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Subject: Engineering, Industrial And Manufacturing Engineering Keywords: FSAM; AFED; Additive Manufacturing; Aluminum; Tool Design; Process Optimization

Online: 7 February 2024 (12:59:42 CET)

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Additive Friction Extrusion Deposition (AFED) is a recently developed additive manufacturing technique that promises high deposition rates at low forces. Due to the novelty of the process, the underlying phenomena and their interactions are not fully understood, and in particular the processing strategy and tool design are still in their infancy. This work contributes to the state of the art of AFED through a comprehensive analysis of its working principles and an experimental program including a representative sample component. The working principle and process mechanics of AFED are broken down into their individual components. Forces, their origins and effects on the process are described, and measures of process efficiency and theoretical minimum energy consumption are derived. Three geometrical features of the extrusion die are identified as most relevant to the active material flow, process forces and deposition quality: the topography of the inner and outer circular surfaces and the geometry of its extrusion channels. Based on this, the experimental program investigates seven different tool designs in terms of efficiency, force reduction and throughput. The experiments using AA 6061-T6 as feedstock show that AFED is capable of both high material throughput (close to 550 mm³/s) and reduced substrate forces: For example, the forces for a run at 100 mm³/s remained continuously below 500 N, and for a run at 400 mm³/s below 3500 N. Material flow and microstructure of the AFED are assessed from the macrosections. Significant differences are found between the advancing and retracting sides for both process effects and material flow. Banded structures show strong similarities to other solid state processes. The fabrication of the sample components demonstrates that AFED is already capable of producing industrial grade components. In mechanical testing, interlayer bonding defects result in a more brittle failure behavior in the direction of the structure, in the microstructure show strong similarities to other solid-state processes. The manufacturing of the sample components demonstrates that AFED is already capable of producing industrial grade components. In mechanical tests, interlayer bonding defects result in a more brittle failure behavior in the direction of the structure, while in the horizontal direction of the structure mechanical properties corresponding to a T4 temper have been achieved.

Preprint ARTICLE | doi:10.20944/preprints202311.1038.v1

Automobiles’ Acceleration Analysis When Crossing Road Intersections

Federico Scattolin, Alfonso Micucci

Subject: Engineering, Transportation Science And Technology Keywords: Car Acceleration; Traffic Accidents; Road Design; CAV Software Development

Online: 16 November 2023 (11:12:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0902.v1

Spatial Cognition and 3-Dimensional Vertical Urban Design Guidelines - Cognitive Measurement and Modelling for Human Centre Design

Hee Sun Choi, Gerhard Bruyns, Wang Zhang, Sky David Cheng, Saijal Sharma

Subject: Social Sciences, Urban Studies And Planning Keywords: Vertical Urbanism; Human Centric Design; Spatial Cognition and Psychology

Online: 16 October 2023 (08:22:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1972.v1

Designing Effective Instructional Feedback Using Diagnostic and Visualization System: Evidence from a High School Biology Class

Lin Ma, Xuedi Zhang, Zhifeng Wang, Heng Luo

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: instructional feedback; feedback design; cognitive diagnosis; visualization; high school

Online: 28 June 2023 (09:47:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1320.v1

Job Crafting and Work-Life Balance in a Mature Organization

Jarosław Stanisław Kardas

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: job crafting; work-life balance; job design; mature organization

Online: 18 May 2023 (10:03:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0724.v1

Gellan Gum/Alginate Microparticles As Drug Delivery Vehicles: Doe Production Optimization and Drug Delivery

Henrique Carrêlo, Maria Teresa Cidade, João Paulo Borges, Paula Soares

Subject: Chemistry And Materials Science, Biomaterials Keywords: Microparticles; Gellan Gum; Alginate; Design of Experiments; Coaxial airflow

Online: 10 May 2023 (09:53:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0535.v1

Design Path for a Social Robot for Emotional Communication for Children with Autism Spectrum Disorder (ASD)

Sandra Cano, Jaime Díaz-Arancibia, Jeferson Arango-López, Julia Elena Libreros, Matías García

Subject: Computer Science And Mathematics, Robotics Keywords: Human-Robot Interaction; Autism Spectrum Disorder; User-Centered Design

Online: 8 May 2023 (11:57:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0157.v1

Engineering Self-Adaptive Capabilities in Wireless Sensors Based on Control Algorithms and Model-Based Design Methodologies

Raúl Mario Del Toro Matamoros, Andrei Pruteanu, Rodolfo Elias Haber Guerra

Subject: Engineering, Control And Systems Engineering Keywords: self-adaption; wireless sensors; model-based design; control engineering

Online: 8 December 2022 (10:24:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0397.v1

Sustainable Infrastructure 4.0 - Value Chain Integration through Federated Digital Platforms

Konrad Nübel, Michael Bühler, Thorsten Jelinek

Subject: Engineering, Automotive Engineering Keywords: Sustainable Infrastructure; Governance; Design; Protocols; Implementation; Value Chain; Digitalization

Online: 19 July 2021 (09:11:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0266.v1

Cultural Heritage through Design Thinking

Diana Andreescu

Subject: Social Sciences, Anthropology Keywords: design thinking; innovation; creativity; experience; empathy; thinking; consumer; health

Online: 12 May 2021 (11:14:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0178.v1

Footwear Design Strategies for Thai Footwear Industry to Be Excellence in World Market

Adul Adulyanukosol, Thanin Silpcharu

Subject: Business, Economics And Management, Business And Management Keywords: strategies; design; footwear industry; structural equation model; competitive edge

Online: 13 December 2019 (05:27:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0220.v1

How Size Matters: Diversity for Fragment Library Design

Yun Shi, Mark von Itzstein

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: diversity; fragment-based drug discovery; library design; library size

Online: 19 July 2019 (07:54:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0159.v1

Optimizing Conditions for Scandium Extraction from Bauxite Residue Using Taguchi Methodology

Theopisti Lymperopoulou, Paraskevas Georgiou, Lamprini-Areti Tsakanika, Konstantinos Hatzilyberis, Maria Ochsenkuehn-Petropoulou

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: Taguchi method; experimental design; optimization; scandium; extraction; sulfuric acid

Online: 15 March 2019 (09:34:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0513.v1

Learning Transportation Sustainability through Human Powered Vehicle Design - A Ten-Year Experience at Politecnico di Torino

Paolo Baldissera, Cristiana Delprete

Subject: Engineering, Control And Systems Engineering Keywords: project based learning; human powered vehicles; sustainable transportation design

Online: 23 October 2018 (03:42:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0315.v1

Elevating Art Thinking to a Fine Art

Peter Robbins

Subject: Arts And Humanities, Humanities Keywords: Design thinking, Art thinking, Creativity, Strategy, Fine Art, Printmaking

Online: 17 August 2018 (15:51:17 CEST)

