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Preprint ARTICLE | doi:10.20944/preprints202406.0799.v1

A Malleable Model Development for Critical Systems Supervision Integration

Luciano A. C. Lisboa, Thamiles R. Melo, Ikaro G. S. A. Campos, Matheus B. Aragão, Alexandre S. Ribeiro, Lucas C. Silva, Valéria L. da Silva, Antonio M. N. Lima, Alex A. B. Santos

Subject: Engineering, Electrical And Electronic Engineering Keywords: Critical Systems; Automation System; Supervision; Integration; Reliability; Malleable Model; Formal Languages; Hybrid Power Plant

Online: 12 June 2024 (08:11:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0300.v1

Hydropower Advantages over Batteries in Energy Storage of Off-Grid Systems

Prajwal Shandilya M G, Emanuele Quaranta, Oscar E. Coronado-Hernández, Helena M. Ramos

Subject: Engineering, Civil Engineering Keywords: hydropower; energy storage; pumped storage hydropower (PSH); batteries; net present cost (NPC); levelized cost of energy (LCOE); microgrids

Online: 3 August 2023 (11:27:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1973.v1

Motor Imagery Classification Using Trial Extension in Spatial Domain with Rhythmic Components of EEG

Md. Khademul Islam Molla, Sakir Ahamed, Ahmed M. M. Almassri, Hiroaki Wagatsuma

Subject: Computer Science And Mathematics, Signal Processing Keywords: brain computer interface; classification; electroencephalography; motor imagery task; subband decomposition

Online: 28 July 2023 (11:19:47 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202307.0334.v1

Analysis of Tianeptine in Dietary Supplements

Jared T. Seale, Emily A. Garden, John M. T. French, Owen M. McDougal

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Dietary supplement, μ-opioid-receptor agonist, addiction, antidepressant

Online: 5 July 2023 (13:04:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0109.v2

Spin Orbit Coupling in Orthogonal Charge Transfer States: (TD-)DFT of Pyrene - Dimethylaniline

Shivan Bissesar, Davita M. E. van Raamsdonk, Dáire J. Gibbons, René M. Williams

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: photoinduced electron transfer; triplet state formation; charge recombination; charge separation; intersystem crossing; SOCT-ISC; SOCME; electronic coupling

Online: 16 December 2021 (14:21:43 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202109.0393.v1

Optimising Digital Health Platforms in Saudi Arabia: Determinants from the COVID-19 Pandemic Experience

Saeed M Alghamdi, Abdullah S Alsulayyim, Jaber S Alqahtani, Abdulelah M Aldhahir

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Digital health; Telehealth; Saudi Arabia; Artificial Intelligence; Digital Technology

Online: 22 September 2021 (22:36:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0003.v1

Perturbation Analysis of Calcium, Alkalinity and Secretion during Growth of Lily Pollen Tubes

Lawrence J. Winship, Caleb Rounds, Peter K. Hepler

Subject: Biology And Life Sciences, Plant Sciences Keywords: calcium; protons; exocytosis; tip growth; Lilium; pollen; respiration; perturbation analysis

Online: 1 November 2016 (05:25:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0793.v1

Guinea Pig Sperm Morphology and Fertility under Different Photoperiod

Hurley Abel Quispe-Ccasa, Yander M. Briceño-Mendoza, Ilse Silvia Cayo-Colca

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Cavia porcellus L.; illumination; morphometry; acrosome; sperm nucleus; precocity

Online: 11 May 2023 (05:15:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2148.v1

HIV Drug Resistance Patterns and Characteristics Associated with Clinically Significant Drug Resistance among Children with Virologic Failure on Antiretroviral Treatment in Kenya: Findings from the Opt4Kids Randomized Controlled Trial

Lisa L Abuogi, Patrick Oyaro, Garoma Wakjira, Katherine K Thomas, Andrea Scallon, Irene Mukui, Bhavna H. Chohan, Evelyn Brown, Enericah Karauki, Nashon Yongo, Bilaal Ahmed, Shukri A. Hassan, James Wagude, Eunice Kinywa, Lindah Otieno, Leonard Kingwara, Boaz Oyaro, Lisa M Frenkel, Grace John-Stewart, Rena C Patel

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: HIV; children; drug resistance; virologic failure

Online: 31 August 2023 (09:25:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0697.v1

Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Larynx Preservation in Laryngeal and Hypopharyngeal Cancer

Primož Strojan, Gaber Plavc, Robert Šifrer, Simona Jereb, Boštjan Lanišnik, Marko Kokalj, Ales Grošelj, Cvetka Grašič Kuhar

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: induction chemotherapy; response; organ preservation; laryngeal cancer; hypopharyngeal cancer

Online: 9 September 2024 (13:19:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0507.v1

Small Extracellular Vesicles And Oxidative Pathophysiological Mechanisms In Retinal Degenerative Diseases

Francisco Javier Romero, Manuel Diaz-Llopis, M Inmaculada Romero-Gomez, María Miranda, Rebeca Romero-Wenz, Javier Sancho-Pelluz, Belen Romero, María Muriach, Jorge M Barcia

Subject: Medicine And Pharmacology, Ophthalmology Keywords: retina; exosomes; oxidative stress; autophagy; microrna

Online: 8 January 2024 (04:22:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0390.v1

O-β-GlcNAcylation, Chloroquine and 2-Hydroxybenzohydrazine May Hamper SARS-CoV-2 entry to Human via Inhibition of ACE2 Phosphorylation at Ser787 but Also Induce Disruption of Virus-ACE2 Binding

Waqar Ahmad, Khadija Shabbiri, Nazarul Islam

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; SARS-CoV; ACE2; spike protein; phosphorylation; O-β-GlcNAcylation; molecular docking; chloroquine; 2-hydroxybenzohydrazine

Online: 22 April 2020 (06:01:00 CEST)

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The novel coronavirus COVID- 19 disease is extremely contagious and has been spread worldwide. First COVID-19 case was identified in December, 2019 and within three months, more than one million affected cases and over 65,000 deaths have been reported. SARS-coronavirus 2 (SARS-CoV-2) also known as 2019-nCoV is a causative agent of COVID-19 disease and belongs to the SARS CoV (Severe Acute Respiratory Syndrome corona virus) family. The SARS-CoV-2 enters the human body by binding its viral surface spike protein with the host angiotensin-converting enzyme 2 (ACE2) receptors and cause infection. To prevent the virus entry and its transmission in the human body, we focused on the two domains of ACE2: i) the N-terminal extracellular binding domain (18-740 residues) reported for coronavirus spike interaction, and ii) the C-terminal cytoplasmic region (762-805 residues) to prevent the virus transmission. Therefore, we proposed: i) inhibition of receptor binding domain (RBD) of SARS-CoV-2 and human ACE2 protein may prevent the virus entry to the host and ii) inhibition of phosphorylation at Ser-787 of ACE2 protein may prevent the transmission of the virus in the COVID-19 patients. In the past, the critical role of Ser 787 in human ACE2 protein has been experimentally verified in SARS-CoV transmission, that upon binding to the receptor, SARS- CoV induces CKII- mediated phosphorylation of ACE2 at Ser-787 that in-turn facilitate virus entry to host cells, followed by replication and activation of ACE2, initiates downstream signaling leading to lung fibrosis. Therefore, in this study, we have suggested post-translational modification (PTM) O-β-GlcNAcylation, and two compounds Chloroquine and 2-hydroxybenzohydrazine might share the common pathways to prevent the COVID-19 infection in human. The addition of O-β-GlcNAcylation at same or neighboring Ser/ Thr residues results in phosphorylation inhibition and a change in protein structural and functional confirmations. Thereby, using neural networking methods, we have identified Ser/ Thr residues in ACE2 that are potential sites for phosphorylation and / or O-β-GlcNAcylation. Molecular docking showed that UDP-GlcNAc has more binding affinity with Ser-787 than the phosphoryl group. Moreover, chloroquine and 2-hydroxybenzohydrazine also showed great potential to bind at Ser-787 that may result in inhibition of Ser-787 phosphorylation and downstream signaling. Furthermore, O-β-GlcNAcylation, chloroquine and 2-hydroxybenzohydrazine showed their high affinity at ACE2-SARS-CoV-2receptor binding domain that may prevent the entry of SARS-CoV-2 into human body. In conclusion, inhibition of human ACE2 phosphorylation at Ser-787 and ACE2-SARS-CoV-2 binding domain could be promising targets against SARS-CoV-2 infection.

