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Natalia N. Golosova, Andrey L. Matveev, Nina V. Tikunova, Yana A. Khlusevich, Yulia N. Kozlova, Vera V. Morozova, Igor V. Babkin, Tatiana A. Ushakova, Elena V. Zhirakovskaya, Elisaveta A. Panina, Elena I. Ryabchikova, Artem Y. Tikunov

Subject: Biology And Life Sciences, Virology Keywords: antibiotic resistance; bacteriophage; endolysin; antimicrobial agent; Staphylococcus aureus; Staphylococcus epidermidis; biofilm

Online: 23 January 2024 (00:07:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.2176.v1

Sustainability of Olive Modern Planting Systems and Potential Mitigation Strategies against Climate Change

Riccardo Gucci

Subject: Biology And Life Sciences, Plant Sciences Keywords: olive; planting systems; climate change ;

Online: 28 December 2023 (10:19:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1744.v1

Unlocking the Energy Potential of Polymer Waste: Innovations in Recycling and Energy Generation

Mansour Keshavarzzadeh, Madindwa Mashinini

Subject: Engineering, Energy And Fuel Technology Keywords: Energy; polymer; Recycling; pyrolysis; microwave

Online: 22 December 2023 (11:20:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0813.v1

Lactiplantibacillus plantarum from Unexplored Tunisian Ecological Niches: Antimicrobial Potential, Probiotic and Food Applications

Hiba Selmi, Maria Teresa Rocchetti, Vittorio Capozzi, Teresa Semedo-Lemsaddek, Daniela Fiocco, Giuseppe Spano, Ferid Abidi

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Lactic acid bacteria; probiotic; biocontrol; niches; Tunisian; tomato

Online: 12 October 2023 (10:54:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1584.v1

Bioengineering and Assessment of Antibacterial Potential for Silver Nanoparticles Derived from Synechococcus sp.

Reem Mohammed Alharbi, Neveen Abdel-Raouf, Rania Omar, Sherif Hassan, Khaled N.M. Elsayed, Ibraheem Borie M. Ibraheem

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Synechococcus; silver nanoparticles; biogenic; antibacterial agents

Online: 25 September 2023 (05:36:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1103.v1

Momordica balsamina L.: A Plant with Multiple Therapeutic and Nutritional Potential. A Review

Marème Thiaw, Issa Samb, Manon Genva, Mohamed Lamine Gaye, Marie-Laure Fauconnier

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Momordica balsamina L.; Phytotherapy; phytochemicals; biological properties; Nutritional values; cosmeticl uses

Online: 19 September 2023 (03:52:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1000.v1

Recent Advancements in Genome-Targeting Nucleic Acids and Their Potential for Therapeutic Applications

Yu Mikame, Asako Yamayoshi

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: oligonucleotide therapeutic; triplex-forming oligonucleotide; peptide nucleic acid; antigene; genome editing

Online: 14 September 2023 (11:37:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0207.v1

The Potential Use of Peptides in the Fight against Chagas Disease and Leishmaniasis

Nir Qvit, Mulate Zerihun, Mahesh Kumar, Hayelom Berhe

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Neglected tropic diseases; Parasites; Chagas disease; Leishmaniasis; Life cycle; Drug target; Biochemical mechanisms; Pharmacological therapeutics; Peptides

Online: 6 September 2023 (14:52:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1259.v1

Growing in saltwater: biotechnological potential of novel Methylotuvimicrobium- and Methylomarinum-like methanotrophic bacteria

Ekaterina N. Tikhonova, Ruslan Z. Suleimanov, Igor Y. Oshkin, Aleksey A. Konopkin, Diana V. Fedoruk, Nikolai V. Pimenov, Svetlana N. Dedysh

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: methanotrophic bacteria; Methylomonarinum; Methylotuvimicrobium; single-cell protein; growth in seawater; genome analysis.

Online: 17 August 2023 (08:01:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0499.v1

Systems Biology and Cytokines Potential Role in Lung Cancer Immunotherapy Targeting Autophagic Axis

Riya Khilwani, Shailza Singh

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Cytokines; autophagy; NSCLC; therapeutics; IL6; IL17; IL23

Online: 7 August 2023 (10:05:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1440.v1

Anti-inflammatory and Antifibrotic Potential of Longidaza in the Bleomycin-induced Pulmonary Fibrosis

Angelina Pakhomova, Olga Pershina, Pavel Bochkov, Natalia Ermakova, Edgar Pan, Lubov Sandrikina, Yulia Dagil, Lena Kogai, Wolf-Dieter Grimm, Mariia Zhukova, Sergey Avdeev

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: interstitial lung disease; idiopathic pulmonary fibrosis; hyaluronic acid; Longidaza

Online: 21 July 2023 (02:36:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1686.v2

Biotechnological Potential of Microorganisms for Mosquito Population Control and Reduction of Vector Competence

Ricardo de Melo Katak, Amanda Montezano Cintra, Bianca Correa Burini, Osvaldo Marinotti, Jayme A. Souza-Neto, Elerson Matos Rocha

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Biotechnology; microorganisms; bacteria; fungi; vector control; mosquitoes

Online: 27 June 2023 (14:18:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1586.v1

Assessment of Emissions and Potential Occupational Exposure to Carbon Monoxide during Biowaste Composting

Karolina Sobieraj, Karolina Giez, Jacek A. Koziel, Andrzej Białowiec

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: solid waste management; waste treatment; environmental risk assessment; municipal waste; indoor air quality; gas emissions

Online: 22 June 2023 (09:41:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0353.v1

Surface Treatment of Biochar—Methods, Surface Analysis and Potential Applications: A Comprehensive Review

Marlena Gęca, Ahmed M. Khalil, Arvind K. Bhakta, Youssef Snoussi, Piotr Nowicki, Małgorzata Wiśniewska, Mohamed M. Chehimi

Subject: Biology And Life Sciences, Toxicology Keywords: biomass conversion; thermochemical treatment; surface chemical modification; coupling agents; biochar implementation

Online: 20 March 2023 (08:31:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0054.v1

Mechanistic Insights and Therapeutic Potential of Natural Products in Amelioration of Wound Healing

Pooja Sharma, Dinesh Kumar, Richa Shri, Kamal Dua, Fidele Ntie-Kang, Suresh Kumar

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: natural products; wound healing; phytomolecules; cytotocxic; curcumin

Online: 3 March 2023 (03:37:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0005.v1

Potential Forage Hybrid Markets for Enhancing Sustainability and Food Security in East Africa

Jhon Jairo Junca Paredes, Jesús Fernando Flórez Herrera, Karen Johanna Enciso Valencia, Luis Miguel Hernández Mahecha, Natalia Triana Ángel, Stefan Burkart

Subject: Business, Economics And Management, Economics Keywords: potential markets; improved forages; food systems; food security; forage hybrids; nutrition

Online: 1 February 2023 (02:45:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0076.v1

Molecular Docking and Dynamics Identifies Potential Repurposed Drug Candidates for COVID-19 Studies

Mohammed Muzaffar-Ur-Rehman, Chougule Suryakant, Ala Chandu, Banoth Kumar, Renuka Joshi, Snehal Jadhav, Sankaranarayanan Murugesan, Seshadri Vasan

