pasteurization; solar pasteurizer; milk treatment; coliform bacteria; pathogens

Online: 15 May 2024 (08:52:35 CEST)

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Solar pasteurization, as a means of treating milk in remote rural areas without electrical power, is based on using solar energy to thermally inactivate pathogenic microorganisms at temperatures below the boiling point to maintain or improve milk quality. A solar milk pasteurizer of flat‐plate water‐heating glass acting as the solar collector, connected to a stainless-steel cylindrical milk vat, was constructed and evaluated in Navrongo, in the tropical savanna zone of Ghana, West Africa. The novel approach taken in this project is to integrate the solar collection and heat exchanger into a single unit using materials and fabrication techniques readily available in the developing world. The vat comprises a 1.5 mm thick stainless steel cylindrical tank, a 2.2 cm wide hot water jacket, and an outer layer of 5.0 mm thick aluminium foil insulation. Hot water produced by the collector was used for pasteurizing milk. The optimum quantity of milk that this device could pasteurize under the study conditions was 8 L. The device could pasteurize raw milk to a maximum temperature of 74 °C at 14:00 h GMT. The ambient temperature during the pasteurization ranged from 30 °C to 43 °C. The microbial analysis before and after the pasteurization was done, and the result shows that the total bacteria count before pasteurization was 6.6x10⁶ log CFU/mL per unit volume, and the total bacteria count after pasteurization was 1.0x10² log CFU/mL. By acceptable standards, the total bacteria count after pasteurization is within a safe range for consumption, and coliform counts were negative. The solar milk pasteurization system is cost-effective. Hence, it is appropriate for milk producers in arid pastoral areas without electricity to adopt the solar pasteurizer as an alternative to firewood as a fuel source for milk pasteurization. This approach can potentially create a cottage industry that may also play a crucial role as a water treatment technology that will improve the health of rural populations.

Preprint ARTICLE | doi:10.20944/preprints202209.0288.v1

Use of Human Lung Tissue Models for Screening of Drugs Against SARS-CoV-2 Infection

Alexander J McAuley, Petrus Jansen van Vuren, Muzaffar-Ur-Rehman Mohammed, Faheem Faheem, Sarah Goldie, Shane Riddell, Nathan J Gödde, Ian K Styles, Matthew P Bruce, Simran Chahal, Stephanie Keating, Kim R Blasdell, Mary Tachedjian, Carmel M O'Brien, Nagendrakumar Balasubramanian Singanallur, John Noel Viana, Aditya V Vashi, Carl M Kirkpatrick, Christopher A MacRaild, Rohan M Shah, Elizabeth Vincan, Eugene Athan, Darren J Creek, Natalie L Trevaskis, Sankaranarayanan Murugesan, Anupama Kumar, Seshadri S Vasan

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; Therapeutics; Drug Repurposing; 3D Tissue Models

Online: 20 September 2022 (03:24:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1175.v1

Photoinactivation of Mycobacterium tuberculosis and Mycobacterium smegmatis by Near-Infrared Radiation Using a Trehalose-Conjugated Heptamethine Cyanine

Natalia V. Kozobkova, Michael P. Samtsov, Anatol P. Lugovski, Nikita V. Bel’ko, Dmitri C. Tarasov, Arseny S. Kaprelyants, Alexander P. Savitsky, Margarita O. Shleeva

Subject: Biology And Life Sciences, Biophysics Keywords: Mycobacterium tuberculosis; mycobacteria; antibacterial photodynamic inactivation; trehalose; dormant mycobacteria; tricarbocyanine dye

Online: 18 June 2024 (08:27:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0438.v1

Whole Genome Sequencing and Analysis of Tumour-Forming Radish (Raphanus sativus L.) Line

Xenia A. Kuznetsova, Irina E. Dodueva, Alexey Afonin, Emma Gribchenko, Lavrentiy Glebovich Danilov, Maria S. Gancheva, Varvara E. Tvorogova, Nikita A. Galynin, Ludmila A. Lutova

Subject: Biology And Life Sciences, Plant Sciences Keywords: spontaneous tumours; Raphanus sativus; inbred lines; genomic sequence; single nucleotide variants

Online: 8 May 2024 (15:19:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0046.v1

Airway Management and General Anesthesia in Pediatric Patients with Disabilities Undergoing Dental Surgery: A Retrospective Study

Alessandra Ciccozzi, Ettore Lupi, Stefano Necozione, Filippo Giovannetti, Antonio Oliva, Roberta Ciuffini, Chiara Angeletti, Franco Marinangeli, Alba Piroli

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: difficult airway; pediatrics; general anesthesia; psycho-physical disorders

Online: 1 May 2024 (05:46:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1372.v1

NHE1 Protein in Repetitive Mild TBI-Mediated Neuroinflammation and Neurological Function Impairment

John Paul Bielanin, Shamseldin Ayman Hassan Metwally, Helena C.M. Oft, Satya S. Paruchuri, Lin Lin, Okan Capuk, Nicholas D. Pennock, Shanshan Song, Dandan Sun

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: concussion; diffuse axonal injury; neuroinflammation; oxidative stress; white matter injury

Online: 22 April 2024 (06:51:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0355.v1

Evaluation of the Potential of Urinary Volatilomic Patterns of COVID-19 Patients Infected With SARS-CoV-2 for Disease Diagnosis. An Exploratory Study

Giulia Riccio, Joana Neto, Cristina V. Berenguer, Cristina P. Ornelas, Viviana Greco, Jorge Pereira, Rosa Perestrelo, José S. Câmara

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: VOMs; urine; COVID-19; volatilomics; HS-SPME/GC-MS

Online: 4 April 2024 (08:10:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0178.v1

Eco-Friendly Microencapsulation of Lacticaseibacillus Paracasei Using Cissampelos pareira Leaf Extract as Natural Encapsulating Materials

Sasi Vimon, Chonticha Romyasamit, Rawiwan Chanpakdee, Sumaree Boonplu, Chackrit Nuengjamnong, Fonthip Makkliang, Suthinee Sangkanu, Veeranoot Nissapatorn, Phirabhat Saengsawang, Tina S. Dalgaard, Watcharapong Mitsuwan

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Cissampelos pareira; Lacticaseibacillus paracasei; microencapsulation; natural encapsulating material; probiotic supplementation

Online: 4 March 2024 (15:33:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0232.v1

Preventing The Next Pandemic: Is Live Vaccine Efficacious Against Monkeypox, or There is a Need for Killed Virus and mRNA Vaccines?

Abdelaziz Abdelaal, Abdullah Reda, Basant Ismail Lashin, Basant E. Katamesh, Aml M. Brakat, Balqees Mahmoud AL-Manaseer, Sayanika Kaur, Ankush Asija, Nimesh K. Patel, Soney Basnyat, Ali A. Rabaan, Saad Alhumaid, Hawra Albayat, Mohammed Aljeldah, Basim R. Al shammari, Amal H. Al-Najjar, Ahmed K. Al-Jassem, Sultan T. AlShurbaji, Fatimah S. Alshahrani, Ahlam Alynbiawi, Zainab H. Alfaraj, Duaa H. Alfaraj, Ahmed H Aldawood, Yub Raj Sedhai, Victoria Mumbo, Alfonso J. Rodriguez-Morales, Ranjit Sah

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Monkeypox; Vaccine; Outbreak

Online: 15 July 2022 (12:12:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0225.v1

Impacts of a Changing Earth on Microbial Dynamics and Human Health Risks in the Continuum between Beach Water and Sand

Chelsea J. Weiskerger, João Brandão, Warish Ahmed, Asli Aslan, Lindsay Avolio, Brian D. Badgley, Alexandria B. Boehm, Thomas A. Edge, Jay M. Fleisher, Christopher D. Heaney, Luisa Jordao, Julie L. Kinzelman, James S. Klaus, Gregory T. Kleinheinz, Päivi Meriläinen, Jean Pierre Nshimyimana, Mantha Phanikumar, Alan M. Piggot, Tarja Pitkänen, Clare Robinson, Michael J. Sadowsky, Christopher Staley, Zachery R. Staley, Erin M. Symonds, Laura J. Vogel, Kevan M. Yamahara, Richard L. Whitman, Helena M. Solo-Gabriele, Valerie J. Harwood

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pathogen, climate change, sand, water quality, modeling

Online: 22 January 2019 (17:28:22 CET)

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Humans may be exposed to microbial pathogens at recreational beaches via environmental sources, such as water, sand, and aerosols. Although infectious disease risk from exposure to waterborne pathogens has been an active area of research for decades, sand is a relatively unexplored reservoir of pathogens and fecal indicator bacteria (FIB). Beach sand and water habitats provide unique advantages and challenges to pathogen introduction, growth, and persistence, as well as continuous exchange between habitats. Models of FIB and pathogen fate and transport in sandy beach habitats can help predict the risk of infectious disease from recreational water use, but filling knowledge gaps such as decay rates and potential for microbial growth in beach habitats is necessary for accurate modeling. Climatic variability, whether natural or anthropogenically-induced, adds complexity to predictive modeling, but may increase human exposure to waterborne pathogens via extreme weather events, warming of water bodies and sea level rise in many regions. The popularity of human recreational beach activities, combined with predicted climate change scenarios, could amplify the risk of human exposure to pathogens and related illnesses. Other global change trends such as increased population growth and urbanization are expected to exacerbate contamination events and the predicted impacts of increasing levels of waterborne pathogens on human health. Such changes will alter microbial population dynamics in beach habitats, and will consequently affect the assumptions and relationships used in population models and quantitative microbial risk assessment (QMRA). Here, we discuss the literature on microbial population and transport dynamics in sand-water continuum habitats at beaches, how these dynamics can be modeled, and how climate change and other anthropogenic influences (e.g., land use, urbanization) should be considered when using and developing more holistic, beachshed-based models.

Preprint ARTICLE | doi:10.20944/preprints201811.0369.v1

Development of New Target Stations for the South African Isotope Facility

Gideon F. Steyn, Lyndon S. Anthony, Faical Azaiez, Shadley Baard, Robert A. Bark, A. Hugo Barnard, Philip Beukes, Johan I. Broodryk, J. Lowry Conradie, John C. Cornell, J. Garrett de Villiers, Stuart G. Dolley, Herman du Plessis, William D. Duckitt, Dirk T. Fourie, Mike E. Hogan, Ivan H. Kohler, Kobus J. Lawrie, Chris Lussi, Joele P. Mira, K. Vuyo Mjali, Hendrik W. Mostert, Clive Naidoo, Fhumulani Nemulodi, David Saal, Nieldane P. Stodart, Rainer W. Thomae, Johan van Niekerk, Pieter A. van Schalkwyk

Subject: Physical Sciences, Applied Physics Keywords: radionuclide production; target stations; targetry; 70 MeV cyclotron

Online: 16 November 2018 (04:01:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1219.v1

A Prospective Study on the Progression, Recurrence, and Regression of Cervical Lesions: Assessing Various Screening Approaches

Tudor-Catalin Giscă, Iulian-Valentin Munteanu, Ingrid Andrada Vasilache, Alina-Sinziana Melinte-Popescu, Simona-Ruxandra Volovat, Ioana Sadyie Scripcariu, Raluca Anca Balan, Răzvan Socolov, Ioana Pavaleanu, Alexandru Carauleanu, Constantin Cristian Vaduva, Marian Melinte-Popescu, Ana-Maria Adam, Gigi Adam, Petronela Vicoveanu, Demetra Socolov

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: cervical lesions; HPV genotyping; p16/Ki67 dual staining; cervical cytology; clinical risk factors.

