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Preprint ARTICLE | doi:10.20944/preprints201702.0087.v1

Metal-Free α-C(sp³)–H Functionalized Oxidative Cyclization of Tertiary N,N-Diaryl Amino Alcohols: Theoretical Approach for Mechanistic Pathway

Zakir Ullah, Mihyun Kim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: α-C(sp3)–H functionalization; oxidative cyclization; tertiary amine; 6-exo-trig; metal free

Online: 23 February 2017 (10:40:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0499.v1

Psychotic Arousal and the Psychopathology of Acute Schizophrenia. An Exploratory Study of the Experiential Emotional State in Acute Psychosis

Maria Margariti, Ilias Vlachos, Dimitra Mpourazana, Panagiotis Aristotelidis, Miriana Selakoviz, Maria Ifanti, Charalambos Papageorgiou

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: psychotic arousal scale; emotional arousal; psychotic emergence; psychotic experiences; abnormal subjective experiences; abnormal experiential feelings

Online: 7 August 2024 (10:54:58 CEST)

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Background: Increasing research data suggests that dysfunction of emotional brain systems may be an important contributor for the psychophysiology of schizophrenia. However, contemporary psychopathology consistently underestimates the role of emotions in the phenomenology of the disease. Psychotic arousal (PA) is a conceptually-defined psychopathological construct aimed to portray the experiential emotional state of acute psychosis. The concept provides an explanatory model for the emergence of psychosis, and the formation and maintenance of delusions based on neurobiological models on the formation of core consciousness and subjectivity. This is the first exploratory study of the major assumptions, endorsed in the project summarised as follows: 1) Psychotic arousal is a discrete state, eligible to investigation; 2) Abnormal experiential feelings are an integral part of this state; 3) The state is responsive to antipsychotic intervention during the first weeks of treatment.Methods: We developed accordingly the Psychotic Arousal Scale (PAS), explored its first psychometric properties and tested its relation to other psychopathological measures. 55 acute schizophrenia patients were evaluated with the PAS, the Positive and Negative Syndrome Scale, the Brown Assessment of Beliefs Scale, the Hamilton Anxiety, and the Calgary Depression. Cronbach α coefficients, t- test analysis, correlations and mixed linear regression models were applied for testing internal reliability of the scale, associations between parameters and sensitivity to change in three time periods during therapeutic intervention.Results: Results of the study support that (PA) is eligible for investigation as a discrete psychopathological state, abnormal experiential feelings are an integral part of this state, it presents high affinity with other affective measures, its degree of severity relates to the delusions’ conviction, and is amenable to antipsychotics early in treatment during the acute psychotic episode.Conclusions: Findings of this exploratory study are connotative of the presence of an emotional arousal impregnated by abnormal experiential feelings during acute psychosis, largely overlooked by contemporary psychopathology.

Preprint ARTICLE | doi:10.20944/preprints202406.1107.v1

Two-Tier Efficient QoE Optimization for Partitioning and Resource Allocation in UAV-Assisted MEC

Huaiwen He, Xiangdong Yang, Feng Huang, Hong Shen

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Unmanned aerial vehicle; Multi-access edge computing; Task offloading; Large-scale IoT network; Shrinkage ratio

Online: 17 June 2024 (08:02:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1525.v1

Validity evidence for using the Situational Motivation Scale to assess pre-clerkship medical student motivation.

Brian Wasicek, Douglas McHugh

Subject: Medicine And Pharmacology, Other Keywords: Medical students; motivation; situational motivation scale; SIMS validity evidence; undergraduate medical education; pre-clerkship curriculum

Online: 23 May 2024 (09:50:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1310.v1

Large-Scale Solar Potential Analysis as a Use Case of Urban Digital Twins

Evgeny Shirinyan, Dessislava Petrova-Antonova

Subject: Engineering, Architecture, Building And Construction Keywords: 3D city model; urban digital twin; solar radiation analysis; CAD tool application at city scale

Online: 20 May 2024 (20:16:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1768.v1

Pilot Testing of Useful Tools Validity for Frailty Assessment in Greece: Translated PRISMA-7 Tool, Modified Fried Criteria and Clinical Frailty Scale

George Soulis, Efstathia Kyriakopoulou, Aristea Leventouri, Eleni Zigkiri, Vasiliki Efthymiou, Zikos Kentros, Anastasia Koutsouri

Subject: Public Health And Healthcare, Primary Health Care Keywords: Frailty; Greek Translation of PRISMA-7; Modified Fried criteria; Greek version of Clinical Frailty Scale

Online: 28 March 2024 (12:12:26 CET)

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The importance of frailty in older people is getting constant recognition as an important aspect both in terms of public health, as well in personal level for the appropriate management of an older person health condition. This is reflected by the continuously increasing number of research studies carried out in several settings across different countries. Sometimes this is very solid, but in other cases there is a considerable gap in terms of accurate and well grounded documentation of frailty status. This is the case in Greece, where we are missing clinically validated tools to approach frailty. We are missing frailty screening tools, such as for instance PRISMA 7, the gold standard tool of Fried criteria is somehow problematic since the question referring to physical activity originates from a questionnaire that has not been translated and validated, while Clinical Frailty Scale has been validated for the translation but not for the capacity to detect frailty. Aim of this study is to validate these tools for their accuracy to detect frailty by using a measurable index of frailty, previously proposed for use in clinical studies: the Short Physical Performance Battery (SPPB). 74 male and female participants have been evaluated for their frailty status using different tools. We observed that PRISMA 7 translation detects frailty only when one question is removed at a cut-off of ≥ 2 and indicated a sensitivity of 88.1%, and specificity of 99.9% with a good correlation with SPPB measurements (r = 0.858; p < 0.001). When CFS was validated using SPPB it demonstrated a very good correlation (r = -0.838; p < 0.001 respectively) as it was the case for the modified Fried Criteria (r = -0.725; p < 0.001). All items demonstrated a good correlation between them. We can here propose that we can accurately assess frailty status in the community setting by using a modified version of Fried criteria, Clinical Frailty Scale translation in Greek and we can screen for frailty by using the Greek translation of PRISMA 7 only after removing the item 6 of the questionnaire.

Preprint ARTICLE | doi:10.20944/preprints202403.0136.v1

Integrating Genome-Scale Metabolic Models with Patient Plasma Metabolome to Study Endothelial Metabolism In Situ

Fernando Silva-Lance, Isabel Montejano-Montelongo, Eric Bautista, Lars K. Nielsen, Pär I. Johansson, Igor Marin de Mas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Metabolic Network Analysis; Genome-Scale Metabolic Models; Exo-Metabolomics Integration; Sampling Algorithms; Endothelial Cell Metabolism

Online: 4 March 2024 (14:02:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1569.v1

Experimental and Numerical Study of the Effect of Carbonate Rock Dissolution on Absolute Permeability of 408 Heterogeneous and Naturally Fractured Samples

Zhibek K. Akasheva, Bakytzhan K. Assilbekov, Darezhat A. Bolysbek, Berik A. Iskakov, Kenbai Sh. Uzbekaliyev, Gani I. Issayev

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Absolute permeability; pore-scale modeling; percolation threshold porosity; dissolution; power law; X-ray microcomputed tomography

Online: 24 November 2023 (11:27:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1702.v1