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This article uses a contemporary and revelatory case study to explore the relationship between three conversations in the innovation literature: design thinking, creativity in strategy and, the emerging area of art-thinking. Businesses are increasingly operating in a VUCA environment where they need to design better experiences for their customers and better outcomes for their firm and the Arts are no exception. Innovation, or more correctly growth through innovation, is a top priority for business and although there is no single, unifying blueprint for success at innovation, design thinking is the process that is receiving most attention and getting most traction. Design thinking teaches businesses to think with the creativity and intuition of a designer; to show a deep understanding of; and have empathy with the user. But design thinking has limitations. By placing the consumer at the very heart of the innovation process, design thinking can often lead to more incremental than radical ideas. Now there is a new perspective emerging, art-thinking, in which the objective is not to design a journey from current scenario; A to improved position: B. Art thinking requires the creation of B and spends more time in the open ended, problem space, staking out possibilities and looking for uncontested space. In Dublin, we examine a case of the oldest, largest and most prestigious fine art gallery and studio where most of the country’s best-known and successful visual artists both make, exhibit and sell their art. Graphic Studio Dublin is primarily a printmaking studio, established by artists over 60 years ago. It has facilities for woodblock, lino-print, silkscreen, intaglio and carborundum etching spread over four floors of a centrally located studio where the artists have access 24/7. But two years ago it found itself on the brink of collapse having borrowed heavily to invest in new facilities during the period of Ireland’s economic collapse. Its loans were sold to a vulture-fund who were about to foreclose in a move that would have seen a generation of Irish Artists displaced. A new board of directors was empaneled and they introduced some art thinking principles to bring the organisation back from the brink. They used an art-thinking mindset and design thinking tools to restore the fortunes of this venerable, artist-led institution and it worked.

Preprint REVIEW | doi:10.20944/preprints201705.0003.v3

Introducing Sustainability in Value Models to Support Design Decision Making: A Systematic Review

Marco Bertoni

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: sustainability; value modeling; decision support; value driven design; review

Online: 12 June 2017 (13:51:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0658.v1

Quantitative and Qualitative Analysis of Main Effects and Interaction Parameters in Thermoacoustic Refrigerators Performance

Humberto Peredo Fuentes, Carlos Amir Escalante Velazquez

Subject: Physical Sciences, Applied Physics Keywords: Thermoacoustics; Design of experiments; Linear Thermoacoustic Theory; Pearson Analysis; ANOVA; Transfer Function

Online: 9 September 2024 (11:48:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1938.v1

Exploring the Interior Designers’ Attitudes toward Sustainable Interior Design Practices: The Case of Jordan

Mousa S. Mohsen, Rana Matarneh

Subject: Engineering, Architecture, Building And Construction Keywords: Sustainability; Environmental Sustainability; Economic Sustainability; Social Sustainability; Sustainable Interior Design Practices; Jordan

Online: 29 August 2023 (08:58:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1314.v1

High Pressure Processing of Traditional Hardaliye Drink: Effect on Quality and Shelf-Life Extension

Bahar Atmaca, Merve Demiray, Gulsun Akdemir Evrendilek, Nurullah Bulut, Sibel Uzuner

Subject: Biology And Life Sciences, Food Science And Technology Keywords: hardaliye drink; high hydrostatic pressure; shelf-life extension; Box-Behnken design; optimization

Online: 19 June 2023 (07:32:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0448.v1

Optimization of High-Temperature CO₂ Capture by Lithium Orthosilicate-Based Sorbents Using Response Surface Methodology

Eleonora Stefanelli, Flavio Francalanci, Sandra Vitolo, Monica Puccini

Subject: Engineering, Chemical Engineering Keywords: solid sorbent; lithium orthosilicate; CO2 capture; high-temperature; adsorption; design of experiments

Online: 5 July 2024 (06:59:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0759.v1

Feminist Architecture and Challenging Gender-Biased Urbanization through Architectural Practice: An Overview of Equitable Environment

Armita Khalatbari

Subject: Social Sciences, Urban Studies And Planning Keywords: feminist architecture; social inequalities; gender norms; architectural practice-equitable urbanism; inclusive design

Online: 13 March 2024 (17:06:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0712.v1

Extrusion-Based Additive Manufacturing Driven Design and Testing of the Snapping Interlocking Metasurface Mechanism ShroomLock

Philip Gloyer, Lucca Nikita Schek, Hans Lennart Flöttmann, Paul Wüst, Christina Völlmecke

Subject: Engineering, Mechanical Engineering Keywords: additive manufacturing; FFF printing; printing parameters; experiment; interlocking metasurfaces; manufacturing-driven design

Online: 11 October 2023 (10:48:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0608.v1

Investigation of Micro Gas Turbine Systems for High Speed Long Loiter Tactical Unmanned Air Systems

James Large, Apostolos Pesyridis

Subject: Engineering, Mechanical Engineering Keywords: Unmanned Air Vehicles; Micro Gas Turbine Performance; Low Pressure Compressor; Preliminary Design

Online: 25 October 2018 (13:09:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1410.v1

Innovations in Additive Manufacturing: Pressure Capacity Assessment of L-PBF Produced Microchannel Heat Exchangers for Industrial Applications

Jiabao An, Luyao Guo, Junjia Zou, Keliang Zhang, Yiheng Zhong, Taimingwang Liu, Long Huang, Yi Chen

Subject: Engineering, Mechanical Engineering Keywords: Laser Powder Bed Fusion (L-PBF); Microchannel Heat Exchangers; Channel Pressure Capacity; Tube Porosity; Experimental Design

Online: 17 July 2024 (10:57:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1860.v1

Nutritional, Biochemical and Functional Properties of Pearl Millet and Moringa oleifera Leaf Powder Composite Meal Powders

Faith Sibanda, Anthony Olusegun Obilana, Victoria Jideani

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Pearl millet, Moringa oleifera; fermentation; malting; compositing; optimization; mixture design

Online: 26 January 2024 (07:23:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0972.v1

Numerical Simulation of a Dovetail Tee and Its Role in Pipeline Improvement at LNG Fueling Stations

Zhangyang Kang, Rufei Tan, Qiongqiong Yao, Junmiao Zhang

Subject: Engineering, Energy And Fuel Technology Keywords: numerical simulation; liquefied natural gas; tee; fluid dynamics; hydraulic calculation; optimal design

Online: 12 January 2024 (04:04:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0396.v1

Exhaustive Computational Studies on Pyrimidine Derivatives as GPR119 agonist for the Development of Compounds against NIDDM

Priyanshu Nema, Shivangi Agarwal, Shivam Kumar Kori, Ajay Kumar, Varsha Kashaw, Vandana Soni, Arun K Iyer, Sushil Kumar Kashaw