Preprint ARTICLE | doi:10.20944/preprints201809.0445.v1

New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity

Barbara S. Gregorí Valdes, Clara S. B. Gomes, Pedro T. Gomes, José R. Ascenso, Hermínio P. Diogo, Lídia M. Gonçalves, Rui Galhano dos Santos, Helena M. Ribeiro, João C. Bordado

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: biocompatibility; GPC/SEC; keratinocyte cells; NMR; polyurethane; renewable sources

Online: 22 September 2018 (23:23:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0808.v1

Association between Molecular Initiating Events (MIEs) in Drug-Induced Hiccups

Ryuichiro Hosoya, Reiko Ishii-Nozawa, Tomoko Terajima, Hajime Kagaya, Yoshihiro Uesawa

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: drug-induced hiccups; FAERS; nuclear receptor; stress response pathways

Online: 15 February 2024 (01:25:14 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201611.0127.v1

In-Situ Assessment of PAHs in Contaminated Sea Sediments

Emanuela Frapiccini, Evgeniya Prokofyeva, Antonina Bondarenko, Maria Letizia Ruello, Mauro Marini

Subject: Environmental And Earth Sciences, Environmental Science Keywords: persistent organic pollutants, bioavailability, Diffusive Gradient Thin film (DGT), passive probe, degradation

Online: 25 November 2016 (09:59:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201607.0034.v1

Flaring γ-ray emission from high redshift blazars

Monica Orienti, Filippo D'Ammando, Marcello Giroletti, Justin Finke, Daniele Dallacasa

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxies: active; gamma-rays: general; radiation mechanisms: non-thermal

Online: 15 July 2016 (04:40:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0311.v1

Phytochemical Properties and Heavy Metal Contents of Commonly Consumed Alcoholic Beverages Flavoured with Herbal Extract in Nigeria

Oladapo T. Okareh, Tosin M. Oyelakin, Oluwaseun Ariyo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: phytochemical; heavy metals; flavoured alcoholic beverages; herbal extract

Online: 23 May 2018 (05:15:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.2041.v1

Effect of Omega 3 Fatty Acids on Inflammation Resolution in Pa-Tients with Obesity: A Randomized Placebo-Controlled Trial

Joel Torres-Vanegas, Roberto Rodriguez-Echevarria, Wendy Campos-Perez, Citlalic Rodriguez-Reyes, Samantha Reyes-Perez, Mariana Perez-Robles, Erika Martinez-Lopez

Subject: Public Health And Healthcare, Primary Health Care Keywords: Diet; Obesity; Omega-3; Low-grade inflammation; Specialized pro-resolving mediators

Online: 29 June 2024 (06:14:53 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202406.0709.v1

Trans-Catena-Poly[[(Bis-(μ-N,N’-Bis[(Pyridin-3-yl)Methyl]Ethanediamide))-Diaqua-Cadmium(II)] Bis(Nitrate) Tetrahydrate)]

Anna Caria, Enrico Podda, Carla Aragoni, Riccardo Lai, Anna Pintus, Massimiliano Arca

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: oxalamide; oxalic acid derivatives; hydrogen bonding; Cd; XRD; DFT

Online: 11 June 2024 (12:40:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1881.v1

Improving Speed Characteristics of High Torque Density Motors for Physical Human-Robot Interaction using Independent 3-Phase Winding Structure

Junghwan Park, Handdeut Chang

Subject: Engineering, Electrical And Electronic Engineering Keywords: High Torque Density Motor; Safe pHRI(physical Human-Robot interaction); Independent 3-phase; Motor Controller

Online: 29 March 2024 (16:18:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0028.v1

Post-Translational Regulation of a Bidomain Glycerol-3-Phosphate Dehydrogenase Catalyzing Glycerol Synthesis under Salinity Stress in Chlamydomonas reinhardtii

Itzela Cruz-Powell, Binita Subedi, Yeongho Kim, Daniela Morales-Sanchez, Heriberto Cerutti

Subject: Biology And Life Sciences, Life Sciences Keywords: osmotic stress; glycerol-3-phospate phosphatase; phosphorylation; kinase inhibition; chloroplast

Online: 1 March 2024 (07:48:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2055.v1

Existence of a Hölder Continuous extension on embedded balls of the 3-Torus for the Periodic Navier Stokes Equations

Terry Eleftherios Moschandreou

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Navier-Stokes; PNS; 3-Torus; periodic; ball; sphere; Hölder; continuous; uniqueness; Riemann Surface

Online: 27 December 2023 (05:23:24 CET)

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\abstract{The existence of vorticies is well known in fluid mechanics and particularly in turbulence theory. In the context of the millennium problem of the Clay Institute on the existence (or not) of Global solutions in time of the Periodic Navier Stokes equations (PNS) results are now proposed to confirm that Global solutions do not exist in the general case of PNS defined on $\mathbb{T}^3$. This corresponds to part ($D$) proposition in the Navier Stokes problem as posted by C.Fefferman. Recent work has shown that for the Euler equations defined on the 3-Torus there exists a H\"older continuous solution for the third component of velocity $v_3$ at the center of each cell or cube of the 3-Torus Lattice. It has also been determined that as the kinematic viscosity changes from the corresponding value at $\nu=0$ to the fully viscous case for the Periodic Navier Stokes equations (PNS) at the value $\nu=1$ the solution reaches a peak ($\frac{\partial v_3}{\partial y_3} = 0$ ) in $y_3$. (third component of $\vec{r}=(y_1,y_2,y_3)$ in Cartesian co-ordinates) Here in the viscous case there exists a dipole which is not centered at the center of the cell of the Lattice. This immediately implies that since the dipole by definition has an equal in magnitude positive and negative peak in the third component of velocity, then the dipole Riemann cut-off surface is covered by a closed surface which is the sphere $\|\vec{r}\|=1$ and where a given cell of dimensions $[-1,1]^3$ is circumscribed on a sphere of radius $1$. For such a closed surface containing a dipole it necessarily follows that the flux at the surface of the sphere of $v_3$ wrt to surface normal $\vec{n}$ is zero including at $y_i, i=1\dots 3$ is zero at the points where the surface of sphere touches the cube walls. At the finite time singularity on the sphere a rotation boundary condition is deduced. Here $\frac{\partial v_3}{\partial \vec{n}}= \vec{n}\cdot \nabla v_3$. Also a boundary condition on the sphere shows rotation of sphere. Finally as a result, on the sphere a solution for $v_3$ is obtained which is proven to be H\"older continuous and it is proven that it is possible to extend H\"older continuity on the sphere uniquely to all of the interior of the ball.}

Preprint CASE REPORT | doi:10.20944/preprints202308.1607.v1

Successful Management, in a Low-Resource Setting, of Disseminated Tuberculosis in a 3-Year Old Boy: A Case Report

Josina Chilundo, Arlindo Muhelo, Zita Ahivaldino, Helton Zucula, Sheila Macuacua, Ana Cristina, Damiano Pizzol, Lee Smith, Giuseppe Maggioni

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: tuberculosis; disseminated TB; low-income setting

Online: 23 August 2023 (09:15:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0261.v1

Machine Learning Approach for Analyzing 3-Year Outcomes of Patients with Brain Arteriovenous Malformation (AVM) after Stereotactic Radiosurgery (SRS)

Mirko Jerber Rodríguez Mallma, Marcos Vilca-Aguilar, Luis Zuloaga-Rotta, Rubén Borja-Rosales, María Salas-Ojeda, David Mauricio

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: brain arteriovenous malformation; prognosis; prediction; machine learning; artificial intelligence; decision tree; logistic regression

Online: 5 July 2023 (04:35:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0301.v1

Remote Monitoring of Canine Patients Treated for Pruritus during the COVID Pandemic in Florida Using a 3-D Accelerometer

Michael Canfield, Robert P. Lavan, Timberly Canfield, Gal Gingold, Jennifer Thomas, Bridgette Sampeck, Tonya Springer, Rob Armstrong

Subject: Medicine And Pharmacology, Dermatology Keywords: pruritus; 3D-accellerometer; monitoring; allergic skin disease; canine atopic dermatitis

Online: 5 June 2023 (10:13:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0308.v1

Influence of Hydrogen Generation During Thermal Processes of Water Decomposition on the Surface of Nano- ZrO₂+3 mol.%Y₂O₃

Gunel Imanova, Elmar Asgerov, Sakin Jabarov, Mustafa Kaya, Aleksandr Doroshkevich

Subject: Physical Sciences, Thermodynamics Keywords: Nano-ZrO2+3 mol.%Y2O3; Hydrogen generation; Kinetics; Thermal processes; Adsorption, Desorption.