Research on the Shock Environment Characteristics of Marine Diesel Engine Based on a Large Floating Impact Platform

Yu Zhang, Jun Li, Chun hui Zhang, Wei Chen, Zhi peng Du, Xiao bin Li

Subject: Engineering, Marine Engineering Keywords: large-scale floating shock platform (LFSP); shock environments; underwater explosion; marine diesel engines; shock spectra

Online: 26 October 2023 (11:40:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1180.v1

Piloting Bioethanol Production from Source-Separated Food Waste Boosts TRL

Fotis Chatzimaliakas, Diogenis Christianides, Dimitris Malamis, Sofia Mai, Elli Maria P. Barampouti

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: Source-separated kitchen waste; Simultaneous saccharification and fermentation; Bioethanol yield; Pilot-Scale; Fresh food waste

Online: 22 October 2023 (09:05:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0774.v1

Comparative Study of Two Commercial Brain Volumetry Software: Assessing Medial Temporal Lobe Atrophy

Jimin Kim, Se Won Oh, Jee-Young Kim, Regina EY Kim, Donghyeon Kim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; volumetry software; MRI; medial temporal lobe atrophy; Scheltens’ scale; NeuroQuant®; Aqua®

Online: 12 October 2023 (05:35:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0676.v1

Remaining Useful Life Prediction of Rolling Bearings Based on Multi-scale Permutation Entropy and SSA-LSTM

Hongju Wang, Xi Zhang, Mingming Ren, Tianhao Xu, Chengkai Lu, Zicheng Zhao

Subject: Engineering, Mechanical Engineering Keywords: remaining useful life; maximum correlation kurtosis deconvolution; multi-scale permutation entropy; long short-term memory

Online: 11 September 2023 (11:30:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0762.v1

Burden of Care of Family Caregivers for People Diagnosed with Serious Mental Disorders in a Rural Health District in Kwa-Zulu-Natal, South Africa

Jabulile Thembelihle Ndlovu, Kebogile Elizabeth Mokwena

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Zarit Burden Interview scale; burden of care; home care giving; severe mental illness; rural setting

Online: 10 August 2023 (05:32:21 CEST)

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Jabulile Ndlovu1 and Kebogile Mokwena1, 2 1 Department of Public Health, Sefako Makgatho Health Sciences University, Pretoria, South Africa 2 Research Chair in Substance abuse and population Mental Health, Sefako Makgatho Health Sciences University, Pretoria, South Africa Corresponding author: jabulilendlovu5@gmail.com Abstract An estimated 6% of the world population has serious mental illness, with one in four families having a member with some form of psychiatric disorder, who are mostly cared for by their relatives within a family setting. Although caregiving in a home setting is reported to be associated with significant mental distress, the burden of such distress is rarely measured. The purpose of this study was to quantify the burden of care among family caregivers of relatives with serious mental disorders, as well as to explore possible association between the caregiver burden of care and a range of caregiver and Mental Health Care User (MHCU) variables in a rural district in Kwa-Zulu Natal, South Africa. The Zarit Burden Interview (ZBI) scale was used to collect data from 357 caregivers, and STATA 14 was used to analyze data. The ages of the sample ranged from 18 to 65, with a mean of 50.29, and the majority (86%) were female and unemployed (83%). The ZBI scores ranged from 8 to 85, with a mean of 41.59. The majority (91%) tested positive for caregiver burden of care, which ranged from mild to severe. Using the Pearson Chi-square test of association (p=0.05), variables that were significantly associated with the burden of care were clinically related (caregiver self-reported depression, MHCU diagnosis, recent relapse of the MHCU), socio-economic (caregiver family monthly income, MHCU disability grant status and MHCU employment status) and socio-demographic (MHCU gender and MHCU level of education). The prevalence of burden of care is high and severe, and scarcity of resources in families and communities contribute to the high burden of care in these rural communities.

Preprint ARTICLE | doi:10.20944/preprints202307.0346.v1

Characterisation of the Contact between Cross-Country Skis and Snow: On the Multi-Scale Interaction between Ski Geometry and Ski-Base~Texture

Kalle Kalliorinne, Gustav Hindér, Joakim Sandberg, Roland Larsson, Hans-Christer Holmberg, Andreas Almqvist

Subject: Engineering, Mechanical Engineering Keywords: Cross-Country Skiing; Sports Equipment; Multi-Scale; Contact Mechanics; Ski-Camber Profile; Ski-Base Texture

Online: 5 July 2023 (15:37:49 CEST)

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At the highest level of endurance sports, the differences in finishing times are small, so equipment is constantly being constantly improved to enhance the athletes' performance. For instance, one dominant resistive force in connection with cross-country skiing is the friction between the skis and snow and since the 1930s, research designed to understand and reduce this friction has been ongoing. The mechanisms involved in ski-snow friction include compaction, micro-ploughing, adhesion, viscosity, and water-bridging. Of these, adhesive and viscous friction have been most studied, while much less is presently known about compaction, micro-ploughing, and water-bridging. At the macro-scale, the ski-camber profile plays a key role in determining whether, with respect to friction, a particular cross-country ski is suitable for use under a given set of conditions. Through its influence on where ski-snow contact occurs, this ski-camber profile has a profound impact on adhesive and viscous friction, micro-ploughing, the formation of water bridges, and the rate of compaction. Different contact zones with different apparent areas of contact and pressure have been found to be most suitable for different conditions. In addition, the micro-scale texture of the ski base is also an important determinant of ski-snow friction. Topographical measurements of this texture can be achieved with white-light interferometer and recent characterisation has focused on the mechanical properties of contact. In numerous tribological studies the interactions between features at different scales are modelled. In most tribological systems, features on several scales influence friction and ski-snow contact is certainly no exception. Accordingly, the current investigation was designed to evaluate the multi-scale properties of different combinations of two skis with two different base textures. The real area of contact and the average interfacial separation and total average reciprocal interfacial separation between the ski and snow were taken into consideration. We found that different macro- and micro-scale properties of the ski favour different mechanisms of friction. Both the profile of the ski camber and texture of the base play decisive roles in determining viscous friction. At the same time, the texture of the ski base exerts a greater impact on the average real contact pressure, real contact area and minimal average interfacial separation between the ski and snow than does the ski-camber profile.