Subject: Biology And Life Sciences, Life Sciences Keywords: Pyrimidine; Homology Modelling; Pharmacophore Mapping; 3D-QSAR; Molecular Docking; ADMET; Drug Design

Online: 9 October 2023 (09:36:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0045.v1

The Emerging Role and Trends of UAE Education Sector in Circular Economy - A Change Management Prospective

Shankar Subramanian Iyer

Subject: Environmental And Earth Sciences, Environmental Science Keywords: circular economy; eco-design; business education; economics education; competencies; Management Education; ADKAR

Online: 5 May 2022 (15:57:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0095.v1

Calibration of Design Fatigue Factors for Offshore Wind Turbine Support Structure Based on Fatigue Test Database

Wangwen Zhao, Wei-Ting Hsu

Subject: Engineering, Mechanical Engineering Keywords: fatigue; design fatigue factor; offshore wind turbine foundation; corrosion fatigue; target reliability

Online: 4 September 2020 (11:00:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202003.0020.v1

Situation Awareness–Oriented Patient Monitoring with Visual Patient Technology: A Qualitative Review of the Primary Research

David W. Tscholl, Julian Rössler, Sadiq Said, Alexander Kaserer, Donat R. Spahn, Christoph B. Noethiger

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: visual patient; patient monitoring; avatar-based technology; situation awareness; user-centered design

Online: 2 March 2020 (00:56:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1005.v1

Could You Evaluate Sounds in a Virtual Environment?: Evaluation Components of Auditory Experience in a Metaverse Environment

Byoungwoo Park, Kiechan Namkung, Younghwan Pan

Subject: Arts And Humanities, Other Keywords: metaverse environment; auditory presence; AUX evaluation; evaluation questionnaire design; principal component analysis

Online: 15 September 2023 (05:33:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0051.v1

Topology Optimization of Large-Scale 3D Morphing Wingstructures

Peter Dørffler Ladegaard Jensen, Fengwen Wang, Ignazio Dimino, Ole Sigmund

Subject: Engineering, Automotive Engineering Keywords: Topology Optimization; Morphing Wing; Aerospace Design Optimization; Smart and Adaptive Structures; Feature Mapping

Online: 2 July 2021 (12:28:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0253.v1

Studies of Halogen Bonding Induced by Pentafluorosulfanyl Aryl Iodides: A Potential Group of Halogen Bond Donors in a Rational Drug Design

Yuji Sumii, Kenta Sasaki, Seiji Tsuzuki, Norio Shibata

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: halogen bonding; fluorine; iodine; pentafluorosulfanyl; titration; ab initio calculation; NMR study; drug design

Online: 25 August 2019 (15:41:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0512.v1

Rational Food Design Targeting Micronutrient Deficiencies in Adolescents: Nutritional, Acoustic-Mechanical and Sensory Properties of Chickpea-Rice Biscuits

Clara Talens, Laura Garcia-Fontanals, Paula Fabregat, Mónica Ibargüen

Subject: Biology And Life Sciences, Food Science And Technology Keywords: micronutrient deficiencies; rational food design; adolescents; biscuits; texture; chickpea flour; targeted nutrition

Online: 28 January 2023 (03:06:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0270.v1

Optimization of Ternary Binders Based on Flash-Calcined Sediments and Ground Granulated Blast Furnace slag Using a Mixture Design

Ahmed Zeraoui, Walid Maherzi, Mahfoud Benzerzour, Nor-Edine Abriak

Subject: Engineering, Civil Engineering Keywords: sediments; circular economy; cement; ternary eco-binders; flash calcination method; mixture design

Online: 15 September 2021 (15:25:47 CEST)

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Preprint ESSAY | doi:10.20944/preprints201704.0120.v2

Synthesis and Anti-Tumor Activity of Oleanolic Acid Derivatives

Kuai ZhenYu, Lei Li, Shengwen Zhan, Chunlin Li, Yuwei Zhao, Hongrong Chen, Yanqiu Meng

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: oleanolic acid derivatives; synthesis; anti-tumor activity; molecular docking; computer-aided drug design

Online: 24 April 2017 (12:08:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0604.v1

People-Centeredness, Chronic Conditions and Diversity Sensitive eHealth: Exploring Emancipation of the ‘Health Care System’ and the ‘Patient’ in Health Informatics

Lars Botin, Pernille S. Bertelsen, Christian Nøhr

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: eHealth; end-user; chronic disease; participatory design; socio-technical; diversity in care

Online: 29 October 2020 (09:30:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0424.v1

The Value of N-of-1 Data in Zoological Medicine: A Methodological Review

Charles O. Cummings, Jessica Eisenbarth, David D.R. Krucik

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: systematic review; meta-analysis; evidence synthesis; RCT; N-of-1 trial; single subject design

Online: 22 December 2022 (07:56:51 CET)

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N-of-1 data are unavoidable in zoological medicine. Accordingly, zoological medicine clinicians and investigators need research techniques that can make use of these data. This article reviews two methodologies for using both observational and experimental N-of-1 data: 1) systematic reviews and meta-analyses of case reports and 2) prospective N-of-1 trials. Systematic reviews of case reports and other observational evidence are formal, unbiased summaries of clinical characteristics of a particular disease-taxon combination. They offer advantages to narrative reviews by minimizing omission of relevant articles, thereby reducing the potential for mischaracterization of the literature. Meta-analyses are extensions of systematic reviews that quantitatively synthesize the data from the included articles. While valuable, systematic reviews and meta-analyses of case reports can have limited interpretations due to publication bias and confounding present in their source materials. In contrast to case reports, N-of-1 trials are prospective study designs that allow clinicians to make strong inferences about the effect of an intervention in a particular patient. They are double-blinded, single patient, multi-crossover studies that are of particular value in fields where it is difficult to recruit sufficient patients for conventional randomized control trials (RCTs), such as zoological medicine. Because they require multiple crossover periods, N-of-1 trials are ideal for evaluating short-acting interventions in patients with somewhat stable chronic diseases, such as osteoarthritis. More complex than conventional therapeutic trials, N-of-1 trials require prior consideration of how to achieve blinding, appropriate placebo controls, quantitative primary outcomes, analysis methods, and ethical approval. Aggregation of N-of-1 trials allows estimation of the average treatment effect across the population with fewer participants than a conventional RCT. While systematic reviews and meta-analyses of case reports can be used to synthesize the observational N-of-1 data already in existence, N-of-1 trials offer an exciting way to prospectively generate strong evidence that will be useful for evidence-based decision-making.