Online: 20 December 2021 (10:50:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0115.v1

The Distribution of Tryptophan-Dependent Indole-3-Acetic Acid Synthesis Pathways in Bacteria Unraveled by Large-Scale Genomic Analysis

Pengfan Zhang, Tao Jin, Sunil Kumar Sahu, Jin Xu, Qiong Shi, Huan Liu, Yayu Wang

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Indole-3-acetic acid; Bacteria; Pathways; Genomes; Metagenomes

Online: 9 April 2019 (12:59:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0059.v1

Properties of Ferrite Garnet (Bi, Lu, Y)₃(Fe, Ga)₅O₁₂ Thin Film Materials Prepared by RF Magnetron Sputtering

Mohammad Nur E Alam, Mikhail Vasiliev, Vladimir Belotelov, Kamal Alameh

Subject: Physical Sciences, Optics And Photonics Keywords: magneto-optics; magnetic thin films; optical constants

Online: 3 May 2018 (08:59:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0014.v1

A Helical Charge Simulation based 3-D Method for Calculating AC Stranded Conductor’s Corona Loss in the Corona cage

Yunpeng Liu, Shilong Huang, Shugang Liu, Daran Liu, Zhicheng Huang

Subject: Engineering, Electrical And Electronic Engineering Keywords: corona loss; helical charge; 3-D calculation model; stranded conductor; sag

Online: 1 November 2017 (17:03:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.1664.v1

Diagnosis and Management of Severe Water-Related Skin and Soft Tissue Sepsis: A Summative Review of the Literature

Shanisa Naidoo, Arnold M Zwane, Ahmed Paruk, Timothy Craig Hardcastle

Subject: Medicine And Pharmacology, Surgery Keywords: Soft tissue; necrotizing infection; water borne; vibrio; fungal; aeromonas; debridement; negative pressure wound care

Online: 23 May 2023 (14:43:28 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202209.0380.v1

A Novel Design For A COVID-19 Diagnosis System Using Machine Learning And Drone Technology (COVIDRONE-20)

Asweel KK Mehaboob, Priya Darshini Natarajan, Munawar Peringadi Vayalil, Shamsudheen Marakkar, Mufeeda C. Koyilot, Khader Shameer, Kamlesh K. Yadav

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: UAV Technology; Information Processing; Machine Learning; IR Technology; Covid-19; Multi-modal machine learning; Machine vision; Computer vision

Online: 26 September 2022 (05:46:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0569.v1

Assessment of the Errors in the Transmission of the Orientation and Cartographic System from the Surface to an Underground Mine

Lluís Sanmiquel, Marc Bascompta, Josep M. Rossell

Subject: Engineering, Civil Engineering Keywords: shaft plumbing; ventilation; plumb oscillation; gravity force and earth rotation

Online: 30 July 2018 (09:07:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0993.v1

Methylmercury Intoxication Affects Epididymal White Adipose Tissue and Liver Function in Young ApoE Knockout Mice

Synara C. Lopes, Paola Caroline L. Leocadio, Gabriella C. V. Ciurleo, Gabriella A. Matos, Mirna M. d'Auriol Souza, Maria José N. de Paiva, Flavia Zandonadi, Alessandra Sussulini, Ramon da S. Raposo, Francisco Leomar da Silva, Davila Zampieri, Aline M. A. Martins, Jacqueline Isaura A. Leite, Reinaldo B. Oriá

Subject: Biology And Life Sciences, Toxicology Keywords: methylmercury; ApoE; epididymal white fat; metabolomics; dyslipidemia; oxidative stress; liver steatosis

Online: 15 May 2024 (10:31:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0225.v1

Impacts of a Changing Earth on Microbial Dynamics and Human Health Risks in the Continuum between Beach Water and Sand

Chelsea J. Weiskerger, João Brandão, Warish Ahmed, Asli Aslan, Lindsay Avolio, Brian D. Badgley, Alexandria B. Boehm, Thomas A. Edge, Jay M. Fleisher, Christopher D. Heaney, Luisa Jordao, Julie L. Kinzelman, James S. Klaus, Gregory T. Kleinheinz, Päivi Meriläinen, Jean Pierre Nshimyimana, Mantha Phanikumar, Alan M. Piggot, Tarja Pitkänen, Clare Robinson, Michael J. Sadowsky, Christopher Staley, Zachery R. Staley, Erin M. Symonds, Laura J. Vogel, Kevan M. Yamahara, Richard L. Whitman, Helena M. Solo-Gabriele, Valerie J. Harwood

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pathogen, climate change, sand, water quality, modeling

Online: 22 January 2019 (17:28:22 CET)

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Humans may be exposed to microbial pathogens at recreational beaches via environmental sources, such as water, sand, and aerosols. Although infectious disease risk from exposure to waterborne pathogens has been an active area of research for decades, sand is a relatively unexplored reservoir of pathogens and fecal indicator bacteria (FIB). Beach sand and water habitats provide unique advantages and challenges to pathogen introduction, growth, and persistence, as well as continuous exchange between habitats. Models of FIB and pathogen fate and transport in sandy beach habitats can help predict the risk of infectious disease from recreational water use, but filling knowledge gaps such as decay rates and potential for microbial growth in beach habitats is necessary for accurate modeling. Climatic variability, whether natural or anthropogenically-induced, adds complexity to predictive modeling, but may increase human exposure to waterborne pathogens via extreme weather events, warming of water bodies and sea level rise in many regions. The popularity of human recreational beach activities, combined with predicted climate change scenarios, could amplify the risk of human exposure to pathogens and related illnesses. Other global change trends such as increased population growth and urbanization are expected to exacerbate contamination events and the predicted impacts of increasing levels of waterborne pathogens on human health. Such changes will alter microbial population dynamics in beach habitats, and will consequently affect the assumptions and relationships used in population models and quantitative microbial risk assessment (QMRA). Here, we discuss the literature on microbial population and transport dynamics in sand-water continuum habitats at beaches, how these dynamics can be modeled, and how climate change and other anthropogenic influences (e.g., land use, urbanization) should be considered when using and developing more holistic, beachshed-based models.

Preprint ARTICLE | doi:10.20944/preprints202107.0486.v1

Quantitative Assessment of the Economic Impacts of Horticulture Research and Extension at MSU Coastal Research and Extension Center

Benedict C. Posadas, Patricia R. Knight, Eric T. Stafne, Christine E.H. Coker, Gary Bachman, James DelPrince, Scott A. Langlois, Eugene K. Blythe

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Economic impact; ornamental horticulture; fruits and nuts; vegetables; flowers; horticulture research; extension

Online: 21 July 2021 (11:14:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.2166.v1

Artificial Intelligence in the Interpretation of Videofluoroscopic Swallowing Studies: Implications and Advances for Speech Pathologists

Anna M Girardi, Elizabeth A Cardell, Stephen P Bird

Subject: Public Health And Healthcare, Primary Health Care Keywords: dysphagia; artificial intelligence; videofluoroscopic swallowing study; deep learning; machine learning; imaging; speech pathology

Online: 31 August 2023 (10:42:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1875.v1

Modelling the Decamerisation Cycle of PRDX1 and the Inhibition-Like Effect on Its Peroxidase Activity

Christopher J. Barry, Ché S. Pillay, Johann M. Rohwer

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Enzyme kinetics; Hydrogen peroxide; Isothermal titration calorimetry; Oligomerisation; Parameter estimation; Peroxiredoxin; Quantitative redox biology; Systems biology

Online: 27 June 2023 (09:46:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1488.v1

Improving Bug Assignment and Developer Allocation in Soft-ware Engineering through Interpretable Machine Learning Models

Mina Samir Shenouda, Nada H. Sherief, Walid M. Abdelmoez

Subject: Computer Science And Mathematics, Computer Science Keywords: Explainability; Explainable AI; XAI; Recommendation; Bugs

Online: 22 May 2023 (09:42:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0901.v1

Combined Therapies with Taxanes Based-Chemotherapeutic Drugs in Prostate Cancer: Novel Insights and Future Directions

Rafaella S Coelho, Sandra M Rocha, Cláudio J Maia

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: PCa; taxanes-based drugs; combination therapy; transmembrane proteins

Online: 25 April 2023 (08:34:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0317.v3

Effects of Boswellia serrata Roxb. and Curcuma longa L. in an In Vitro Intestinal Inflammation Model Using Immune Cells and Caco-2

Paolo Governa, Maddalena Marchi, Veronica Cocetta, Bianca De Leo, Philippa T. K. Saunders, Daniela Catanzaro, Elisabetta Miraldi, Monica Montopoli, Marco Biagi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Boswellia serrata Roxb.; Curcuma longa L.; intestinal bowel diseases (IBD); Caco-2; PBMC; HMC-1.1; mast cells; cytokines; trans epithelial electrical resistance (TEER); reactive oxygen species (ROS)

Online: 8 November 2018 (04:53:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0298.v1

A TriAdj-Adjuvanted Chlamydia trachomatis CPAF Protein Vaccine Is Highly Immunogenic in Pigs.