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: COVID-19; drug repurposing; long COVID; molecular docking; molecular dynamics; SARS-CoV-2

Online: 4 January 2023 (09:38:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0221.v1

Prediction of Potential Seagrass Habitat Using Remote Sensing Big Data and Machine Learning

Bohao He, Yanghe Zhao, Siyu Liu, Shahid Ahmad, Wei Mao

Subject: Environmental And Earth Sciences, Oceanography Keywords: seagrass; remote sensing; machine learning; species distribution model (SDM); hybrid model; habitat suitability; niches; meta-heuristic optimization

Online: 15 September 2022 (07:32:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0191.v1

Molecular Detection of the Endosymbiont Wolbachia sp. in Acanthocheilonema Reconditum and Potential Vectors

Yineth Palacios, Reinel Rincón, Angélica Castellanos

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Wolbachia; Aedes sp.; Culex sp.; Ctenocephalides felis; Acanthocheilonema reconditum; poly-merase chain reaction

Online: 16 February 2022 (04:38:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0154.v1

Eﬀects of Lorentz Symmetry Breaking and External Potential on a Relativistic Scalar Particle

Faizuddin Ahmed

Subject: Physical Sciences, Particle And Field Physics Keywords: Lorentz symmetry violation; Relativistic wave-equations; scalar potential; electric & magnetic ﬁeld; biconﬂuent Heun’s Eqiuation

Online: 7 June 2021 (08:47:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0472.v1

Effect of Storage Conditions on Storability and Antioxidant Potential Of Pears CV. ‘Conference’

Grzegorz P. Łysiak, Krzysztof Rutkowski, Dorota Walkowiak-Tomczak

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: rootstock; 1-MCP; cost-effectiveness of technology, controlled atmosphere, cold storage, ORAC, TSS, acidity, firmness

Online: 20 May 2021 (10:12:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0431.v1

Spatio-temporal Evolution and Improvement Potential of Agricultural Eco-efficiency in Jiangsu Province

Zaijun Li, Meijuan Hu, Tao Jin

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: agricultural eco-efficiency; DEA-SBM model; spatio-temporal evolution pattern; improvement potential; Jiangsu Province

Online: 16 April 2021 (10:34:15 CEST)

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Achieving eco-efficiency in agriculture production at low environmental costs is key to sustainable agriculture. Using the DEA-SBM model, this study evaluated the agricultural eco-efficiency of the 77 counties and districts in China’s Jiangsu province from 1999 to 2018 and analyzed its spatio-temporal evolution pattern and influencing factors. The mains conclusions were as follows: (1) The overall agricultural eco-efficiency and its decomposition terms, pure technology efficiency and scale efficiency, exhibited a fluctuating downward trend. The regional inequality in agricultural eco-efficiency had been widening and exhibited a strong positive spatial association. (2) The agricultural eco-efficiency in Jiangsu province presented a “high south and low north” spatial pattern. High-level agricultural eco-efficiency areas were in the Taihu Plain in Sunan, while low-level agricultural eco-efficiency zones are distributed across Subei City. The High-High-type spatial association pattern is concentrated in the Suzhou-Wuxi-Changzhou region, while the Low-Low areas are mainly in the coastal regions of Subei and Suzhong. (3) The spatial pattern of PTE and SE generally exhibited a “high south and low north” distribution. Areas with positive growth in agricultural eco-efficiency, PTE, and SE, were situated in Xuzhou, Nanjing city, and the bordering regions between Yangzhou and Huai’an, and Changzhou and Wuxi. (4) The excessive redundant use and application of pesticides, chemical fertilizer, agricultural diesel, labor, land, and agricultural carbon emission have been the primary factor affecting Jiangsu's agricultural eco-efficiency. Irrigation had also signficantly impacted agricultural eco-efficiency, while mechanical power and agricultural film had minimal effect. The majority of counties and districts in Subei, Suzhong, and Ningzhen Yang Hilly region have issues regarding their excessive usage of chemical fertilizer, pesticide, chemical fertilizer, agricultural diesel, labor, and land. The findings of this study can contribute towards a better understanding of agricultural eco-efficiency and spatial association effect and can help policymakers increase agricultural eco-efficiency.

Preprint REVIEW | doi:10.20944/preprints202104.0068.v1

Classical and microRNA Regulated Epigenetic Mechanisms as Potential Mediators of the Metabolic Syndrome

Farha Ramzan, Mark Hedley Vickers, Richard Francis Mithen

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA methylation; histone modification; epigenetic diet; microRNAs; prediabetes

Online: 2 April 2021 (14:08:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0197.v1

Integrative Systems Biology Approaches to Identify Potential Biomarkers and Pathways of Cervical Cancer

Arafat Rahman Oany, Mamun Mia, Tahmina Pervin, Salem A. Alyami, Mohammad Ali Moni

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Systems biology; cervical cancer; prognostic biomarker; differentially expressed genes.

Online: 5 March 2021 (21:25:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0549.v1

Potential Role of Birds in Japanese Encephalitis Virus Zoonotic Transmission and Genotype Shift

Muddassar hameed, Abdul wahaab, mohsin nawaz, sawar khan, Jawad Nazir, liu ke, jianchao wei, Zhiyong Ma

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Japanese encephalitis virus; birds; genotype shift; JEV genotype I; JEV genotype III

Online: 26 January 2021 (16:47:47 CET)

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Working Paper REVIEW

Tissue Fibrosis, Aging and the Potential Use of Cannabinoids as Anti-Fibrotic Agents

Nazar Pryimak, Mariia Zaiachuk, Olga Kovalchuk, Igor Kovalchuk

Subject: Biology And Life Sciences, Plant Sciences Keywords: fibrosis; medicinal plants; Cannabis sativa; cannabinoids; anti-fibrotic

Online: 22 October 2020 (12:41:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0268.v1

Leishmaniases and Schistosomiasis Comorbidity Potential in Kenya: The Need for Follow Up Studies

Christopher Khayeka-Wandabwa, Christopher O. Anjili, Venny C.S. Nyambati, Lydiah H. Kutima, Joseph K. Choge, Lucy K. Karani, William. Kipchirchir Kemei

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Concomitance; Schistosomiasis; Comorbidity; Leishmaniases; Th1 and Th2

Online: 13 October 2020 (09:44:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0260.v1

The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease

Jingyuan Li, Zuguang Ye

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COPD; muco-obstructive lung diseases; airway mucus hypersecretion; MUC5AC; cell differentiation

Online: 11 August 2020 (09:20:57 CEST)

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Working Paper REVIEW

The Reuse of Public Datasets in the Life Sciences: Potential Risks and Rewards

Katharina Sielemann, Alenka Hafner, Boas Pucker

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: data science; reuse; sequencing data; genomics; bioinformatics; databases; computational biology; open science

Online: 16 July 2020 (12:39:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0105.v1

Nutraceutical and Medicinal Property of Mulberry Fruits: A Review on Its Pharmacological Potential

Amit Mandal

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Mulberry fruit; phytochemicals; bioactive components; pharmacological properties

Online: 7 April 2020 (13:25:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints201910.0189.v1