Online: 21 February 2024 (10:22:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.1618.v1

Aflatoxin's Toll on Health: Insights into Human and Animal Impact

Jai P. Rai, Jeetu Narware, Ritesh Kumar, Randeep Kumar, Puja Pandey, Nishant Prakash, Somnath K. Holkar, Nadeem Akhtar, Sawant Shraddha Bhaskar, Santosh Kumar, Rekha Balodi, Vinod Upadhyay, Anirudh Chattopadhyay, Kaushik Banerjee, Mohammed Wasim Siddiqui, Akoijam Ratankumar Singh, S. Aravindan, Nisha Kumari, Udai B Singh, Abhijeet Ghatak

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: aflatoxin; human health; animal health; aflatoxicoses; fungi; Feed contamination; aflatoxin toxicity; aflatoxin detection; aflatoxin management

Online: 24 May 2024 (10:09:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0284.v1

Building Consensus around the Assessment and Interpretation of Symbiodiniaceae Diversity

Sarah Davies, Matthew H. Gamache, Lauren I. Howe-Kerr, Nicola G. Kriefall, Andrew C. Baker, Anastazia T. Banaszak, Line K. Bay, Anthony J. Bellantuono, Debashish Bhattacharya, Cheong Xin Chan, Danielle C. Claar, Mary Alice Coffroth, Ross Cunning, Simon K. Davy, Javier del Campo, Erika M. Diaz-Almeyda, Jorg C. Frommlet, Lauren E. Fuess, Raul A. Gonzalez-Pech, Tamar L. Goulet, Kenneth D. Hoadley, Emily J. Howells, Benjamin C. C. Hume, Dustin W. Kemp, Carly, D. Kenkel, Sheila A. Kitchen, Todd C. LaJeunesse, Senjie Lin, Shelby McIlroy, Ryan McMinds, Matthew R. Nitschke, Clinton A. Oakley, Raquel S. Peixoto, Carlos Prada, Hollie M. Putnam, Kate Quigley, Hannah G. Reich, James Davis Reimer, Mauricio Rodriguez-Lanetty, Stephanie Rosalas, Osama S. Saad, Eugenia M. Sampayo, Scott Santos, Eiichi Shoguchi, Edward G. Smith, Michael Stat, Timothy G. Stephens, Marie E. Strader, David J. Suggett, Timothy D. Swain, Cawa Tran, Nikki Traylor-Knowles, Christian R. Voolstra, Mark E. Warner, Virginia M. Weis, Rachel Wright, Tingting Xiang, Hiroshi Yamashita, Maren Ziegler, Adrienne M.S. Correa, John Everett Parkinson

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Symbiodinaceae; genetic diversity; coral symbiosis

Online: 21 June 2022 (04:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2495.v1

Development of Geotechnical Seismic Isolation System in the Form of Vertical Barriers: Effectiveness and Perspective

Yerik T. Bessimbayev, Assylbek S. Shadkam, Ulugbek T. Begaliev, Meyram M. Begentayev, Dossym K. Suleyev, Zhanar O. Zhumadilova, Tuleukhan I. Irgebayev, Yerlan Y. Ussipbekov

Subject: Engineering, Architecture, Building And Construction Keywords: earthquake; seismic; ground dynamics; response spectrum; barriers; geotechnical seismic isolation; rubber-soil mixture; damping

Online: 31 July 2024 (08:00:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1732.v1

Anti-Proliferative and Cytoprotective Activity of Ethylenediurea Derivatives with Alkyl and Oxygen-containing Groups as Substituents

Maxim S. Oshchepkov, Leonid Kovalenko, Antonida Kalistratova, Galina Sherstyanykh, Evgenia Gorbacheva, Alexey Antonov, Karina Ustinova, Nisreen Khadour, and Mikhail Akimov

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: carbamates; oxamates; synthetic cytokinins; substituted ureas; anti-oxidative effect; cytotoxicity; oxidative stress

Online: 27 May 2024 (10:27:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1199.v1

Clinical Correlation of Transcription Factor SOX3 in Cancer: Unveiling Its Role in Tumorigenesis

Helen Lima Del Puerto, Ana Paula G.S. Miranda, Dinah Qutob, Enio Ferreira, Felipe H.S. Silva, Bruna M. Lima, Barbara A. Carvalho, Bruna R. Souza, Eduardo Gutseit, Diego C. Castro, Emanuele T. Pozzolini, Nayara O. Duarte, Thacyana B.G. Lopes, Daiana Y.O. Taborda, Stella M. Quirino, Ahmed Elgerbi, John S. Choy, Adam Underwood

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: SOX3; Cancer; Apoptosis; EMT; Invasion; Migration; Cell cycle; Proliferation; Prognosis; Therapeutics

Online: 18 April 2024 (13:42:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0533.v1

Exploring the Dual Benefits of Fermented and Non-fermented Garlic on Growth, Antioxidative Capacity, Immune Responses, and Histology in Grey Mullet (Liza ramada)

Mohammed F. El Basuini, Mahasen M. E. A. Shaban, Abdelaziz M. El-Hais, Ali A. Soliman, Nermeen M. Abu-Elala, Islam I. Teiba, Mayada Alhoshy, Ghada R. Sallam, Ronick S. Shadrack, Kumbukani Mzengereza, Akram Ismael Shehata

Subject: Biology And Life Sciences, Aquatic Science Keywords: Allium sativum; Antioxidant status; Digestive enzymes; Feed additives; Fermented garlic; Growth performance; Liza ramada

Online: 6 September 2024 (11:11:47 CEST)

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This study investigated the effects of dietary garlic powder and fermented garlic powder supplementation at 1% and 2% levels on growth performance, digestive tract efficacy, blood biochemistry, immunity, and antioxidant status of Liza ramada (n=225 fish; 86.00±0.42 g) over a 60-day period. Fish fed diets supplemented with both forms of garlic at both levels exhibited significantly improved final body weight, weight gain, specific growth rate, and feed conversion ratio compared to the control group. Digestive enzyme activities (amylase, lipase, and protease) were significantly enhanced in all supplemented groups. Blood biochemical analysis revealed reduced glucose levels and increased total protein in garlic-supplemented groups, with no adverse effects on liver or kidney function markers. Immune parameters, including lysozyme activity, bactericidal activity against Streptococcus agalactiae, alternative complement pathway (ACP), and, respiratory burst (NBT) were significantly enhanced in garlic-supplemented groups, with fermented garlic showing more pronounced effects. Antioxidant enzyme activities (SOD, CAT, and GPx) were also significantly increased in all supplemented groups, particularly in those fed fermented garlic. No significant differences in survival rates were observed among treatments. The results suggest that both garlic powder and fermented garlic powder supplementation, especially at the 2% level, can effectively improve growth, feed utilization, immune function, and antioxidant status in L. ramada. Fermented garlic generally demonstrated superior effects, indicating its potential as a beneficial feed additive in aquaculture. Based on these findings, it is recommended to incorporate fermented garlic powder at a 2% level in L. ramada diets to optimize growth performance and health status. Further research is warranted to investigate the long-term effects and cost-effectiveness of this supplementation strategy in commercial aquaculture settings.

Preprint ARTICLE | doi:10.20944/preprints202405.1623.v2

Methodologies Toward Optimization of Y₂O₃:Eu@SiO₂ Nanoparticles as Photosensitizers for X-Ray Activated Photodynamic Therapy (XPDT) of Cancer

Hannah J. Zhang, Tristan Ide, Maharajan Sivasubramanian, Lara Leoni, Jeffrey S. Souris, Divya Brahmbhatt, Eve Tanios, Ariel Pan, Shih-Hsun Cheng, Nai-Tzu Chen, Leu-Wei Lo, Chin-Tu Chen

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Cancer; Y₂O₃:Eu@SiO₂Nanoparticles; Photodynamic Therapy; Photosensitizer ; ;

Online: 23 July 2024 (09:47:03 CEST)

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Traditional photodynamic therapy (PDT) is often limited in its efficacy by insufficient light penetration, inefficient photosensitizer energy transfer, and inadequate target tissue oxygenation. X-ray activated PDT (XPDT), using nanoparticle (NPs) photosensitizers comprised of europium-doped yttrium oxide cores encased within silica shells (Y₂O₃:Eu@SiO₂), offers the potential of overcoming most of these limitations. Aimed at maximizing the generation of reactive oxygen species (ROS), this study reports methodologies for investigation of the effects of synthesis conditions on the characteristics of Y₂O₃:Eu@SiO₂NP. Transmission electronic microscope (TEM) revealed that the NP core diameter was linearly, positively correlated with condensation time (R2 = 0.7357, p < 0.05) and linearly, negatively correlated with urea concentration (R2 = 0.958, p < 0.05). The addition of cetyltrimethylammonium bromide (CTAB) during core synthesis demonstrated enhanced particle dispersion. Silica coating via APTES-1 and TEOS-3 conditions resulted in Y₂O₃:Eu@SiO₂ NPs that generated the highest ROS, with 8.7-fold and 8.9-fold increase respectively in relative fluorescence intensity at 8 Gy irradiation compared to a 5.2-fold increase in PBS under the same condition. In vivo evaluation using 18F-fluorothymidine positron emission tomography (18F-FLT PET) of mouse xenografts of a human prototypical cancer (ovarian) revealed a 55% reduction in tumor proliferation of radiation-sensitive CAOV3 tumors treated with Y₂O₃:Eu@SiO₂ NPs compared to a 19% reduction in tumor proliferation of radiation-resistant SKOV3 tumors on the fourth day post-treatment. Taken together, these findings suggest Y₂O₃:Eu@SiO₂ NPs can serve as effective photosensitizers for XPDT and their performance characteristics can be optimized by selecting synthesis conditions and parameters to deliver the desirable therapeutic effects, offering novel approaches to circumventing many of the limitations of conventional PDT in the treatment of cancer.

Preprint ARTICLE | doi:10.20944/preprints202407.1236.v1

The Improvement of Adaptive Immune Responses towards COVID-19 Following Diphtheria-Tetanus-Pertussis and SARS-CoV-2 Vaccinations in Indonesian Children: Exploring Roles of Heterologous Immunity

Theresia Santi, Juandy Jo, Alida Roswita Harahap, Retno Asti Werdhani, Sri Rezeki S. Hadinegoro, Ivo Novita SahBandar, Ari Prayitno, Zakiudin Munasir, Yvan Vandenplas, Badriul Hegar

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Children; SARS-CoV-2-specific immune response; Heterologous immunity; Diphtheria-tetanus-pertussis vaccine; Inactivated COVID-19 vaccine

Online: 17 July 2024 (04:12:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0230.v1

Definition of a Multi-omics Signature for Esophageal Adenocarcinoma Prognosis Prediction

Luca Lambroia, Carola Conca Dioguardi, Simone Puccio, Andrea Pansa, Giorgia Alvisi, Gianluca Basso, Javier Cibella, Federico S. Colombo, Salvatore Marano, Silvia Basato, Rita Alfieri, Simone Giudici, Carlo Castoro, Clelia Peano

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Esophageal-Adenocarcinoma; Cancer; immunotherapy; treatment; single-cell RNA; single-cell sequencing; RNA sequencing; transcriptional signature; response to therapy; immune infiltrate.