Jessica A Proctor, Maria Stadler, Lizette M Cortes, David Brodsky, Lydia Poisson, Volker Gerdts, Alex I Smirnov, Tatyana I Smirnova, Subarna Barua, Kenneth W Beagley, Jon M Harris, Toni Darville, Tobias Käser

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chlamydia trachomatis; vaccination; adjuvant; swine; One Health; animal model; chlamydial protease-like activity factor

Online: 6 March 2024 (10:48:38 CET)

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Chlamydia trachomatis (Ct) infections are the most common sexually-transmitted infection (STI). Despite effective antibiotics for Ct, undetected infections or delayed treatment can lead to infertility, ectopic pregnancies, and chronic pelvic pain. Besides humans, chlamydia poses similar health challenges in animals such as C. suis (Cs) in pigs. Based on the similarities between humans and pigs as well as their chlamydia species, we use pigs as a large biomedical animal model for chlamydia research. In this study, we use the pig model to develop a vaccine candidate against Ct. The vaccine candidate consists of TriAdj-adjuvanted chlamydial protease-like activity factor (CPAF) protein. We tested two weekly administration options – twice intranasal (IN) followed by twice intramuscular (IM), or twice IM followed by twice IN. We assessed the humoral immune response not only in serum by CPAF-specific IgG including antibody avidity determination but also in cervical and rectal swabs by CPAF-specific IgG and IgA ELISAs. The systemic T-cell response was analyzed upon in vitro CPAF-restimulation via IFN-γ and IL-17 ELISpots as well as intracellular cytokine staining flow cytometry. Our data demonstrate that while the IN/IM vaccination mainly led to non-significant systemic immune responses, the vaccine candidate is highly immunogenic if administered IM/IN. This vaccination strategy induced high serum anti-CPAF IgG levels with strong avidity as well as high IgA and IgG levels in vaginal and rectal swabs and in uterine horn flushes. In addition, this vaccination strategy prompted a pronounced cellular immune response: Besides inducing IL-17 production, the vaccine candidate induced a strong IFN-γ response by CD4 T cells. In the IM/IN vaccinated pigs, these cells also significantly downregulated their CCR7 expression – a sign for differentiation into peripheral tissue homing effector/ memory cells. Conclusively, this study demonstrates strong immunogenicity of the IM/IN administered TriAdj-adjuvanted Ct CPAF vaccine candidate. Future studies will test vaccine efficacy of this promising Ct vaccine candidate. In addition, this project demonstrates suitability of the Cs pre-exposed outbred pig model for Ct vaccine development. Thereby, we aim to open the bottleneck of large animal models to facilitate the progression of Ct vaccine candidates into clinical trials.

Preprint ARTICLE | doi:10.20944/preprints202407.1539.v1

Simulation and Optimisation of Utility-Scale PV-Wind Systems with Pumped Hydro Storage

Rodolfo Dufo-López, Juan M. Lujano-Rojas

Subject: Engineering, Electrical And Electronic Engineering Keywords: Photovoltaic; wind turbines; pumped hydro storage (PHS); simulation; optimisation

Online: 19 July 2024 (06:38:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0141.v1

Parental Self-Compassion and Child Adjustment: The Mediating Role of Parental Depressive Symptoms

Rebecca Y. M. Cheung, Zechen Li, Audrey Pui Lam Ho

Subject: Social Sciences, Psychology Keywords: externalizing problems; internalizing problems; parental depression; prosocial behavior; self-compassion

Online: 15 April 2022 (09:11:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2256.v1

Micronutrients and Major Depression: A Mendelian Randomization Study

Rebecca E Carnegie, Jie Zheng, Maria C Borges, Hannah J Jones, Kaitlin H Wade, Hannah M Sallis, Sarah J Lewis, David M Evans, Joana A Revez, Jonathan Evans, Richard M Martin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mendelian randomization; vitamins; minerals; micronutrients; major depressive disorder

Online: 2 September 2024 (11:18:21 CEST)

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Background: Various vitamins and minerals have been implicated in the aetiology of depression. Objective: To estimate the effects of micronutrient exposures on major depressive disorder (MDD) and recurrent depression (rMDD) using Mendelian randomization (MR). Methods: We undertook a comprehensive bidirectional MR study of multiple micronutrient exposures on MDD and rMDD. Summary statistics were obtained from the Psychiatric Genomics Consortium (PGC) genome wide association studies (GWASs) of MDD (cases = 116,209; controls = 314,566), and rMDD (cases=17,451; controls=62,482). Results: None of the micronutrients with available genetic instruments were strongly associated with MDD or rMDD using traditional MR methods. However, using methods to increase analytical power by accounting for genetically correlated variants (e.g. cIVW), highlighted five micronutrients with possible causal effects. Point estimates for rMDD were the largest magnitude, with three micronutrients suggestive of a protective effect: serum iron (OR_cIVW 0.90 per SD increase; 95% CI 0.85- 0.95; p=0.0003); erythrocyte copper (OR_cIVW0.97; 95% CI 0.95- 0.99; p=0.0004); and 25(OH) vitamin D (OR_cIVW 0.81; 0.66- 0.99; p=0.04). Apparent adverse effects of increased selenium on the risk of MDD (OR_cIVW 1.03; 95% CI 1.02-1.05; p=0.0003) and rMDD (OR_cIVW 1.08; 95% CI 1.00-1.08; p=0.06), and serum magnesium on rMDD (OR_cIVW 1.21; 1.01- 1.44; p=0.04); were less consistent between methods and may be driven by pleiotropy. Conclusions: Our results suggest weak evidence for a protective effect of iron, copper and 25(OH)D on major depressive outcomes, with mixed evidence for selenium and magnesium. There was no evidence to support a causal effect of any other micronutrients on MDD or rMDD, although genetic instruments were lacking, with insufficient power to detect small but important effects. Future micronutrient supplementation trials should ensure ample statistical power given modest causal effect estimates, and consider potential risks of supplementation, as some micronutrient effect estimates suggested potential harm in excess.

Preprint REVIEW | doi:10.20944/preprints202310.1640.v1

Radiotracers for Imaging of Inflammatory Biomarkers TSPO and COX-2 in the Brain and in the Periphery

Bright Uzuegbunam, Christoph Rummel, Damiano Librizzi, Carsten Culmsee, Behrooz Hooshyar Yousefi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Tracer development; neuroinflammation; pneumonia; myocarditis; translocator protein (TSPO); cyclooxygenase-2 (COX-2); positron emission tomography (PET); single-photon emission tomography (SPECT)

Online: 25 October 2023 (11:31:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1219.v1

Biology and Behavior of SARS-COV-2 Contagion with Emphasis on Treatment Strategies, Risk Assessment, and Resilience

James Baldwin, Samina Noorali, Ashok Vaseashta

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; risk assessment; mitigation; resilience; pandemic modeling; lessons learned

Online: 17 May 2023 (09:59:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0387.v1

Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic Context

Shamrat Kumar Paul, Md. Saddam, Mohammad Ahsan Habib, Md. Abrar Fahim, Afsana Mimi, Saiful Islam, Bristi Paul, Md Mostofa Uddin Helal

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: BCL-2 family protein; BCL-2 Domains; Apoptosis; Cancer; Biomarkers; Therapeutic Agents

Online: 22 February 2023 (14:56:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0036.v1

COVID-19 in Infants and Children under 2 years – Lung Ultrasound Score Correlated with Biomarkers and Symptoms

Emil Robert Stoicescu, Jovan Lovrenski, Roxana Iacob, Simona Cerbu, Daniela Iacob, Emil Radu Iacob, Septimiu Radu Susa, Ioana Mihaiela Ciuca, Andreea Ciornei-Hoffman, Cristian Oancea, Diana Luminita Manolescu

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: lung ultrasound; infants; children; COVID-19; SARS-CoV-2; multisystem inflammatory syndrome.