The Potential Influence of the Microbiome on the Development and Progression of ADHD

Stephanie Bull-Larsen, M. Hasan Mohajeri

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: microbiome; microbiota-gut-brain axis; ADHD; attention-deficit-hyperactive-disorder

Online: 17 October 2019 (09:04:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0120.v1

The potential of different Autotaxin inhibitor types regulating catalysis-dependent and -independent signalling

Fernando Salgado Polo, Anastassis Perrakis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Lysophosphatidic acid; Autotaxin; inhibitor; allosteric; orthosteric; lipid chaperone; signalling, GPCR

Online: 11 September 2019 (13:18:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints201907.0256.v1

Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability

Bart Vanhaesebroeck, Benoit Bilanges, Ralitsa R Madsen, Katie Dale, Evelyn Lau, Elina Vladimirou

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: PI 3-kinase; chromosomal instability; PI3K inhibitor; cancer; tumour evolution; centrosome

Online: 23 July 2019 (11:01:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0249.v1

Methane Hydrate Stability and Potential Reserves in the Levant Basin, Southeastern Mediterranean Sea

Ziv Tayber, Aaron Meilijson, Zvi Ben-Avraham, Yizhaq Makovsky

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: gas hydrates, methane stability, seismic interpretation, Levant basin, eastern Mediterranean, climate change

Online: 22 April 2019 (12:06:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0233.v1

Comparing the Potential of Multispectral and Hyperspectral Data for Monitoring Oil Spill Impact

Shruti Khanna, Maria J. Santos, Susan L. Ustin, Kristen Shapiro, Paul J. Haverkamp, Mui Lay

Subject: Environmental And Earth Sciences, Environmental Science Keywords: vegetation indices; LANDSAT; WorldView-2; RapidEye; AVIRIS

Online: 25 January 2018 (04:37:02 CET)

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Oil spills from offshore drilling and coastal refineries often cause degradation of coastal wetlands that can take a long time to recover. Early oil detection may prevent losses and speed up recovery if monitoring of the initial oil extent, oil impact, and recovery are in place. Satellite imagery data can provide a cost-effective alternative to expensive airborne imagery or labor intensive field campaigns for monitoring effects of oil spills on wetlands. However, these satellite data may be restricted in their ability to detect and map ecosystem recovery post-spill given their spectral measurement properties and temporal frequency. In this study, we assessed whether spatial and spectral resolution, and other sensor characteristics influence the ability to detect and map vegetation stress and die-off due to oil. We compared how well three satellite multispectral sensors: WorldView2, RapidEye and Landsat EMT+, match the ability of the airborne hyperspectral AVIRIS sensor to map oil-induced vegetation stress, recovery, and die-off after the DeepWater Horizon oil spill in the Gulf of Mexico in 2010. We found that finer spatial resolution (3.5m) provided better delineation of the oil-impacted wetlands and better detection of vegetation stress along oiled shorelines in saltmarsh wetland ecosystems. As spatial resolution become coarser (3.5m to 30m) the ability to accurately detect and map stressed vegetation decreased. Spectral resolution did improve the detection and mapping of oil-impacted wetlands but less strongly than spatial resolution, suggesting that broad-band data may be sufficient to detect and map oil-impacted wetlands. AVIRIS narrow-band data performs better detecting vegetation stress, followed by WorldView2, RapidEye and then Landsat 15m (pan sharpened) data. Higher quality sensor optics and higher signal-to-noise ratio (SNR) may also improve detection and mapping of oil-impacted wetlands; we found that resampled coarser resolution AVIRIS data with higher SNR performed better than either of the three satellite sensors. The ability to acquire imagery during certain times (midday, low tide, etc.) or a certain date is also important in these tidal wetlands; WorldView2 imagery captured at high-tide detected a narrower band of shoreline affected by oil likely because some of the impacted wetland was below the tideline. These results suggest that while multispectral data may be sufficient for detecting the extent of oil-impacted wetlands, high spectral and spatial resolution, high-quality sensor characteristics, and the ability to control time of image acquisition may improve assessment and monitoring of vegetation stress and recovery post oil spills.

Preprint ARTICLE | doi:10.20944/preprints201711.0175.v1

Spatial Pattern of Traffic Induced Carbon Monoxide and Potential Health Risk in Karachi

Imran Ahmed Khan, Mudassar Hassan Arsalan

Subject: Environmental And Earth Sciences, Environmental Science Keywords: carbon monoxide; COHb; air pollution; GIS interpolation; spatial analysis; respiratory diseases

Online: 27 November 2017 (09:13:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0090.v1

Self-Perceived Health Among Migrants Seen in Médecins du Monde Free Clinics in Europe: Impact of Length of Stay and Wealth of Country of Origin on Migrants’ Health

Simon Jean-Baptiste Combes, Nathalie Simonnot, Fabienne Azzedine, Abdessamad Aznague, Pierre Chauvin

Subject: Social Sciences, Demography Keywords: migrant health; length of stay; Médecins du Monde; self-perceived health; migration; Human Development Index

Online: 11 June 2019 (09:04:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0761.v1

Anticancer Potential of Valencia Peanut (Arachis hypogaea L.) Skin Extract against Cervical Cancer Cells In Vitro and in Nude Mouse Xenograft Models

Jarckrit Jeeunngoi, Gulsiri Senawong, Sanun Jogloy, Jeerati Prompipak, Arunta Samankul, Suppawit Utaiwat, Khanutsanan Woranam, Banchob Sripa, Thanaset Senawong

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: cervical cancer; apoptosis; Arachis hypogaea L.; drug combination; xenograft model; peanut skin extract

Online: 12 June 2024 (12:17:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0211.v1

Probiotic Potential of Lactobacilli and Bifidobacteria Found in Breast Milk in Gabon: Isolation, Identification, Antibacterial Activity and Perspective for Antibiotherapy.

Brice Boris Legba, Natacha Moussadji, Paulin Essone Ndong, Lamine Saïd Baba-Moussa, Victorien Tamègnon Dougnon, Selidji Todagbé Agnandji, Adjimon Gbènakpon Gatien Lokossou

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Breast milk; Lactobacilli and Bifidobacteria; Probiotic power; Gabon

Online: 2 July 2024 (14:47:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0546.v1

Unlocking Phytate with Phytase: A Meta-Analytic View of Meat-type Chicken Muscle Growth and Bone Mineralization Potential

Emmanuel Nuamah, Utibe Mfon Okon, Eungyeong Jeong, Yejin Mun, Inhyeok Cheon, Byungho Chae, Frederick Nii Ako Odoi, Dong-wook Kim, Nag-Jin Choi

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Broilers; Calcium; Exogenous enzyme; Growth performance; Phosphorus; Mineral utilization; Welfare

Online: 10 June 2024 (09:28:01 CEST)