Online: 3 July 2024 (00:25:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0057.v1

Effects of Modulating BMP9, BMPR2, and AQP1 on Bmp-Signaling in Human Pulmonary Microvascular Endothelial Cells

Nikolaos S. Lotsios, Chrysi Keskinidou, Ioanna Dimopoulou, Anastasia Kotanidou, David Langleben, Stylianos E Orfanos, Alice Georgia Vassiliou

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: PAH; BMP9; BMPR2; AQP1

Online: 1 July 2024 (09:21:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0261.v1

Tumor-Intrinsic Enhancer of Zeste Homolog 2 Controls Immune Cell Infiltration, Tumor Growth and Lung Metastasis in a Triple Negative Breast Cancer Model

Lenore Monterroza, Maria M. Parrilla, Sarah G. Samaranayake, Dormarie E. Rivera-Rodriguez, Sung Bo Yoon, Ramireddy Bommireddy, Justin Hosten, Luisa Cervantes Barragan, Adam Marcus, Brian S. Dobosh, Periasamy Selvaraj, Rabindra Tirouvanziam

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CD4+ T-cell; CD8+ T-cell; invasion; myeloid-derived suppressor cell; triple-negative breast cancer; tumor-infiltrating neutrophils

Online: 3 April 2024 (11:06:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0385.v1

Consistency and Quality of ChatGPT Responses Compared to Clinical Guidelines for Ovarian Cancer: A Delphi Approach.

Dario Piazza, Federica Martorana, Annabella Curaba, Daniela Sambataro, Maria Rosaria Valerio, Alberto Firenze, Basilio Pecorino, Paolo Scollo, Vito Chiantera, Giuseppe Scibilia, Paolo Vigneri, Vittorio Gebbia, Giuseppa Scandurra

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: artificial intelligence; ChatGPT; ovarian carcinoma; guidelines

Online: 7 March 2024 (09:48:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0975.v1

19G EUS-FNA versus 22G EUS-FNB for Pancreatic Tumors: A Retrospective Comparative Study

Nobuhiro Katsukura, Shinpei Doi, Jun Hayakawa, Kanji Okamoto, Tomohiro Akutsu, Yuta Namura, Go Saito, Tomohiro Kikuyama, Takako Adachi, Kotaro Matsumoto, Ayako Watanabe, Hiromichi Tsunashima, Takayuki Tsujikawa, Tatsuya Aso, Mikiko Takahashi

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: endoscopic ultrasound-guided tissue acquisition; solid pancreatic lesions; fine needle aspiration needles; fine needle biopsy needles

Online: 12 September 2024 (11:34:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1529.v1

Investigation of the Potential of Concomitant Radiation Therapy and Gold Nanoparticles for Pancreatic Cancer

Alexandra Martins, Brigida Costa Ferreira, Manuela Gaspar, Sandra Vieira, Joana Lopes, Ana S Viana, António Paulo, Filipa Mendes, Maria Paula Cabral Campello, Rui Martins, Catarina Pinto Reis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pancreatic cancer; megavoltage radiation therapy; gold nanoparticles; cell viability

Online: 24 June 2024 (04:07:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1324.v1

The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma

Ilaria Baglivo, Vitaliano Nicola Quaranta, Silvano Dragonieri, Stefania Colantuono, Francesco Menzella, David Selvaggio, Giovanna Elisiana Carpagnano, Cristiano Caruso

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: ; allergic asthma; epithelial barrier damage; protease allergen; type 2 inflammation; airway remodeling ;

Online: 19 April 2024 (10:38:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1285.v1

Trichoderma virens and Pseudomonas chlororaphis Differentially Regulate Maize Resistance to Anthracnose Leaf Blight and Insect Herbivores When Grown in Sterile versus Non-sterile Soils

Pei-Cheng Huang, Peiguo Yuan, John M. Grunseich, James Taylor, Eric-Olivier Tiénébo, Elizabeth A. Pierson, Julio S. Bernal, Charles M. Kenerley, Michael V. Kolomiets

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Trichoderma virens; Pseudomonas chlororaphis; induced systemic resistance; jasmonic acid; Spodoptera frugiperda; Diabrotica virgifera virgifera

Online: 22 March 2024 (03:19:43 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202403.1157.v1

COVID-19 Therapeutics Use by Social Deprivation in England, July 2020–April 2023

Angela Falola, Hanna Squire, Sabine Bou-Antoun, Alessandra Løchen, Colin S. Brown, Alicia Demirjian

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: antivirals; community; COVID-19; deprivation; hospital; therapeutics

Online: 20 March 2024 (12:31:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1144.v1

Development of PCR-Multiplex Assays for Identification of the Herpotrichiellaceae Family and Agents Causing Chromoblastomycosis

Gabriel S.M. Sousa, Rodrigo S. De Oliveira, Alex B. De Souza, Ruan C. Monteiro, Elaine P. T. E. Santo, Luciano C. Franco Filho, Denison L.O. Moraes, Sarah R. De Sá, Silvia H. M. Da Silva

Subject: Biology And Life Sciences, Other Keywords: chromoblastomycosis; phaeohyphomycosis; PCR-Multiplex; Herpotrichiellaceae; sequencing; phenotypic; molecular biology.

Online: 19 March 2024 (12:35:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1253.v1

Antiviral Effect of Antimicrobial Peptoids and a Murine Model of Respiratory Coronavirus Infection

Maxim Lebedev, Aaron Benjamin, Sathish Kumar, Natalia Molchanova, Jennifer S. Lin, Kent J. Koster, Julian L. Leibowitz, Annelise E. Barron, Jeffrey D. Cirillo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Peptoid; MHV; SARS-CoV-2; Antimicrobials

Online: 22 February 2024 (09:24:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0770.v1

Ovarian Morphology in Non-hirsute, Normo-Androgenic, Eumenorrheic Premenopausal Women From a Multi-ethnic Unselected Siberian Population

Ludmila Lazareva, Larisa Suturina, Alina Atalyan, Irina Danusevich, Iana Nadeliaeva, Lilia Belenkaya, Irina Egorova, Kseniia Ievleva, Natalia Babaeva, Daria Lizneva, Richard S. Legro, Ricardo Azziz

Subject: Medicine And Pharmacology, Reproductive Medicine Keywords: pelvic ultrasound; follicle number per ovary; FNPO; ovarian volume; PCOM; upper normal limits; referral population

Online: 14 February 2024 (05:32:02 CET)

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Preprint REVIEW | doi:10.20944/preprints201608.0090.v1

Intestinal Organoids—Current and Future Applications

Andre M. C. Meneses, Kerstin Schneeberger, Hedwig S. Kruitwagen, Louis C. Penning, Frank G. van Steenbeek, Iwan Burgener, Bart Spee

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: intestinal organoids; dog; practical applications

Online: 9 August 2016 (11:38:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0129.v1

Transcriptome-wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations

Jia Wen, Munan Xie, Bryce Rowland, Jonathan D. Rosen, Quan Sun, Amanda L. Tapia, Huijun Qian, Madeline H. Kowalski, Yue Shan, Kristin L. Young, Marielisa Graff, Maria Argos, Christy L. Avery, Stephanie A. Bien, Steve Buyske, Jie Yin, Hélène Choquet, Myriam Fornage, Chani J. Hodonsky, Eric Jorgenson, Charles Kooperberg, Ruth J.F. Loos, Yongmei Liu, Jee-Young Moon, Kari E. North, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Wei Zhao, Lulu Shang, Tao Wang, Xiang Zhou, Alexander P. Reiner, Laura M. Raffield, Yun Li

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: TWAS; non-European; blood cell traits

Online: 4 June 2021 (09:56:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1254.v1

The Role of New Research Parameters of the BC 6800 Plus Analyzer in the Differential Diagnosis of Lymphoid Neoplasms

S. Sacchetti, Daniela Ferrante, L. Giacomini, V. Zanotti, M. Bellia, A. Patriarca, G. Gaidano, U. Dianzani, R. Rolla

Subject: Biology And Life Sciences, Life Sciences Keywords: acute lymphoblastic leukemia; chronic lymphocytic leukemia; early diagnosis; leukocyte parameters; other lymphoproliferative disorders; morphological parameters

Online: 16 August 2024 (18:21:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1556.v1

Age-Dependent Changes in Protist and Fungal Microbiota in a Peruvian Cattle Genetic Nucleus

Richard Estrada, Yolanda Romero, Carlos Quilcate, Deisy Dipaz, Carol S. Alejos-Asencio, Silvia Leon, Wuesley Yusmein Alvarez-García, Diorman Rojas, Wigoberto Alvarado, Jorge L. Maicelo, Carlos I. Arbizu

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: microbial diversity; cattle; hematological parameters; gut microbiota

Online: 24 June 2024 (09:49:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1425.v1

A Nationwide Study of the Delayed Diagnosis and the Clinical Manifestations of Predominantly Antibody Deficiencies and CTLA4-Mediated Immune Dysregulation Syndrome in Greece

Androniki Kapousouzi, Fani Kalala, Styliani Sarrou, Evangelia Farmaki, Nikolaos Antonakos, Ioannis Kakkas, Alexandra Kourakli, Vasiliki Labropoulou, Charikleia Kelaidi, Georgia Tsiouma, Maria Dimou, Theodoros Vassilakopoulos, MICHAEL VOULGARELIS, Ilias Onoufriadis, Eleni Papadimitriou, Sophia Polychronopoulou, Evangelos J Giamarellos-Bourboulis, Argiris Symeonidis, Christos Hadjichristodoulou, Anastasios E. Germenis, Matthaios Speletas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: predominantly antibody deficiencies, common variable immunodeficiency, IgA deficiency, IgG subclass deficiency, CTLA4, diagnosis

Online: 26 February 2024 (12:46:08 CET)

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Predominantly antibody deficiencies (PAD) represent the most common type of primary immu-nodeficiencies in humans, characterized by a wide variation in disease onset, clinical manifesta-tions, complications and outcome. Considering that the prevalence of PAD in Greece is unknown and there is limited knowledge on clinical and laboratory characteristics of affected patients, we conducted a nationwide study, including 153 patients (male/female: 66/87; median age: 43.0 years; range: 7.0-77.0) diagnosed and/or followed-up between April 2007 to September 2023. Furthermore, we classified our cohort into five Groups according to their medical history, im-munoglobulin levels, and CTLA4-mutational status: 123 had common variable immunodeficien-cy (CVID), 12 with CVID-like disease (with a history of a previous B-cell depletion immunother-apy for autoimmune or malignant disease), seven with combined IgA and IgG subclass deficien-cies, five with immune dysregulation syndrome and CTLA4 defects, and six with unclassified hypogammaglobulinemia. We demonstrated a remarkable delay of PAD diagnosis, several years after the onset of related symptoms (median: 9.0 years, range: 0-43.0). Family history of PAD was only 11.8%, with the majority of patients considered sporadic cases. Most patients were diag-nosed in the context of a diagnostic work-up for recurrent infections, or recurrent/resistant auto-immune cytopenias. Interestingly, ten patients (5.6%) had no history of infection, diagnosed due to either recurrent/resistant autoimmunity, or during a work-up of their medical/family history. Remarkable findings included an increased prevalence of lymphoproliferation (60.1%) and atopy (24.2%), while 39 patients (25.5%) developed bronchiectasis and 16 (10.5%) granulomatous dis-ease. Patients with CTLA4 defects displayed a variable clinical phenotype at diagnosis, with four patients diagnosed during a work-up of re-current infections, while one also displayed a massive splenomegaly. Cancer was a common complication in our cohort (25 patients, 16.3%), with B-cell malignancies representing the most common neoplasms (56.7%). Our findings indicate the necessity of awareness about PAD and their complications, aiming for early diagnosis and appropriate management of affected patients

Preprint ARTICLE | doi:10.20944/preprints202406.1979.v1

Design of a Strategic Platform for the Smart Supervision of Public Expenditure for Colombia in the Context of Society 5.0