Online: 2 December 2022 (02:29:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0655.v1

SARS-CoV-2 and Rohingya Refugee Camp, Bangladesh: Uncertainty and How the Government Took Over the Situation

Md. Kamrujjaman, MD. Shahriar Mahmud, Shakil Ahmed, Md. Omar Qayum, Mohammad Morshad Alam, Md Nazmul Hassan, Md Rafiul Islam, Kaniz Fatema Nipa, Ummugul Bulut

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; Rohingya Refugee camp; Mathematical model; Numerical results; Basic reproduction number.

Online: 25 December 2020 (12:06:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0085.v1

Conformation and Domain Movement Analysis of Human Matrix Metalloproteinase-2: Role of Associated Zn²⁺ and Ca²⁺ Ions

Leah Voit-Ostricki, Sandor Lovas, Charles R. Watts

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: molecular dynamics; matrix metalloproteinase; domain movement; zinc binding protein; calcium binding protein

Online: 4 July 2019 (18:07:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0280.v1

Effects of Breast Cancer and Type 2 Diabetes Mellitus on Pulmonary Volumes and Pressures in Adult Women

Rodrigo Muñoz Cofré, Mariano del Sol, Gonzalo Palma Rozas, Washington Valverde Ampai, Daniel Conei Valencia, Gabriel Nasri Marzuca-Nassr, Paul Medina González, Máximo Escobar Cabello

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: diabetes mellitus; breast cancer; pulmonary volumes

Online: 27 June 2019 (06:08:48 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202212.0518.v1

Epitope Coverage of Anti-SARS-CoV-2 Nucleocapsid IgA and IgG Antibodies Correlates With Protection Against Re-Infection by New Variants in Subsequent Waves of the COVID-19 Pandemic

Michelle O. Mullins, Muneerah Smith, Hazel Maboreke, Andrew J. M. Nel, Ntobeko A. B. Ntusi, Wendy A. Burgers, Jonathan M. Blackburn

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: immunoassay; epitope coverage; quantitative antibody binding; protein microarray; SARS-CoV-2 antibodies; humoral response; SARS-CoV-2 re-infection

Online: 27 December 2022 (10:43:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202001.0148.v1

Ultrasound-Guided Nerve Hydrodissection for Pain Management: An Updated Review of Anatomy and Techniques

King Hei Stanley Lam, Chen-Yu Hung, Yi-Pin Chiang, Kentaro Onishi, Thomas B. Clark, Dean K Reeves, Su Daniel

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: nerve hydrodissection; pain management; ultrasonography; neuropathic pain

Online: 15 January 2020 (12:09:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.1016.v1

Significance and Applications of the Microalgae Chlamydomonas and its Bacterial Consortia

María J Torres, Carmen M Bellido-Pedraza, Angel Llamas

Subject: Biology And Life Sciences, Life Sciences Keywords: Algal-microbial consortia; microalga; Chlamydomonas; bioremediation; biofertilization; high-value added products.

Online: 14 June 2024 (11:32:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0256.v1

Evaluation of the Technical Wind Energy Potential of Kisii Region Based on the Weibull and Rayleigh Distribution Models

Laban N. Ongaki, Christopher M. Maghanga, Joash Kerongo

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: wind speed; wind power; scale factor and shape factor

Online: 12 October 2018 (05:13:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202112.0438.v1

X-Ray Diffraction Techniques for Mineral Characterization: A Review for Engineers of the Fundamentals, Applications, and Research Directions

Asif Ali, Yi Wai Chiang, Rafael M. Santos

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: X-ray diffraction; Mineral characterization; Crystal structure; Bragg’s law; Lattice parameters; Crystallography; Unit cell

Online: 27 December 2021 (15:53:09 CET)

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Working Paper ARTICLE

D-Amino Acid Substituted Peptides as Potential Alternatives of Homochiral L-Configurations

Jianxun Shen

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: D-amino acids; homochirality; molecular modeling; secondary structure occupancy; stability

Online: 21 January 2021 (12:44:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1751.v1

CP Violation: Differing Binding Energy Levels of Quarks and Antiquarks, and their Transitions in Λ-baryons and B-mesons

Dimitris M Christodoulou, Demosthenes Kazanas

Subject: Physical Sciences, Particle And Field Physics Keywords: CP Violation; Flavor Symmetries; Properties of Hadrons; Quark Masses; Quark-Gluon Plasma

Online: 22 July 2024 (14:44:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0255.v1

The Interacting Head Motif Structure does not Explain the X-Ray Diffraction Patterns from Relaxed Vertebrate Skeletal and Insect Flight Muscles

Carlo Knupp, Edward Morris, John M. Squire

Subject: Biology And Life Sciences, Biophysics Keywords: bony fish muscle, insect flight muscle, myosin filament structure, myosin crossbridge cycle, thick filament activation, interacting heads motif

Online: 23 July 2019 (10:57:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0239.v1

Intake of the Artificial Sweetener Acesulfame-Potassium Alone and in Combination with a High-Fat Diet Leads to Differential and Sex-Specific Effects on Metabolic Function in Mice

Pania E Bridge-Comer, Mark H. Vickers, Clare M. Reynolds

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: adipose tissue; non-nutritive sweeteners; artificial sweeteners; high-fat diet; glucose intolerance

Online: 8 June 2021 (15:56:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1653.v1

Assessment of Wound Bed Delivery of Galectin-3 to Modulate Macrophage Polarization, Re-epithelialization and Collagen Synthesis in a Murine Model of Excisional Skin Healing

Karrington M McLeod, Madeleine Dr Gregerio, Dylan Tinney, Justin JW Carmichael, David Zuanazzi, Walter L. Siqueira, Amin Rizkalla, Douglas William Hamilton

Subject: Chemistry And Materials Science, Biomaterials Keywords: Wound chronicity; macrophage; keratinocytes; lectins; matricellular proteins; arginase-I, keratin 17; Re-epithelialization

Online: 22 August 2024 (11:43:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0961.v1

Immunogenicity and Safety of a Newly Developed Live Attenuated Varicella Vaccine in Healthy Children: A Multi-National, Randomized, Double-Blinded, Active-Controlled, Phase 3 Study

Ui Yoon Choi, Ki Hwan Kim, Hye-Kyung Cho, Dong Ho Kim, Sang Hyuk Ma, Young Youn Choi, Chun Soo Kim, Maria Rosario Capeding, Ilya Angelica Rochin Kobashi, Hun Kim, Ji Hwa Ryu, Su Jeen Lee, Ho Keun Park, Jong-Hyun Kim

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Varicella; vaccine; immunogenicity; safety; children, clinical trial

Online: 14 July 2023 (03:51:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0167.v1

Use of 3-Way Voting of Machine Learning Algorithms Improves Prediction Performance of the Efficacy of Antisense-Mediated Exon Skipping and Reduces the Computational Burden

Alex Zhu, Shuntaro Chiba, Yuki Shimizu, Katsuhiko Kunitake, Yasushi Okuno, Yoshitsugu Aoki, Toshifumi Yokota

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: antisense oligonucleotides; exon skipping; machine learning; ensemble learning; personalized medicine; n-of-1 therapy; splice switching; genetic disease; splicing; RNA

Online: 9 March 2023 (04:43:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0787.v1

Latent Class Analysis: A Data Discovery Approach for Exploring Dietary Intake Patterns among Sudanese Children Aged 0 to 2

Gamal Saad Mohamed Khamis, Zakaryia M. S. Mohammed, Mohyaldein Salih, Ali Sati, Abaker A. Hassaballa, Asharaf F. A. Mahmoud, Omer M.A. Hamed, Faroug A. Abdalla, Elzain A. Gumma, Ahmad M. A. Adam

Subject: Computer Science And Mathematics, Analysis Keywords: Latent Class Analysis; BIC; AIC; CAIC; SABIC; Machine Learning; dietary patterns; Sociodemographic Factors; Public Health

Online: 12 June 2024 (11:23:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0370.v1

A Novel Design of Oral Appliance for Monitoring the EMG of the Genioglossus Muscle in Wakefulness

Thamer Y Marghalani, Haitham M Al-Angari, Ruwaa M Salamah

Subject: Engineering, Bioengineering Keywords: Obstructive sleep apnea; Genioglossus muscle; Electromyogram; Oral appliance; OSA diagnosis; Dental de-vice.