Preprint ARTICLE | doi:10.20944/preprints202306.0780.v1

A Lightweight Detection Algorithm for Unmanned Surface Vehicles Based on Multi-Scale Feature Fusion

Lei Zhang, Xiang DU, Renran Zhang, Jian Zhang

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: unmanned surface vehicle; multi-scale feature; lightweight detection algorithm; dynamic head; coordinate convolution; YOLOv7-tiny

Online: 12 June 2023 (07:09:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0536.v1

Wave Behavior Characteristics of Elastically Supported Fluid-Conveying Carbon Nanotubes under the Influence of Magnetic Fields

Qian Deng, Ming Li, Liufei Lv

Subject: Physical Sciences, Other Keywords: Fluid conveying carbon nanotubes; Timoshenko beams; Small-scale effects; Magnetic flux; Non-local strain gradients

Online: 7 June 2023 (10:39:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0094.v1

Sustainable Metabolic Engineering Design Development Employing a Complex Objective Function

Reinis Muiznieks, Elina Dace, Egils Stalidzans

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: economic sustainability; environmental sustainability; social sustainability; genome scale metabolic model; metabolic engineering; growth coupled production

Online: 3 May 2023 (04:32:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0249.v1

Validation of the Cooling Model for TMCP Processing of Steel Sheets with Oxide Scale by Industrial Experiment Data

Emmanuil Beygelzimer, Yan Beygelzimer

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: rolled flat products; accelerated cooling; temperature; mathematical model; oxide scale; Ther-mo-Mechanical Controlled Process

Online: 17 June 2022 (05:14:37 CEST)

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Working Paper REVIEW

Machine Learning of Spatial Data

Behnam Nikparvar, Jean-Claude Thill

Subject: Social Sciences, Geography, Planning And Development Keywords: spatial machine learning; spatial dependence; spatial heterogeneity; scale; spatial observation matrix; learning algorithm; deep learning

Online: 6 August 2021 (14:18:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0569.v1

Effects of Clinical Characteristics on Sleep Quality in Patients with Chronic Temporomandibular Disorders

Yeon-Hee Lee, Q-Schick Auh, Jung-Sub An, Tae Kim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Sleep quality; Chronic pain; Temporomandibular disorder; Pittsburgh Sleep Quality Index; STOP-Bang; Epworth Sleepiness Scale

Online: 23 June 2021 (11:11:14 CEST)

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Objectives: This study aimed to investigate and compare sleep quality between patients with chronic temporomandibular disorder and healthy controls, and to analyze the association of sleep quality with disease characteristics, obstructive sleep apnea risk factors, and excessive daytime sleepiness. Methods: Chronic temporomandibular disorder patients (n=503) and 180 age- and sex-matched healthy controls were included, who completed well-organized clinical report and answered questions on sleep quality (Pittsburgh Sleep Quality Index), sleep apnea risk factors (STOP-Bang questionnaire), and excessive daytime sleepiness (Epworth sleepiness scale). Results: Mean global Pittsburgh Sleep Quality Index scores were significantly higher in the patients (6.25±2.77) than in healthy controls (6.25±2.77) (p<0.001). Poor sleep was significantly more prevalent in the patient group (56.9%) than in healthy controls (22.2%) (p<0.001). Compared with healthy controls, chronic temporomandibular disorder patients had a higher likelihood of obstructive sleep apnea. (STOP-Bang total score ≥3; 7.2% vs. 16.1%; p<0.01) and higher excessive daytime sleepiness (Epworth sleepiness scale score ≥10; 12.8% vs. 19.7%; p<0.05). Age (odds ratio=2.551; p<0.001), female sex (odds ratio=1.885; p=0.007), total Epworth sleepiness scale score (odds ratio=1.839; p=0.014), and headache attributed to temporomandibular disorder (odds ratio=1.519; p=0.049) were the most powerful predictors of poor sleep (global Pittsburgh Sleep Quality Index score ≥5) in chronic temporomandibular disorder patients. Conclusion: Chronic temporomandibular disorder patients had sleep quality impairment. Various factors, including peripheral and central factors, affect the patient's sleep quality. Therefore, in addition to sleep quality and sleep-related problems, the underlying central mechanism for poor sleep quality should be assessed when treating chronic temporomandibular disorder patients.

Preprint ARTICLE | doi:10.20944/preprints202105.0282.v2

Design Optimization of Centrifugal Microfluidic "Lab-on-a-Disc" Systems towards Fluidic Larger-Scale Integration

Jens Ducrée

Subject: Computer Science And Mathematics, Software Keywords: centrifugal microfluidics, Lab-on-a-Disc, large-scale integration, reliability, tolerances, band width, packing density

Online: 8 June 2021 (12:07:35 CEST)

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Working Paper ARTICLE

Single Image Rain Removal Based on Multi-Scale and Channel Attention Mechanism

Qiuling Liu, Gang Zhou, Zhenhong Jia

Subject: Computer Science And Mathematics, Computer Science Keywords: Single image deraining; Multi-layer Laplacian pyramid; Multi-scale feature extraction module; Channel attention module.

Online: 31 May 2021 (11:41:25 CEST)

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Working Paper ARTICLE

A New 3D Geological Modeling Method Based On Remote Sensing and Its Application in Ya 'an Area Sichuan Province

Zhaoyang Ma, Lihai Zhang, Yan Wang, Guifan Zhu, Yinping Liang

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Multi-source heterogeneity; remote sensing; large-scale high-precision modeling; grid division; geostatistics; spatial interpolation

Online: 20 January 2021 (16:19:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0409.v1

Personalized Biometrics of Physical Pain Agree with Its Psychological Perception by Participants with Sensory Over Responsivity

Jihye Ryu, Tami Bar-Shalita, Yelena Granovsky, Irit Weissman-Fogel, Elizabeth B. Torres

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: EEG; pain biometrics; stochastic analyses; micro-movements spikes; sensory over responsivity; standardized scale; personalized pain

Online: 16 December 2020 (13:19:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0298.v2

Cosmic Ray Extremely Distributed Observatory

Piotr Homola, Dmitriy Beznosko, Gopal Bhatta, Łukasz Bibrzycki, Łukasz Bratek, Michalina Borczyńska, Nikolay M. Budnev, Dariusz Burakowski, David Edwin Alvarez-Castillo, Kevin Almeida Cheminant, Aleksander Ćwikła, Punsiri Dam-o, Niraj Dhital, Alan Duffy, Piotr Głownia, Krzysztof Gorzkiewicz, Dariusz Góra, Alok C. Gupta, Zuzana Hlávková, Martin Homola, Joanna Jałocha, Robert Kamiński, Michał Karbowiak, Marcin Kasztelan, Renata Kierepko, Marek Knap, Péter Kovács, Szymon Kuliński, Bartosz Łozowski, Marek Magryś, Mikhail V. Medvedev, Justyna Mędrala, Jerzy W. Mietelski, Justyna Miszczyk, Alona Mozgova, Antonio Napolitano, Vahab Nazari, Y. Jack Ng, Michał Niedźwiecki, Cristina Oancea, Bogusław Ogan, Gabriela Opiła, Krzysztof Oziomek, Maciej Pawlik, Marcin Piekarczyk, Bożena Poncyljusz, Jerzy Pryga, Matías Rosas, Krzysztof Rzecki, Jilberto Zamora-Saa, Katarzyna Smelcerz, Karel Smolek, Weronika Stanek, Jarosław Stasielak, Slawomir Stuglik, Jolanta Sulma, Oleksandr Sushchov, Manana Svanidze, Kyle Tam, Arman Tursunov, José-M. Vaquero, Tadeusz Wibig, Krzysztof W. Woźniak

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: cosmic rays; cosmic ray ensembles; extensive air showers; large scale cosmic ray correlations; CREDO Collaboration

Online: 15 October 2020 (16:13:43 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202005.0287.v1

The Impacts of COVID-19 to Small Scale Fisheries in Tun Mustapha Park, Sabah, Malaysia; What Do We Know So Far?