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The inclusion of exogenous phytase in broiler P and Ca deficient diets in response to heightened concerns over excessive P excretion into the environment over the years has remarkably been documented. However, responses among these studies have been inconsistent because of the several factors affecting P utilization. For this reason, a systematic review with meta-analysis of results from forty-one studies published from 2000 to February 2024 was evaluated to: 1) quantitatively summarize the size of phytase effect on growth performance, bone strength, and mineralization in broilers fed P and Ca deficient basal diets and 2) estimate and explore the heterogeneity of the effect sizes of outcomes using sub-group and meta-regression analyses. The quality of the included studies was assessed using the Cochrane Collaboration’s SYRCLE Risk of Bias checklists for animal studies. Additionally, applying the random-effects models, Hedges’ g effect size of supplementation with phytase was calculated using the R software to determine the standardized mean difference (SMD) at a 95% confidence interval. Sub-group analysis and meta-regression further explored heterogeneity (P_SMD ≤ 0.05, I² > 50%, n ≥ 10). The meta-analysis showed that supplemental phytase increases ADFI and BWG and reduces FCR at each time point of growth (< 0.0001). Additionally, phytase supplementation consistently increased tibia ash, P and Ca, and bone strength (< 0.0001) of broilers fed P and Ca deficient diets. Results of the subgroup and meta-regression analyses showed that age and strain of broiler, dietary P source, and duration of phytase exposure significantly influence the effect size of phytase on growth and bone parameters. In conclusion, phytase can attenuate the effect of reducing dietary available phosphorus and calcium and improve ADFI, BWG, and reduced FCR, especially when added to starter diets. It further enhances bone ash, bone mineralization, and bone-breaking strength of broilers, even though the effects of bone ash and strength can be maximized in the starter phase of growth. However, the effect sizes of phytase were related to the age and strain of the broiler, dietary P source, and duration of phytase exposure rather than the dosage.

Preprint REVIEW | doi:10.20944/preprints202407.2387.v1

Chemical Diversity of Ketosteroids as Potential Therapeutic Agents

Valery M Dembitsky

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ; ketosteroids; microorganisms; fungal endophytes; invertebrates; plant; anticancer activity ;

Online: 30 July 2024 (10:26:40 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.0222.v1

Amentoflavone: Exploring Potential Therapeutic Applications for Diabetes Mellitus

Ivan Vito Ferrari, Mauro Di Mario

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: aldose reductase; diabetes mellitus; amentoflavone; docking analysis

Online: 4 December 2023 (14:49:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1583.v1

A Comprehensive Review on Therapeutic Potential of Nanobodies

Fatma Haddad, Ghadeer Dokmak, Shahla Kanwal, Rafik Karaman

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: nanobody; therapeutic nanobody; production; imaging; diagnosis; single-domain antibodies; VHHs

Online: 25 October 2023 (12:11:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0625.v1

Therapeutic Potential of Anthracene Derivatives for Breast Cancer

Estera Okon, Katarzyna Gawel-Beben, Agata Jarzab, Wojciech Koch, Wirginia Kukula-Koch, Anna Wawruszak

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: anthracene derivatives; breast cancer; natural products; biological activity; emodin; aloe-emodin; hypericin; chrysophanol; rhein; physcion

Online: 11 October 2023 (04:46:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0462.v1

SLO3: A Conserved Regulator of Sperm Membrane Potential

Maximilian D. Lyon, Juan J. Ferreira, Ping Li, Shweta Bhagwat, Alice Butler, Kelsey Anderson, Maria Polo, Celia M. Santi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: membrane hyperpolarization; SLO3; contraception; potassium channels; sperm; acrosomal exocytosis; capacitation; hyperactivated motility; SLO channels; male fertility

Online: 6 June 2023 (14:01:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0926.v1

The Potential of Visual ChatGPT For Remote Sensing

Lucas Prado Osco, Eduardo Lopes de Lemos, Wesley Nunes Gonçalves, Ana Paula Marques Ramos, José Marcato Junior

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: artificial intelligence; image analysis; visual language model

Online: 25 April 2023 (10:47:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0548.v1

Micronutrient Biosynthesis Potential of Spontaneous Grain Fermentation Microbiomes

Margaret I. Dania, Bahram Faraji, James Wachira

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: millet; fermentation; microbiome; metagenomics; vitamins; biosynthesis

Online: 29 November 2022 (09:42:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0200.v1

The Membrane Potential Has a Primary Key Equation

Hirohisa Tamagawa, Toi Nakahata, Ren Sugimori, Bernard Delalande

Subject: Biology And Life Sciences, Biophysics Keywords: membrane potential; Nernst equation; ion adsorption; surface charge; surface potential

Online: 16 May 2022 (08:12:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0194.v1

Helicobacter Pylori Urease: Potential Contributions to Alzheimer’s Disease

Augusto F. Uberti, Natália Callai-Silva, Matheus V. C. Grahl, Angela R. Piovesan, Eduarda G. Nachtigall, Cristiane R. G. Furini, Celia Regina Carlini

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Helicobacter pylori; urease; neuroinflammation; tau hyperphosphorylation; pro-inflammatory cytokines; object recognition test; elevated plus maze; SH-SY5Y neuroblastoma cells; BV-2 microglia

Online: 13 January 2022 (15:37:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0129.v3

A Potential Benefit of Hypochlorous Acid - Facial Sanitisation

Avis Aman Nowbuth, Josh Barrie Armstrong, Thomas Eugene Cloete, Pieter Rousseau Fourie

Subject: Medicine And Pharmacology, Other Keywords: HOCl; hypochlorous; antimicrobial; antiinflammatory; SARS-CoV-2; infections; sanitisation

Online: 3 December 2021 (10:13:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0029.v1

Potential-Growth Indicators Revisited: More Merits of Indication

Dmitrii O. Logofet, Valerii N. Razzhevaikin

Subject: Computer Science And Mathematics, Discrete Mathematics And Combinatorics Keywords: discrete-structured population; matrix population model; population projection matrices; calibration; net reproductive rate; reproductive uncertainty; colony excavation; Diophantine systems

Online: 1 June 2021 (11:49:45 CEST)

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Working Paper REVIEW

The Rationale for Potential Pharmacotherapy of COVID-19

Maha Saber-Ayad, Mohamed A. Saleh, Eman Abu-Gharbieh

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; redmdesivir; cholorquine; therapy; SARS-CoV-2

Online: 10 May 2020 (18:26:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0532.v1

Potential Role of Cellular Senescence on Coronavirus Infections

Prem Chapagain

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: cellular senescence; SARS-CoV-2; coronavirus; aging

Online: 30 April 2020 (13:58:41 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202001.0358.v3

Potential Natural Compounds for Preventing SARS-CoV-2 (2019-nCoV) Infection

Hansen Chen, Qiaohui Du

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: SARS-CoV-2 (2019-nCoV); Baicalin; Scutellarin; Hesperetin; Nicotianamine; Glycyrrhizin

Online: 10 March 2020 (05:09:22 CET)

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Preprint REVIEW | doi:10.20944/preprints201905.0239.v1

Clinical Potential of Oligonucleotide Therapeutics against Pancreatic Cancer

Kazuki Takakura, Atsushi Kawamura, Yuichi Torisu, Shigeo Koido, Naohisa Yahagi, Masayuki Saruta

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: oligonucleotide therapeutics; RNA interference; antisense; aptamer; decoy; pancreatic cancer

Online: 20 May 2019 (10:12:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints201804.0152.v1