Preprint ARTICLE | doi:10.20944/preprints202303.0078.v1

Study on Imagery Modeling of Solid Wood Chairs in Big Data

Le Xu, Younghuan Pan

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Furniture design; Multidimensional scaling; Kansei engineering; Modeling imagery; Factor analysis; Triangular fuzzy theory

Online: 6 March 2023 (02:02:30 CET)

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With the continuous improvement of people's quality of life and aesthetics, furniture products have higher requirements. Excellent solid wood chairs are the most representative products in furniture to enhance space and taste and whose design may significantly impact consumers' emo-tional experience and purchase decisions. This study aims to evaluate how the modeling imagery of solid wood chairs affects user preferences and emotional experiences. The development of the current era is inseparable from the analysis of big data. Firstly, a representative sample was ob-tained by multidimensional scaling (MDS), and the sample was analyzed and evaluated by fac-tor analysis. Moreover, five groups of adjective vocabulary were selected to describe the model-ing imagery of solid wood chairs, such as "balanced and coordinated", "unique and novel", "prac-tical and simple", "quality and detailed" and "traditional and plain". Further, the triangular fuzzy theory was applied to analyze and discuss the 12 types of solid wood chairs in the five groups of adjective vocabulary. Then the study verified that the differences in the evaluations of the 12 sam-ples in the "unique and novel" and "quality and detailed" groups were significant, but more minor differences in the groups of "traditional and plain", "balanced and coordinated" and "practical and simple". Through comprehensive comparison, five groups with similar modeling imagery were created, and solid wood chairs with different modeling imagery should be placed in suita-ble spaces. According to the results of this study, the evaluation of the modeling imagery of solid wood chairs can not only rely on subjective judgments but can be reasonably described through data analysis and mathematical algorithms. It can scientifically and effectively reflect the poten-tial perception needs of consumers on the modeling imagery of solid wood chairs, as well as help to improve the design efficiency of the furniture product development stage.

Preprint ARTICLE | doi:10.20944/preprints202108.0336.v1

A Novel Solution for Controlling Hardware Components of Accelerators and Beamlines

Victoria Mazalova, Igor Khokhriakov, Olga Merkulova, Alexander Nozik

Subject: Physical Sciences, Applied Physics Keywords: control system; system design; reactive system; physics facility; experiment control; x-ray spectroscopy

Online: 16 August 2021 (12:39:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1295.v1

Innovation of a Novel Low-Power Modified-GDI QCA-Based Logic Circuit

Hamidreza Sadrarhami, S. Mohammadali Zanjani, Mehdi Dolatshahi, Behrang Barekatain

Subject: Engineering, Electrical And Electronic Engineering Keywords: Modified gate diffusion input; Quantum-dot cellular automata; Low-power design; Polarization; QCADesigner

Online: 21 November 2023 (10:48:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0281.v1

Structural Optimization Design of Microfluidics Chips Based on Fast Sequence Pair Algorithm

Chuang Wu, Jiju Sun, Haithm Yahya Mohammed Almuaalemi, A S M Muhtasim Fuad Sohan, Binfeng Yin

Subject: Engineering, Bioengineering Keywords: microfluidic chip; simulated annealing algorithm; fast sequence pair algorithm; structural design; optimization algorithm

Online: 6 July 2023 (02:37:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0517.v1

Conceptualizing the Human Drivers of Low Tree Diversity in Planted Urban Landscapes

Deborah R. Hilbert, Andrew K. Koeser, Michael Andreu, Gail Hansen, Lara A. Roman, Mack Thetford, Grant L. Thompson

Subject: Environmental And Earth Sciences, Environmental Science Keywords: city trees; landscape design; landscape architecture; socio-ecological system; urban ecosystem; urban forest

Online: 30 August 2022 (09:54:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0013.v1

Making Less Vulnerable City: Resilience as a New Paradigm of Smart Planning

Francesca Moraci, Maurizio Francesco Errigo, Celestina Fazia, Gianluca Burgio, Sante Foresta

Subject: Arts And Humanities, Architecture Keywords: resilient urban design; smart planning; climate change; resilient regional laws; pleasant public space

Online: 2 January 2018 (12:03:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2140.v1

Multi-objective Design and Optimization of Hardware Friendly Grid-Based Sparse MIMO Arrays

S. Gokhun Tanyer, Paul Dent, Murtaza Ali, Curtis Davis, SenthinelKumar Rajagopal, Peter F. Driessen

Subject: Engineering, Electrical And Electronic Engineering Keywords: grid-based sparse MIMO arrays; array design and optimization; mitigation of mutual coupling; adaptive desirability function; grating-lobe free arrays; side lobe reduction; machine learning

Online: 26 July 2024 (06:49:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0172.v1

Enhancing the Cell-Free Expression of Native Membrane Proteins by in-Silico Optimisation of the Coding Sequence - An Experimental Study of the Human Voltage-Dependent Anion Channel

Sonja Zayni, Samar Damiati, Susana Moreno-Flores, Fabian Amman, Ivo Hofacker, Eva Kathrin Ehmoser

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cell-free membrane protein expression; translation enhancer; translation initiation; ribosome docking site; sequence design.

Online: 7 July 2021 (10:20:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1033.v2

Designing Microfluidic PCR Chip Device Using CFD Software for the Detection of Malaria

Meynard R. Austria, Jon Patrick T. Garcia, Lemmuel L. Tayo, Alvin R. Caparanga, Bonifacio Jr T. Doma

Subject: Engineering, Bioengineering Keywords: polymerase chain reaction (PCR); Computational Fluid Dynamics (CFD); Plasmodium falciparum; microfluidic chip design

Online: 10 August 2023 (10:30:52 CEST)

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Working Paper ARTICLE

Mechanical Design and Performance Analyses of a Rubber-Based Peristaltic Micro-Dosing Pump

Thomas Zehetbauer, Andreas Plöckinger, Carina Emminger, Umut D. Çakmak

Subject: Engineering, Automotive Engineering Keywords: hydraulic pump; micro-dosing; peristaltic; hyper-elasticity; viscoelasticity; holistic design methodology; elastomer compound

Online: 21 July 2021 (10:12:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0161.v2

High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2

Olujide O. Olubiyi, Maryam Olagunju, Monika Keutmann, Jennifer Loschwitz, Birgit Strodel

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; docking; drug repurposing; natural products; in silico drug design; viral replication inhibition

Online: 1 June 2020 (02:42:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0652.v1

Effects of Supply Chain Design and Collaboration on Customers’ Satisfaction of Instant Noodles in Ekiti State, Nigeria

Oluleye Seun Ogunmola, Kayode Kingsley Arogundade

Subject: Business, Economics And Management, Business And Management Keywords: supply chain management; logistics; collaboration; cooperation; supply chain design; customer satisfaction; distribution; regression; noodles

Online: 29 October 2018 (04:45:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0079.v1

Design and Assessment of an Austenitic Stainless Alloy for Laser Powder Bed Additive Manufacturing