Online: 4 July 2024 (09:18:54 CEST)

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Obstructive sleep apnea (OSA) is a prevalent source of sleep-disordered breathing, generally caused by common factors in modern life. OSA is most commonly associated with dysfunctions in the genioglossus (GG) muscles. In this study, we present the first version of a medical device that measures the electromyogram (EMG) of the GG. The prototype is composed of a (custom-made) 3D-printed mouthpiece. Impressions were taken for the lower arch and scanned with a lab scanner to be converted into digital impressions. ExoCad software was used to design the appliance. Fusion 360 software was then used to modify the design and create tubes to house the electrodes in a bilateral configuration to secure excellent and continuous contact with the GG muscle. Silver-silver chloride electrodes were incorporated within the appliance through the created tubes to record the muscle EMG. In this preliminary prototype, the EMG amplifier was placed outside the mouth, and isolated electric wires were connected to the amplifier input. Simple tests that included a group of OSA patients and a control group were done during wakefulness to check the comfort and stability of the device, understand the nature of GG EMG, and study which OSA might affect the daytime performance of the GG. The GG EMG was acquired from the participants for 60 seconds at Rest state when the participant rested his tongue without doing any activity. Then, the subject pushes his tongue against the fontal teeth with steady force while keeping the mouth closed (Active state). Several features were extracted from the acquired EMG: The results showed that mean power and standard deviation were higher in the control group than in the OSA group (p < 0.01). Regarding the wavelength during active state, the control group had a significantly longer wavelength than the OSA group (p < 0.01). Meanwhile, the mean frequency was higher in the OSA group (p < 0.01) at rest. Future research should focus on developing the device to be more user-friendly and easily used at home during wakefulness and sleep.

Preprint ARTICLE | doi:10.20944/preprints201806.0202.v1

The Feasibility of Using Marble Cutting Waste in a Sustainable Building Clay Industry

Medhat S. El-Mahllawy, Ayman M. Kandeel, Mahmoud L. Latif , Abdeen M. El Nagar

Subject: Engineering, Architecture, Building And Construction Keywords: marble cutting waste; stabilized clay bricks; hydrated lime; Shaq El-Thoban

Online: 13 June 2018 (05:23:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0018.v1

Select Venous Analytes and Fibrinogen Determination Using Two Methods in Brown Pelicans

Amelia G Gessner-Knepel, Jordan Gentry, Sharon Schmalz, Karen Russell, Jennifer Jill Heatley

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: brown pelican; fibrinogen; chemistry; bloodwork; blood gas

Online: 1 April 2024 (10:13:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1719.v1

Production of Bio-based Polyol from Coconut Fatty Acid Distillate (CFAD) and Crude Glycerol for Rigid Polyurethane Foam Applications

Ma. Louella D. Salcedo, Christine Joy M. Omisol, Anthony O. Maputi, Dave Joseph E. Estrada, Blessy Joy M. Aguinid, Dan Michael A. Asequia, Daisy Jane D. Erjeno, Glenn Apostol, Henry Siy, Roberto M. Malaluan, Arnold C. Alguno, Gerard G. Dumancas, Arnold A. Lubguban

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: coconut fatty acid distillate; rigid polyurethane foam; bio-based polyols; high open-cell content foam; thermal insulating material

Online: 25 June 2023 (05:41:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0459.v1

Chemical Characterization of the Lichen-symbiont Microalga Asterochloris erici and Study of Its Cytostatic Effect on the L929 Murine Fibrosarcoma Cell Line

M. Concepción Matesanz, Mercedes Villa-Carvajal, Javier Linares, Sonia Morante-Zarcero, Isabel Sierra, Eva Barreno, Myriam Catalá, M. Teresa Portoles

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: bioactivity; phytochemistry; cytostatic, cytotoxicity; microalga

Online: 20 May 2021 (09:11:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0284.v1

Building Consensus around the Assessment and Interpretation of Symbiodiniaceae Diversity

Sarah Davies, Matthew H. Gamache, Lauren I. Howe-Kerr, Nicola G. Kriefall, Andrew C. Baker, Anastazia T. Banaszak, Line K. Bay, Anthony J. Bellantuono, Debashish Bhattacharya, Cheong Xin Chan, Danielle C. Claar, Mary Alice Coffroth, Ross Cunning, Simon K. Davy, Javier del Campo, Erika M. Diaz-Almeyda, Jorg C. Frommlet, Lauren E. Fuess, Raul A. Gonzalez-Pech, Tamar L. Goulet, Kenneth D. Hoadley, Emily J. Howells, Benjamin C. C. Hume, Dustin W. Kemp, Carly, D. Kenkel, Sheila A. Kitchen, Todd C. LaJeunesse, Senjie Lin, Shelby McIlroy, Ryan McMinds, Matthew R. Nitschke, Clinton A. Oakley, Raquel S. Peixoto, Carlos Prada, Hollie M. Putnam, Kate Quigley, Hannah G. Reich, James Davis Reimer, Mauricio Rodriguez-Lanetty, Stephanie Rosalas, Osama S. Saad, Eugenia M. Sampayo, Scott Santos, Eiichi Shoguchi, Edward G. Smith, Michael Stat, Timothy G. Stephens, Marie E. Strader, David J. Suggett, Timothy D. Swain, Cawa Tran, Nikki Traylor-Knowles, Christian R. Voolstra, Mark E. Warner, Virginia M. Weis, Rachel Wright, Tingting Xiang, Hiroshi Yamashita, Maren Ziegler, Adrienne M.S. Correa, John Everett Parkinson

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Symbiodinaceae; genetic diversity; coral symbiosis

Online: 21 June 2022 (04:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1277.v1

Impact of Zirconium Carbide Particles on the Microstructure and Mechanical Characteristics of As-Cast and Heat Treated Al7475-Zirconim Carbide Composites

Vijayakumar R, Vidyadhar Pujar, Hemanth Raju T, Jagadeesha T, Udayashankar S, Dayanand M. Goudar, K. Raju, Deesy G. Pinto

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Al7475; Zirconium carbide; Heat Treatment; Tensile Strength; Compression Strength

Online: 17 September 2024 (08:34:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0751.v1

Unravelling Abiotic Stress Physiology in Cotton (Gossypium hirsutum L.): Biotechnological Interventions in Mitigating Abiotic Stress

Akshay M. Patil, Bhausaheb D. Pawar, Sopan Ganpatrao Wagh, Nanasaheb R. Markad, Nandu K. Bhute, Harshraj Shinde, Rahul Mahadev Shelake, Jan Červený, Rajendra. S. Wagh

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Abiotic stress; cotton; CRISPR/Cas9; stress tolerance; stress physiology; heat; drought; salinity.

Online: 13 May 2024 (11:20:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1245.v1

Sulfides, Sulfosalts and Sulfates in the Epithermal Au-Ag-Te Emmy Deposit (Khabarovsk Territory), Far East, Russia: Implications for the Mineralization Process

Tamara Yu. Yakich, Panagiotis Voudouris, Darya V. Levochskaia, Alexey K. Mazurov, Michail V. Shaldybin, Yuriy M. Lopushnyak, Alexey S. Ruban, Alexey E. Erofeev, Mikhail S. Minakov, Prokopiy N. Maximov, Ekaterina A. Sinkina, Ksenia V. Bestemianova, Maxim A. Rudmin

Subject: Environmental And Earth Sciences, Other Keywords: epithermal Au-Ag-Te emmy deposit; far east; pyrite; oscillatory zoning; sulfosalts; Aluminum-Phosphate-Sulfate (APS) minerals

Online: 16 August 2024 (12:43:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0085.v1

Ligand Docking Methods to Recognize Allosteric Inhibitors for G-protein Coupled Receptors

K Harini, S Jayashree, Vikas Tiwari, Sneha Vishwanath, Ramanathan Sowdhamini

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: allosteric ligands; AutoDock; cognate ligands; Tanimoto co-efficient; GPCRs

Online: 3 December 2020 (13:08:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0328.v1

Detection of Sensors Used for Adversarial Examples against Machine Learning Models

Ade Kurniawan, Yuichi Ohsita, Shyam Maisuria, Masayuki Murata

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Adversarial examples; compromised sensor; detection; multiple sensors; human activity recognition