Potential Animal Reservoir of Mycobacterium ulcerans: Systematic Review

Avishek Singh, John McBride, Brenda Govan, Mark Pearson

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: mycobacterium ulcerans; animal reservoir; transmission

Online: 11 April 2018 (13:54:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0354.v1

Trichoderma: Population Structure and Genetic Diversity of Species with High Potential for Biocontrol and Biofertilizer Applications

Adnan Ismaiel, Dilip Kumar Lakshman, Prashant P Jambhulkar, Daniel P Roberts

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: biocontrol agent; biofertilizer; sustainable agriculture; Trichoderma species; population structure and genetic diversity

Online: 6 February 2024 (13:15:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0954.v1

Elucidating the Neuroinflammatory and Neuroprotective Activity of Phytochemicals in Cannabis sativa and their potential Entourage Effects

Ahmad K Al-Khazaleh, Xian Zhou, Deep Jyoti Bhuyan, Gerald W Münch, Elaf Adel Al-Dalabeeh, Kayla Jaye, Dennis Chang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neuroinflammatory; Neuroprotective diseases; Phytochemicals; Cannabis Sativa; Entourage effects; Synergistic effects; Terpenes; Flavonoids; Cannabinoids

Online: 13 December 2023 (10:31:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0251.v1

The Interaction between CD4+ T Cells and BDNF in Depression and Its Potential Implications for Therapy

Michel-Edwar Mickael, Norwin Kubick, Jarosław Olav Horbańczuk, Piotr Religa, Mariusz Sacharczuk

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: CD4; TH17,TH2; depression

Online: 5 October 2023 (05:50:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1475.v1

Molecular and Pharmacokinetic Aspects of Acetylcholinesterase Inhibitory Potential of the Oleanane-type Triterpenes and Their Glycosides

Katarzyna Stępnik, Wirginia Kukula-Koch, Wojciech Płaziński

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: acetylcholinesterase inhibitory test; molecular docking; blood-brain barrier permeation; memory impairment; AChE inhibition kinetics

Online: 21 August 2023 (13:46:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0765.v1

Synthesis and Biological Evaluation of New Quinoline and Anthranilic Acid Derivatives as Potential Quorum-Sensing Inhibitors

Ivana Perković, Tanja Poljak, Kirsi Savijoki, Pekka Varmanen, Gordana Maravić-Vlahoviček, Maja Beus, Anja Kučević, Ivan Džajić, Zrinka Rajić

Subject: Medicine And Pharmacology, Pharmacy Keywords: 4-amino-7-chloroquinoline; 1,3,4-oxadiazole; anthranilic acid; synthesis; quorum sensing; anti-biofilm; P. aeruginosa; PQS

Online: 12 July 2023 (21:25:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1546.v1

Assessing Potential Links between Climate Variability and Mean and Extreme Surface Temperatures throughout the United States

Jason Giovannettone

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: climate variability; climate indices; low-frequency oscillations; temperature; ENSO; heat waves; Western Hemisphere Warm Pool

Online: 21 June 2023 (11:55:48 CEST)

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In order to better understand the extent to which global climate variability is linked to the frequency and intensity of heat waves and overall changes in temperature throughout the United States (US), correlations between long-term monthly mean, minimum, and maximum temperatures measured at sites throughout the contiguous US and low-frequency variability of multiple climate indices (CIs) are analyzed over the period 1948 to 2018 using correlation analysis. The Pearson’s correlation coefficient is used to assess correlation strength, while Leave-One-Out Cross-Validation and a bootstrapping technique (p-value) are used to address potential serial and spurious correlation and assess the significance of each correlation. Three parameters defined the sliding windows over which surface temperature and CI values were averaged: window size, lag time between the temperature and CI windows, and the beginning month of the temperature window. A 60-month sliding window size and 0 lag time resulted in the strongest correlations overall; beginning months were optimized on an individual site basis. Strong (r >= 0.60) and significant (p-value <= 0.05) correlations were identified. The Western Hemisphere Warm Pool (WHWP) and El Niño/Southern Oscillation (ENSO) exhibited the strongest links to temperatures in the western US, tropical Atlantic sea surface temperatures to temperatures in the central US, the WHWP to temperatures throughout much of the eastern US, and atmospheric patterns over the northern Atlantic to temperatures in the Northeast and Southeast. The final results were compared to results from previous studies focused on precipitation and coastal sea levels. Regional consistency was found regarding links between the northern Atlantic and overall weather and coastal sea levels in the Northeast and Southeast as well as on weather in the upper Midwest. Though the MJO and WHWP revealed dominant links with precipitation and temperature, respectively, throughout the West, ENSO revealed consistent links to sea levels and surface temperatures along the West Coast. These results help focus future research regarding specific mechanisms of climate variability that appear the exhibit strong links to US regional weather and sea level variability and prediction.

Preprint REVIEW | doi:10.20944/preprints202306.1246.v1

Ruminant Trace Minerals Deficiency and the Potential Link Between the Source and Rumen Interaction. A Review

Antal Vigh, Adriana Dalila Criste, Nicolae Corcionivoschi, Christine Gerard

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: ruminant; trace minerals; solubility; fermentation

Online: 16 June 2023 (13:38:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0513.v1

Mechanisms of Action of Polyacetylenes’ Anti-Inflammatory Function and Their Potential in Cancer Chemoprevention and Treatment

Ruyuf Alfurayhi, Lei Huang, Kirsten Brandt

Subject: Biology And Life Sciences, Food Science And Technology Keywords: polyacetylenes; phytochemicals; anti-inflammatory; anticancer.

Online: 28 January 2023 (03:24:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0097.v1

Design of New Potent and Selective Thiophene-based KV1.3 Inhibitors and their Potential for Anticancer Activity

Špela Gubič, Louise Antonia Hendrickx, Xiaoyi Shi, Žan Toplak, Štefan Možina, Kenny M. Van Theemsche, Ernesto Lopes Pinheiro-Junior, Steve Peigneur, Alain J. Labro, Luis A. Pardo, Jan Tytgat, Tihomir Tomašič, Lucija Peterlin Mašič

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: KV1.3; potassium ion channels; antiproliferative activity; apoptosis; anticancer drugs

Online: 9 May 2022 (03:35:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0346.v1

Micropropagation of Rare Scutellaria Havanensis Jacq. And Preliminary Studies on Antioxidant Capacity and Anti-cancer Potential

Lani Irvin, Yarelia Zavala Ortiz, Kamila Rivera Rivera, Brajesh Nanda Vaidya, Samantha H Sherman, Juan A Negron Berrios, Nirmal Joshee, Alok Arun

Subject: Biology And Life Sciences, Plant Sciences Keywords: Conservation; HCT 116 cells; polyphenol; trichomes

Online: 16 August 2021 (14:50:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0499.v1

Application of NDVI in Environmental Justice, Health and Inequality Studies – Potential and Limitations in Urban Environments

Carsten Juergens, Matthias Fabian Meyer-Heß

Subject: Social Sciences, Geography, Planning And Development Keywords: greenspace; NDVI; environmental justice; greenness; Sentinel; satellite; urban green; health equity

Online: 24 August 2020 (03:07:41 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201612.0122.v1

The Food and Beverage Occurrence of Furfuryl Alcohol and β-myrcene – Two Emerging Potential Human Carcinogens?