Mariam Assi, Julien Favre, Marcin Brykala, Franck Tancret, Anna Fraczkiewicz

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: alloy design; computational thermodynamics; Laser Powder Bed Fusion (LPBF); austenitic stainless steels ;

Online: 2 September 2024 (09:45:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0693.v1

Management of the Engineering Data for Manufacturing

Gurcan Atakok, Mufit Cun

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Industry 4.0; Product Data Management; Product Life Cycle Management; Concurrent Engineering; Validation of Design

Online: 31 August 2020 (04:17:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1270.v1

An Approach for the Construction of Assistive Technology for People with Disabilities in Educational Processes

Manuela Muñoz Romero, Juan Diego Ochoa Vargas, Yesid Montoya Góez, Mario Alejandro Giraldo Vásquez

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: assistive technology; design thinking; disability; inclusion; low-income; people with disabilities; socioeconomic factors

Online: 22 February 2024 (07:18:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0771.v1

Beyond Brainstorming: Design Thinking as a Catalyst for Transformation

Roberto Moraga-Díaz, Maria Laguna Fernandez

Subject: Business, Economics And Management, Business And Management Keywords: agile; innovation; lean; culture; Co-creation; Design Thinking; customer-centricity

Online: 12 August 2024 (09:28:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1270.v1

From the “One Molecule – One Target – One Disease” Concept towards Looking for Multi-target Therapeutics for Treating Non-polio Enterovirus (Npev) Infections

Hugo Roux, Franck Touret, Pascal Rathelot, Patrice Vanelle, Manon Roche

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Enterovirus; Multi-target directed ligand; Clinical Trials; Combination; Drug design

Online: 16 July 2024 (08:27:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1655.v1

A Two-Stage Twisted Blade μ-Vertical Axis Wind Turbine – An Enhanced Savonius Rotor Design

Andrés Pérez-Terrazo, Martin Moreno, Iván Trejo-Zúñiga, J. Alberto López

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: VAWT; Energy Harvesting; Two-Stage Design; Renewable Energy; Wind Technology

Online: 2 March 2024 (17:13:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1975.v1

Fail-Safe Topology Optimization Using Damage Scenarios Filtering

Wuhe Sun, Yong Zhang, Yunfei Liu, Kai Cheng, Fei Cheng

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: topology optimization; fail-safe design; dage scenarios filtering; snsitivity analysis

Online: 26 December 2023 (09:47:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0893.v1

Characterizing the Digital Twin in Structural Mechanics

Rebecca Richstein, Kai-Uwe Schröder

Subject: Engineering, Mechanical Engineering Keywords: Archetypes, Design, Digital Twin, Structural Health Monitoring, Structural Mechanics, Taxonomy

Online: 12 December 2023 (12:09:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1572.v1

Insights Beyond Functionality: Empowering Digital Mental Health User Experiences Through Participatory Engagement and Evaluation

Harold Ngabo-Woods

Subject: Social Sciences, Psychiatry And Mental Health Keywords: Mental Health; Digital Health; Interaction; User Experience; Participatory Design; Telehealth

Online: 26 November 2023 (05:35:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1734.v1

Rehabilitation Chair Design Based on Functional Technology Matrix and Multi-Level Evaluation Methods

Xinyan Yang, Zhongfeng Zhang

Subject: Public Health And Healthcare, Other Keywords: product design; rehabilitation chair; AHP; entropy weighting; grey relational analysis

Online: 26 September 2023 (13:40:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0830.v1

Improving Borehole Design and Upgrading Its Hydraulic Properties: Case Studies from Unconsolidated Aquifers in Israel

Joseph Guttman, Zigmund Barenblat

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Borehole design; drilling methods enhancements; pumping tests, drilling enhancements ranking

Online: 13 September 2023 (07:59:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0467.v1

Digital Platforms That Do Well and Do Good. Platform Architecture for Sustainability

Andrea Carolina Soto R.

Subject: Business, Economics And Management, Business And Management Keywords: Digital platforms; sustainability; business model design; business models for sustainability

Online: 7 August 2023 (10:42:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1143.v1

Using Wash’Em to design handwashing programmes for crisis-affected populations in Zimbabwe: A Process Evaluation

Astrid Hasund Thorseth, Jennifer Lamb, Constancia Vimbayi Mavodza, Mandikudza Tembo, Anesu Petra Mushangari, Eddington Zinyandu, Thomas Heath, Sian White

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Handwashing; Programme Design; Behaviour Change; Hygiene, Humanitarian Crises; Process Evaluation

Online: 18 July 2023 (05:47:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0158.v1

A Goal-Directed Trajectory Planning using Active Inference in UAV-Assisted Wireless Networks

Ali Krayani, Khalid Khan, Lucio Marcenaro, Mario Marchese, Carlo Regazzoni

Subject: Engineering, Telecommunications Keywords: UAVs; Wireless Networks; Trajectory Design; AI-enabled Radios; Active Inference

Online: 4 July 2023 (07:27:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1854.v1

How Buildings Relate Classifying Architectural Interactions

Marco Enia, Flavio Martella

Subject: Arts And Humanities, Architecture Keywords: Architectural relations; Design theory; Architectural theory; Architectural relations; Relational architecture

Online: 26 May 2023 (04:45:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0660.v2

Signal Design, Detection, and Identification Technology for Ground-Penetrating Communication Based on Ground Electrode Current Field

Jingang He, Zhong Su, Zhan Xu, Yaxing Zha, Xiaowen Wen, Xin Zhou

Subject: Computer Science And Mathematics, Information Systems Keywords: current field; ground-penetrating communication; signal design; detection and identification

Online: 25 May 2023 (05:08:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1608.v1

Greenery-Covered Towers: Examining Innovative Design Approaches

Kheir Al-Kodmany

Subject: Arts And Humanities, Architecture Keywords: high-rise buildings; vegetation; advantages; disadvantages; biophilic design; sustainability; greenwashing

Online: 23 May 2023 (08:06:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0034.v1

Working from Home, Telework, and Psychological Wellbeing? A Systematic Review

Joseph Crawford

Subject: Business, Economics And Management, Business And Management Keywords: remote work; telework; systematic literature review; work design; workforce planning

Online: 2 September 2022 (05:54:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0139.v1

Functionally Graded Material Fabricated by Powder-based Laser Directed Energy Deposition: From Conventional to Complex Concentrated Alloys

Kun Li, Xin Wang, Wei Xiong

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Directed energy deposition; functionally graded materials; precipitation; high-throughput design

Online: 15 April 2022 (08:31:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0102.v1

Ecosystem Thinking and Methods in Design Morphology

Song Qiu, Weizi Xu, Xiao Zhang, Qiang Cui, Siyu Jin

Subject: Arts And Humanities, Architecture Keywords: Design Morphology; Ecosystem Thinking and Methods; Ecological Environment; Form Community

Online: 7 February 2022 (16:31:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0100.v1