Joannie Jomitol, Adam J. Payne, Sarmalin Sakirun, Mohd. Omar Bural

Subject: Biology And Life Sciences, Aquatic Science Keywords: COVID-19; small scale fisheries; artisarnal fishers; coastal communities; marine protected area; Malaysia; fisheries; impacts

Online: 17 May 2020 (08:46:10 CEST)

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Working Paper ARTICLE

Effect of Interlayer Cooling Time, Constraint and Tool Path Strategy on Deformation of Large Components made by Laser Metal Deposition with Wire

Yousub Lee, Yashwanth Bandari, Peeyush Nandwana, Brian Gibson, Brad Richardson, Srdjan Simunovic

Subject: Engineering, Mechanical Engineering Keywords: large-scale additive manufacturing; interlayer cooling time; tool path optimization; part deformation; Ti-6Al-4V

Online: 10 November 2019 (09:04:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0010.v1

The Effect of Propeller Scaling Methodology on the Performance Prediction

Stephan Helma, Heinrich Streckwall, Jan Richter

Subject: Engineering, Marine Engineering Keywords: propeller scale effects; propeller open-water efficiency; surface roughness; equivalent profile; strip method; betai method

Online: 1 March 2018 (15:58:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0677.v1

Irreversibility as a Measure of Loss of Working Capacity of a Chemical Reaction as a Thermodynamic Process: Definition With Partial Application of Extreme Values of Internal Energy and Entropy

Mihalj Poša

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: Gibbs free energy; isentropic process; maximum non-expansion work; De Donder's equation; local equilibrium; irreversibility

Online: 9 July 2024 (07:50:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0032.v1

Is the Sublingual Artery a Reliable Alternative for Intraoral Anastomoses in Head and Neck Free Flap Reconstruction? Anatomical Basis and Preliminary Results

Vasco Starke, Jürgen Wallner, Robert Stigler, Sidney Mannschatz, Jakob Müller, Erich Brenner

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Sublingual artery; Pedicle; Microvascular free flap reconstruction; Intraoral anastomosis; Head and neck cancer; Tumor surgery

Online: 1 July 2024 (11:29:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1868.v1

Patient Outcomes in Resected Combined Hepatocellular Cholangiocarcinoma (cHCC-ICC) and Intrahepatic Cholangiocarcinoma: A Single Center Study

Rick Y. Lin, Doga Kahramangil, Muhammet Ozer, Thomas J. George, Ibrahim Nassour, Steven J. Hughes, Ali Zarrinpar, Ilyas Sahin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Combined Hepatocellular Cholangiocarcinoma (cHCC-ICC), Intrahepatic Cholangiocarcinoma (ICC), Surgical Resection, Recurrence-Free Survival, Overall Survival

Online: 26 June 2024 (13:16:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1113.v1

Evolving Biomarkers in Kidney Transplantation

Maurizio Salvadori, alberto rosati, Giuseppina Rosso

Subject: Medicine And Pharmacology, Transplantation Keywords: Kidney rejection; biomarkers; subclinical rejection; donor derived cell free DNA; gene expression profile; urinary cytokines

Online: 17 April 2024 (11:18:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0159.v1

Automating Laser Vision Correction

Diego de Ortueta

Subject: Medicine And Pharmacology, Ophthalmology Keywords: automated; transepithelial photorefractive keratectomy; TransPRK; photorefractive keratectomy; aberration free; refraction; AMARIS; Peramis; MS-39; OCT.

Online: 4 March 2024 (12:19:05 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202402.1628.v1

A New Minimally Invasive Technique for Thoracolumbar Focal Kyphosis Due to Osteoporotic Vertebral Fracture

Masato Tanaka, Abd El Kader Al Askar, Chetan Kuwamat, Shashank J Ekade, Shinya Arataki, Tadashi Komatsubara, Takuya Taoka, Koji Uotani, Kensuke Shinohara

Subject: Medicine And Pharmacology, Surgery Keywords: Osteoporotic vertebral fractures; thoracolumbar focal kyphosis; C-arm free; novel technique; oblique lumbar interbody fusion

Online: 28 February 2024 (12:03:37 CET)

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Study design: Technical note. Objectives: To present a new technique of treatment for a patient with thoracolumbar focal kyphosis due to osteoporotic verte-bral fracture (OVFs). Background : OVFs are common among the elderly population. Following a severe wedged fracture, patients often experience low back pain and disruptions in activities of daily living. Reconstruction surgeries, such as corpectomy, are among the treatment options for this condition. However, corpectomy requires longer surgical times and involves a significant amount of blood loss. Materials and Methods : An 80-year-old woman presented to our hospital with severe low back pain and gait disturbance. She had experienced an L2 OVF six years prior. Although she had no neurological deficit, she could not walk more than 200m due to pain. Preoperative spinal radiographs revealed severe sagittal malalignment, with the L2 vertebra collapsed and focal kyphosis of L1-3 measuring 34 degrees. Results: The patient underwent anterior and posterior surgery in the right decubitus position using a C-arm free technique. The surgical time was 133 minutes with an estimated blood loss of 100 ml. Hyperlordotic cages were inserted in the upper and lower disc space via a lateral approach, while percutaneous pedicle screws (PPS) were inserted from a posterior approach. These procedures were performed simultaneously under navigation guidance only. Post-operative images showed excellent spinal alignment, with local kyphosis reduced from 34 to 14 degrees, and no major or severe complications occurred. At one-year follow-up, the patient was able to walk smoothly, with her visual analogue scale for low back pain improving from 73mm to 13mm, and her Oswestry Disability Index improving from 53.3% to 13.3%. Conclusions/Level of Evidence : The simultaneous use of hyperlordotic cages and PPS is an effective and innovative navigation technique that yields promising outcomes for thoracolumbar focal kyphosis resulting from OVFs. This approach not only reduces surgical time but also minimizes intraoperative blood loss. Level V.

Preprint REVIEW | doi:10.20944/preprints202401.0078.v1

Recent Advances in Real-time Label-Free Detection of Small Molecules

Andy Chieng, Zijian Wan, Shaopeng Wang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: small molecule; label-free; real-time detection; biosensor; optical transduction; electrochemical transduction; piezoelectric transduction ;

Online: 3 January 2024 (02:34:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1306.v1

Modification of Polylactide with Methacrylic Acid by Graft Copolymerization

Dmitry Belov

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polylactide; methacrylic acid; grafting copolymerization; free radical polymerization; UV-irradiation; static cation exchange capacity (SCEC)

Online: 18 December 2023 (12:24:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0695.v1

Pre-operative Malnutrition in Patients with Ovarian Cancer: What are the Clinical Implications? Results of a Prospective Study

Sara Nasser, Esra Bilir, Xezal Derin, Rolf Richter, Jacek P Grabowski, Paulina Ali, Hagen Kulbe, Radoslav Chekerov, Elena Braicu, Jalid Sehouli

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: malnutrition; ovarian cancer; overall survival; nutritional risk screening score; nutrition; phase angle; progression-free survival

Online: 13 November 2023 (08:32:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0339.v1

Strategies for Improving the Sustainability of Fare-Free Policy for the Elderly through Preferences by Travel Modes

Jaewoong Yun

Subject: Engineering, Transportation Science And Technology Keywords: Public service obligation; Fare-free policy; Heterogeneity of mode choice; Stated preference; Latent class model

Online: 5 September 2023 (15:01:12 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202307.1664.v1