Alex O. Okaru, Dirk W. Lachenmeier

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: furfuryl alcohol; β- myrcene; carcinogens; occurrence

Online: 25 December 2016 (08:21:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0307.v1

Bringing onco-innovation to Europe’s healthcare systems: the unexploited potential of biomarker testing, real world evidence and the potential of Tumour Agnostics. The lesson from BRCA1/2 genetic testing

Denis Horgan, Gennaro CILIBERTO, Pierfranco Conte, Giuseppe CURIGLIANO, Luis Seijo, Luis M. Montuenga, Luis Paz-Ares, Marina Chiara Garassino, Penault-Llorca Frederique, Fabrizia GALLI, Isabelle Ray-Coquard, Denis Querleu, David R. Baldwin, Susana Banerjee, Peter H.J. Riegman, Keith Kerr, Benjamin Horbach, Reinhard Büttner, Hendrik Van Poppel, Anders Bjartell, Giovanni Codacci-Pisanelli, Westphalen Christoph Benedikt, Fabien CALVO, Jasmina Koeva-Balabanova, Stephen Hall, Angelo Virgilio Paradiso, Dipak. Kalra, Christa M. Cobbaert, Rocio Varea Mendez, Zorana Maravic, Vassiliki Fotaki, Jaafar Bennouna, Estelle Cauchin, Núria Malats, Iñaki Gutiérrez-Ibarluzea, Benjamin Gannon, Ken Mastris, Chiara Benini, William M. Gallagher, Simonetta Buglioni, Alastair Kent, Elisabetta Munzone, Ivica Belina, Jan P. van Meerbeeck, Michael Joe Duffy, Elzbieta. Sarnowska, Beata Jagielska, Sarah Mee, Ettore Domenico Capoluongo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer biomarkers, BRCA1/2, genomics; European recommendation

Online: 14 August 2020 (04:27:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0462.v1

Somatic Landscape of Intracranial Epidermoid Cysts Reveals Immune-Associated Mechanistic and Potential Actionable Targets

Shruthi Kondaboina, Oscar Parrish, Carolina Angelica Parada, Manuel Ferreira Jr

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Intracranial epidermoid cysts; rare cancers; whole-exome sequencing; targeted therapy

Online: 5 September 2024 (12:10:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1854.v1

Prospects of Creating a Geopark in Ulytau Region of Kazakhstan: Geoheritage and Geotourism Potential

Saida Nigmatova, Heroy ZHOLTAEV, Tatyana Pirogova, Alma Bekbotayeva, Ilnura Madiyarova, Arman Seidali, Balzhan Kalibek, Bakhtyar Kozhakhmet

Subject: Environmental And Earth Sciences, Other Keywords: geoheritage; geoeducation; sustainable tourism; geopark; Ulytau; Central Kazakhstan; Zheskazgan copper deposit

Online: 26 August 2024 (17:03:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1676.v1

Chicken Embryo Fibroblast Viability and Trans-Differentiation Potential for Cultured Meat Production Across Passages

So-Hee Kim, Chan-Jin Kim, Eun-Yeong Lee, Young-Hwa Hwang, Seon-Tea Joo

Subject: Biology And Life Sciences, Food Science And Technology Keywords: chicken embryo fibroblast; cultured fat; cultured meat; adipogenic trans-differentiation; adipocyte; primary fibroblast; passage

Online: 23 August 2024 (07:08:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1754.v1

Angiotensin II alters Mitochondrial Membrane Potential and Lipid Metabolism in Rat Colonic Epithelial Cells

Darby D. Toth, Christopher L Souders II, Sarah J Patuel, Cole D English, Isaac Konig, Emma Ivantsova, Wendi Malphurs, Jacqueline Watkins, Kaylie A Costa, John A Bowden, Jasenka Zubcevic, Christopher J. Martyniuk

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: colonocytes; bioenergetics; lipidomics; lipids; mitochondria; angiotensin II

Online: 23 July 2024 (07:31:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0451.v1

Assessing ChatGPT’s Efficacy and Potential in Conducting Psychological Counseling through Simulations in School Counseling

Yang Ni, Yanzhuo Cao

Subject: Public Health And Healthcare, Health Policy And Services Keywords: ChatGPT; Mental Health; Conversational AI; Psychological Counseling; Efficacy; NLP; Risks; Empathy; School Counseling

Online: 5 July 2024 (00:03:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1529.v1

Investigation of the Potential of Concomitant Radiation Therapy and Gold Nanoparticles for Pancreatic Cancer

Alexandra Martins, Brigida Costa Ferreira, Manuela Gaspar, Sandra Vieira, Joana Lopes, Ana S Viana, António Paulo, Filipa Mendes, Maria Paula Cabral Campello, Rui Martins, Catarina Pinto Reis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pancreatic cancer; megavoltage radiation therapy; gold nanoparticles; cell viability

Online: 24 June 2024 (04:07:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1378.v1

Recent Advance Bakuchiol Application as a Potential Alternative to Retinol in Skincare and Cosmetics

Norisca Aliza Putriana, Patihul Husni, Soraya Ratnawulan Mita

Subject: Medicine And Pharmacology, Pharmacy Keywords: Bakuchiol; anti-aging; anti-hyperpigmentation; anti-oxidant; anti-inflammatory; anti-acne; and anti-melanogenesis

Online: 18 January 2024 (07:23:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0541.v1

Unraveling the Potential of ALK-Targeted Therapies in NSCLC: Comprehensive Insights and Future Directions

Hannaneh Parvaresh, Ghazaal Roozitalab, Fatemeh Golandam, Payam Behzadi, Parham Jabbarzadeh Kaboli

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: NSCLC; ALK inhibitors; lung cancer; targeted therapy; precision medicine

Online: 8 January 2024 (11:27:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2127.v1

Unlocking the Potential of In Vitro Photoautotrophy for Eryngium foetidum: Biomass, Morphophysiology, and Acclimatization

Darlyara Reis Silva, Marion Nayon Braga Soares, Maria Cristina Rocha Silva, Mariana Costa Lima, Vitória Karla de Oliveira Silva-Moraes, Givago Lopes Alves, Anyela Marcela Ríos-Ríos, Aldilene da Silva Lima, Marcos Vinícius Marques Pinheiro, Thais Roseli Corrêa, Diego Silva Batista, Fábio Afonso Mazzei Moura de Assis Figueiredo, Fabrício de Oliveira Reis, Tiago Massi Ferraz, Sérgio Heitor Sousa Felipe

Subject: Biology And Life Sciences, Plant Sciences Keywords: culantro; gas exchange rate; natural ventilation; plant tissue culture; sucrose supplementation; wild coriander

Online: 28 December 2023 (09:04:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1158.v1

An Assessment of Urban Wind Potential and the Stakeholders Involved in Energy Decision-Making

Alexander Vallejo Díaz, Idalberto Herrera Moya, Edwin Garabitos Lara, Cándida K. Casilla Victorino