A Switched Capacitor Memristor Emulator using Stochastic Computing

Carola de Benito, Oscar Camps, Mohamad Moner Al Chawa, Stavros G. Stavrinides, Rodrigo Picos

Subject: Engineering, Electrical And Electronic Engineering Keywords: memristor; emulator; analog design; switched capacitor; stochastic computing; mixed signal

Online: 7 December 2021 (11:41:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0376.v1

Pumping Schedule Optimization in Acid Fracturing Treatment by Unified Fracture Design

Rahman Lotfi, Mostafa Hosseini*, Davood Aftabi, Alireza Baghbanan, Guanshui Xu

Subject: Engineering, Energy And Fuel Technology Keywords: Acid fracturing; UFD; Optimization; Fracture geometry; Acid type; Design parameters

Online: 26 October 2021 (12:01:51 CEST)

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Working Paper SHORT NOTE

The Tripping Point – Minimum Planting Widths for Small-Stature Trees in Dense Urban Developments

Andrew K. Koeser, Richard J. Hauer, Deborah R. Hilbert, Robert J. Northrop, Hunter Thorn, Drew C. McLean, Allyson B. Salisbury

Subject: Biology And Life Sciences, Forestry Keywords: ecosystem disservices; green infrastructure; site design; tree selection; urban forestry

Online: 31 August 2021 (11:42:48 CEST)

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Preprint ESSAY | doi:10.20944/preprints202102.0247.v1

Using Pathway Modeling to Evaluate and Improve Student-Centered Teaching Practices in Co-Taught College Science Courses

Xinnian Chen, John Redden, Aiyana Bobrownicki, Julia Gill, Mark Graham

Subject: Business, Economics And Management, Accounting And Taxation Keywords: course pathway modeling; student-centered classroom; course evaluation; course design

Online: 10 February 2021 (09:01:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0332.v1

An Egocentric Network Contact Tracing Experiment

Andrew Pilny, C. Joseph Huber

Subject: Social Sciences, Media Studies Keywords: contact tracing; ego networks; experimental design; social networks; field theory

Online: 14 December 2020 (13:06:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202005.0376.v1

Computational Strategies to Combat COVID-19: Useful Tools to Accelerate SARS-CoV-2 and Coronavirus Research

Franziska Hufsky, Kevin Lamkiewicz, Alexandre Almeida, Abdel Aouacheria, Cecilia Arighi, Alex Bateman, Jan Baumbach, Niko Beerenwinkel, Christian Brandt, Marco Cacciabue, Sara Chuguransky, Oliver Drechsel, Robert D. Finn, Adrian Fritz, Stephan Fuchs, Georges Hattab, Anne-Christin Hauschild, Dominik Heider, Marie Hoffmann, Martin Hölzer, Stefan Hoops, Lars Kaderali, Ioanna Kalvari, Max von Kleist, René Kmiecinski, Denise Kühnert, Gorka Lasso, Pieter Libin, Markus List, Hannah F. Löchel, Maria J. Martin, Roman Martin, Julian Matschinske, Alice C. McHardy, Pedro Mendes, Jaina Mistry, Vincent Navratil, Eric Nawrocki, Áine Niamh O'Toole, Nancy Palacios-Ontiveros, Anton I. Petrov, Guillermo Rangel-Piñeros, Nicole Redaschi, Susanne Reimering, Knut Reinert, Alejandro Reyes, Lorna Richardson, David L. Robertson, Sepideh Sadegh, Joshua B. Singer, Kristof Theys, Chris Upton, Marius Welzel, Lowri Williams, Manja Marz

Subject: Biology And Life Sciences, Virology Keywords: virus bioinformatics; SARS-CoV-2; sequencing; epidemiology; drug design; tools

Online: 23 May 2020 (11:01:11 CEST)

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Working Paper REVIEW

Sequencing Enabling Design and Learning in Synthetic Biology

Pierre-Aurelien Gilliot, Thomas E. Gorochowski

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: sequencing; omics; synthetic biology; systems biology; machine learning; biological design

Online: 23 April 2020 (03:47:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0087.v1

While We Wait for a Vaccine Against SARS-CoV-2, Why Not Think About Available Drugs?

Francisco J. Barrantes

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Coronavirus; COVID-19; SARS-CoV-2; design drugs; ACE2; prophylaxis

Online: 7 April 2020 (11:02:13 CEST)

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At the time of reception of this article (April 2, 2020), efforts to develop a specific vaccine against SARS-Cov-2, the causative agent of the coronavirus disease 2019 (COVID-19), had just begun trial phase 1, but full validation of this and other current developments is likely to take many more months to reach completion. The ongoing pandemic constitutes a major health burden of world proportions that is also having a devastating impact on whole economies worldwide, the knock-on effects of which could be catastrophic especially in poorer countries. Alternative measures to ameliorate the impact and hamper or minimally slow down disease progression are urgently called for. This review discusses past and currently evolving data on the etiological agent of the current pandemic, SARS-CoV-2, and its host cell receptors with a view to disclosing alternative drugs for palliative or therapeutic approaches. Firstly, SARS-CoV-2 exhibits marked tropism for cells that harbor the membrane-bound metalloprotease angiotensin-converting enzyme 2 (ACE2) at their plasmalemma, predominantly in cells lining the oral cavity, upper respiratory tract, and bronchoalveolar cells, making these epithelial mucosae the most likely viral receptor cell targets and entry routes. Secondly, the crystal structures of several coronavirus spike proteins in complex with their cell host target receptors, and of SARS-Cov-2 in complex with an inhibitor, are now available at atomic resolution through X-ray diffraction and cryo-electron microscopy studies. Thirdly, viral entry of other viruses has been successfully blocked by inhibiting viral endogenous proteases or clathrin/dynamin-dependent endocytosis, the same internalization pathway followed by ACE2 and some viruses. Fourthly, the target cell-surface receptor molecules and SARS-CoV-2 possess other putative sites for drugs potentially modulating receptor activity or virus processing. A multi-pronged pharmacological approach attacking more than one flank of the viral-receptor interactions is worth considering as a front-line strategy.