The Kinetic and Energetic Pull of Chemical Entropy

Josh Baker

Subject: Physical Sciences, Chemical Physics Keywords: Entropy, Chemical Thermodynamics, Free Energy, Reaction Energy Landscape, Microstates, Micropathways, Non-Equilibrium, Kinetics, Entropic Funnel

Online: 25 July 2023 (07:43:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0165.v1

Modelling Time–Dependent Flow through Railway Ballast

Raed Alrdadi, Michael H. Meylan

Subject: Engineering, Civil Engineering Keywords: free surface; steady state; unsteady state; railway ballast; fouling ratio; specific yield; finite element method

Online: 9 March 2023 (03:31:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0325.v2

Streptavidin-Modified Iron Oxide Hybrid Nanozymes for Magnetic Enrichment and Bioelectrocatalytic Sensing of Circulating Tumor RNA

Kevin M. Koo

Subject: Chemistry And Materials Science, Biomaterials Keywords: nanozymes; circulating tumor nucleci acid; liquid biopsy; magnetic enrichment; minimal residual disease; cell-free RNA

Online: 24 October 2022 (10:33:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0086.v1

Rapid and Sensitive Point of Care Detection of MRSA gDNA by Nanoelectrokinetic Sensors

Rania Oueslati, Yu Jiang, Jiangang Chen, Jie Jayne Wu

Subject: Engineering, Electrical And Electronic Engineering Keywords: DNA sensor; point of care diagnostics; methicillin-resistant Staphylococcus aureus; label free biosensor; AC electrokicetics

Online: 5 April 2021 (10:11:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0607.v1

Whey Proteins Characterization, Free Amino Acids Profile and Antimicrobial Study of Some Dairy Drinks based on Milk Serum

Doina Prodan, Miuța Filip, Mihaela Vlassa, Marioara Moldovan, Rahela Carpa, Viorica Tarmure, and Andreea Simona Popa

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Milk Serum; whey proteins; RP-HPLC-UV; free amino acids; RP-HPLC-FLD; antimicrobial study

Online: 25 September 2020 (11:45:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0245.v2

Measurement of the Radius of Metallic Plates Based on a Novel Finite Region Eigenfunction Expansion (FREE) Method

Ruochen Huang, Mingyang Lu, Zhijie Zhang, Qian Zhao, Yuedong Xie, Yang Tao, Tian Meng, Anthony Peyton, Theodoros Theodoulidis, Wuliang Yin

Subject: Engineering, Electrical And Electronic Engineering Keywords: Non-destructive testing; finite region eigenfunction expansion (FREE) method; finite dimension; magnetic induction; size measurements

Online: 20 July 2020 (04:16:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0398.v2

Hypothetical Role of Large Nuclear Gravity in Understanding the Significance and Applications of the Strong Coupling Constant in the Light of Up and Down Quark Clusters

U.V.S Seshavatharam, S. Lakshminarayana

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: large nuclear gravity; strong coupling constant; nuclear stability; nuclear binding energy; free nucleons; active nucleons; magic numbers; up and down Quark clusters

Online: 4 December 2019 (04:48:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0302.v1

Google Earth, Google SketchUp and GIS software; An Interoperable Work Flow for Generating Elevation Data

José Gomes dos Santos, Kevin Bento, Joaquim Lourenço Txifunga

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: interoperability; digital elevation model; Google Sketchup; geographical information systems-science; free and open source software

Online: 30 January 2019 (05:28:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0228.v1

Free-Flowing Shear-Thinning Liquid Film in Inclined μ-Channels

Angeliki T. Koupa, Yorgos G. Stergiou, Aikaterini A. Mouza

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: free-flowing film; FFMR; inclined μ-channel; non-Newtonian; shear thinning; μ-PIV; me-niscus

Online: 19 December 2018 (03:03:12 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0243.v1

Label-Free Biosensors Based Onto Monolithically Integrated Onto Silicon Optical Transducers

Michailia Angelopoulou, Sotirios Kakabakos, Panagiota Petrou

Subject: Physical Sciences, Optics And Photonics Keywords: integrated optical sensors; monolithic integration; broad-band interferometers; label-free; multiplexed detection; on-site determinations

Online: 13 September 2018 (14:44:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0431.v1

Importance of HIV cell-to-cell transmission - implications for neutralizing antibody

Tuckweng Kok, Peng Li

Subject: Biology And Life Sciences, Virology Keywords: HIV, cell-to-cell transmission, designer antigens, neutralizing antibody, cell-free, high multiplicity of infection

Online: 24 August 2018 (10:25:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0282.v1

Environmental Issues Related to the Elderly and Physically Disabled People in Different Life Situations

Dušan Katunský, Carsten Brausch

Subject: Engineering, Civil Engineering Keywords: demographic change; barrier-free design; living space; quality of life; specific needs; modular home design

Online: 16 July 2018 (11:51:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0055.v1

Enthalpy and Free Energy of Formation of Diamido and Monoamido Phosphoric Acid

Neale R. Neelameggham

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: amidophosphoric acid; diamidophosphate; prebiotic phosphoryl compound; phosphonitrogen glass; enthalpy; Gibbs Free energy; biomimetic nitrogen fixation

Online: 7 February 2018 (05:12:33 CET)

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Preprint REVIEW | doi:10.20944/preprints201711.0197.v1

A Consideration of the Relationship between Animals and Their Environment

Ian G. Colditz

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: affordance; umwelt; agency; active inference; allostasis; immune cognition; situated Darwinism; information; entropy; free energy principle

Online: 30 November 2017 (09:02:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0230.v1

Epidemic Analysis and Mathematical Modelling of H1N1 (A) with Vaccination

Jagan Mohan Jonnalagadda, Kartheek Gaddam

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: basic reproduction number; disease free equilibrium; endemic equilibrium; local asymptotic stability; global asymptotic stability; influenza

Online: 30 August 2016 (08:54:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0777.v1

Delineating Ecological Functional Zones and Grades for Multi-Scale Ecosystem Management

Yan Zhang, Shuhan Liu, Peiheng Yu, Yanchi Lu, Yang Zhang, Jinting Zhang, Yiyun Chen

Subject: Environmental And Earth Sciences, Ecology Keywords: ecosystem services; ecological functional zones; tradeoffs and synergies; self-organizing feature mapping; multi-scale management ;

Online: 10 September 2024 (09:42:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1537.v1

Converting Candlenut Shell Waste into Graphene for Electrode Applications

Rikson Siburian, Kerista Tarigan, Yosia Gopas Oetama Manik, Fajar Hutagalung, Yatimah Alias, Yong Ching Chan, Boon Peng Chang, Jonathan Siow, Amanda Jiamin Ong, Jingfeng Huang, Suriati Paiman, Boon Tong Goh, Lisnawaty Simatupang, Ronn Goei, Alfred Iing Yoong Tok, Yahya Mohd Fakharul Zaman Raja, Fathan Bahfie

Subject: Engineering, Other Keywords: graphene; candlenut (Aleurites moluccanus) shell; Ce/graphene; carbon large scale production; energy storage electrodes

Online: 24 June 2024 (04:28:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1714.v1

Large-Scale Group Decision-Making Method with Public Participation and Its Application in Urban Management

Xiuhong Niu, Yongming Song, Zhongwen Xu

Subject: Business, Economics And Management, Business And Management Keywords: Large-scale group decision-making; Public participation; Multi-granular probabilistic linguistic preference relations; Consensus reaching process