Jaime Alonso Restrepo-Carmona, Juan C. Zuluaga, Diego A. Flórez, Mario S. Gómez, Laura Londoño, Gabriela Gómez, Rosse M. Villamil, Olguer Morales, Ángela M Hurtado, Carlos A. Escobar, Julián Sierra-Pérez, Rafael E. Vásquez

Subject: Business, Economics And Management, Business And Management Keywords: Digital transformation; Smart government; Public expenditure; Fiscal control; Society 5.0

Online: 28 June 2024 (13:47:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0647.v1

Pests and Diseases Management, Agricultural Practices, Production Constraints and Selection Criteria of Elite Cassava Varieties by Smallholder Farmers in Sierra Leone

Vandi Amara, Alusaine Edward Samura, Prince Emmanuel Norman, Sheku Alfred Kanu, Kumba Yannah Karim, Fidele Tiendrebeogo, Angela Obiageli Eni, Justin S Pita

Subject: Biology And Life Sciences, Plant Sciences Keywords: perception; smallholder farmers; biotic stress management strategies; production constraints; variety selection criteria

Online: 11 June 2024 (07:43:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1563.v1

Comparative Studies of Bioactivities and Chemical Components in Fresh and Black Garlics

Kanako Matsuse, Sho Hirata, Mostafa Abdelrahman, Tetsuya Nakajima, Yoshihito Iuchi, Satoshi Kambayashi, Masaru Okuda, Kimiko Kazumura, Benya Manochai, Masayoshi Shigyo

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Allium sativum; black garlic; functional food; anticancer activity; processed food

Online: 26 March 2024 (11:33:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0994.v1

Serendipitous Identification of Azine Anticancer Agents by a Privileged Scaffold Morphing Strategy

Silvia Cesarini, Ilaria Vicenti, Federica Poggialini, Silvia Filippi, Eleonora Mancin, Lia Fiaschi, Elisa De Marchi, Federica Giammarino, Chiara Vagaggini, Bruno Mattia Bizzarri, Raffaele Saladino, Elena Dreassi, Maurizio Zazzi, Lorenzo Botta

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Privileged scaffold; triazines; pyrimidines; pyridines; scaffold morphing; anticancer activity.

Online: 19 February 2024 (16:08:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0062.v1

Antidiarrheal Thymol Derivatives from Ageratina glabrata. Structure and Absolute Configuration of 10-Benzoyloxy-8,9-epoxy-6-hydroxythymol Isobutyrate

Celia Bustos-Brito, Valeria J. Vázquez-Heredia, Fernando Calzada, Lilian Yépez-Mulia, José S. Calderón, Simón Hernández-Ortega, Baldomero Esquivel, Normand García-Hernández, Leovigildo Quijano

Subject: Chemistry And Materials Science, Other Keywords: Ageratina glabrata; thymol derivatives; antiprotozoal and antidiarrheal properties

Online: 6 August 2016 (11:26:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1070.v1

Joint Action of Trichoderma atroviride and a Vegetal Derived-Protein Hydrolysate Improves Yield, Fruit Quality and Economic Profitability of Two Woodland Strawberry Cultivars Grown Under Greenhouse

Lorena Vultaggio, Enrica Allevato, Beppe Benedetto Consentino, Pietro Bellitto, Simona Napoli, Claudio Cannata, Georgia Ntatsi, Sonya Vasto, Sara Baldassano, Salvatore La Bella, Claudio Leto, Leo Sabatino

Subject: Biology And Life Sciences, Plant Sciences Keywords: Fragaria vesca L.; microbial biostimulant; non-microbial biostimulant; biostimulant 2.0; neglected species

Online: 19 March 2024 (10:20:22 CET)

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Woodland strawberry (Fragaria vesca L.) is an underutilized plant species, appreciated by consumers for its qualitative features. Utilizing technical means of production, such as plant biostimulants, that can increase crop productivity and quality could be highly important in woodland strawberry cultivation. The scope of the present study was to appraise the influence of two biostimulants (Trichoderma atroviride and plant protein hydrolysate) - used either alone or combined - on plant performance and economic profitability of two woodland strawberry genotypes (‘Alpine’ and ‘Regina delle Valli’). Overall, data showed that ‘Alpine’ had the highest productive performances, whereas ‘Regina delle Valli’ revealed the highest fruit qualitative traits. T. atroviride inoculation and V-PH application significantly boosted plant marketable yield (+20.5% for T. atroviride and +12.9% for V-PH), total sugars (+1.9% for Trichoderma and +1.4% for V-PH) and anthocyanins (+14.1% for T. atroviride and +9.8% for V-PH) compared to non-treated plants. Plants supplied with both biostimulants had higher marketable yield (+34.8%), mean fruit weight (+6.0%), fruit dry matter (+13.8%), total sugars (+3.5%), ascorbic acid (+12.7%), flavonoid (+26.3%) and anthocyanins (+29.9%) compared to non-treated plants. Furthermore, our study revealed that the highest fruit polyphenols concentration was recorded in both genotypes treated with the combination of biostimulants and in ‘Regina delle Valli’ sprayed with V-PH, whereas the highest antioxidant activity was found in ‘Regina delle Valli’ fruit when plants were supplied with both biostimulants. Our study pointed out that the application of microbial and non-microbial biostimulants, especially in combination, might be an useful strategy for improving performances of underutilized species and, therefore, encourage its cultivation, valorisation and economic profitability (+10195.3 €/ha when plants were exposed to both biostimulants).

Preprint ARTICLE | doi:10.20944/preprints202409.0325.v1

A Comprehensive Analysis of the Lipidomic Signatures in Rhizopus delemar

Basharat Ali, Anshu Chauhan, Mohit Kumar, Praveen Kumar, Hans Carolus, Celia Lobo Romero, Rudy Vergauwen, Ashutosh Singh, Shivaprakash M. Rudramurthy, Patrick Van Dijck, Ashraf S Ibrahim, Rajendra Prasad

Subject: Biology And Life Sciences, Life Sciences Keywords: mucormycosis; drug resistance; posaconazole; amphotericin B; sphingolipids; phospholipids; sterols; mass-spectrometry

Online: 4 September 2024 (08:26:00 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202403.1184.v1

Effect of M694V mutation in the MEFV gene, associated with Familial Mediterranean fever, on the morphology of iPSC-derived macrophages

Elena V. Grigor’eva, Lana V. Karapetyan, Anastasia A. Malakhova, Sergey P. Medvedev, Julia M. Minina, Varduhi H. Hayrapetyan, Valentina S. Vardanyan, Suren M. Zakian, Arsen Arakelyan, Roksana Zakharyan

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Familial Mediterranean fever; macrophages; patient-specific induced pluripotent stem cells; differentiation; MEFV gene

Online: 20 March 2024 (08:24:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0773.v1

Access to Oncology Medicines in Canada: Consensus Forum for Recommendations for Improvement

Sandeep Sehdev, Nigel S. B. Rawson, Olexiy I. Aseyev, Catriona J. Buick, Marcus Butler, Scott Edwards, Sharlene Gill, Joanna Gotfrit, Cyrus C Hsia, Rosalyn A. Juergens, Mita Manna, Joy McCarthy, Som D. Mukherjee*, Stephanie Snow, Silvana Spadafora, David J. Stewart, Jason Wentzell, Ralph P.W Wong, Pawel Zalewski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oncology drugs; health technology assessment; drug prices; drug access; Canada

Online: 14 February 2024 (05:27:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0061.v1

Global Surgery, Obstetric, and Anesthesia Indicator Definitions and Reporting: An Utstein Consensus Report

Justine Ina Davies, Adrian W. Gelb, Julian Gore-Booth, Janet Martin, Jannicke Mellin-Olsen, Christina Åkerman, Emmanuel A. Ameh, Bruce M. Biccard, Geir Sverre Braut, Kathryn Chu, Miliard Derbew, Hege Langli Ersdal, Jose Miguel Guzman, Lars Hagander, Carolina Haylock-Loor, Hampus Holmer, Walter Johnson, Sabrina Juran, Nicolas J. Kassebaum, Tore Laerdal, Andrew J.M. Leather, Michael S. Lipnick, David Ljungman, Emmanuel Malabo Mwenda Makasa, John G. Meara, Mark W. Newton, Doris Østergaard, Teri Reynolds, Lauri J. Romanzi, Vatshalan Santhirapala, Mark G. Shrime, Kjetil Søreide, Margit Steinholt, Emi Suzuki, John E. Varallo, Gerard H.A. Visser, David Watters, Thomas G. Weiser

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: data; indicator; Utstein; consensus; report; health; meeting; anaesthesia; international

Online: 2 April 2021 (12:03:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0599.v1

Effects of ACE Mutations Associated with Alzheimer’s Disease on Blood ACE Phenotype

Olga V. Kryukova, Igor O. Islanov, Elena V. Zaklyazminskaya, Dmitriy O Korostin, Vera A. Belova, Valery V. Cheranev, Zhanna A. Repinskaia, Svetlana A. Tonevitskaya, Alexander G. Tonevitsky, Pavel A. Petukhov, Steven M. Dudek, Olga A. Kost, Denis V. Rebrikov, Sergei M. Danilov

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Angiotensin I-converting enzyme; mutations; conformational changes; blood ACE; screening; Alzheimer’s disease

Online: 11 June 2024 (08:02:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0805.v1

Mineral Density and Frequency of Thyroid Malignancy: A Cross-Sectional Analysis

John Bukasa-Kakamba, Ayrton Bangolo, Pascal Bayauli, Vignesh Krishnan Nagesh, Maria J Mou, Princejeet S Chahal, Sindhuja Chindam, Branly Mbunga, Taieba Mushfiq, Abhishek Thapa, Nidhi L Rao, Isis Kapinga Kalambayi, Rahul Y Rajesh, Ipek B Sarioguz, Vishal K.R. Thoomkuntla, Shamsul Arefin, Navneet Kaur, Manasse Bukasa Mutombo, Satyajeet Singh, Natalia Muto, Surya Vamsi, Pujita Mallampalli, Aliocha Nkodila, Simcha Weissman, Jean René M'buyamba-Kabangu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Thyroid; malignancy; mineral density; kinshasa; Katanga; nodule

Online: 10 September 2024 (11:14:05 CEST)

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Background: Several trace minerals have been shown to be associated with thyroid cancer. However, there is a paucity of data on the characteristics of thyroid nodules in different mineral rich regions of the Democratic Republic of Congo (DRC). The objective of this study is to establish the spectrum of thyroid nodules in different regions of the most mineral wealthy country in the world. Method: We conducted a cross-sectional study, performing descriptive statistics and logistic regression with a p value < 0.05 deemed of statistical significance. We enrolled 529 patients diagnosed with thyroid nodules between 2005 and 2019 in two of the richest provinces in minerals (Katanga and South Kivu) and the capital city, Kinshasa. Results: The mean age was 44.2±14.6 years with a female predominance, with a female to male ratio of 5.4. 66.5% of patients had a family history of thyroid disease. 74 patients had simple nodules, whereas 455 had multiple nodules. 87.7% of patients with nodules were euthyroid. The nodules mostly presented a solid structure (72.2%), hypoechogenicity (84.5%), a macronodule (59.8%), calcification (14.4%) and lymphadenopathy (15.5%). 22.3% of these nodules had a malignant character. The independent factors associated with this malignancy were age ≥60 years (aOR=2.81), Katanga as province of origin (aOR=8.19), solid echostructure (aOR=7.69), hypoechogenicity (aOR=14.19), macronodule (aOR=9.13), calcification (aOR=2.6) and the presence of adenopathy (aOR=6.94). Conclusion: By the way of this first of its kind study, we demonstrated that thyroid nodules were more likely to be malignant if found in patients originating from mineral rich region of Katanga. This high frequency of malignancy in mineral rich regions requires measures aimed at early detection in this population, lower threshold for suspicion of malignancy and adequate training of doctors involved in the management of these patients. This study paves the way for future, more extensive and well-funded studies to better understand the relationship of heavy metals and thyroid cancer incidence in the richest country in heavy metals in the world.