Preprint ARTICLE | doi:10.20944/preprints201904.0270.v1

Infeasibility and Structural Bias in Differential Evolution

Fabio Caraffini, Anna Kononova, David Corne

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: structural bias, algorithmic design, differential evolution, population-based algorithms, optimisation

Online: 24 April 2019 (12:16:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0503.v1

Robust Guaranteed-Cost Preview Repetitive Control for Polytopic Uncertain Discrete-Time Systems

Yong-Hong Lan, Xia Jun-Jun

Subject: Engineering, Control And Systems Engineering Keywords: robust control; preview control; repetitive control; controller design; uncertain systems

Online: 20 November 2018 (12:30:14 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0360.v1

Solvents to Fragments to Drugs: MD Applications in Drug Design

Lucas A. Defelipe, Juan Pablo Arcon, Carlos P. Modenutti, Marcelo A. Marti, Adrián G. Turjanski, Xavier Barril

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Molecular Dynamics, CoSolvent Molecular Dynamics, Drug design, Fragment Screening, Docking

Online: 16 October 2018 (12:15:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.2060.v1

Corporate Social Responsibility in Practice: Environmental Solidarity Initiatives in Colombia Under the Framework of Elinor Ostrom's Principles of Organizational Design

Marietta Bucheli, Juan Fernando Álvarez Rodríguez, Michel Casas-Cuestas

Subject: Business, Economics And Management, Business And Management Keywords: solidarity economy; sustainability; organizational design; corporate social responsibility (CSR); climate change and ecological restoration

Online: 2 July 2024 (03:06:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0076.v1

Design and Manufacturing of Conformal Cooling for Hot Stamping Dies Using Hybrid Process of Laser Metal Deposition (LMD) and Milling

Magdalena Cortina, Jon Iñaki Arrizubieta, Amaia Calleja, Eneko Ukar, Amaia Alberdi

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: additive manufacturing; laser metal deposition; hot stamping; die and mold; conformal cooling; design optimization.

Online: 12 December 2017 (15:24:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1344.v1

Advancement in UV-Visible-IR Camouflage Textiles for Concealment of Defense Surveillance against Multidimensional Combat Backgrounds

Md. Anowar Hossain

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: camouflage textiles; camouflage materials-methods-spectral design; combat backgrounds; reflection; UV-Vis-IR

Online: 23 October 2023 (05:45:06 CEST)

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Target detection of defense technology is being rapidly upgraded with modern surveillance technologies. The latest techniques of surveillance are already being implemented for defense applications. Self-protection and hiding from opposing forces are the key principle for protection of special team in defense. Camouflage textiles aims to create confusing objects for target detection of military personnel. These textiles are applied for military protection such as clothing, weapon, vehicle and location hiding nets/tents, etc. The urgent need of camouflage textiles have been formulated with a technical solution and implementation of right camouflage materials for concealment of defense target signature against dry leaves, green leaves, tree bark-woodland combat background; water-marine combat background; sand-desertland combat background; stone-stoneland combat background; snow-snowland combat background; sky combat background and ice-iceland combat background, concrete-concreteland combat background (DGTWSICB) in ultraviolet-visible-infrared (UV-Vis-IR) spectrums. This hypothesis of optical & surveillance engineering has been coalesced for advancement of UV-Vis-IR-DGTWSICB camouflage textiles technology. The principle of camouflage engineering has been approached by broader spectrum probe in UV-Vis-IR rather than Vis ranges only. Furthermore, single formulation of camouflage textiles has been proposed for multidimensional CBs-DGTWSICB. Electromagnetic spectrum, reflection, electron energy, photonic signal and imaging mechanism in UV-Vis-IR have been presented for optical engineering of concealment, detection, recognition and identification of target signature against DGTWSICB. Spectrum relationship of camouflage materials and DGTWSICB materials have been illustrated and compared in UV-Vis-IR spectrums. Camouflage material design, method design & spectral design; adaptive camouflage; techniques for camouflage textile assessment for digital camera and hyperspectral camera imaging; image processing techniques and a hierarchical model have been demonstrated for augmentation of camouflage textiles in UV-Vis-IR illumination. Therefore, anticipated design of camouflage textiles may enhance high-performance innovation for modern surveillance of military protection related to digital camera, hyperspectral camera and radar. This hypothesis includes advance guideline for camouflage textiles design for CBs-DGTWSICB.

Preprint ARTICLE | doi:10.20944/preprints202306.0595.v1

Analysis of Passive Strategies in Traditional Vernacular Architecture

Pedro Moscoso-García, Andrés Cárdenas-Sánchez, Felipe Quesada-Molina

Subject: Arts And Humanities, Architecture Keywords: Vernacular housing; passive design strategies; indoor thermal environment; building energy performance; dynamic thermal simulations

Online: 8 June 2023 (05:17:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0337.v1

Experimental Study into Optimal Configuration and Operation of Two-Four Rotor Coaxial Systems for e-VTOL Vehicles

Jubilee Prasad Rao, Jonathan E. Holzager, Marco Maia, F. Javier Diez

Subject: Engineering, Mechanical Engineering Keywords: e-VTOL vehicles; coaxial rotors; design optimization; operation; experiments; electric propulsion; propeller pitch

Online: 25 May 2022 (03:34:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0763.v1

Overview of Microbial Fuel Cell (MFC) Recent Advancement from Fundamentals to Applications: MFC Designs, Major Elements, and Scalability

Sami G. A. Flimban, Taeyoung Kim, Iqbal Mohammad Ibrahim Ismail, Sang-Eun Oh

Subject: Engineering, Energy And Fuel Technology Keywords: Microbial fuel cell (MFC); fuel cell elements; design; energy generation; Scaling up; configuration

Online: 2 November 2018 (10:04:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0666.v1

Immunotechniques for the Group Determination of Macrolide Antibiotics Traces in the Environment Using a Volume-Mediated Sensitivity Enhancement Strategy

Maksim A Burkin, Anna N Tevyashova, Elena N Bychkova, Artem O Melekhin, Inna A Galvidis

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: macrolide antibiotics; group recognition; hapten design; enzyme-linked immunosorbent assay; immunobeads assay; immunofiltration

Online: 11 September 2023 (10:40:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1301.v1

Structural Analysis and Lightweight Optimization of a Buoyant Rotor-Type Permanent Magnet Generator for a Direct-Drive Wind Turbine

Joon Ha Hwang, Deok-Je Bang, Gang-Won Jang

Subject: Engineering, Mechanical Engineering Keywords: direct drive; Buoyant Rotor-Type Permanent Magnet (BRPM) generator; topology optimization; lightweight design

Online: 19 June 2023 (05:30:23 CEST)

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Working Paper ARTICLE

On the Optimization of the Bus Network Design: An Analytical Approach Based on a Bi-modal Macroscopic Fundamental Diagram

Igor Dakic, Ludovic Leclercq, Monica Menendez

Subject: Social Sciences, Transportation Keywords: Bus network design; Trip length distribution; Bi-modal MFD; Space allocation; Bus operations

Online: 26 June 2020 (12:26:27 CEST)