Online: 27 May 2024 (13:07:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1203.v1

Computational Thinking Measurement of CS University Students

Raquel Hijón-Neira, Celeste Pizarro, John French, Daniel Palacios-Alonso, Emre Çoban

Subject: Computer Science And Mathematics, Computer Science Keywords: Computational Thinking; Programming; Performance-based assessment platform; Interactive web app; Evaluation methods; Psychometric scale; Students evaluation

Online: 20 May 2024 (10:11:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1531.v1

An Evaluation of the Primary Causative Factors Affecting Durability of Flow Diversion Simple Weirs in Muchinga Province in Zambia

Alex Lushikanda KABWE, Masahiro HYODO, Hidehiko OGATA, Yoshihiro Sagawa, Yoshinao ADACHI, Masayuki ISHII

Subject: Engineering, Other Keywords: farmer-led small-scale irrigation; operation and maintenance; catchment characteristics; durability assessment; local material; farmer perception

Online: 23 April 2024 (17:59:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1419.v1

Gaining Insight Into Teenagers' Experiences of Pain After Laparoscopic Surgeries; A Prospective Study

Mihaela Visoiu, Jacques E. Chelly, Senthilkumar Sadhasivam

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Teenager Postoperative Pain; Visual Analog Pain Scale; Pain Behaviour; Pain Catastrophizing Thoughts; Anxiety; Mood; Laparoscopic Surgeries

Online: 26 February 2024 (11:41:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0371.v1

Is Entropy a Force of Nature?

Martin Johnson

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: dark energy
cosmic background radiation
dark ages
large-scale structure of the Universe

Online: 7 February 2024 (03:37:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0773.v1

Validation of HPV Knowledge Tool and Assessment of HPV Knowledge and Awareness among Students and Staff at IBB University, Niger State, Nigeria: Implications for Health Education and Prevention

Melvin Omone Ogbolu, Miklós Kozlovszky

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Cervical cancer; HPV knowledge; Awareness of HPV infection; Awareness of HPV vaccine; Scale validation; Quantile regression

Online: 10 January 2024 (10:01:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0137.v1

Observational Constraints and Future of the Universe with Dynamic Dark Energy

Florian Neukart

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Hubble tension; Cosmic Microwave Background; Large-scale structures; Dark energy constraints; Future cosmological observations

Online: 3 January 2024 (04:20:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1856.v1

Effects of Anthropogenic Activities on Sardinella maderensis (Lowe, 1838) Fisheries in Coastal Communities of Ibeju-Lekki, Lagos, Nigeria

Temitope Adewale, Denis Aheto, Isaac Okyere, Olufemi Soyinka, Samuel Dekolo

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Small-scale fisheries; anthropogenic threats; Sardinella maderensis; land use change; Nigeria; remote sensing; pollution

Online: 29 November 2023 (06:32:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0416.v2

Implementation of Simulation Modeling of Single and High‐Volume Machine‐Building Productions

Tatyana Nikonova, Nadezhda Savelyeva, Gulnara Zhetessova, Vassiliy Yurchenko, Olegas Černašėjus, Olga Zharkevich, Essim Dandybaev, Andrey Berg, Sergey Vassenkin, Murat Baimuldin

Subject: Engineering, Mechanical Engineering Keywords: technological preparation of production; automation of production processes; small-scale production; single production; machine-building enterprises

Online: 28 November 2023 (17:01:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0401.v1

Influence of Comorbidities on Chronic Obstructive Pulmonary Disease (COPD) Outcomes: Risk Prediction of Acute Exacerbations Using the Cumulative Illness Rating Scale (Cirs)

Domenico Di Raimondo, Edoardo Pirera, Chiara Pintus, Riccardo De Rosa, Martina Profita, Gaia Musiari, Gherardo Siscaro, Antonino Tuttolomondo

Subject: Biology And Life Sciences, Aging Keywords: Comorbidity; Multimorbidity; Chronic Obstructive Pulmonary Disease; COPD; Cumulative Illness Rating Scale; acute exacerbation of COPD (AECOPD)

Online: 7 November 2023 (10:33:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0095.v1

Solar System-Like Systems with Special Reference to Relativistic Quantum Mechanics and Weak Gravitational Field

Peter Gara

Subject: Physical Sciences, Quantum Science And Technology Keywords: Solar system-like systems; Relativistic Quantum Mechanics; Weak Gravity; Proper Time Scale of the Solar System

Online: 4 November 2022 (13:42:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0277.v2

Research on Mechanical Braking Model of Cows Knee Joint

Meng Liu, Kexin Meng, Shuli Mei, Ruyi Xing

Subject: Physical Sciences, Mathematical Physics Keywords: Dairy cow; Lyapunov exponent; bio-mechanical model; Nonlinear dynamics; gait; Weight scale; Three-link model; Fractals

Online: 24 February 2022 (09:57:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0389.v1

Task-Adaptive Embedding Learning with Dynamic Kernel Fusion for Few-Shot Remote Sensing Scene Classification

Pei Zhang, Guoliang Fan, Chanyue Wu, Dong Wang, Ying Li

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: remote-sensing classification; scene classification; few-shot learning; meta-learning; vision transformers; multi-scale feature fusion

Online: 18 August 2021 (14:29:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0235.v1

Sensitivity of Stomate Size in Red Maple (Acer rubrum L.) Trees in Deciduous Forests to Urban Conditions

Covel R. McDermot, Vince D'Amico, Tara Trammell

Subject: Environmental And Earth Sciences, Environmental Science Keywords: abiotic stress; metro-scale; physiological acclimation; urban leaf morphology; red maple trees; stomate size; urban forests

Online: 15 April 2020 (09:32:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0117.v1

An Accelerating and Rotating Planck-Hubble Universe (A Very Simple Model of Quantum Cosmology)

U. V. S. Seshavatharam, S. Lakshminarayana

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: planck scale; quantum cosmology; critical density; ordinary matter; dark matter; expansion velocity; angular velocity; Hubble’s law;

Online: 11 March 2019 (08:01:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0236.v1

Hybrid 3D Models: When Geomatics Innovations Meet Extensive Built Heritage Complexes

Filiberto Chiabrando, Giulia Sammartano, Antonia Spanò, Alessandra Spreafico

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: 3D models; multi-sensor; multi-scale; SLAM; MMS; LiDAR; UAV; data integration; data fusion; cultural heritage

Online: 23 January 2019 (10:08:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0175.v1

Antineutrino Star Model of the Big Bang and Dark Energy

Tom F. Neiser

Subject: Physical Sciences, Particle And Field Physics Keywords: cosmology: theory; gravitation; early universe; dark energy; large-scale structure of universe; cosmic background radiation; neutrinos

Online: 12 June 2018 (08:43:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0258.v2

Revisiting the Derivation of Heisenberg's Uncertainty Principle: The Collapse of Uncertainty at the Planck Scale

Espen Haug

Subject: Physical Sciences, Thermodynamics Keywords: Heisenberg's uncertainty principle; certainty; wave function; Planck scale; Planck mass; Planck particle; Bell's Inequality; superposition; entropy; Compton clock

Online: 5 September 2018 (09:34:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0046.v1