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: urban wind energy; renewable energy; RACI matrix; energy potential, small wind turbines, Dominican Republic

Online: 15 December 2023 (08:57:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0927.v1

Role and Therapeutic Potential of Non-coding RNAs in Astrocytes during Neonatal Brain Injury

Zhiyi Ye, Tianming Yuan

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: astrocyte; non-coding RNAs; miRNAs; lncRNAs; circRNAs; neonatal brain injury; hypoxic-ischemic; neuroinflammation

Online: 13 December 2023 (11:00:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0243.v1

Exploring Elaeagnus Angustifolia: A Comprehensive Review of its Potential in Cancer Treatment and Management

Zain Z Zakaria, Yasmin Ahen, Nawar Haj Ahmed, Sara Sokary, Hiba Bawadi, Maha Al-Asmakh

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Elaeagnus angustifolia; Russian Olive; fruit extract; therapeutic; malignancy; cancer

Online: 6 November 2023 (01:27:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0084.v1

Chemical Compositions of Essential oil Extracted from Eight Thyme Species and Potential Biological Functions

Yanmei Dong, Ziling Wei, Rui Yang, Yanan Zhang, Meiyu Sun, Hongtong Bai, Meiling Mo, Chunlei Yao, Hui Li, Lei Shi

Subject: Biology And Life Sciences, Plant Sciences Keywords: thyme; essetial oil; chemical type; antioxidant; multivariate statistical analysis

Online: 2 November 2023 (07:20:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1350.v1

In-Silico and In-Vitro Functional Validation of Imidazole Derivatives as Potential Sirtuin Inhibitor

Uma Maheswara Rao Dindi, Suhadha Parveen Sadiq, Sammer Al-Ghamdi, Naif Alrudian, Bin Dayelb Salman, Abdulwahab A. Abuderman, Shahidc Mohammad, Thiyagarajan Ramesh, Ravikumar Vilwanathan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Imidazole; Imidazole derivative; Sirtuins; NSCLC; Epigenetics

Online: 18 August 2023 (09:04:18 CEST)

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Sirtuins are a family of Class III epigenetic modifying enzymes involved in regulating cellular processes through the removal of acetyl groups from proteins. They rely on NAD+ as a coenzyme in contrast with classical HDACs (Class I, II, and IV) that depends on Zn+ for their activation, linking their function to cellular energy levels. There are seven mammalian sirtuin isoforms (SIRT1-7), each located in different subcellular compartments. Sirtuins act as master regulators of cellular homeostasis, responding to changes in nutrient availability and energy status. They play vital roles in diverse physiological and pathological conditions, making them promising therapeutic targets for various diseases, including cancer, neurodegenerative disorders, and metabolic diseases. High levels of SIRT6 are involved in the cancer progression of many tumor types and our previous studies revealed that sirtuin 6 was highly expressed in NSCLC cells and its inhibition potentially favored apoptosis and cell cycle arrest. Sirt6 emerged as a promising target and inhibitors of natural and synthetic sources are highly warranted. Imidazole derivatives are often investigated as sirtuin regulators due to their ability to interact with the binding site and modulate their activity. Imidazole bestows many possible substitutions on its ring and neighboring atoms, to design and synthesize derivatives with specific target selectivity and improved pharmacokinetic properties, optimizing drug development. We recently developed imidazole-based derivatives that potentially inhibited classical HDAC enzymes. Therefore, we evaluated the Sirtuin inhibition activity of our in-house compound comprised of imidazole derivatives and the strongest inhibition was observed with Ethyl 2-[5-(4-chlorophenyl)-2-methyl-1-H-Imidazole-4-yl) acetate against Sirt6 by in-silico and protein expression studies. Our results suggested that Ethyl 2-[5-(4-chlorophenyl)-2-methyl-1-H-Imidazole-4-yl) acetate could be a potential novel sirt6 inhibitor.

Preprint ARTICLE | doi:10.20944/preprints202308.0142.v1

ChatGPT as an Academic Advisor: Its Current State and Future Potential Toward Student Empowerment

Daisuke Akiba, Michelle Fraboni

Subject: Social Sciences, Education Keywords: AI; academic advising; artificial intelligence; advising; chatbot; ChatGPT; higher education; student success; student support

Online: 2 August 2023 (04:13:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2002.v1

COVID-19 Vaccination and Potential Predictors for Vaccination Among Students in Bulgarian Medical Universities

Vanya Rangelova, Ralitsa Raycheva, Ani Kevorkyan, Nevena Ivanova, Momchil Baev, Sara Sariyan, Nikoleta Pamukova, Milena Karcheva, Tsonko Paunov

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; vaccines; hesitancy; attitudes; medical students; healthcare workers

Online: 31 July 2023 (02:20:29 CEST)

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University students, particularly those in the healthcare disciplines, constitute a category of particular interest in regard to COVID-19 vaccines and the attitudes to vaccination, as their future professional role will enable them to inform and educate citizens regarding vaccination. The objectives of the study were to investigate the vaccination coverage with a COVID-19 vaccine among students from different degree programs at the Medical universities in Bulgaria behaviors and attitudes toward vaccination with a COVID-19 vaccine. A prospective cross-sectional study in the period September 2021- March 2022 was conducted. Information on demographics, university program, year of study, general attitudes and behavior towards vaccines and attitudes and personal experience with COVID-19 and COVID-19 vaccines were collected. The chi-square test was used to test for associations and binominal logistic regression was used to identify possible predictors for vaccination. A total of 3050 students with a median age of 22 years, predominantly female took part in the study. Three-thirds of the students (73.5%) have been vaccinated against COVID-19. The main reasons for vaccine hesitancy in both group of students were the fear of side effects and the doubts about the safety of the vaccines although non-vaccinated students significantly more frequently express those fears. Respondents who considered to have: a) limited access to sufficient information to inform COVID-19 vaccine uptake; b) lack of public awareness and education campaigns about effectiveness and safety of COVID-19 vaccines; c) insufficient information about COVID-19 vaccines during the University education; and d) had a positive COVID-19 diagnosis were less likely to be vaccinated. Students who have not completed the mandatory immunization cycle according to country schedule were also less likely to have completed COVID-19 vaccination. The students showed an overall positive attitude towards the COVID-19 vaccines. Promoting informational campaigns that emphasize the vaccine's safety will be more effective to further increase the vaccination coverage with COVID-19 vaccines.