Online: 6 November 2023 (08:19:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0196.v1

Interplay of Sensor Quantity, Placement and System Dimension in POD-based Sparse Reconstruction of Fluid Flows

Balaji Jayaraman, S. M. Abdullah Al-Mamun, Chen Lu

Subject: Engineering, Mechanical Engineering Keywords: sparse reconstruction, sensor placement, SVD, POD, compressive sensing, machine learning

Online: 21 February 2019 (05:31:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0623.v1

Precarious or Decent Work? Perceived Working Conditions and Life Satisfaction of SME Workers in Sylhet, Bangladesh

A H M Belayeth Hussain, Noraida Endut, Sumena Sultana

Subject: Social Sciences, Sociology Keywords: precarity; decent works; life satisfaction; SMEs; PLS-SEM

Online: 26 October 2018 (09:36:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1944.v1

Bitter Gourd (Momordica charantia ) is a Potential Source of Gibberellin GA-3 for Accelerating the Growth of Soybean Plants and Improving the Quality and Quantity of Soybean Production

Dine Agustine, Muhammad Andzar Zulfikar, Iman Permana Maksum, Ika Wiani Hidayat, Reginawanti Hindersah, Safri Ishmayana, Ukun MS Soedjanaatmadja

Subject: Chemistry And Materials Science, Food Chemistry Keywords: Gibberellin; bitter gourd; Momordica charantia; phytohormone; Oryza sativa

Online: 27 July 2023 (13:04:01 CEST)

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Momordica charantia is a plant of the Cucurbitaceae family which is known as bitter gourd and grows widely in tropical and subtropical regions of the world. The various properties of bitter gourd are closely related to the substances or compounds they contain. Bitter gourd contains many secondary metabolites including alkaloids, terpenoids, steroids and flavonoids. These chemical compounds are spread in several parts of the plant such as roots, stems, leaves, and fruit. Apart from containing several organic compounds, bitter melon also contains the phytohormone gibberellin which is quite potential and useful as a biostimulant. The aim of the research was to isolate, purify, and determine the content of gibberellin (GA-3) contained in bitter gourd (M. charantia), and to determine its effect on the vegetative and generative growth of soybean plants, as well as the effect of GA-3 application on the nutritional content of soybean seeds. resulting from. Apart from that, it was also observed the effect of GA-3 application on the chlorophyll content of soybean plants, as well as the activity of the alpha-amylase enzyme in treated soybean seeds. The process of isolation and purification of GA-3 was carried out by thin layer chromatography and adsorption column chromatography on Silica Gel G-60. Characterization of GA-3 was carried out by Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC), Fourier Transform Infrared (FT-IR), and Mass Spectroscopy (MS). RP-HPLC and FTIR results from gibberellin GA-3 isolates showed retention times and wave numbers that were relatively the same as GA-3 standards. From the results of the study it was found that the content of the gibberellin GA-3 hormone in bitter gourd was 4.12 mg/g dry weight. The GA-3 isolate had a significant effect on the growth of soybean plants in both the vegetative and generative phases for each parameter observed compared to the control and 1% NPK fertilizer. The protein content in soybean seeds was 38.17%. The chlorophyll content at the end of the vegetative and generative phases were 33.34 and 11.5 CCI, respectively. The addition of GA-3 isolate increased the activity of the α-amylase enzyme in soybean seeds compared to the control with an average of 271.65 U/mL.

Preprint ARTICLE | doi:10.20944/preprints202010.0430.v1

A Theoretical Model to Study the Interactions of Xanthene-1,2, 3-Triazolyl-N-Riboside and Xanthene-Piperidinyl-Benzisoxazole Based Conjugates With the Insulin: Design, Docking and ADME Studies

Bhaskara Nand, Kamlesh Kumari, PRASHANT SINGH

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Conjugates compounds; insulin; docking; ADME

Online: 21 October 2020 (10:45:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0431.v1

Lipid Profile, Lipoprotein Subfractions, and Fluidity of Membranes in Children and Adolescents with Depressive Disorder: Effect of Omega-3 Fatty Acids in A Double-blind Randomized Controlled Study

Barbora Katrenčíková, Magdaléna Vaváková, Iveta Waczulíková, Stanislav Oravec, Iveta Garaiova, Zuzana Nagyová, Nataša Hlaváčová, Zdenka Ďuračková, Jana Trebatická

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depressive disorder; omega-3 fatty acids; lipid profile; fluidity of membrane; children and adolescents

Online: 20 August 2020 (05:48:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0605.v1

Insight and Recommendations for Fragile X Premutation Associated Conditions from the 5th International Conference on FMR1 Premutation

Flora Tassone, Dragana Protic, Emily Allen, Alison D. Archibald, Anna Baud, W Ted Brown, Dejan B. Budimirovic, Jonathan Cohen, Brett Dufour, Rachel Eiges, Nicola Elvassore, Lidia V. Gabis, Samantha J Grudzien, Deborah Hall, David Hessl, Abigail Hogan, Jessica Ezzell Hunter, Peng Jin, Poonnada Jiraanont, Jessica Klusek, R. Frank Kooy, Claudine M Kraan, Cecilia Laterza, Andrea Lee, Karen Lipworth, Molly Losh, Danuta Z Loesch, Reymundo Lozano, Marsha Mailick, Apostolos Manolopoulos, Verónica Martínez-Cerdeño, Yingratana Amabel McLennan, Robert M. Miller, Alice Montanaro, Matthew W. Mosconi, Sarah Potter, Melissa Raspa, Susan M. Rivera, Katharine Shelly, Peter K. Todd, Katarzyna Tutak, Jun Yi Wang, Anne C Wheeler, Tri Indah Winarni, Marwa Zafarullah, Randi Hagerman

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: FMR1 premutation; FXPAC; FXTAS; FXAND; FXPOI; FMR1 molecular and clinical

Online: 10 July 2023 (10:27:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0232.v1

BMAP-27 Peptide Reduces Proliferation and Increases Apoptosis in Primary and Metastatic Colon Cancer Cell Lines

Alakesh Das, Dikshita Deka, Nabajyoti Baidya, Antara Banerjee, Atil Bisgin, Suman Adhikari, Sheikh F. Ahmad, Asim K Duttaroy, Surajit Pathak

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Colon Cancer; Apoptosis; BMAP-27; Peptide therapy; Molecular Docking; MD-Simulation

Online: 2 August 2023 (13:22:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1251.v1

Improving the Sustainability of Caciocavallo Ragusano Cheese Production and Enhancing Its Role on Consumer Health and Liking

Federica Litrenta, Fabrizio Cincotta, Nunziatina Russo, Carmelo Cavallo, Annalisa Amato, Vincenzo Lopreiato, Maria Merlino, Antonella Verzera, Cinzia Lucia Randazzo, Luigi Liotta

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Cheese fatty acids; polyphenols; sustainability; consumer health

Online: 16 September 2024 (15:30:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1846.v1

An Agile Approach for Adopting Sustainable and Environmentally Friendly Energy Solutions with Advanced Computational Techniques

David Abdul Konneh, Harun Or Rashid Howlader, M. H. Elkholy, Tomonobu Senjyu

Subject: Engineering, Energy And Fuel Technology Keywords: n/a; Sustainable Energy Solutions; Renewable Energy Integration; Multi-Criteria Decision Tool; Advanced Computational Techniques; Grid-Connected hybrid System; Optimization Algorithms; Policy Decision Making Metrics; Environmental Sustainability and Energy Security

Online: 28 April 2024 (09:57:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1945.v1

Perirenal Fat CT Radiomics-Based Survival Model for Upper Tract Urothelial Carcinoma: Integrating Texture Features with Clinical Predictors

Abdulrahman Nasser M Al Mopti, Abdulsalam Mohammed Alqahtani, Ali H D Alshehri, Chunhui Li, Ghulam Nabi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Upper tract urothelial carcinoma; Perirenal fat radiomics; Prognostic modelling; CT imaging; Machine learning; texture analysis; survival; prognosis

Online: 25 September 2024 (04:21:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1607.v1

Insights into Signal Behaviour: Dirichlet Problem and Hyperbolic Series Perspective with Fuzzy Approach

Asokan Vasudevan, Yogeesh N, Raja .N, Girija D.K., Rashmi M, Divyashree J

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Signal Approximation; Mathematical Analysis; Fourier Series; Complex Signals; Dirichlet Problem; School; Fuzzy Logics; Hyperbolic Series Identities; Signal Processing; Signal Modelling