Small Scale Hydroelectric Power Plants in Norway. Some Microeconomic and Environmental Considerations

Johannes Idsø

Subject: Business, Economics And Management, Economics Keywords: small scale hydroelectric power; neumann-mortenstern utility theory; environmental effects of hydro power; hydropower and risk

Online: 5 May 2017 (05:32:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0467.v2

Exploring the Role of Circulating Cell-Free DNA in Disease Diagnosis and Therapy

Mohammad Odah

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: circulating cell-free DNA (ccfDNA); molecular diagnostics; liquid biopsies; cancer biomarkers; genomic sequencing; bioinformatics; personalized medicine

Online: 15 August 2024 (16:34:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0661.v1

Thermodynamic Factors Controlling Electron Transfer amongst the Terminal Electron Acceptors of Photosystem I: Insight from Kinetic Modelling

Stefano Santabarbara, Anna Paola Casazza

Subject: Biology And Life Sciences, Biophysics Keywords: electron transfer; standard gibbs free energy difference; reorganisation energy; tunnelling barrier; iron-sulphur cluster; (Phyllo)quinone

Online: 12 August 2024 (03:31:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1504.v1

Theoretical Proof of De Broglie’s Wave Function

Sheng Qin

Subject: Physical Sciences, Theoretical Physics Keywords: de Broglie Wave Function; Matter Wave Function; Free Particle Wave Function; Spatial Distribution of Wave Function

Online: 18 July 2024 (23:43:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1661.v1

Markov Blankets and Mirror Symmetries. Free Energy Minimization and Mesocortical Anatomy

James Wright, Paul Bourke

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: free energy principle; active inference; predictive coding; Markov blankets; cortical development; cortical mesoanatomy; cortical self-organization

Online: 29 February 2024 (05:39:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1502.v1

Comparative Studies between Frequency Domain Analysis and Time Domain Analysis on Free Field One-Dimensional Shear Wave Propagation

Sun-Hoon Kim, Kwang-Jin Kim

Subject: Engineering, Civil Engineering Keywords: earthquake; free field analysis; frequency domain analysis; time domain analysis; finite element analysis; shear wave propagation

Online: 19 January 2024 (10:52:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1461.v1

Efficacy of Immune Checkpoint Inhibitors vs Tyrosine Kinase Inhibitors/Everolimus in Adjuvant Renal Cell Carcinoma: In-direct Comparison of Disease-Free Survival

Andrea Ossato, Lorenzo Gasperoni, Luna Del Bono, Andrea Messori, Vera Damuzzo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: indirect comparison; Shiny method; reconstructed individual patient data; disease free survival; renal cell carcinoma; adjuvant setting

Online: 20 December 2023 (09:30:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1873.v1

Improved DIRECT-type Algorithm Based on a New Approach for Identification of Potentially Optimal Hyper-Rectangles

Naziheddine Belkacem, Lakhdar Chiter, Mohammed Louaked

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Global optimization; Derivative-free global optimization; Diagonal partitioning scheme; DIRECT-type algorithms; Potentially optimal hyper-rectangles

Online: 29 November 2023 (10:22:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0240.v1

Risk Biomarkers for Biochemical Recurrence After Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features

Adalgisa Guerra, Filipe Caseiro Alves, Kris Maes, Rui Maio, Geert Villeirs, Helena Mouriño

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: extracapsular extension; prostate cancer; magnetic resonance imaging; radical prostatectomy; staging; biochemical recurrence; biochemical recurrence-free survival.

Online: 5 October 2023 (02:40:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0627.v1

Multicentric Study from Southern Italy Hospitals on Oncological Outcomes and Prognostic Factors of Open Partial Horizontal Laryngectomies (OPHL) for Laryngeal Cancer

Eugenia Allegra, Maria Rita Bianco, Domenico Michele Modica, Alfio Azzolina, Elio Privitera, Daniele Latella, Federico Occhiuzzi, Mario Galfano, Vincenzo Saita

Subject: Medicine And Pharmacology, Otolaryngology Keywords: open partial horizontal laryngectomy; laryngeal cancer; laryngeal preservation; laryngectomy free survival; disease specific survival; total laryngectomy

Online: 8 August 2023 (10:25:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0016.v1

Absorber Enrichment and Its Implication on the Performance of Lead-free CsSnI₃ Perovskite Solar Cells (PSCs) - A 1D-SCAPS Study

Tajudeen Ahmed, Ibrahim Taofiq, Enock Oladimeji, Durojaiye Koffa

Subject: Physical Sciences, Condensed Matter Physics Keywords: Lead-free perovskite solar cell; CsSnI3 perovskite; charge carrier recombination; absorber enrichment; optimization; power conversion efficiency

Online: 1 August 2023 (05:25:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0528.v1

Sample Delivery Systems for Serial Femtosecond Crystallography at PAL-XFEL

Jaehyun Park, Ki Hyun Nam

Subject: Biology And Life Sciences, Biophysics Keywords: serial femtosecond crystallography; X-ray free electron laser; sample delivery; injector; fixed-target scanning; hybrid method

Online: 19 April 2023 (03:22:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0251.v1

Applicability of Asymmetric Specimens for Residual Stress Evaluation in Fiber Metal Laminates

Johannes Wiedemann, Jan-Uwe R. Schmidt, Christian Hühne

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: fiber metal laminate; hybrid laminate; residual stress; asymmetric laminate; process monitoring; curvature analysis; stress-free temperature

Online: 19 September 2022 (02:03:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0334.v1

Computational Biology and Machine Learning Approaches to Identify the Rubber Tree (Hevea brasiliensis L.) Genome Encoded Potential MicroRNAs Targeting Rubber Tree Virus 1

Muhammad Aleem Ashraf, Hafiza Kashaf Tariq, Jallat Khan, Han Cheng

Subject: Biology And Life Sciences, Plant Sciences Keywords: Rubber tree capillovirus 1; microRNAs; plant-virus interaction; RNAi: computational algorithms; gene silencing, minimum free energy

Online: 22 July 2022 (09:52:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0199.v1

Nano-Structured Na2CaP2O7: a New and Efficient Catalyst for One-Pot Synthesis of 2-Amino-3-Cyanopyridine Derivatives and Evaluation of Their Antibacterial Activity

Redouane Achagar, Abdelhakim Elmakssoudi, Abderrahmane Thoume, Mohamed Dakir, Abdelaziz Elamrani, Yassine Zouheir, Mohamed Zahouily, Zouhair Ait-Touchente, Jamal Jamaleddine, Mohamed M. M. Chehimi

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Catalyst; antibacterial activity; solvent-free conditions; heterogeneous catalysis; Synthesis; cyanopyridines; pyrimidines; nano-structured Na2CaP2O7; catalyst recovery

Online: 21 April 2022 (09:26:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0602.v3

Biochemistry, Not Oncogenes, may Demystify and Defeat Cancer

Jay Kulsh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: carcinogenesis; cancer treatment; cervical cancer; DNA synthesis; free-radical; retinoblastoma; ribonucleotide reductase; somatic mutation theory (SMT)

Online: 28 December 2021 (10:53:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0609.v1

Treatment-Free Remission in Chronic Myeloid Leukaemia: Can We Identify Prognostic Factors?