Preprint ARTICLE | doi:10.20944/preprints202408.1813.v1

LGALS9, LAMP3, PRSS8 and AGRN Predict Hospitalisation Risk in COVID-19 Patients

Thomas McLarnon, Darren McDaid, Seodhna M. Lynch, Eamonn Cooper, Joseph McLaughlin, Victoria E. McGilligan, Steven Watterson, Priyank Shukla, Shu-Dong Zhang, Magda Bucholc, Andrew English, Aaron Peace, Maurice O'Kane, Martin Kelly, Manav Bhavsar, Elaine K. Murray, David S. Gibson, Colum P. Walsh, Anthony J. Bjourson, Taranjit Singh Rai

Subject: Biology And Life Sciences, Virology Keywords: Sars-CoV-2; COVID-19; Biomarker; LGALS9; LAMP3; PRSS8; AGRN; Support Vector Machine; Logistic Regression; Random Forest

Online: 26 August 2024 (12:04:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2401.v1

Staphylococcus aureus Stress Response to Bicarbonate Depletion

Elisa Liberini, Sook-Ha Fan, Arnold S. Bayer, Christian Beck, Jacob Biboy, Patrice François, Joe Gray, Katharina Hipp, Iris Koch, Andreas Peschel, Brigitte Sailer, Daniela Vollmer, Waldemar Vollmer, Friedrich Götz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus; bicarbonate transporter; MpsABC; cell wall; peptidoglycan; transcriptome

Online: 30 July 2024 (11:03:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0531.v1

Properties of Medium-Scale Traveling Ionospheric Disturbances Observed over Mexico During Quiet Solar Activity

Esmeralda Romero-Hernandez, Federico Salinas-Samaniego, Olusegun F. Jonah, Ernesto Aguilar-Rodriguez, Mario Rodríguez-Martínez, Giorgio A. S. Picanço, Clezio M. Denardini, Carlos Guerrero-Peña, Rogelio Aguirre-Gutierrez, Flor Araceli Garcia-Castillo, Sandra A. Ayala-Gomez, Eduardo Perez-Tijerina, Maria A. Sergeeva, J. Americo Gonzalez-Esparza

Subject: Physical Sciences, Space Science Keywords: Traveling Ionospheric disturbances; plasma irregularities; total electron content; Mid-latitude ionosphere

Online: 10 June 2024 (09:16:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.2020.v1

Exorbital Lacrimal Gland Ablation and Regrafting Induce Local, Corneal and Trigeminal Ganglion Inflammation but Not Regeneration or Dry Eye

Adriana de Andrade Batista Murashima, Ariane M. S. Sant'Anna, Jacqueline Ferreira Faustino-Barros, Elisio B. Machado Filho, Lilian Costa Mendes da Silva, Marina Zilio Fantucci, Carolina Maria Módulo, Fernando Chahud, Denny Marcos Garcia, Eduardo M. Rocha

Subject: Medicine And Pharmacology, Ophthalmology Keywords: inflammation; lacrimal functional unit; regeneration

Online: 1 May 2024 (02:58:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0193.v1

Prostate Cancer Lung Metastasis: Clinical Insights and Therapeutic Strategies

Ahmed M. Mahmoud, Amr Moustafa, Carter Day, Mohamed E. Ahmed, Wael Zeina, Usama M. Marzouk, Spyridon Basourakos, Rimki Haloi, Mindie Mahon, Miguel Muniz, Daniel S. Childs, Jacob J. Orme, Irbaz Bin Riaz, A. Tuba Kendi, Bradley J. Stish, Brian J. Davis, Eugene D. Kwon, Jack R. Andrews

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Prostate Cancer; Lung Metastasis; Systemic Therapy; Metastasis-Directed therapy

Online: 2 April 2024 (10:26:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0075.v1

From Pathophysiology to Drug Interactions and Clinical Management of Dyslipidemia in People Living with HIV: Sailing through Rough Seas

Eleni Papantoniou, Konstantinos Arvanitakis, Konstantinos Markakis, Stavros P. Papadakos, Olga Tsachouridou, Djordje S. Popovic, Theocharis Koufakis, Georgios Germanidis, Kalliopi Kotsa

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: HIV; dyslipidemia; metabolic syndrome; antiretroviral therapy; switching strategy

Online: 4 March 2024 (10:40:30 CET)

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Preprint REVIEW | doi:10.20944/preprints201702.0036.v1

Nanoparticle-Mediated Drug Delivery System for Pulmonary Arterial Hypertension

Kazufumi Nakamura, Hiromi Matsubara, Satoshi Akagi, Toshihiro Sarashina, Kentaro Ejiri, Norifumi Kawakita, Masashi Yoshida, Toru Miyoshi, Atsuyuki Watanabe, Nobuhiro NIshii, Hiroshi Ito

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: pulmonary arterial hypertension; prostacyclin; nanoparticle; drug delivery system

Online: 13 February 2017 (09:27:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0699.v1

Assessment of Cassava Pollen Viability and Ovule Fertilizability under Red-Light and Plant-Growth-Regulator Treatments

Julius K. Baguma, Settumba B. Mukasa, Mildred Ochwo-Ssemakula, Ephraim Nuwamanya, Paula Iragaba, Enoch Wembabazi, Michael Kanaabi, Peter T Hyde, Tim L Setter, Titus Alicai, Benard Yada, Williams Esuma, Yona Baguma, Robert S. Kawuki

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: pollen viability; in vitro stainability; in vivo germinability; ovule fertilizability; pollen diameter; pollen ploidy

Online: 11 June 2024 (12:00:37 CEST)

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Understanding pollen and ovule fertility as factors influencing fruit and seed set is important in cassava breeding. Red light (RL) and plant growth regulators (PGRs) have been used to induce or enhance flowering and fruit set in cassava without any reference to effects on pollen viability or ovule fertilizability. This study investigated effects of field-applied RL and PGR on pollen viability and ovule fertilizability. Panels of cassava genotypes, with early or moderate flowering responses were used. RL was administered from dusk to dawn. Two PGRs, a cytokinin (6-benzyl adenine, BA) and an anti‑ethylene (silver thiosulphate, STS) were applied. Pollen viability was assessed basing on pollen grain diameter, in vitro stainability, in vivo germinability, ovule fertilizability and ploidy level. Treating flowers with RL led to increased pollen diameter from 143.6 to 148.5µm, stainability from 82.9 to 93.0%, ovule fertilizability from 52.0 to 56.9% in treated female flowers and 47.7 to 64.3% on using pollen from treated male flowers. Fruit set increased from 51.5 to 71.8% in RL-treated female flowers and from 53.7 to 71.1% when pollen from RL-treated male flowers was used. Seed set followed a trend similar to that of fruit set. Ploidy level of pollen from RL-treated flowers increased slightly and positively correlated with pollen diameter (R2 = 0.09*), ovule fertilization (R2 = 0.20*), fruit (R2 = 0.59*) and seed set (R2 = 0.60*); but negatively correlated with pollen stainability. Treating flowers with PGR did not affect pollen diameter and stainability, but increased ovule fertilizability from 42.9 to 64.9% and fruit set from 23.2 to 51.9% in treated female flowers and 31.3 to 54.7% when pollen from treated male flowers was used. Application of combined BA+STS on male flowers caused the highest ovule fertilizability, fruit and seed set efficiency, though this varied among study genotypes. These results show that RL and PGR treatment of flowers increases pollen viability and ovule fertilizability. This is important for planning pollination strategies in cassava breeding programmes.

Preprint ARTICLE | doi:10.20944/preprints202409.1653.v1

Development of a Rapid Detection Method for Ethylene Glycol and Glycolic Acid in Feline Samples: A Response to Increasing Antifreeze Poisoning Incidents in Korea

HyunYoung Chae, Jae Won Byun, Go-Eun Shin, Kyunghyun Lee, Ah-Young Kim, Bok-Kyung Ku, Md Akil Hossain, Tae-Wan Kim, JeongWoo Kang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Antifreeze poisoning; Ethylene glycol; Glycolic acid; Rapid determination method

Online: 21 September 2024 (06:15:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1433.v1

Radiotracer Innovations in Breast Cancer Imaging: A Review of Recent Progress

Mohamad Haidar, Joe Rizkallah, Omar El Sardouk, Nour El Ghawi, Nadine Omran, Zeinab Hammoud, Nina Saliba, Arafat Tfayli, Hiba Moukadem, Ghina Berjawi, Lara Nassar, Fahad Marafi, Partha Choudhary, Habibollah Dadgar, Alyaa Sadeq, Alain S. Abi-Ghanem

Subject: Medicine And Pharmacology, Other Keywords: breast cancer; molecular imaging; nuclear medicine; positron emission tomography; radiopharmaceuticals; radiotracers; tumor detection; 18F-fluorodeoxyglucose

Online: 21 August 2024 (04:33:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0594.v1

Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients

Sean McCallion, Thomas McLarnon, Eamonn Cooper, Andrew English, Steven Watterson, Melody Chemaly, Cathy M. McGeough, Amanda Eakin, Tan Ahmed, Philip Gardiner, Adrian Pendleton, Gary Wright, Declan McGuigan, Maurice O'Kane, Aaron Peace, Ying Kuan, David S. Gibson, Paula L. McClean, Catriona Kelly, Victoria E. McGilligan, Elaine K. Murray, Frank McCarroll, Anthony J. Bjourson, Taranjit Singh Rai

Subject: Biology And Life Sciences, Aging Keywords: Senescence; chronic kidney disease; acute kidney injury; biomarker; machine learning

Online: 8 August 2024 (08:48:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0925.v1

Antimicrobial Effects of Photodynamic Therapy Delivered via Hydrogels for Inhibiting Staphylococcus aureus: A Systematic Review

Ricardo S Moura, João Pedro R. Afonso, Diego A. C. P. G. Mello, Renata K. Da Palma, Iransé Oliveira-Silva, Rodrigo F. Oliveira, Deise A. A. P. Oliveira, Dante B. Santos, Carlos Hassel M. Silva, Orlando A. Guedes, Giuseppe Insalaco, Luís V. F. Oliveira

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Hydrogels; Antimicrobial Effects; Photodynamic Therapy

Online: 11 July 2024 (10:22:28 CEST)

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Staphylococcus aureus is a gram-negative bacterium that causes superficial and deep infections that can be mild or potentially fatal. Recently, the bacterium has gained significant attention due to the increased incidence of multidrug-resistant (MDR) strains that make treatment with antibiotics dif-ficult. Owing to the MDR strains, alternative therapies such as antimicrobial photodynamic therapy (PDT) have emerged as good options to treat non-systemic infections. PDT combines a photosensi-tiser (PS) with light and oxygen to generate free radicals that destroy bacterial structures such as the plasma membrane, matrix, and genetic material. This systematic review aimed to identify the ef-fectiveness of PDT delivered using different types of hydrogels for treating wounds, burns, and contamination by S. aureus. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Bibliographic research was conducted using the PubMed, Web of Science, and Scopus databases. Only full articles published in English between 2013 and 2024 from any country of origin (without restrictions) were included. The research was carried out from 15 June 2023 to 15 June 2024 and did not use any automatic biblio-graphic search tool. The articles collected were identified using keywords and selected using in-clusion and exclusion criteria in accordance with the PRISMA protocol. Seven articles were in-cluded that presented a good set of evidence associated with the use of PDT against S. aureus in in vitro and in vivo studies. To conclude, PDT can effectively complement antimicrobial therapy against S. aureus, in the healing of wounds and burns. The effectiveness of this technique depends on the PS used, hydrogel type, and lesion location. Some studies have already demonstrated the ef-fectiveness of PDT but most were in vitro and a few in vivo. Further studies are required to demonstrate the safety and efficacy of PDT delivered via hydrogels in in vivo models of bacterial infection.