Online: 22 August 2024 (08:25:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1053.v1

Increasing the Photovoltaic Efficiency of Semiconductor (Cu1-xAgx)2ZnSnS4 Thin Thin Films through Ag Content Modification

A. M. Bakry, Lamiaa El-Sherif, S. Hassaballa, Essam Shaaban

Subject: Physical Sciences, Applied Physics Keywords: CdS layer; (Cu1-xAgx)2ZnSnS4 thin layers; Structural analysis; Spectroscopic ellipsometry; Optical properties; Heterojunctions

Online: 17 June 2024 (08:44:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2061.v1

A Verifiable Multi-Secret Sharing Scheme for Hierarchical Access Structure

Irfan Alam, Amal S. Alali, Shakir Ali, Muhammad S. M. ASRI

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: access structure; multi-secret; hierarchy; verification; secret sharing; polynomial

Online: 30 May 2024 (13:46:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1509.v1

Retinal Microcirculation Measurements in Response to Endurance Exercises Analysed by Adaptive Optics Retinal Camera

Maria Anna Żmijewska, Zbigniew M. Wawrzyniak, Maciej Janiszewski, Anna Zaleska-Żmijewska

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: adaptive optics; retinal microcirculation; autoregulation; physical exercise; WRL

Online: 26 March 2024 (11:47:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202406.1800.v1

Synthesis of 2-Azetidinones via Cycloaddition Approaches: An Update

Franca Maria Cordero, Donatella Giomi, Fabrizio Machetti

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: 2-azetidinone; β-lactam; cycloaddition; ketene; imine; isocyanate; nitrone.

Online: 26 June 2024 (08:06:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.2116.v1

Biological Properties of SARS-CoV-2 Omicron Variant Sublineages

Andrey V. Shipovalov, Anna V. Zaykovskaya, Gleb A. Kudrov, Irina A. Drachkova, Maria E. Antonets, Maksim P. Lyukhanov, Sergey A. Bodnev, Tatyana V. Bauer, Tatyana V. Tregubchak, Elena K. Ivleva, Oleg S. Taranov, Oleg V. Pyankov

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2 virus; Omicron variant; coronavirus evolution; Vero E6 cells; BALB/c mice; Syrian hamster

Online: 27 December 2023 (14:30:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0194.v1

SARS-CoV-2 Impact on Red Blood Cell Morphology

Kirill Kondratov, Alexander Artamonov, Vladimir Mikhailovskii, Anastasiya Velmiskina, Sergey Mosenko, Evgeniy Grigoryev, Anna Anisenkova, Yuri Nikitin, Svetlana Apalko, Natalya Sushentseva, Andrey Ivanov, Sergey Shcherbak

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: COVID-19; erythrocyte; red blood cells; cytokine storm; severe COVID-19; low voltage scanning electron microscopy; erythrocyte size

Online: 4 October 2023 (04:10:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0086.v1

mtDNA Single Nucleotide Variants Associated with Type 2 Diabetes

Enrique García Gaona, Alheli García Gregorio, Camila García Jimenez, Mildred Alejandra López-Olaiz, Paola Mendoza-Ramírez, Daniel Fernandez-Guzman, Rolando Alberto Pillado Sánchez, Axel David Soto Pacheco, Laura Yareni Zuñiga, María Guadalupe Sánchez-Parada, Ana Elizabeth González Santiago, Luis Miguel Román Pintos, Rolando Castañeda Arellano, Luis Daniel Hernández-Ortega, Arieh Roldán Mercado-Sesma, Felipe de Jesús Orozco-Luna, Carlos Villa Angulo, Rafael Villa Angulo, Raúl C. Baptista-Rosas

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: mtDNA; mitogenome; Type 2 diabetes; polymorphism; SNP

Online: 5 September 2023 (10:22:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0876.v1

Cellular-Host Interaction of SARS-CoV-2 Gamma Variant

Aline Miranda Scovino, Elizabeth Chen Dahab, Israel Diniz-Lima, Etiele de Senna Silveira, Shana Priscila Coutinho Barroso, Karina Martins-Cardoso, Dirlei Nico, Celio Geraldo Freire-de-Lima, Leonardo Freire-de-Lima, Natalia Valente, Valeria Nacife, Ana Machado, Mia Araújo, Gustavo Fioravanti Vieira, Alex Pauvolid-Corrêa, Marilda Mendonça Siqueira, Alexandre Morrot

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS-CoV-2; P.1 variant; B.1 strain; cytokines; COVID-19; macrophages; neutrophils

Online: 13 July 2023 (04:34:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0438.v1

Self-Starting Soliton-Comb Regimes in χ(2) Microresonators

Boris Sturman, Evgeni Podivilov, Segey Smirnov

Subject: Physical Sciences, Optics And Photonics Keywords: microresonator; frequency comb; soliton; phase matching; walk-off; lithium niobate

Online: 17 April 2023 (10:03:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0381.v1

Simulation of ICESat-2 DEM using Machine Learning Algorithms

Shruti Pancholi, A Abhinav, Ashutosh Bhardwaj

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Cartosat-1; CartoDEM; Digital Elevation Model; DEM interpolation; DEM simulation; Machine Learning; ICESat-2

Online: 23 January 2023 (01:26:40 CET)

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Digital Elevation Model (DEM) is a representation of elevation data that represent terrain with or without overlaying objects of the Earth. It is the ideal and most widely used method for determining topography. DEMs are generated from various techniques such as traditional Surveying, Photogrammetry, InSAR, LiDAR, Clinometry and radargrammetry. It has been observed that mostly LiDAR-generated DEMs provide the best accuracy. The unavailability of LiDAR data in most of the region restricts global researchers from high-resolution and accurate DEMs. The recent launch of ICESat-2 with a 13m beam footprint and 0.7m pulse interval, promises elevations at high orbital precision. Its accuracy is of the order of few centimeters in complex topography, because of this ICESat-2 proves to be a good source to generate high-accuracy DEMs. ICESat-2 provides discrete photon data with elevations of points on the Earth’s surface. Traditional interpolation techniques tend to over-smooth the estimated space and still are unable to justify the complicated continuity in the topographical data. Machine learning algorithms are widely being used to extract patterns and spatial extent in geographic data. To estimate a DEM from ICESat-2 LiDAR point data, machine learning regression algorithms are implemented in this study. The present study has been performed for a plain region of Ghaziabad, Uttar Pradesh, India. Studies have shown that Cartosat-1 DEM V3 R1 product provides an accuracy of the order of 2m in predominantly plain regions, hence taken for this region. Current work focuses on comparing various regression-based machine-learning techniques to interpolate DEM from ICESat-2 data The RMSE of the interpolated DEM resulted from the Gradient Boosting Regressor, Random Forest Regressor, Decision Tree Regressor, and Multi-Layer Perceptron Regressor was 7.13m, 7.01m, 7.15m, and 3.76m, respectively when evaluated against the TANDEM-X DEM of the same region. The MLP Regressor is found to perform the best among the four algorithms tested.

Preprint REVIEW | doi:10.20944/preprints202111.0127.v1

Apoptosis in Type 2 Diabetes, Can It be Prevented?

Agnieszka Kilanowska, Agnieszka Ziółkowska

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Apoptosis; preclinical research; diabetes type 2; HIPPO pathway

Online: 8 November 2021 (11:45:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0221.v1

Bounds on the sum of (log(p))² Terms

Jan Feliksiak

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Infimum of the sum of log p terms squared; Supremum of the sum of log p terms squared; Lower and Upper bounds on the sum of log p terms squared

Online: 9 July 2021 (13:17:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0145.v1

Mouth Washing Impaired SARS-CoV-2 Detection in Saliva

Monique Melo Costa, Nicolas Benoit, Hervé Tissot-Dupont, Matthieu Million, Bruno Pradines, Samuel Granjeaud, Lionel Almeras

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: saliva; COVID-19 diagnosis; coronavirus; SARS-CoV-2

Online: 6 July 2021 (12:26:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0233.v1

Influence of Fermions on Vortices in SU(2)-QCD

Zeinab Dehghan, Sedigheh Deldar, Manfried Faber, Rudolf Golubich, Roman Höllwieser

Subject: Physical Sciences, Acoustics Keywords: quantum chromodynamics; confinement; center vortex model; vacuum structure

Online: 8 April 2021 (11:13:44 CEST)

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