Hilbeen Hisham Saifullah, Claire Marie Lucas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic myeloid leukaemia; chronic phase; Tyrosine kinase inhibitor; Treatment free remission; deep molecular response; BCR-ABL.

Online: 25 June 2021 (08:13:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0502.v1

Efficacy Modeling of New Multi-Functional Benzophenone-Based System for Free-Radical/Cationic Hybrid Photopolymerization Using 405 nm LED

Jui-Teng Lin, Jacques Lalevee

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: polymerization kinetics; conversion efficacy; free radical and cationic radical; benzophenone–triphenylamine amine; photoredox catalyst; 3D bioprinting

Online: 21 June 2021 (10:37:40 CEST)

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Working Paper REVIEW

Information Theory for Agents in Artificial Intelligence, Psychology, and Economics

Michael Harre

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Decision Theory; Psychology; Artificial Intelligence; Economics; Artificial Neural Networks; Neuroscience; Information Theory; Bayesian Learning; Free Energy

Online: 3 March 2021 (11:38:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0177.v1

Effects of Methylprednisolone on Ventilator-Free Days in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome and COVID-19

Mohamed Badr, Bruno De Oliveira, Khaled Abdallah, Ashraf Nadeem, Yeldho Varghese, Dnyaseshwar Munde, Shameen Salam, Baraa Abduljawad, Khaled Saleh, Hussam Elkambergy, Ahmed Rida, Ahmed Bayrlee, Ali Wahla, Jamil Dibu, Rehan Haque, Fadi Hamed, Nadeem Rahman, Jihad Mallat

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; acute respiratory distress syndrome; methylprednisolone; mechanical ventilation; ventilator-free days; SARS-CoV-2 infection

Online: 11 January 2021 (10:13:42 CET)

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Objectives: There are limited data regarding the efficacy of methylprednisolone in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) requiring invasive mechanical ventilation. We aimed to determine whether methylprednisolone increases the number of ventilator-free days (VFDs) among these patients. Design: Retrospective single-center study Setting: Intensive care unit Patients: All patients with ARDS due to confirmed SARS-CoV-2 infection and requiring invasive mechanical ventilation between 1 March and 29 May 2020 were included Interventions: None Measurements and Main Results: The primary outcome was ventilator-free days (VFDs) during the first 28 days, defined as being alive and free from mechanical ventilation. The primary outcome was analyzed with competing-risks regression based on Fine and Gray’s proportional subhazards model. Death before day 28 was considered to be the competing event. A total of 77 patients met the inclusion criteria. Thirty-two patients (41.6%) received methylprednisolone. The median dose was 1 mg.kg-1 (IQR: 1-1.3 mg.kg-1) and median duration of 5 days (IQR:5-7 days). Patients who received methylprednisolone had a mean 18.8 VFDs (95% CI, 16.6-20.9) during the first 28 days vs. 14.2 VFDs (95% CI, 12.6-16.7) in patients who did not receive methylprednisolone (difference, 4.61; 95% CI, 1.10-8.12; P = 0.001). In the multivariable competing-risks regression analysis and after adjusting for potential confounders (ventilator settings, prone position, organ failure support, severity of the disease, tocilizumab, and inflammatory markers), methylprednisolone was independently associated with a higher number of VFDs (subhazards ratio: 0.10, 95%CI: 0.02-0.45; p=0.003). Hospital mortality did not differ between the two groups (31.2% vs. 28.9%, p=0.82). Hospital length of stay was significantly shorter in the methylprednisolone group (24 days [IQR:15-41 days] vs. 37 days [IQR:23-52 days], p=0.046). The incidence of positive blood cultures was higher in patients who received methylprednisolone (37.5% vs. 17.8%, p=0.052). However, 91% of patients who received methylprednisolone also received tocilizumab. The number of days with hyperglycemia was similar in the two groups. Conclusions: Methylprednisolone was independently associated with increased VFDs and shortened hospital length of stay. The combination of methylprednisolone and tocilizumab was associated with a higher rate of positive blood cultures. Further trials are needed to evaluate the benefits and safety of methylprednisolone in moderate or severe COVID-19 ARDS.

Preprint ARTICLE | doi:10.20944/preprints201912.0239.v1

An Appropriate Amount of OptiCell Benefits the Microbial Diversity and Gut Health of Chickens

Linyue Hou, Baosheng Sun, Yu Yang

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: OptiCell; microbial diversity; gut microbiota; gut health; free-range chickens; caged chickens; SCFA; mucus layer; welfare

Online: 18 December 2019 (05:25:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0290.v1

A Recent Optimization and Advancement in the Development of Microwave-Assisted Extraction of Microbial Bioactive Compounds

Hassan Hadi Mehdi AL Rubaiy, Ammar Altemimi, Ali Khudair Jaber Al Rikabi, Uttpal Anand, Naoufal Lakhssassi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: microbial antioxidants; bioactive compounds; microwave extract; aspergillus flavus; rice, antioxidant compounds; free radical; phenolic compounds; temperatures

Online: 26 September 2019 (03:39:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0454.v1

Discovering the health promoting potential of fermented papaya preparation- its future perspectives for the dietary management of oxidative stress during diabetes

Jhoti Somanah-Bhugowandeen, Manish Putteeraj, Okezie Aruoma, Theeshan Bahorun

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Carica papaya; fermented papaya preparation (FPP); free radical scavenging; antioxidant; oxidative stress; anti-diabetic; anti-carcinogenic

Online: 24 July 2018 (11:39:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0009.v1

10m Sentinel-2A Cloud-Free Composite – Southern Africa 2016

Fabrizio Ramoino, Florin Tutunaru, Fabrizio Pera, Olivier Arino

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Sentinel-2; remote sensing; European Space Agency; Copernicus; continental; cloud-free; composite; darkest pixel; maximum NDVI

Online: 2 June 2017 (05:03:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0464.v1

Efficient Large-Scale Urban Parking Prediction: Graph Coarsening Based on Real-Time Parking Service Capability

Yixuan Wang, Zhenwu Chen, Kangshuai Zhang, Yunduan Cui, Lei Peng

Subject: Engineering, Transportation Science And Technology Keywords: Large-scale urban parking prediction; Real-time parking service capacity; Graph coarsening; Temporal convolutional autoencoder; Graph attention

Online: 5 September 2024 (12:07:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1051.v9

Energy Renormalization in a Berry Geometrical Phase: Low-Energy Perturbations of the Strong Interaction and the QCD Mass Gap

Mark Gibbons

Subject: Physical Sciences, Particle And Field Physics Keywords: Berry geometrical phase; dual superconductivity; scale- and gauge-invariance; hyperbolic curvature; strong gravity; renormalization; QCD mass gap

Online: 18 April 2024 (14:04:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0717.v1

A Novel Five-Surface Phosphor-in-Glass for High Illumination and Excellent Color Uniformity in Larger Scale LEDs

Hong-Wei Huang, Chien-Wei Huang, Yi-Chian Chen, Hsing-Kun Shih, Wei-Chih Cheng, Chun-Nien Liu, Chia-Chin Chiang

Subject: Engineering, Electrical And Electronic Engineering Keywords: Five-surface phosphor layer; phosphor-in-glass; laser engraving process; chip scale package; white light-emitting diode.

Online: 9 July 2024 (08:42:12 CEST)

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