Preprint ARTICLE | doi:10.20944/preprints202406.1623.v1

Increasing Endoglin Deletion in Endothelial Cells Exacerbates the Severity of Brain Arteriovenous Malformation in Mouse

zahra Sshabani, Leandro Barbosa Do Prado, Rui Zhang, Wan Zhu, Sonali S Shaligram, Alka Yadav, Calvin Wang, hua su

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Arteriovenous malformations; Endothelial cells; Endoglin; Hereditary Hemorrhagic Telangiectasia

Online: 24 June 2024 (11:05:52 CEST)

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Abstract: Endoglin (ENG) is a causative gene of type 1 hereditary hemorrhagic telangiectasia (HHT1). HHT1 patients have arteriovenous malformations (AVMs) in multiple organs, including the brain. In mice, Eng deletion induced by R26RCreER or SM22aCre leads to AVM development in the brain and other organs. We have reported that the severity of brain AVM in mice with activin receptor-like kinase 1 (Alk1, an HHT2 causative gene) mutation is correlated with the number of Alk1 negative endothelial cells (ECs). We hypothesized that increase of Engnegative ECs will enhance AVM severity. To increase EC Eng deletion, we used a codon improved cre (icre), which is more potent in recombination of floxed alleles than the wild type (WT) cre. R26RCreER;Eng^f/f mice that have Rosa promoter driving and tamoxifen (TM) inducible WT cre expression globally and PdgfbiCreER;Eng^f/f that have Pdgfb promoter driving and TM inducible icre expression in ECs were treated with 3 intra-peritoneal injections of TM (2.5 mg/25g of body weight) to delete Eng globally or in the ECs. AAV-VEGF was stereotactically injected into the brain to induce brain focal angiogenesis and brain AVM. We found that iCre caused more Eng deletion in the brain indicated by lower level of Eng proteins (p<0.001) and fewer Eng positive ECs (p=0.01) than mice with WT cre. Mice with iCre mediated Eng deletion have more abnormal vessels (p=0.02), CD68⁺ macrophages (p=0.002), and hemorrhage (p=0.04), and less vascular pericyte and smooth muscle coverage than mice with WT cre. In addition, arteriovenous shunts were detected in the intestines of icre mice, a phenotype that have not been detected in WT cre mice before. RNAseq analysis showed that 8 out of the 10 top upregulated pathways identified by Gene Ontology (GO) analysis are related to the inflammation. Therefore, increase of Eng deletion in ECs exacerbates AVM severity, which is associated with enhanced inflammation. Strategies that can reduce Eng negative ECs could be used to develop new therapies to reduce AVM severity for HHT1 patients.

Preprint ARTICLE | doi:10.20944/preprints202403.1414.v1

Effects of Influenza Vaccine on the Immune Responses to SARS-CoV-2 Vaccination

A Riccomi, CM Trombetta, Maria Dorrucci, Daniela Di Placido, Nunzia Sanarico, Francesca Farchi, Roberto Giuseppetti, Umbertina Villano, C Marcantonio, Serena Marchi, Antonio Ciaramella, P Pezzotti, E Montomoli, C Valdarchi, AR Ciccaglione, S. Vendetti

Subject: Public Health And Healthcare, Other Keywords: Influenza vaccine; SARS-CoV-2 vaccine; immune response to vaccination

Online: 25 March 2024 (08:03:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1352.v1

Oral Iron Absorption of Ferric Citrate Hydrate and Hepcidin-25 in Hemodialysis Patients: A Prospective, Multicenter, Observational Riona-Oral Iron Absorption Trial

Naohisa Tomosugi, Yoshitaka Koshino, Chie Ogawa, Kunimi Maeda, Noriaki Shimada, Kimio Tomita, Shoichiro Daimon, Tsutomu Shikano, Kazuyuki Ryu, Toru Takatani, Kazuya Sakamoto, Satonori Ueyama, Daisuke Nagasaku, Masato Nakamura, Shibun Ra, Masataka Nishimura, Chieko Takagi, Yoji Ishii, Noritoshi Kudo, Shinsuke Takechi, Takashi Ishizu, Takamoto Yanagawa, Masamichi Fukuda, Yutaka Nitta, Takayuki Yamaoka, Taku Saito, Suzuko Imayoshi, Momoyo Omata, Joji Oshima, Akira Onozaki, Hiroaki Ichihashi, Yasuhisa Matsushima, Hisahito Takae, Ryoichi Nakazawa, Koichi Ikeda, Masato Tsuboi, Keiko Konishi, Shouzaburo Kato, Maki Ooura, Masaki Koyama, Tsukasa Naganuma, Makoto Ogi, Shigeyuki Katayama, Toshiaki Okumura, Shigemi Kameda, Sayuri Shirai

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: oral iron absorption; ferric citrate hydrate; hemodialysis; hepcidin-25; iron shift

Online: 18 August 2023 (11:20:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1767.v1

Usefulness of Tumor Marker Score for Prediction of Prognosis in Hepatocellular Carcinoma Patients Treated with Atezolizumab plus Bevacizumab: A Multicenter Retrospective Study

Kazunari Tanaka, Kunihiko Tsuji, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Tomomitsu Matono, Hidekatsu Kuroda, Yutaka Yata, Hideko Ohama, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Keisuke Yokohama, Hiroki Nishikawa, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Takashi Kumada

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; tumor marker; atezolizumab plus bevacizumab; prognosis; predictive model

Online: 26 June 2023 (09:42:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1360.v1

In Vitro and In Vivo Evaluation of the Effects of Drug 2c and Derivatives on Ovarian Cancer Cells

Marianna Maddaloni, Rossella Farra, Barbara Dapas, Fulvia Felluga, Fabio Benedetti, Federico Berti, Sara Drioli, Mattia Vidali, Maja Cemazar, Urska Kamensek, Claudio Brancolini, Erminio Murano, Francesca Maremonti, Mario Grassi, Alice Biasin, Flavio Rizzolio, Enrico Cavarzerani, Bruna Scaggiante, Roberta Bulla, Andrea Balduit, Giuseppe Ricci, Gabriella Zito, Federico Romano, Serena Bonin, Eros Azzalini, Gabriele Baj, Domenico Tierno, Gabriele Grassi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ovarian cancer; 2C; apoptosis; E2F1, in silico docking.

Online: 19 April 2024 (16:08:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1076.v1

Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Yandra Cervelim Nunes, Nathalia. M. Mendes, Enzo Pereira de Lima, Amanda Chabrour Chehadi, Caroline Barbalho Lamas, Jesselina F. S. Haber, Manoela dos Santos Bueno, Adriano Cressoni Araújo, Vitor C. Strozze Catharin, Claudia Rucco. P. Detregiachi, Lucas Fornari Laurindo, Masaru Tanaka, Sandra Maria Barbalho, Maria José Sanches Marin

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Curcuma longa; curcumin; aging; inflammation; oxidative stress; frailty; neurodegeneration; sarcopenia; cardiovascular diseases; clinical trials

Online: 12 July 2024 (14:59:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1759.v1

Sex-Biased Associations of Circulating Ferroptosis Inhibitors with Reduced Lipid Peroxidation and Better Neurocognitive Performance in People with HIV

Harpreet Kaur, Ravi Kumar Alluri, Kunling Wu, Robert C Kalayjian, William S Bush, Frank J Palella, Susan L Koletar, Corrilynn O Hileman, Kristine M Erlandson, Ronald J Ellis, Roger J Bedimo, Babafemi O Taiwo, Katherine K Tassiopoulos, Asha R Kallianpur

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: HIV; ferritin heavy-chain; ferritin light-chain; ferroptosis; lipid peroxidation; iron; oxidative stress; neurocognitive impairment; neurocognitive domains

Online: 24 August 2024 (00:22:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1940.v1

Severe Obesity Defined by Percentiles of WHO and Cardiometabolic Risk in Youth with Obesity

Giuliana Valerio, Procolo Di Bonito, Anna Di Sessa, Giada Ballarin, Valeria Calcaterra, Domenico Corica, Maria Felicia Faienza, Francesca Franco, Maria Rosaria Licenziati, Claudio Maffeis, Giulio Maltoni, Emanuele Miraglia del Giudice, Anita Morandi, Enza Mozzillo, and Malgorzata Wasniewska

Subject: Public Health And Healthcare, Other Keywords: Body mass index Z-score; cardiometabolic risk; severe obesity; World Health Organization.

Online: 25 September 2024 (10:25:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1231.v1

The L1014F Knockdown Resistance Mutation Is Not a Strong Correlate of Phenotypic Resistance to Pyrethroids in Florida Populations of Culex quinquefasciatus

Alden S Estep, Neil D Sanscrainte, Jason Stuck, Isik Unlu, Agne Prasauskas, Stephanie J Mundis, Nicholas Cotter, Ana L Romero-Weaver, Troy J Fedirko, Natalie L Kendziorski, Kyle J Kosinski, Daviela Ramirez, Eva A Buckner

Subject: Biology And Life Sciences, Insect Science Keywords: Culex quinquefasciatus; insecticide resistance; knockdown resistance (kdr); CDC bottle bioassay; Florida

Online: 23 February 2024 (06:26:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1311.v1

Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Bio-Logical and Pharmacological Profiling

Nadine Alvarez, Gregory C Adam, John A Howe, Vijeta Sharma, Matthew D Zimmerman, Enriko Dolgov, Risha Rasheed, Fatima Nizar, Khushboo Sahay, Andrew M Nelson, Steven Park, Xiaoyan Zhou, Christine Burlein, John F Fay, Daniel V Iwamoto, Carolyn M Bahnck-Teets, Krista L Getty, Shih Lin Goh, Imad Salhab, Keith Smith, Christopher W Boyce, Tamara D Cabalu, Nicholas Murgolo, Nicholas G Fox, Todd W Mayhood, Valerie Shurtleff, Mark E Layton, Craig A Parish, John A McCauley, David B Olsen, David S Perlin

Subject: Biology And Life Sciences, Virology Keywords: Coronavirus; SARS-CoV-2; MERS-CoV; 3CLPro; antivirals; protease inhibitors

Online: 19 June 2024 (05:53:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1195.v1

Sourdough Bread and Metabolic Risk Factors. A Randomized, Controlled Trial in Subjects with Metabolic Syndrome

Karla Alejandra Pérez-Vega, Albert Sanllorente, María-Dolores Zomeño, Ana Quindós, Júlia Muñoz-Martínez, Mireia Malcampo, Ana Aldea-Perona, Álvaro Hernáez, Aleix Lluansí, Marc Llirós, Isidre Elias, Núria Elias-Masiques, Xavier Aldeguer, Daniel Muñoz, Sònia Gaixas, Gemma Blanchart, Helmut Schröder, Javier Hernando-Redondo, Nerea Carrón, Pedro González-Torres, Valentini Konstantinidou, Montserrat Fitó, Olga Castañer

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: sourdough bread; metabolic syndrome; sICAM; PAI-1; blood pressure

Online: 18 June 2024 (08:19:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1708.v1

Modelling Lysosomal Storage Disorders in an innovative way: Establishment and Characterization of Stem Cell Lines from Human Exfoliated Deciduous Teeth of Mucopolysaccharidoses Type II Patients