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Public transport systems are considered to be a crucial aspect of a sustainable urban development, as they allow more passengers to efficiently travel across an urban area at low environmental and economic costs. Multiple factors can influence the public transport level of service. All take roots in the network structure and the operating regime, i.e. how bus lines are arranged atop the street network and how the service frequency is adjusted to meet urban mobility patterns. This is known as the bus network design problem and has been the subject of several studies. The problem is so challenging that most studies until now resort to strong assumptions such as a static description of the peak hour demand, homogeneous user behavior, and equal trip lengths. Potential effects of different types of user behavior and trip lengths patterns on the user and/or operator cost function have not been investigated whatsoever. Moreover, the existing studies have not considered the effects of the bus network structure on private car users, the level of interactions between the two modes, and the passenger mode choice that depends on the traffic conditions. This paper aims to close this gap and provide a general framework considering multiple trip length patterns, two types of user behavior, and the effects that the bus network structure might have on the traffic performance and passenger mode choice. For modeling different trip length patterns, the proposed approach combines all origin-destination pairs with the same trip length and uses the trip length distribution as an intermediate level of abstraction. As such, it allows to solve the optimal bus network design problem in an analytical way, while considering a more realistic setting including network congestion, mixed traffic, and different mode choice decisions depending on trip lengths and walking preferences. Numerical analysis reveals that both, the user behavior and the trip length patterns, have significant effects on the operator and user cost function. Results show that the probability of choosing any given mode is not constant across the user trip lengths, but follows certain distribution. This distribution is not unique, but varies across the trip length patterns, indicating the importance of modeling the mode choice at the trip length level. Finally, the analysis demonstrates the significance of addressing simplifications made in previous studies.

Preprint CONCEPT PAPER | doi:10.20944/preprints201811.0622.v1

A Conceptual Model for Safety-Based Theory of Lean Construction

Soheila Moaveni, Seyed Y. Banihashemi, Mohammad Mojtahedi

Subject: Engineering, Architecture, Building And Construction Keywords: prevention through design; safety climate; lean construction; transformation-flow-value; lean project delivery system

Online: 30 November 2018 (07:57:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0109.v1

A Hybrid Method for Calculating the Chemical Composition of Steel with the Required Hardness After Cooling from the Austenitizing Temperature

Jacek Trzaska, Wojciech Sitek

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: steel; artificial neural networks; genetic algorithm; optimization; materials by design; heat treatment; hardness

Online: 4 December 2023 (04:15:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1168.v1

Advanced Optimization of Surface Characteristics and Material Removal Rate for Biocompatible TI6Al4V using WEDM Process with BBD and NSGA II

Anbazhagan Nagadeepan, Govindarajalu Jayaprakash, Vagheesan Senthilkumar

Subject: Engineering, Mechanical Engineering Keywords: WEDM; Box-behnken design; NSGA-II; material removal rate; surface roughness; Titanium alloy.

Online: 16 June 2023 (04:25:59 CEST)

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Working Paper ARTICLE

Ucuùba (Virola surinamensis) Fat-Based Nanostructured Lipid Carriers for Nail Drug Delivery of Ketoconazole: Development and Optimization Using Box-Behnken Design

Rayanne R. Pereira, Matteo Testi, Francesca Rossi, Jose O.C. Silva Junior, Roseane M. Ribeiro-Costa, Ruggero Bettini, Patrizia Santi, Cristina Padula, Fabio Sonvico

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Amazonian fat; Ucuùba fat; Box Behnken Design; solid lipid nanoparticles; antifungal therapy; onychomycosis

Online: 23 April 2019 (12:57:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0601.v1

Meta-Analysis and Review of in silico Methods in Drug Discovery – Part 1: Technological Evolution and Trends from Big Data to Chemical Space

Arife Uzundurukan, Mark Nelson, Christopher Teske, Md Shahidul Islam, Elzagheid Mohamed, John Victor Christy, Holli-Joi Martin, Eugene Muratov, Samantha Glover, DOMENICO FUOCO

Subject: Biology And Life Sciences, Life Sciences Keywords: Data science; Big data; Data mining; Bioinformatics; Chemometric; Medicinal chemistry; Targets; Knowledge discovery; Artificial intelligence, Machine learning, Deep learning; Data integration; Metadata, Database; QSAR; Collaborative drug discovery; Structure-based drug design; Ligand-based drug discovery; Clinical trials; Product development.

Online: 10 May 2024 (10:15:20 CEST)

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BackgroundThe present review summarizes the state-of-the-art of in silico methods and techniques that are the most useful in drug discovery, their relationship with data science, as well as the successful application of data science, machine learning (ML) and artificial intelligence (AI) applications. A meta-analysis of the various technologies available is furthermore proposed as a guideline for the non-expert, reader relative to the several subject areas is also discussed in this article. The scope of this meta-analysis is to rank the enlisted technologies by their field of applications and to depict the latter according to knowledge accessibility, from students to experts.Method The search strategy utilized for this review first produced a general collection of 900 papers without duplications, which were subsequently streamlined and divided into two independent collections: the top 300 most-cited papers of all time (since 2000) and the papers with the highest interest for a systematic review analysis (high-impact exciting papers). Results In Part 1, we discuss the most cited and quality 97 articles in these top 300 papers most relevant to the field of in silico drug discovery. The different disciplines are listed according to their industrial and economic incurred to society, independently from the “metric” results of how many new drug approvals (NDAs) each discipline has generated to date.ConclusionBig data, the ensemble of known items stored in publicly available databases, has improved our understanding of the many fates of a potential drug candidate during its development and even after its commercialization. Moreover, the combination of new screening techniques and “omics” with old drugs has led to a new paradigm in which the unknown knowledge of any biological molecule and its cellular structure, now plays an important role as a target for a series of yet-to-be-developed drugs: the chemical space. Furthermore, leveraging big data, data science, ML, and AI can revolutionize drug discovery by swiftly analyzing massive datasets, predicting efficacy and safety profiles, streamlining development, cutting costs, and boosting success rates for new drugs. AI also speeds up the search for promising drug candidates, advancing innovative therapies.

Preprint ARTICLE | doi:10.20944/preprints201807.0441.v1

A Feasibility Review of innovative Prefabricated Footing Systems for Residential Structures

Bertrand Teodosio, Shanaka Kristombu Baduge, Tuan Duc Ngo, Priyan Mendis, Maral Tecer, David Heath

Subject: Engineering, Architecture, Building And Construction Keywords: prefabricated footing system; residential structures; reactive soils; modular construction; design for manufacture and assembly

Online: 24 July 2018 (05:45:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2066.v1

Mechanisms and Adsorption Capacities of Natural and Eco-friendly Nanoparticles for Heavy Metals and Phosphate Ions from Water Using the DSD Approach

Jovana Jokić Govedarica, Dragana Tomašević Pilipović, Vesna Gvoić, Đurđa Kerkez, Anita Leovac Maćerak, Nataša Slijepčević, Gábor Kozma, Milena Bečelić Tomin

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Eco-friendly green synthesis; Nano zero-valent iron; Cadmium; Nickel; Definitive screening design

Online: 31 August 2023 (03:03:28 CEST)

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