Preprint REVIEW | doi:10.20944/preprints202307.1953.v1

Multiple Roles of RUNX Gene Family in Hepatocellular Carcinoma and Their Potential Clinical Implications

Milena Krajnović, Bojana Kožik, Ana Božović, Snežana Jovanović-Ćupić

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: RUNX; hepatocellular carcinoma; oncogenes; tumour suppressors; biomarkers

Online: 28 July 2023 (09:29:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0608.v1

Educational Model of Electric Potential, Electrochemical Reactions, and Species Transport in PEM Fuel Cell

Ambrož Kregar, Klemen Zelič, Andraž Kravos, Tomaž Katrašnik

Subject: Physical Sciences, Chemical Physics Keywords: Fuel Cell; PEMFC; Modelling

Online: 8 June 2023 (08:25:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2272.v1

The Hypocholesterolemic Potential of the Edible Algae Fucus Vesiculosus: Proteomic and Quantitative PCR Analysis

Rebeca André, Rita Pacheco, Ana Catarina Alves, Hugo M. Santos, Mafalda Bourbon, Maria-Luísa Serralheiro

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Fucus vesiculosus; cholesterol synthesis; cholesterol excretion; , Ezetimibe; , NPC1L1; ABCG5; qRT-PCR; mRNA

Online: 31 May 2023 (14:54:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1466.v1

Phenolic Composition and Wound Healing Potential Assessment of Moroccan Henna (Lawsonia inermis) Aqueous Extracts

Soukaina El Massoudi, Abdellah Zinedine, João Miguel Rocha, Meryem Benidir, Ilham Najjari, Lahsen El Ghadraoui, Meryem Benjelloun, Faouzi Errachidi

Subject: Medicine And Pharmacology, Pharmacy Keywords: Lawsonia inermis; Henna; leaves; phytochemical; wound healing activity; Morocco

Online: 22 May 2023 (05:30:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0836.v1

Analysis of Inverter Circulating Current and Magnetic Potential For flux-weakening Drive of BLDCM

XiaoKun Li, Song Wang, Lidong Xia

Subject: Engineering, Electrical And Electronic Engineering Keywords: BLDC, flux-weakening; circulating current; magnetic potential

Online: 24 April 2023 (09:00:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0491.v1

Therapeutic Potential of Alternanthera Brasiliana and Fridericia Platyphylla Plants on Bone Healing in Rats

Camila Silva de Morais Pinheiro, Vicente pinheiro Neto, Joice Cortez de Sá Sousa, José Ribamar Da Silva Júnior, Cláudia Quintino da Rocha Oliveira, Ellen Caroline da Silva Penha, Thalisson Kaynan Reis Silva, Ícaro Rodrigo Dutra Cunha, Antônio Carlos Romão Borges, Fábio Henrique Evangelista De Andrade, Marilene Oliveira da Rocha Borges

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Bone healing; bone fracture; herbal medicine; osteogenesis; bone alkaline phosphatase

Online: 27 January 2023 (06:31:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0459.v1

Silk Biomaterials is an Essential Tool and Potential Applications in Biomedical Industries-A Review

Rhishika Dutta, Pramod T, Ajay Kumar Oli, Renuka Jyothi S., Vishwanatha T., Veeresh Nandikolmath, Sadashiv S. O., Sharangouda J. Patil

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: silk, biocompatibility, reduced immune response, silk hydrogel, biodegradation, biomaterial

Online: 25 January 2023 (14:19:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0055.v1

Hydrogeophysical, Environmental and Groundwater Potential Assessment in the Ternate Basin, North Maluku Province, Indonesia

Kadri Daud, Henny Pramoedyo, Aminudin Afandhi, Ishardita Pambudi Tama

Subject: Physical Sciences, Applied Physics Keywords: Aquifer, Ternate Island, Regional geology, Groundwater potential, Hydrogeochemistry zone.

Online: 2 November 2022 (11:02:30 CET)

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Ternate Island is a volcanic island resulting from the activity of the Gamalama Volcano which is located in the northern Maluku archipelago, Indonesia. Ternate Island is famous as the only island that produces special spices and is the zero point of the world's spice route because the main producer of cloves is here. As a small island, Ternate Island has several limitations including the availability of water resources. Given the scarcity of surface water on the island of Ternate, groundwater in shallow aquifers and deep aquifers is the main source of fresh water which is important for irrigation activities, tourism, services and supporting urban and industrial infrastructure, as well as drinking water needs for people who live densely and are concentrated in the east. and the southern part of the island which is now the city of Ternate. The phenomenon of groundwater utilization in Ternate City is generally massively carried out to support economic activities in the city of Ternate. The purpose of this study was to evaluate the potential and quality of groundwater resources which are an important part of water management on the island of Ternate by microzoning the quality of groundwater for the sustainability of the city which is famous as the world's spice city based on its groundwater potential. Determination of groundwater samples as many as 67 wells distributed on the island of Ternate, 58 well sample points were categorized as free aquifers (MA-SG) and 7 points of depressed aquifers (SB). Ternate island area of 102 km2 with volcanic geology in 3 rock categories. Geological distribution also affects the hydrogeological potential and groundwater quality on the island of Ternate. Piper's trilinear diagram and stiff diagram methods were adopted for the assessment of the main ion quality of groundwater and the distribution of groundwater potential was interpolated with cubic splines to obtain correlations between sample points based on basic parameters of volcanic hydrogeology. The total potential for groundwater recharge is 1,291 million m3/year, there are 5 groundwater quality zones spread among 67 sample points with 76% distribution of elements Calcium Bicarbonate (CaCO3), Sodium Bicarbonate (NaHCO₂), magnesium bicarbonate Mg(HCO3)2 and widely distributed on the island of ternate, while 25% magnesium chloride (MgCl2) and potassium chloride (KCL) are scattered locally on the island of ternate. On an ongoing basis the bicarbonate facies micro-zonation is hydrogeochemical with local flow interactions in volcanic deposits, where infiltration tends to be close to the groundwater sample point, while the chloride facies is a groundwater zone that is correlated with flow patterns from upstream to downstream and has interacted with magma or was intruded. seawater is characterized by high Ca and TDS.

Preprint REVIEW | doi:10.20944/preprints202208.0530.v1

Potential Co-Disposal of Food Waste and Sewage Sludge in South Africa: A Review

Shalongo Angula, Teboho Mofokeng, David Ikumi, Moses Basitere

Subject: Engineering, Civil Engineering Keywords: Resource recovery; circular economy; food waste; anaerobic co-digestion

Online: 31 August 2022 (03:10:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0355.v1

Thin-Layer Chromatography (TLC) in Screening of Botanicals – its Versatile Potential and Selected Applications

Teresa Kowalska, Mieczysław Sajewicz

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: TLC screening of plants; TLC screening of psychoactive plants; TLC-direct bioautography; effect directed detection; chemotaxonomy of plants; quality control of medicinal plants; quality control of alimentary products; quality control of cosmetic products

Online: 25 July 2022 (07:50:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0417.v1

Nano-lipids based on Ginger Oil and Lecithin as A Potential Drug Delivery System

Hung Quach, Tuong-Vi Le, Thanh-Thuy Nguyen, Phuong Nguyen, Cuu Khoa Nguyen, Le Hang Dang

Subject: Chemistry And Materials Science, Nanotechnology Keywords: lecithin; ginger oil; essential oil; nano-lipid; drug delivery system

Online: 30 June 2022 (08:00:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0061.v1

A Beacon in the Galaxy: Updated Arecibo Message for Potential FAST and SETI Projects

Jonathan H. Jiang, Hanjie Li, Matthew Chong, Qitian Jin, Philip E. Rosen, Xiaoming Jiang, Kristen A. Fahy, Stuart F. Taylor, Zhihui Kong, Jamilah Hah, Zonghong Zhu

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Galaxy; Interstellar; Radio Message; Civilization; Earth; Binary; Radio Telescope

Online: 3 March 2022 (10:24:20 CET)

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