Sofia Carvalho, Juliana Inês Santos, Luciana Moreira, Ana Joana Duarte, Paulo Gaspar, Hugo Rocha, Marisa Encarnação, Diogo Ribeiro, Matilde Barbosa Almeida, Mariana Gonçalves, Hugo David, Liliana Matos, Olga Amaral, Luísa Diogo, Sara Ferreira, Constança Santos, Esmeralda Martins, Maria João Prata, Luís Pereira de Almeida, Sandra Alves, Maria Francisca Coutinho

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Mucopolysaccharidosis type II; Disease Modelling; in vitro models; induced Pluripotent Stem Cells (iPSCs); Dental Pulp Stem Cells (DPSCs); SHED: Stem cells from Human Exfoliated Deciduous teeth (SHEDs)

Online: 29 February 2024 (13:03:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0565.v1

Simultaneous Integrated Boost (Sib) Intensity-Modulated Radiotherapy for Treatment of Bone Metastases: Analysis of a Breast Cancer Cohort

Fabio Marazzi, Valeria Masiello, Alessandra Fabi, Stefania Manfrida, Barbara Corvari, Valentina Lancellotta, Ciro Mazzarella, Silvia Longo, Martina De Angeli, Francesca Moschella, Alba Di Leone, Armando Orlandi, Serena Bracci, Giuseppe Ferdinando Colloca, Mariangela Massaccesi, Luca Boldrini, Luca Tagliaferri, Gianluca Franceschini, Emilio Bria, Riccardo Masetti, Vincenzo Valentini, Maria Antonietta Gambacorta, Francesco CELLINI

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; SIB-IMRT; bone metastases; precision medicine

Online: 10 June 2024 (14:18:11 CEST)

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Aims. Bone metastases have an incidence of up to 75% in metastatic breast cancer, thanks to the evolution of imaging we can identify them in the oligometastatic phase. With the introduction of target therapies and increasingly effective conjugated antibodies, it is increasingly common to treat patients with radiotherapy although asymptomatic (if single or ≤5 bone lesions). Volumes and doses in this setting do not yet have a clear guidelines. In this study, the aim is to administer to the macroscopically evident disease an ablative dose that favors the local control of disease. Aim of this retrospective analysis is to evaluate the outcome of pts receiving SIB for treatment of bone metastases. Material and Methods. A retrospective analysis including mBC patients (pts) undergone RT on bone metastases was conducted for pts treated between January 2014 and January 2022. Primary endpoint was freedom from local progression (FFLP). Rate of disease progression after radiotherapy (DP-AR) and overall survival (OS) were secondary endpoints. Subgroup analysis (age, immunophenotype, line of therapy) were performed. Results. Among 954 mBC who underwent radiotherapy for metastases, 85 pts underwent SIB-IMRT with a boost on macroscopic lesion of 8-6 Gy in 5 fr. Mean follow up was 41 months (6-61.5 m). Nineteen pts had single bone metastase (22.4%), 20 pts were oligometastatic (23,5%), 46 pts were plurimetastatic (54,1%). FFLP was 17 months (95% CI 3.2-61.5 m). Only 6 pts (7%) had local relapse on SIB-IMRT site during follow up. DP-AR was 13,2 m (95% CI 3.1-56.9 m). OS was 82,7 m (95% CI 10.6-343 m). Local-relapse was not associated with age, immunophenotype or sistemic line ongoing. Among secondary outcomes, DP-AR resulted associated to immunophenotype (p 0.002). DP-AR and OS were not significantly associated with local relapse (respectively p 0.148 and p 0.4). Conclusions. Pts with breast tumor can be treated with SIB-IMRT on bone metastases with a 93% of local control at 17 months from radiotherapy. Further data are needed to individuate pts who can benefit of dose-escalation and also sinergic effect with systemic therapies to possibly increase DP-AR.

Preprint REVIEW | doi:10.20944/preprints202406.0886.v1

Aspirin in Primary Prevention: Looking for Who Enjoys It!

Roberta Della Bona, Simona Giubilato, Marco Palmieri, Stefano Benenati, Roberta Rossini, Stefania Angela Di Fusco, Filippo Novarese, Giuseppe Mascia, Nicola Gasparetto, Antonio Di Monaco, Laura Gatto, Filippo Zilio, Carlotta Sorini Dini, Francesco Borrello, Giovanna Geraci, Carmine Riccio, Leonardo De Luca, Furio Colivicchi, Massimo Grimaldi, Michele Massimo Giulizia, Italo Porto, Fabrizio Giovanni Oliva

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: aspirin; primary prevention; cardiovascular risk; platelet; bleeding; thrombosis; diabetes; guidelines; cancer

Online: 13 June 2024 (11:51:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1629.v1

Region-Specific Decellularization of Porcine Uterine Tube Extracellular Matrix: A New Approach for Reproductive Tissue-Engineering Applications

Gustavo Henrique Doná Rodrigues Almeida, Raquel Souza da Silva, Mariana Sversut Gibin, Victoria Helen de Souza Gonzaga, Henrique dos Santos, Rebeca Piatniczka Igleisa, Leticia Alves Fernandes, Iorrane Couto Fernandes, Thais Naomi Gonçalves Nesiyama, Franciele Sato, Mauro Luciano Baesso, Luzmarina Hernandes, Jaqueline de Carvalho Rinaldi, Flavio Vieira Meirelles, Claudete S. Astolfi-Ferreira, Antonio José Piantino Ferreira, Ana Claudia Oliveira Carreira

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: uterine tube; extracellular matrix; reproduction; decellularization; biomaterial

Online: 24 May 2024 (11:56:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1519.v1

A Multi-epitope Protein for High-Performance Serodiagnosis of Chronic Chagas Disease in Elisa and Lateral Flow Platforms

Evandro R. Dias, Andressa M. Durans, Barbara B. Succar, Luiz André L. T. Pinto, Guilherme C. Lechuga, Mariana G. Miguez, Janaina Figueira-Mansur, Ana Paula C. Argondizzo, Aline R. Bernardo, Rafaela L. Diniz, Gabriela S. Esteves, Edimilson D. Silva, Carlos M. Morel, José Borges-Pereira, Salvatore Giovanni De-Simone, Angela C. V. Junqueira, D. William Provance, Jr

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chagas disease; Diagnostics; ELISA; Lateral Flow tests; Synthetic protein; T. cruzi

Online: 21 August 2024 (08:40:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0184.v1

Carbohydrate Hydrolytic Activity, Antibiotic Resistance and Stress Tolerance of Lacticaseibacillus paracasei BCRC-16100 and Lacticaseibacillus paracasei ZFM54 for Probiotics Using Genomic and Biochemical Approaches

Peter James Icalia Gann, Jimmbeth Zenila P. Fabia, Althea Gay B. Pagurayan, Ma. Joy Theresa Agcaoili, Ryan James J. Pascual, Suerte M. Baranda, Arc Josam J. Racho, Marvielyn P. Olivar, Jayson F. Cariaga, Alvin Domingo, Dionisio S. Bucao, Shirley C. Agrupis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: probiotics; nutrient digestion; antibiotic resistance; antibacterial activity; whole genome sequence

Online: 2 April 2024 (10:16:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0500.v1

Symptoms and Management of Cow’s Milk Allergy: Perception and Evidence

Emma Robert, Hani Al-Hashmi, Ali I Al-Mehaidib, Muath Al-Turaiki, Wajeed Aldekhail, Waleed Al-Herz, A Alkhabaz, Khalid O Bawakid, Ahmed Elghoudi, Mostafa El-Hodhod, Ahmad Ali Hussain, Nagla M Kamal, T Loie Goronfalah, Basil Nasrallah, Kalpani Segupta, Ilse Broekaert, Magnus Domellof, Flavia Indrio, Alexandre Lapillonne, Corina Pienar, Carmen Ribes_Koninckx, Ranaan Shamir, Hania Szajewska, Nikhil Thapar, Rut Anne Thomassen, Elvira Verduci, Cristina E West, Yvan Vandenplas

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Cow's milk allergy; Infants; Extensively hydrolysed formula; Amino acid-based formula; Soy formula; Rice hydrolysed formula; Probiotic; Prebiotic; Synbiotic

Online: 7 September 2023 (13:25:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1373.v1

Endoscopic Management of Post-Esophagectomy Delayed-Gastric-Conduit-Emptying (DGCE): Results from a Cohort Study in a Tertiary Referral Center with Comparison between Procedures

Giuseppe Dell’Anna, Francesco Vito Mandarino, Jacopo Fanizza, Ernesto Fasulo, Alberto Barchi, Rukaia Barà, Edoardo Vespa, Edi Viale, Francesco Azzolini, Lorella Fanti, Silvia Battaglia, Francesco Puccetti, Andrea Cossu, Ugo Elmore, Lorenzo Fuccio, Vito Annese, Alberto Malesci, Riccardo Rosati, Silvio Danese

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: delayed gastric conduit emptying; esophagectomy; endoscopic pneumatic dilation; botulinum toxin ;

Online: 20 September 2024 (03:26:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0942.v1

ARFI of the Liver and of the Spleen, Combined with Spleen Dimension and Platelet Count in New Ratio Scores, Identifies Cirrhotic Patients with High-Risk Oesophageal Varices

Antonio F.M. Vainieri, Elisa Brando, Antonio De Vincentis, Giulia Di Pasquale, Valentina Flagiello, Paolo Gallo, Francesca Barone, Teresa Massaro Cenere, Evelyn Di Matteo, Antonio Picardi, Giovanni Galati, Claudia Altamura, Carlo Altomare, Paola Balestrieri, Myriam Carpenito, Livio Cortese, Fabio Costa, Alessandro Ferrini, Daria Maggi, Diana Lelli, Antonella Grasso, Simona Mega, Giuseppina Pacella, Andrea Palermo, Claudia L. Piccolo, Simone Scarlata, Lorenzo Schiavoni, Serena Stigliano

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: ARFI; acoustic radiation forced impulse; platelet count; spleen; oesophageal varices

Online: 19 February 2024 (14:51:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1093.v1

Detection of Human Adenovirus and Rotavirus in Untreated Wastewater in Lusaka, Zambia: Opportunity for Establishment of Wastewater Surveillance System for the Community

Ngonda Saasa, Ethel M’kandawire, Joseph Ndebe, Mulenga Mwenda, Fred Chimpukutu, Andrew Nalishuwa Mukubesa, Fred Njobvu, Doreen Mainza Shempela, Jay Sikalima, Carol Chiyesu, Bruce Muvwanga, Sarah M. Nampokolwe, Clement Sulwe, Thokozile Khondiwa, Todd Jennings, Ameck Kamanga, Edgar Simulundu, Conceptor Mulube, Wizaso Mwasinga, Jelaimo Mumeka, John Simwanza, Patrick Sakubita, Otridah Kapona, Chilufya Susan Aneta Mulenga, Musole Chipoya, Kunda Musonda, Nathan Kapata, Nyambe Sinyange, Muzala Kapina, Joyce Siwila, Misheck Shawa, Masahiro Kajihara, Ayato Takada, Hirofumi Sawa, Simulyamana A. Choonga, Roma Chilengi, Earnest Muyunda, King S. Nalubamba, Bernard M. Hang’ombe

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Wastewater; Adenovirus; Rotavirus; Enteric virus; concentration methods

Online: 19 March 2024 (05:18:35 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0218.v2

State of the Art of Automated Buses

Jaagup Ainsalu, Ville Arffman, Mauro Bellone, Maximilian Ellner, Taina Haapamäki, Noora Haavisto, Ebba Josefson, Azat Ismailogullari, Eetu Pilli-Sihvola, Olav Madland, Raitis Madzulaitis, Jaanus Muur, Sami Mäkinen, Ville Nousiainen, Eetu Rutanen, Sami Sahala, Boris Schønfeldt, Piotr Smolnicki, Ralf-Martin Soe, Juha Sääski, Magdalena Szymańska, Ingar Vaskinn, Milla Åman

Subject: Engineering, Automotive Engineering Keywords: driverless buses, autonomous vehicles, intelligent transportation, legal issues of autonomous driving

Online: 1 August 2018 (13:45:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0017.v1

2018 Atmospheric Motion Vector (AMV) Intercomparison Study

David Santek, Richard Dworak, Sharon Nebuda, Steve Wanzong, Régis Borde, Iliana Genkova, Javier García-Pereda, Renato Galante Negri, Manuel Carranza, Kenichi Nonaka, Kazuki Shimoji, Soo Min Oh, Byung-Il Lee, Sung-Rae Chung, Jaime Daniels, Wayne Bresky

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: atmospheric motion vectors; AMVs; intercomparison; himawari; CPTEC/INPE; EUMETSAT; JMA; KMA; NOAA; NWCSAF

Online: 2 August 2019 (05:44:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1063.v1

COVID-19 Outcomes in Kidney Transplant Recipients in a German Transplant Center

Michael Mikhailov, Klemens Budde, Fabian Halleck, Georgios Eleftheriadis, Marcel Naik, Eva Schrezenmeier, Friederike Bachmann, Mira Choi, Wiebke Duettmann, Ellen Von Hoerschelmann, Nadine Koch, Lutz Liefeldt, Christian Lücht, Henriette Straub-Hohenbleicher, Johannes Waiser, Ulrike Weber, Bianca Zukunft, Bilgin Osmanodja

Subject: Medicine And Pharmacology, Transplantation Keywords: kidney transplant recipients, immunosuppression, vaccination, SARS-CoV-2, COVID-19, Omicron

Online: 15 August 2023 (08:32:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0417.v1

Substance Use Disorders and Risk of Cardiovascular and Cerebrovascular Disease: Analysis of the Nationwide Inpatient Sample Database

Harshil Patel, Urvish Patel, Medhat Chowdhury, Andrew Assaf, Chaithanya Avanthika, Mohammed Nor, Mohamed Rage, Apoorva Madapu, Sravani Konatham, Mamatha Vodapally, Vatsalya Bhat, Anupa Gnawali, Mohamed Mohamed, Nawal Abdi, Faizan Ahmad Malik, Shamik Shah, Marcel Elias Zughaib

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Recreational substance abuse; drug abuse; marijuana; amphetamine; acute ischemic stroke; risk factors; young adult; NIS; Stroke; Sudden Cardiac Death

Online: 27 September 2022 (09:41:00 CEST)

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Background: Substance use continues to be on the rise in the United States and has been linked to new onset cardiovascular (CVDs) and cerebrovascular disorders (CeVDs) leading to hospitalizations. We aimed to study the association of different subtypes of substance use disorders (SUDs) among hospitalized patients, with the different subtypes of CVDs and CeVDs, using the National Inpatient Sample (NIS) Database. Additionally, we aimed to assess the odds of hospitalizations with new onset CVDs and CeVDs among patients with different types of SUDs. Methods: A retrospective study of the NIS database (2016-2017) using the ICD-10-CM codes was performed. The hospitalizations with a secondary diagnosis of SUDs were identified. Weighted univariate analysis using the chi-square test and multivariate survey logistic regression analysis was performed to evaluate for the incidence, prevalence, and odds of association between vascular events and SUDs. Results: There were a total of 58,259,589 hospitalizations, out of which 21.42% had SUDs. Out of all the hospitalized patients between the age 18-50, more patients had SUDs than not (31.83%, p< 0.0001). This difference existed for all the different subtypes of SUDs including alcohol related disorder (42.61%), amphetamine dependence (76.17% vs 31.83%), cannabis related disorder (75.17%), cocaine related disorders (57.87%), hallucinogen related disorder (82.91%), inhalant related disorders (67.25%), opioid related disorders (52.86%), and nicotine dependence (35.72%). We found a significant association of acute ischemic stroke with amphetamine dependence (OR 1.23, 95%CI 1.14-1.33), cocaine related disorders (1.17, 1.12-1.23) and nicotine dependence (1.42, 1.40-1.43). Similarly, the association of intracerebral hemorrhage was higher with amphetamine dependence (2.58, 2.26-2.93), and cocaine related disorders (1.62, 1.46-1.79). The association of subarachnoid hemorrhage was noted to be higher with amphetamine dependence (1.82, 1.48-2.24) and nicotine dependence (1.47, 1.39-1.55). In terms of association of cardiovascular disorders with SUDs,the patients with myocardial infarction had higher odds of nicotine dependence (1.85, 1.83-1.87) than not, Similarly, the patients with angina pectoris were noted to have a higher association with cocaine related disorders (2.21, 1.86-2.62), and those with atrial fibrillation had a higher association alcohol related disorders (1.14, 1.11-1.17). Conclusion: Our study demonstrates the variability of CVD and CeVD in patients hospitalized for SUD. Findings from our study may help promote increased awareness and early management of these events. Further studies are needed to evaluate specific effects of frequency and dose on the incidence and prevalence of CVD and CeVD in patients with SUD.

Preprint ARTICLE | doi:10.20944/preprints202107.0009.v1

Outcomes and Timing of Bedside Percutaneous Tracheostomy of COVID-19 Patients Over a Year in Intensive Care Unit

Nardi Tetaj, Micaela Maritti, Giulia Stazi, Maria Cristina Marini, Daniele Centanni, Gabriele Garotto, Ilaria Caravella, Cristina Dantimi, Matteo Fusetti, Carmen Santagata, Manuela Macchione, Giada De Angelis, Filippo Giansante, Donatella Busso, Rachele Di Lorenzo, Silvana Scarcia, Alessandro Carucci, Ricardo Cabas, Ilaria Gaviano, Nicola Petrosillo, Andrea Antinori, Fabrizio Palmieri, Gianpiero D'Offizi, Stefania Ianniello, Paolo Campioni, Francesco Pugliese, Francesco Vaia, Emanuele Nicastri, Giuseppe Ippolito, Luisa Marchioni

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Intensive care unit; percutaneous tracheostomy; COVID-19; early tracheostomy; late tracheostomy; ICU length of stay; health care workers; mechanical ventilation.

Online: 1 July 2021 (11:04:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1295.v1

Phenotypic Characterization of a Diverse Population of Cannabis sativa for Agronomic, Morphological, and Biochemical Traits

Éliana Lapierre, Maxime De Ronne, Rosemarie Boulanger, Davoud Torkamaneh

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: cannabis; breeding; phenotype; correlations

Online: 20 September 2023 (02:35:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0548.v1

Impact of TSPO Receptor Polymorphism on [18F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders

Franziska J. Vettermann, Stefanie Harris, Julia Schmitt, Marcus Unterrainer, Simon Lindner, Boris-Stephan Rauchmann, Carla Palleis, Endy Weidinger, Leonie Beyer, Florian Eckenweber, Sebastian Schuster, Gloria Biechele, Christian Ferschmann, Vladimir M. Milenkovic, Christian H. Wetzel, Rainer Rupprecht, Daniel Janowitz, Katharina Buerger, Robert Perneczky, Günter U. Höglinger, Johannes Levin, Christian Haass, Joerg C. Tonn, Maximilian Niyazi, Peter Bartenstein, Nathalie L. Albert, Matthias Brendel

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: microglia; neurodegeneration; Alzheimer’s disease; neurooncology; 4R-tauopathies; TSPO-PET

Online: 20 April 2021 (13:28:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0427.v1

Environmental Suitability for Sea Ranching Harvest Type of Sandfish Sea Cucumber Holothuria Scabra Jaeger 1833 in Karimunjawa National Park, Indonesia

Mujiyanto Mujiyanto, Yayuk Sugianti, Adriani Sri Nastiti, Sri Turni Hartati, Amran Ronny Syam, Arip Rahman, Retno Widihastuti, Krismono Krismono, Didik Wahju Hendro Tjahjo, Masayu Rahmia Anwar Putri, Sri Endah Purnamaningtyas, Bambang Sulardiono, Dwi Handoko Seputro, Andri Warsa, Lismining Pujiyani Astuti, Amula Nurfiarini, Danu Wijaya

Subject: Environmental And Earth Sciences, Environmental Science Keywords: sea cucumber; enhancement; Holothuria scabra; sea ranching

Online: 28 September 2022 (03:24:25 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202107.0075.v1

Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops Truncatus), an Essential Step in the Conservation of at-Risk Dolphins.

Ashley Barratclough, Cynthia R. Smith, Forrest M. Gomez, Theoni Photopoulou, Ryan Takeshita, Enrico Pirotta, Len Thomas, Abby M. McClain, Celeste Parry, Joseph A Zoller, Steve Horvath, Lori H Schwacke

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: DNA methylation; epigenetic aging; bottlenose dolphin; chronological age

Online: 5 July 2021 (07:59:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0791.v1

Ultrasonic Non-Contact Air-Coupled Technique For Assessment Of Sandwich Composites Plates Using Antisymmetric Lamb Waves

Eduardo Moreno, Roberto Giacchetta, Ricardo Gonzalez, David Sanchez, Olalla Sanchez, Andrea Torre, Guillermo Cosarinsky, Wagner Coelho

Subject: Engineering, Other Keywords: guided waves; ultrasonic lamb waves; air-coupled transducer; composite sandwich plate

Online: 13 September 2023 (07:55:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0344.v1

Geochemistry Acidic Water of Banyupait River Effect Seepage of Crater Water Ijen Volcano, Asembagus, Situbondo, East Java, Indonesia

Dwi Fitri Yudiantoro, Bambang Agus Irawan, Intan Paramita Haty, Dewi Sri Sayudi, Arum Suproboriniaru, Bawaningrum Sekarwati, Paramita Ismaya, Mirzam Abdurrachman, Isao Takashima

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: stratovolcano; crater; acid; REE; health

Online: 15 August 2020 (09:20:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0295.v1

Design of Three Phase Solid State Transformer Deployed within Multi-Stage Power Switching Converters

Umair Tahir, Ghulam Abbas, Dan Ovidiu Glavan, Valentina E. Balas, Umar Farooq, Marius M. Balas, Ali Raza, Muhammad Usman Asad, Jason Gu

Subject: Engineering, Control And Systems Engineering Keywords: decoupled controller; ferrite material; proportional integral (PI); solid state transformer (SST); space vector pulse width modulation (SVPWM); voltage source converter (VSC); voltage source inverter (VSI)

Online: 26 July 2019 (01:02:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1291.v1

Exploring the Mechanism of Topical Application of Clematis Florida in the Treatment of Rheumatoid Arthritis through Network Pharmacology and Experimental Validation

Ting Lei, Chang Jiang, Li Zhao, Jizhou Zhang, Qing Xiao, Yanhong Chen, Jie Zhang, Chunquan Zhou, Gong Wang, Jing Han

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Clematis Florida; rheumatoid arthritis; network pharmacology; NF-κ B; MAPK

Online: 19 June 2024 (07:03:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1176.v1

Properties of Superelastic Nickel-Titanium Wires After Clinical Use

Inés Alcaraz, Javier Moyano, Ariadna Pàmies, Guillem Ruiz, Montserrat Artés, Xavier Gil, Andreu Puigdollers

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: NiTi; Superelasticity; Sterilization; Mechanical properties

Online: 18 July 2023 (13:41:45 CEST)

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